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Aliases for C7orf55-LUC7L2 Gene

Aliases for C7orf55-LUC7L2 Gene

  • C7orf55-LUC7L2 Readthrough 2 3 5

External Ids for C7orf55-LUC7L2 Gene

Previous GeneCards Identifiers for C7orf55-LUC7L2 Gene

  • GC07P139031
  • GC07P139036
  • GC07P139041
  • GC07P139342
  • GC07P139343
  • GC07P139345
  • GC07P139346
  • GC07P139348
  • GC07P139350

Summaries for C7orf55-LUC7L2 Gene

Entrez Gene Summary for C7orf55-LUC7L2 Gene

  • This locus represents naturally occurring readthrough transcription between the neighboring C7orf55 (chromosome 7 open reading frame 55) and LUC7L2 (LUC7-like 2) genes on chromosome 7. The readthrough transcript encodes a fusion protein that shares sequence identity with each individual gene product. [provided by RefSeq, Jul 2012]

GeneCards Summary for C7orf55-LUC7L2 Gene

C7orf55-LUC7L2 (C7orf55-LUC7L2 Readthrough) is a Protein Coding gene. GO annotations related to this gene include poly(A) RNA binding and mRNA binding. An important paralog of this gene is LUC7L2.

Additional gene information for C7orf55-LUC7L2 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C7orf55-LUC7L2 Gene

Genomics for C7orf55-LUC7L2 Gene

Regulatory Elements for C7orf55-LUC7L2 Gene

Enhancers for C7orf55-LUC7L2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07H139339 1.5 ENCODE dbSUPER 0.7 +0.2 153 3 MLX DMAP1 YY1 ZNF143 SP3 NFYC ZC3H11A MEF2D SSRP1 ZNF610 LUC7L2 UBN2 ENSG00000273391 TTC26 KLRG2 LOC100499191 C7orf55-LUC7L2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around C7orf55-LUC7L2 on UCSC Golden Path with GeneCards custom track

Promoters for C7orf55-LUC7L2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000218930 -131 2800 MLX DMAP1 YY1 ZNF143 SP3 NFYC ZC3H11A MEF2D SSRP1 ZNF610

Genomic Location for C7orf55-LUC7L2 Gene

Chromosome:
7
Start:
139,341,132 bp from pter
End:
139,423,457 bp from pter
Size:
82,326 bases
Orientation:
Plus strand

Genomic View for C7orf55-LUC7L2 Gene

Genes around C7orf55-LUC7L2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C7orf55-LUC7L2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C7orf55-LUC7L2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C7orf55-LUC7L2 Gene

Proteins for C7orf55-LUC7L2 Gene

  • Protein details for C7orf55-LUC7L2 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    A0A0A6YYJ8
    Recommended name:
    Putative RNA-binding protein Luc7-like 2
    Protein Accession:
    A0A0A6YYJ8

    Protein attributes for C7orf55-LUC7L2 Gene

    Size:
    458 amino acids
    Molecular mass:
    54224 Da
    Quaternary structure:
    No Data Available

neXtProt entry for C7orf55-LUC7L2 Gene

Protein Expression for C7orf55-LUC7L2 Gene

Post-translational modifications for C7orf55-LUC7L2 Gene

No Post-translational modifications

Other Protein References for C7orf55-LUC7L2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for C7orf55-LUC7L2 Gene

Domains & Families for C7orf55-LUC7L2 Gene

Gene Families for C7orf55-LUC7L2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for C7orf55-LUC7L2 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C7orf55-LUC7L2: view

No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for C7orf55-LUC7L2 Gene

Function for C7orf55-LUC7L2 Gene

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C7orf55-LUC7L2 Gene

Localization for C7orf55-LUC7L2 Gene

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for C7orf55-LUC7L2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005685 U1 snRNP IEA --
genes like me logo Genes that share ontologies with C7orf55-LUC7L2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from COMPARTMENTS for C7orf55-LUC7L2 Gene

Pathways & Interactions for C7orf55-LUC7L2 Gene

SuperPathways for C7orf55-LUC7L2 Gene

No Data Available

Interacting Proteins for C7orf55-LUC7L2 Gene

Gene Ontology (GO) - Biological Process for C7orf55-LUC7L2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006376 mRNA splice site selection IEA --
genes like me logo Genes that share ontologies with C7orf55-LUC7L2: view

No data available for Pathways by source and SIGNOR curated interactions for C7orf55-LUC7L2 Gene

