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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

C7orf55-LUC7L2 Gene

protein-coding   GIFtS: 22
GCID: GC07P139031

C7orf55-LUC7L2 readthrough
  Search for C7orf55-LUC7L2
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Aliases
for C7orf55-LUC7L2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
C7orf55-LUC7L2 Readthrough1 2
C7orf55-LUC7L2 Protein2

External Ids:    HGNC: 446711   Entrez Gene: 1009969282   Ensembl: ENSG000001469637   UniProtKB: Q9Y3833   

Export aliases for C7orf55-LUC7L2 gene to outside databases


Summaries
for C7orf55-LUC7L2 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for C7orf55-LUC7L2:
This locus represents naturally occurring readthrough transcription between the neighboring C7orf55 (chromosome 7 open
reading frame 55) and LUC7L2 (LUC7-like 2) genes on chromosome 7. The readthrough transcript encodes a fusion protein
that shares sequence identity with each individual gene product. (provided by RefSeq, Jul 2012)

UniProtKB/Swiss-Prot: LC7L2_HUMAN, Q9Y383
Function: May bind to RNA via its Arg/Ser-rich domain




Genomic Views
for C7orf55-LUC7L2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
 Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for C7orf55-LUC7L2
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for C7orf55-LUC7L2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C7orf55-LUC7L2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q   Ensembl cytogenetic band:  7q34   HGNC cytogenetic band: 7q34

C7orf55-LUC7L2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
C7orf55-LUC7L2 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P139031:  view genomic region     (about GC identifiers)

Start:
 139,025,105 bp from pter      End:
 139,108,200 bp from pter
Size:
 83,096 bases      Orientation:
 plus strand

Proteins
for C7orf55-LUC7L2 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: LC7L2_HUMAN, Q9Y383 (See protein sequence)
Recommended Name: Putative RNA-binding protein Luc7-like 2  
Size: 392 amino acids; 46514 Da
Subunit: Interacts with SCNM1 (By similarity)
Subcellular location: Nucleus speckle (By similarity). Nucleus, nucleoplasm (By similarity). Note=Colocalizes with
SCNM1 and SNRNP70 in nuclear speckles (By similarity)
Sequence caution: Sequence=AAD34069.1; Type=Frameshift; Positions=388;
Secondary accessions: B7Z500 Q8IUP9 Q9NVL3 Q9NVN7 Q9UQN1
Alternative splicing: 3 isoforms:  Q9Y383-1   Q9Y383-2   Q9Y383-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for C7orf55-LUC7L2: NX_Q9Y383

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9Y383

    • C7orf55-LUC7L2 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_001231513.1  
    ENSEMBL proteins: 
     ENSP00000393173   ENSP00000410850   ENSP00000347005   ENSP00000393012   ENSP00000440222  
     ENSP00000440433   ENSP00000441604   ENSP00000263545  

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    Protein Domains /
    Families
    for C7orf55-LUC7L2 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    C7orf55-LUC7L2 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR004882 LUC7-rel

    Graphical View of Domain Structure for InterPro Entry Q9Y383

    ProtoNet protein and cluster: Q9Y383

    UniProtKB/Swiss-Prot: LC7L2_HUMAN, Q9Y383
    Similarity: Belongs to the Luc7 family


    Function
    for C7orf55-LUC7L2 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: LC7L2_HUMAN, Q9Y383
    Function: May bind to RNA via its Arg/Ser-rich domain

    miRNA
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    In Situ Assay
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    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0019899enzyme binding ----
    GO:0046872metal ion binding ----


    C7orf55-LUC7L2 for ontologies           About GeneDecksing



    Pathways & Interactions
    for C7orf55-LUC7L2 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for C7orf55-LUC7L2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/635 Interacting proteins for C7orf55-LUC7L2 (Q9Y3831, 2, 3 ENSP000003470054) via UniProtKB, MINT, STRING, and/or I2D (see all 635)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GADD45GO952572, 3, ENSP000002525064MINT-8256206 MINT-3979205 I2D: score=5 STRING: ENSP00000252506
    MAP1LC3BQ9GZQ82, 3MINT-8259668 MINT-65406 I2D: score=6 
    CHD3Q128732, 3MINT-7945693 MINT-65822 I2D: score=5 
    NSFP464592, 3MINT-7945693 MINT-64921 I2D: score=5 
    NUTF2P619702, 3, ENSP000002191694MINT-63951 I2D: score=5 STRING: ENSP00000219169
    About this table

    Drugs & Compounds
    for C7orf55-LUC7L2 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for C7orf55-LUC7L2
    Search CenterWatch for drugs/clinical trials and news about C7orf55-LUC7L2 / LC7L2 

    Transcripts
    for C7orf55-LUC7L2 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for C7orf55-LUC7L2 gene: 
    NM_001244584.2  

    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000448820 ENST00000435096 ENST00000354926(uc003vux.3 uc003vuy.3)
    ENST00000456182 ENST00000463912(uc003vuz.1) ENST00000498518(uc003vva.3)
    ENST00000482860 ENST00000541515 ENST00000545899 ENST00000541170 ENST00000263545(uc011kqs.2 uc011kqt.2)


    miRNA
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    Inhib. RNA
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    Primer
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      Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat C7orf55-LUC7L2

