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C7orf55-LUC7L2 Gene

protein-coding   GIFtS: 23
GCID: GC07P139041

C7orf55-LUC7L2 Readthrough

  Search for C7orf55-LUC7L2
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
C7orf55-LUC7L2 Readthrough1 2
C7orf55-LUC7L2 Protein2

External Ids:    HGNC: 446711   Entrez Gene: 1009969282   Ensembl: ENSG000001469637   UniProtKB: Q9Y3833   

Export aliases for C7orf55-LUC7L2 gene to outside databases

Previous GC identifers: GC07P139031 GC07P139036


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for C7orf55-LUC7L2 Gene:
This locus represents naturally occurring readthrough transcription between the neighboring C7orf55 (chromosome 7
open reading frame 55) and LUC7L2 (LUC7-like 2) genes on chromosome 7. The readthrough transcript encodes a
fusion protein that shares sequence identity with each individual gene product. (provided by RefSeq, Jul 2012)

GeneCards Summary for C7orf55-LUC7L2 Gene:
C7orf55-LUC7L2 (C7orf55-LUC7L2 readthrough) is a protein-coding gene. An important paralog of this gene is LUC7L.

UniProtKB/Swiss-Prot: LC7L2_HUMAN, Q9Y383
Function: May bind to RNA via its Arg/Ser-rich domain




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Search for regulatory transcription factor binding sites for C7orf55-LUC7L2
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for C7orf55-LUC7L2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat C7orf55-LUC7L2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q   Ensembl cytogenetic band:  7q34   HGNC cytogenetic band: 7q34

C7orf55-LUC7L2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
C7orf55-LUC7L2 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P139041:  view genomic region     (about GC identifiers)

Start:
139,025,105 bp from pter      End:
139,108,198 bp from pter
Size:
83,094 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: LC7L2_HUMAN, Q9Y383 (See protein sequence)
Recommended Name: Putative RNA-binding protein Luc7-like 2  
Size: 392 amino acids; 46514 Da
Subunit: Interacts with SCNM1 (By similarity)
Sequence caution: Sequence=AAD34069.1; Type=Frameshift; Positions=388;
Secondary accessions: B7Z500 Q8IUP9 Q9NVL3 Q9NVN7 Q9UQN1
Alternative splicing: 3 isoforms:  Q9Y383-1   Q9Y383-2   Q9Y383-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for C7orf55-LUC7L2: NX_Q9Y383

Explore proteomics data for C7orf55-LUC7L2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See C7orf55-LUC7L2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001231513.1  
    ENSEMBL proteins: 
     ENSP00000441604   ENSP00000477492   ENSP00000347005   ENSP00000393012   ENSP00000263545  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR004882 Luc7-rel

    Graphical View of Domain Structure for InterPro Entry Q9Y383

    ProtoNet protein and cluster: Q9Y383

    UniProtKB/Swiss-Prot: LC7L2_HUMAN, Q9Y383
    Similarity: Belongs to the Luc7 family


    C7orf55-LUC7L2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: LC7L2_HUMAN, Q9Y383
    Function: May bind to RNA via its Arg/Ser-rich domain

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003729mRNA binding ----
    GO:0005515protein binding ----
    GO:0019899enzyme binding ----
         
    C7orf55-LUC7L2 for ontologies           About GeneDecksing


    Animal Models:
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    LC7L2_HUMAN, Q9Y383: Nucleus speckle (By similarity). Nucleus, nucleoplasm (By similarity). Note=Colocalizes with
    SCNM1 and SNRNP70 in nuclear speckles (By similarity)

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005685U1 snRNP ----
    GO:0016607nuclear speck ----

    C7orf55-LUC7L2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for C7orf55-LUC7L2
    Interactions:

        Search GeneGlobe Interaction Network for C7orf55-LUC7L2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for C7orf55-LUC7L2 (Q9Y3831, 2, 3 ENSP000003470054) via UniProtKB, MINT, STRING, and/or I2D (see all 710)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MAP1LC3BQ9GZQ81, 2, 3EBI-352851,EBI-373144 MINT-8259668 MINT-65406 I2D: score=6 
    GADD45GO952572, 3, ENSP000002525064MINT-8256206 MINT-3979205 I2D: score=5 STRING: ENSP00000252506
    CHD3Q128732, 3MINT-7945693 MINT-65822 I2D: score=5 
    NSFP464592, 3MINT-7945693 MINT-64921 I2D: score=5 
    NUTF2P619702, 3, ENSP000002191694MINT-63951 I2D: score=5 STRING: ENSP00000219169
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006376mRNA splice site selection ----

