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Aliases for C7orf60 Gene

Aliases for C7orf60 Gene

  • Chromosome 7 Open Reading Frame 60 2 3
  • Hypothetical Protein FLJ31818 2
  • EC 2.1.1.- 4

External Ids for C7orf60 Gene

Previous GeneCards Identifiers for C7orf60 Gene

  • GC07M112247
  • GC07M112459
  • GC07M106827

Summaries for C7orf60 Gene

GeneCards Summary for C7orf60 Gene

C7orf60 (Chromosome 7 Open Reading Frame 60) is a Protein Coding gene. GO annotations related to this gene include methyltransferase activity.

UniProtKB/Swiss-Prot for C7orf60 Gene

  • Probable S-adenosyl-L-methionine-dependent methyltransferase.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C7orf60 Gene

Genomics for C7orf60 Gene

Regulatory Elements for C7orf60 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for C7orf60 Gene

Start:
112,819,147 bp from pter
End:
112,939,916 bp from pter
Size:
120,770 bases
Orientation:
Minus strand

Genomic View for C7orf60 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for C7orf60 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C7orf60 Gene

Proteins for C7orf60 Gene

  • Protein details for C7orf60 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q1RMZ1-BMT2_HUMAN
    Recommended name:
    Probable methyltransferase BTM2 homolog
    Protein Accession:
    Q1RMZ1
    Secondary Accessions:
    • Q8N3D0
    • Q96MV7

    Protein attributes for C7orf60 Gene

    Size:
    405 amino acids
    Molecular mass:
    46324 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB71169.1; Type=Frameshift; Positions=259; Evidence={ECO:0000305};

neXtProt entry for C7orf60 Gene

Proteomics data for C7orf60 Gene at MOPED

Post-translational modifications for C7orf60 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C7orf60 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for C7orf60 Gene

Domains for C7orf60 Gene

Protein Domains for C7orf60 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for C7orf60 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q1RMZ1

UniProtKB/Swiss-Prot:

BMT2_HUMAN :
  • Q1RMZ1
Family:
  • Belongs to the BMT2 family.
genes like me logo Genes that share domains with C7orf60: view

No data available for Gene Families for C7orf60 Gene

Function for C7orf60 Gene

Molecular function for C7orf60 Gene

UniProtKB/Swiss-Prot Function: Probable S-adenosyl-L-methionine-dependent methyltransferase.

Enzyme Numbers (IUBMB) for C7orf60 Gene

Gene Ontology (GO) - Molecular Function for C7orf60 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016433 rRNA (adenine) methyltransferase activity IEA --
genes like me logo Genes that share ontologies with C7orf60: view

Animal Model Products

CRISPR Products

miRNA for C7orf60 Gene

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for C7orf60

In Situ Assay Products

Flow Cytometry Products

No data available for Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for C7orf60 Gene

Localization for C7orf60 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for C7orf60 Gene COMPARTMENTS Subcellular localization image for C7orf60 gene
Compartment Confidence
cytosol 2
nucleus 2
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for C7orf60 Gene

Pathways for C7orf60 Gene

SuperPathways for C7orf60 Gene

No Data Available

Interacting Proteins for C7orf60 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000297145%0d%0a9606.ENSP00000261758%0d%0a
Selected Interacting proteins: ENSP00000297145 for C7orf60 Gene via STRING

Symbol External ID(s) Details
MESDC2

Gene Ontology (GO) - Biological Process for C7orf60 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0031167 rRNA methylation IEA --
genes like me logo Genes that share ontologies with C7orf60: view

No data available for Pathways by source for C7orf60 Gene

Transcripts for C7orf60 Gene

mRNA/cDNA for C7orf60 Gene

Unigene Clusters for C7orf60 Gene

Chromosome 7 open reading frame 60:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for C7orf60

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for C7orf60

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for C7orf60 Gene

No ASD Table

Relevant External Links for C7orf60 Gene

GeneLoc Exon Structure for
C7orf60
ECgene alternative splicing isoforms for
C7orf60

Expression for C7orf60 Gene

mRNA expression in normal human tissues for C7orf60 Gene

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for C7orf60 Gene

SOURCE GeneReport for Unigene cluster for C7orf60 Gene Hs.489734

genes like me logo Genes that share expressions with C7orf60: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for C7orf60 Gene

Orthologs for C7orf60 Gene

This gene was present in the common ancestor of animals.