Drugs & Compounds for C7orf55-LUC7L2 Gene

No Compound Related Data Available

Transcripts for C7orf55-LUC7L2 Gene

mRNA/cDNA for C7orf55-LUC7L2 Gene

(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for C7orf55-LUC7L2 Gene

No ASD Table

Relevant External Links for C7orf55-LUC7L2 Gene

GeneLoc Exon Structure for
C7orf55-LUC7L2
ECgene alternative splicing isoforms for
C7orf55-LUC7L2

Expression for C7orf55-LUC7L2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for C7orf55-LUC7L2 Gene

Protein differential expression in normal tissues from HIPED for C7orf55-LUC7L2 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (11.1) and Heart (9.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from MaxQB and MOPED for C7orf55-LUC7L2 Gene



Protein tissue co-expression partners for C7orf55-LUC7L2 Gene

- Elite partner
genes like me logo Genes that share expression patterns with C7orf55-LUC7L2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for C7orf55-LUC7L2 Gene

Orthologs for C7orf55-LUC7L2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for C7orf55-LUC7L2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia -- 34
  • 98 (a)
OneToMany
dog
(Canis familiaris)
Mammalia LUC7L2 34
  • 98 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Luc7l2 34
  • 95 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 93 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 85 (a)
OneToMany
chicken
(Gallus gallus)
Aves LUC7L2 34
  • 85 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 86 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii C1H7orf55 34
  • 59 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG7564 34
  • 44 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea B0495.8 34
  • 33 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes LUC7 34
  • 27 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 58 (a)
OneToMany
Species where no ortholog for C7orf55-LUC7L2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for C7orf55-LUC7L2 Gene

ENSEMBL:
Gene Tree for C7orf55-LUC7L2 (if available)
TreeFam:
Gene Tree for C7orf55-LUC7L2 (if available)

Paralogs for C7orf55-LUC7L2 Gene

Paralogs for C7orf55-LUC7L2 Gene

(2) SIMAP similar genes for C7orf55-LUC7L2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with C7orf55-LUC7L2: view

Variants for C7orf55-LUC7L2 Gene

Sequence variations from dbSNP and Humsavar for C7orf55-LUC7L2 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs1000078372 -- 139,356,027(+) AACCA(C/T)TGGGC intron-variant
rs1000154260 -- 139,366,595(+) CGATT(C/T)ATATA intron-variant
rs1000162485 -- 139,359,653(+) GCCAG(A/C)CCTAC intron-variant, upstream-variant-2KB
rs1000163825 -- 139,379,124(+) TGCTG(A/G)AATTA intron-variant
rs1000174566 -- 139,339,878(+) GACAC(A/G)GCACA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for C7orf55-LUC7L2 Gene

Variant ID Type Subtype PubMed ID
esv2292861 CNV deletion 18987734
esv2371727 CNV deletion 18987734
esv2735212 CNV deletion 23290073
esv2735231 CNV deletion 23290073
esv3572165 CNV loss 25503493
esv3572166 CNV loss 25503493
nsv1110976 OTHER inversion 24896259
nsv1117762 CNV deletion 24896259
nsv1137296 CNV deletion 24896259
nsv478581 CNV novel sequence insertion 20440878

Variation tolerance for C7orf55-LUC7L2 Gene

Residual Variation Intolerance Score: 22.8% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C7orf55-LUC7L2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
C7orf55-LUC7L2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C7orf55-LUC7L2 Gene

Disorders for C7orf55-LUC7L2 Gene

Relevant External Links for C7orf55-LUC7L2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
C7orf55-LUC7L2

No disorders were found for C7orf55-LUC7L2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C7orf55-LUC7L2 Gene

Publications for C7orf55-LUC7L2 Gene

  1. Mitochondrial Protein Interaction Mapping Identifies Regulators of Respiratory Chain Function. (PMID: 27499296) Floyd BJ … Pagliarini DJ (Molecular cell 2016) 3 60
  2. Expression of conjoined genes: another mechanism for gene regulation in eukaryotes. (PMID: 20967262) Prakash T … Taylor TD (PloS one 2010) 3 60
  3. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier LW … Wilson RK (Nature 2003) 3 60
  4. Toward a complete human genome sequence. (PMID: 9847074) Sanger Center … Genome Sequencing Center (Genome research 1998) 3 60

Products for C7orf55-LUC7L2 Gene

Sources for C7orf55-LUC7L2 Gene

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