    GeneLoc Exon Structure

    5/11 Alternative Splicing Database (ASD) splice patterns (SP) for C7orf55-LUC7L2 (see all 11)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10a · 10b · 10c ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16a ·
    SP1:                                -     -     -     -     -     -     -     -     -                                                                           
    SP2:                                                                                                                                                            
    SP3:                                -     -           -     -     -     -     -     -                                                                           
    SP4:                                -     -           -     -                                                                                                   
    SP5:                                -     -     -     -     -     -           -     -                                                                           

    ExUns: 16b
    SP1:      
    SP2:      
    SP3:      
    SP4:      
    SP5:      


    ECgene alternative splicing isoforms for C7orf55-LUC7L2

    Expression
    for C7orf55-LUC7L2 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section
    		 See probesets specificity/sensitivity at GeneAnnot
    CGAP TAG: --

    See C7orf55-LUC7L2 Protein Expression from SPIRE MOPED and PaxDB    SABiosciences Custom PCR Arrays for C7orf55-LUC7L2
    Primer
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    In Situ
    Assay Products:     
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    Orthologs
    for C7orf55-LUC7L2 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for C7orf55-LUC7L2 gene from 7/23 species (see all 23)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves Q5ZLW7_CHICK6
    		 LUC7-like 2
    		 91(a)
    		 1 ↔ 1
    		 1(51011943-51034693)
    lizard
    (Anolis carolinensis)    		 Reptilia LUC7L26
    		 --
    		 75(a)
    		 1 ↔ 1
    		 GL343614.1(225716-264359)
    zebrafish
    (Danio rerio)    		 Actinopterygii zgc:1588036
    		 zgc:158803
    		 62(a)
    		 1 ↔ 1
    		 1(55708458-55722416)
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG75646
    		 --
    		 46(a)
    		 1 → many
    		 3L(17507398-17510036)
    worm
    (Caenorhabditis elegans)    		 Secernentea B0495.86
    		 Uncharacterized protein B0495.8
    		 30(a)
    		 1 → many
    		 II(7705482-7707430)
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons UNE66
    AT5G174406
    		 LUC7 related protein
    		 28(a)
    27(a)
    		 many ↔ many
    many ↔ many
    		 3(786320-790077)
    5(5749762-5753643)
    rice
    (Oryza sativa)    		 Liliopsida --
    --
    		 RNA-binding protein Luc7-like, putative, expressed...
    RNA-binding protein Luc7-like, putative, expressed...
    		 29(a)
    26(a)
    		 many ↔ many
    many ↔ many
    		 3(35439307-35445340)
    2(23723380-23728528)


    ENSEMBL Gene Tree for C7orf55-LUC7L2 (if available)
    TreeFam Gene Tree for C7orf55-LUC7L2 (if available) 

    Paralogs
    for C7orf55-LUC7L2 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for C7orf55-LUC7L2 gene
    SREK12  LUC7L2  SRSF112  RSRC22  LUC7L32  ZC3H132  PNISR2  RBM252  
    PRPF38B2  TRAF3IP12  

    C7orf55-LUC7L2 for paralogs           About GeneDecksing



    Genomic Variants
    for C7orf55-LUC7L2 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section
    SABiosciences Cancer Mutation PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing C7orf55-LUC7L2
    DNA2.0 Custom Variant and Variant Library Synthesis for C7orf55-LUC7L2

    Disorders / Diseases
    for C7orf55-LUC7L2 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    		   --

    Publications
    for C7orf55-LUC7L2 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for C7orf55-LUC7L2 gene, integrated from 9 sources (see all 13):
    (articles sorted by number of sources associating them with C7orf55-LUC7L2)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. The DNA sequence of human chromosome 7. (PubMed id 12853948)1, 2 Hillier L.W.... Wilson R.K. (2003)
    2. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    3. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (2011)
    4. Expression of conjoined genes: another mechanism for gene regulation in eukaryotes. (PubMed id 20967262)1 Prakash T....Taylor T.D. (2010)
    5. Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (2010)
    6. Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (2009)
    7. Jmjd6 catalyses lysyl-hydroxylation of U2AF65, a protein associated with RNA splicing. (PubMed id 19574390)2 Webby C.J....Boettger A. (2009)
    8. A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (2008)
    9. ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage. (PubMed id 17525332)2 Matsuoka S.... Elledge S.J. (2007)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)

    External Searches for C7orf55-LUC7L2 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
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    Genome Databases showing C7orf55-LUC7L2 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 100996928 HGNC: 44671 Ensembl:ENSG00000146963 euGenes: HUgn100996928 ECgene: C7orf55-LUC7L2
    H-InvDB: C7orf55-LUC7L2

    Other Databases showing C7orf55-LUC7L2 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing C7orf55-LUC7L2 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    		   --

    Intellectual Property
    for C7orf55-LUC7L2 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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