Orthologs for C7orf60 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C7orf60 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia C4H7orf60 35
  • 95.14 (n)
  • 96.3 (a)
C7orf60 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C14H7orf60 35
  • 94.24 (n)
  • 96.79 (a)
C7orf60 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia B630005N14Rik 35
  • 89.5 (n)
  • 94.54 (a)
B630005N14Rik 16
B630005N14Rik 36
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia C7orf60 36
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia C7orf60 36
  • 93 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC500034 35
  • 90.16 (n)
  • 96.28 (a)
chicken
(Gallus gallus)
Aves C1H7ORF60 35
  • 80.89 (n)
  • 88.09 (a)
C1H7ORF60 36
  • 89 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia C7orf60 36
  • 71 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.7372 35
tropical clawed frog
(Silurana tropicalis)
Amphibia c7orf60 35
  • 72.92 (n)
  • 76.14 (a)
Str.2026 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.858 35
zebrafish
(Danio rerio)
Actinopterygii C25H7orf60 36
  • 71 (a)
OneToOne
zgc:153606 35
  • 68.36 (n)
  • 75.67 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008978 35
  • 47.33 (n)
  • 40.96 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG3570 35
  • 43.37 (n)
  • 36.92 (a)
CG3570 36
  • 31 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 43 (a)
OneToOne
Species with no ortholog for C7orf60:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C7orf60 Gene

ENSEMBL:
Gene Tree for C7orf60 (if available)
TreeFam:
Gene Tree for C7orf60 (if available)

Paralogs for C7orf60 Gene

No data available for Paralogs for C7orf60 Gene

Variants for C7orf60 Gene

Sequence variations from dbSNP and Humsavar for C7orf60 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs9810 -- 112,819,410(+) ATTCT(C/T)AGGAG utr-variant-3-prime
rs494324 -- 112,892,583(+) gggca(A/C)tatag intron-variant
rs498377 -- 112,907,319(-) tttgg(G/T)ctttc intron-variant
rs500280 -- 112,876,088(+) CCCAA(A/G)TAACT intron-variant
rs501621 -- 112,886,785(+) ccccc(A/G)cacag intron-variant

Structural Variations from Database of Genomic Variants (DGV) for C7orf60 Gene

Variant ID Type Subtype PubMed ID
esv2422365 CNV Duplication 17116639
nsv464689 CNV Gain 19166990
nsv7405 OTHER Inversion 18451855
esv2752144 CNV Gain 17911159
esv2752145 CNV Gain 17911159
nsv5905 CNV Loss 18451855
esv2735042 CNV Deletion 23290073
dgv2130e1 CNV Complex 17122850
nsv483110 CNV Loss 15286789
esv2735043 CNV Deletion 23290073
esv2665494 CNV Deletion 23128226
nsv499470 CNV Loss 21111241
esv2421832 CNV Deletion 20811451
nsv442063 CNV CNV 18776908
dgv1129n67 CNV Loss 20364138
nsv514443 CNV Loss 21397061

Relevant External Links for C7orf60 Gene

HapMap Linkage Disequilibrium report
C7orf60
Human Gene Mutation Database (HGMD)
C7orf60

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C7orf60 Gene

Disorders for C7orf60 Gene

Relevant External Links for C7orf60

Genetic Association Database (GAD)
C7orf60
Human Genome Epidemiology (HuGE) Navigator
C7orf60
genes like me logo Genes that share disorders with C7orf60: view

No data available for UniProtKB/Swiss-Prot for C7orf60 Gene

Publications for C7orf60 Gene

  1. Conduct disorder and ADHD: evaluation of conduct problems as a categorical and quantitative trait in the international multicentre ADHD genetics study. (PMID: 18951430) Anney R.J. … Gill M. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2008) 3 48
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for C7orf60 Gene

Sources for C7orf60 Gene

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