    C7orf55-LUC7L2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for C7orf55-LUC7L2 (LC7L2)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for C7orf55-LUC7L2 gene: 
    NM_001244584.2  

    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000541170 ENST00000608368 ENST00000435096 ENST00000354926(uc003vux.3 uc003vuy.3)
    ENST00000456182 ENST00000463912(uc003vuz.1) ENST00000498518(uc003vva.3)
    ENST00000482860 ENST00000263545(uc011kqs.2 uc011kqt.2)
    miRNA
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    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for C7orf55-LUC7L2 (see all 11)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10a · 10b · 10c ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16a ·
    SP1:                                -     -     -     -     -     -     -     -     -                                                                           
    SP2:                                                                                                                                                            
    SP3:                                -     -           -     -     -     -     -     -                                                                           
    SP4:                                -     -           -     -                                                                                                   
    SP5:                                -     -     -     -     -     -           -     -                                                                           

    ExUns: 16b
    SP1:      
    SP2:      
    SP3:      
    SP4:      
    SP5:      


    ECgene alternative splicing isoforms for C7orf55-LUC7L2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    See probesets specificity/sensitivity at GeneAnnot
    CGAP TAG: --

    C7orf55-LUC7L2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    C7orf55-LUC7L2 Protein Expression
        Custom PCR Arrays for C7orf55-LUC7L2
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for C7orf55-LUC7L2 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves LUC7L26
    Gallus gallus LUC7-like 2 (S. cerevisiae) (LUC7L2)...
    89(a)
    1 → many
    1(48977566-49008823)
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    90(a)
    1 → many
    GL343614.1(225716-254675)
    zebrafish
    (Danio rerio)
    Actinopterygii C1H7orf556
    C7orf55-LUC7L2 readthrough
    63(a)
    1 → many
    1(55708458-55722416) ENSDARG00000019765
    fruit fly
    (Drosophila melanogaster)
    Insecta CG75646
    --
    47(a)
    1 → many
    3L(17507398-17510036)
    worm
    (Caenorhabditis elegans)
    Secernentea B0495.86
    Protein B0495.8, isoform a
    35(a)
    1 → many
    II(7705535-7707483) WBGene00015207
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes LUC76
    Essential protein associated with the U1 snRNP com...
    29(a)
    1 → many
    IV(300214-300999) YDL087C
            Species with no ortholog for C7orf55-LUC7L2

    ENSEMBL Gene Tree for C7orf55-LUC7L2 (if available)
    TreeFam Gene Tree for C7orf55-LUC7L2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for C7orf55-LUC7L2 gene
    LUC7L2  LUC7L32  
    2 SIMAP similar genes for C7orf55-LUC7L2 using alignment to 2 protein entries:     F8WEU3_HUMAN (see all proteins):
    CGI-59    LUC7L

    C7orf55-LUC7L2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing C7orf55-LUC7L2
    DNA2.0 Custom Variant and Variant Library Synthesis for C7orf55-LUC7L2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for C7orf55-LUC7L2 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with C7orf55-LUC7L2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The DNA sequence of human chromosome 7. (PubMed id 12853948)1, 2 Hillier L.W.... Wilson R.K. (Nature 2003)
    2. Expression of conjoined genes: another mechanism for gene regulation in eukaryotes. (PubMed id 20967262)1 Prakash T....Taylor T.D. (PLoS ONE 2010)
    3. Jmjd6 catalyses lysyl-hydroxylation of U2AF65, a protein associated with RNA splicing. (PubMed id 19574390)2 Webby C.J....Boettger A. (Science 2009)
    4. A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (Proc. Natl. Acad. Sci. U.S.A. 2008)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (Nat. Genet. 2004)
    7. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PubMed id 10810093)2 Lai C.-H.... Lin W.-C. (Genome Res. 2000)
    8. Toward a complete human genome sequence. (PubMed id 9847074)1 Sulston J.E. and Waterston R. (Genome Res. 1998)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 100996928 HGNC: 44671 Ensembl:ENSG00000146963 euGenes: HUgn100996928 ECgene: C7orf55-LUC7L2
    H-InvDB: C7orf55-LUC7L2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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      --

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for C7orf55-LUC7L2 gene:
    Search GeneIP for patents involving C7orf55-LUC7L2

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