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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

C7orf61 Gene

protein-coding GIFtS: 36
GCID: GC07M100054 (predicted)

chromosome 7 open reading frame 61

Search for C7orf61
in

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Chromosome 7 Open Reading Frame 61¹ ²
IMAGE:4839025¹
Uncharacterized Protein C7orf61²

External Ids:	HGNC: 22135¹	Entrez Gene: 402573²	Ensembl: ENSG00000185955⁷	UniProtKB: Q8IZ16³

Export aliases for C7orf61 gene to outside databases

Previous GC identifers: GC07M099893 GC07M094687

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000007.13 NC_018918.1 NT_007933.15 NT_079595.2

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the C7orf61 gene promoter:
SRF PPAR-gamma1 SRF (504 AA) PPAR-gamma2 ITF-2 Tal-1beta YY1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: C7orf61 promoter sequence

Search SABiosciences Chromatin IP Primers for C7orf61

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C7orf61

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q22.1 Ensembl cytogenetic band: 7q22.1 HGNC cytogenetic band: 7q22.1

C7orf61 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
C7orf61 gene location

GeneLoc information about chromosome 7 GeneLoc Exon Structure

GeneLoc location for GC07M100054: view genomic region (about GC identifiers)

Start:	100,054,238 bp from pter	End:	100,061,894 bp from pter
Size:	7,657 bases	Orientation:	minus strand

1 alternative location:

Chr7-,CRA_TCAG 99,414,322-99,421,978

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CG061_HUMAN, Q8IZ16 (See protein sequence)

Recommended Name: Uncharacterized protein C7orf61

Size: 206 amino acids; 23862 Da

Explore the universe of human proteins at neXtProt for C7orf61: NX_Q8IZ16

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q8IZ16

C7orf61 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_001004323.1

ENSEMBL proteins:

ENSP00000327732 ENSP00000412290

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ProtoNet protein and cluster: Q8IZ16

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Animal Models:

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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for C7orf61

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

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Search CenterWatch for drugs/clinical trials and news about C7orf61 / CG061

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for C7orf61 gene:

NM_001004323.1

Unigene Cluster for C7orf61:

Chromosome 7 open reading frame 61

Hs.632306 [show with all ESTs]

Unigene Representative Sequence: NM_001004323

2 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000332375(uc003uuz.1) ENST00000418952

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Additional cDNA sequence: BC031966.1

2 DOTS entries:

DT.308758 DT.100730752

24/355 AceView cDNA sequences (see all 355):

BU172117 CB122706 T34080 BQ229311 BF110010 BM695102 BE041417 BF110000

BQ221916 BF512593 BM919061 AW074091 BU956618 CR595620 CR612991 AW005084

BF110003 AI360926 AW028300 CA424090 NM_001004323 AI933069 CR600230 AA300675

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

C7orf61 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TATTCCAGTT

About this image

C7orf61 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 3 LifeMap Cells

Name

Category

PureStem™ endothelial progenitor 30-MV2-12 (Embryonic Progenitor Cell)

Blood, Endothelium

PureStem™ endothelial progenitor RP1-MV2-18 (Embryonic Progenitor Cell)

Endothelium

PureStem™ endothelial progenitor 30-MV2-14 (Embryonic Progenitor Cell)

Endothelium

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See C7orf61 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for C7orf61

SOURCE GeneReport for Unigene cluster: Hs.632306

SABiosciences Custom PCR Arrays for C7orf61

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In Situ
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

--

ENSEMBL Gene Tree for C7orf61 (if available)
TreeFam Gene Tree for C7orf61 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 7 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs116294489^1,2	F	--	100053819(+)	`CAGACG/ACACAA`	1	--	int¹		1		WA	118
rs192739886^1,2		--	100053880(+)	`GTAGTA/GGGCTA`	1	--	int¹		0	--	--	--	--
rs115576077^1,2		--	100053958(+)	`CCTAAA/TTACCT`	1	--	int¹		1		WA	118
rs7778122^1,2	C,F,H	--	100054057(+)	`TTACAA/GACAGG`	1	--	int¹		9		NS NA WA	1012
rs184040057^1,2		--	100054103(+)	`AGAAAC/TGTGCT`	1	--	int¹		0	--	--	--	--
rs73161772^1,2	C,F	--	100054177(+)	`GGGGTC/TTCTCC`	1	--	int¹		1		NA	120
rs201441317^1,2	C	--	100054503(+)	`CCGAAC/TGGCCC`	2	I V	mis¹		0	--	--	--	--
rs200188453^1,2		--	100054569(+)	`CTGCGC/TCCTCA`	2	T A	mis¹		0	--	--	--	--
rs199738450^1,2		--	100054627(+)	`AGAAGA/GTGTGC`	1	--	int¹		0	--	--	--	--
rs201450357^1,2		--	100054636(+)	`GCATGC/TGTAAA`	1	--	int¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for C7orf61 (100054238 - 100061894 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for C7orf61
1 CNV: 4549

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for C7orf61 gene integrated from 9 sources:
(articles sorted by number of sources associating them with C7orf61)

Utopia: connect your pdf to the dynamic
world of online information

Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)^{1, 2, 3} Scherer S.W.... Tsui L.-C. (2003)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)^{1, 3} Strausberg R.L....Marra M.A. (2002)
hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)¹ Lamesch P.... Vidal M. (2007)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)² Gerhard D.S....Malek J. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 402573	HGNC: 22135	AceView: THG-1andMGC43036	Ensembl:ENSG00000185955	euGenes: HUgn402573
ECgene: C7orf61	H-InvDB: C7orf61

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for C7orf61	Pharmacogenomics, SNPs, Pathways

Intellectual Property for C7orf61 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for C7orf61 gene:
Search GeneIP for patents involving C7orf61

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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About This Section


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C7orf61 Gene

chromosome 7 open reading frame 61

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C7orf61 Gene

chromosome 7 open reading frame 61

Aliasesfor C7orf61 gene

Summariesfor C7orf61 gene

Genomic Viewsfor C7orf61 gene

Proteinsfor C7orf61 gene

Protein Domains /Familiesfor C7orf61 gene

Functionfor C7orf61 gene

Pathways & Interactionsfor C7orf61 gene

Drugs & Compoundsfor C7orf61 gene

Transcriptsfor C7orf61 gene

Expression for C7orf61 gene

Orthologsfor C7orf61 gene

Paralogsfor C7orf61 gene

Genomic Variantsfor C7orf61 gene

Disorders / Diseasesfor C7orf61 gene

Publicationsfor C7orf61 gene

External Searches for C7orf61 gene

Genome Databases showing C7orf61 gene

Other Databases showing C7orf61 gene

Specialized Databases showing C7orf61 gene

Intellectual Propertyfor C7orf61 gene

Productsfor C7orf61 gene

View Random Gene

Aliases
for C7orf61 gene

Summaries
for C7orf61 gene

Genomic Views
for C7orf61 gene

Proteins
for C7orf61 gene

Protein Domains /
Families
for C7orf61 gene

Function
for C7orf61 gene

Pathways & Interactions
for C7orf61 gene

Drugs & Compounds
for C7orf61 gene

Transcripts
for C7orf61 gene

Expression
for C7orf61 gene

Orthologs
for C7orf61 gene

Paralogs
for C7orf61 gene

Genomic Variants
for C7orf61 gene

Disorders / Diseases
for C7orf61 gene

Publications
for C7orf61 gene

Intellectual Property
for C7orf61 gene

Products
for C7orf61 gene