C7orf50 Gene
protein-coding GIFtS: 43
GCID: GC07M001036
|
|
chromosome 7 open reading frame 50
| |
Aliases
for C7orf50 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Chromosome 7 Open Reading Frame 501 2 | | YCR016W1 2 | | MGC112571 | | Uncharacterized Protein C7orf502 |
Export aliases for C7orf50 gene to outside databasesPrevious GC identifer: GC07M001004 |
Summaries
for C7orf50 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for C7orf50 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000007.13 NC_018918.1 NT_007819.17 NT_079592.2
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the C7orf50 gene promoter:
AML1a GATA-3 NCX/Ncx CUTL1 LUN-1 HNF-3beta C/EBPalpha CHOP-10 c-Rel En-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for C7orf50
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C7orf50 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 7p22.3 Ensembl cytogenetic band: 7p22.3 HGNC cytogenetic band: 7p22.3C7orf50 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 7 GeneLoc Exon Structure GeneLoc location for GC07M001036: view genomic region
(about GC identifiers)
Start:
|
1,036,623 bp from pter |
End:
|
1,177,896 bp from pter |
Size:
|
141,274 bases |
Orientation:
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minus strand |
1 alternative location:
| Chr7-,CRA_TCAG 1,091,227-1,231,128 |
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Proteins
for C7orf50 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CG050_HUMAN, Q9BRJ6 (See
protein sequence)Recommended Name: Uncharacterized protein C7orf50 Size: 194 amino acids; 22083 DaExplore the universe of human proteins at neXtProt for C7orf50: NX_Q9BRJ6
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9BRJ6
C7orf50 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (3 alternative transcripts):
NP_001127867.1 NP_001127868.1 NP_115726.1
ENSEMBL proteins: ENSP00000380286 ENSP00000350011 ENSP00000407380 ENSP00000396542 ENSP00000420130 ENSP00000380288
Human Recombinant Protein Products:
C7orf50 Antibody Products:
Assay Products for C7orf50: |
Protein
Domains /
Families
for C7orf50 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
C7orf50 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q9BRJ6ProtoNet protein and cluster: Q9BRJ6 |
Function
for C7orf50 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for C7orf50 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for C7orf50 (see all 4)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 3): C7orf50 (NM_001134396) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for C7orf50 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C7orf50 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C7orf50 |
|
Pathways & Interactions
for C7orf50 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for C7orf50
STRING Interaction
Network Preview (showing 5 interactants - click image to see 7)
5/9 Interacting proteins for C7orf50 (Q9BRJ63 ENSP000003500114) via UniProtKB, MINT, STRING, and/or I2D (see all 9)About this table
|
Drugs & Compounds
for C7orf50 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for C7orf50
Search CenterWatch for drugs/clinical trials and news about C7orf50 / CG050
|
Transcripts
for C7orf50 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for C7orf50 gene (3 alternative transcripts): NM_001134395.1 NM_001134396.1 NM_032350.5 Unigene Clusters for C7orf50: Chromosome 7 open reading frame 50 Hs.653258 [show with all ESTs], Hs.732316 [show with all ESTs]Unigene Representative Sequences: AF495721, BC0259718 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000397098 ENST00000357429(uc003sju.2) ENST00000412051(uc021zyn.1)
ENST00000488073 ENST00000444428 ENST00000491163 ENST00000465681(uc003sjv.3)
ENST00000397100(uc011jvt.1 uc011jvu.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for C7orf50 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for C7orf50 (see all 4)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 3): C7orf50 (NM_001134396) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for C7orf50 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C7orf50 |
Additional cDNA sequence: BC025971.1 24 DOTS entries: DT.91907980 DT.97796328 DT.100775643 DT.100777953 DT.315254 DT.105928 DT.97854938 DT.91939323 DT.100774582 DT.121047520 DT.121047613 DT.95378605 DT.100876524 DT.121047588 DT.80100360 DT.91753309 DT.100758543 DT.100774583 DT.97854937 DT.121047563 DT.121047593 DT.80100361 DT.121047617 DT.92324190 24/378 AceView cDNA sequences (see all 378): CN482429 AW499540 BU190423 BE222788 BU632354 BM918342 AI870620 AI784139 BM680098 BC004286 BQ953580 BU729456 AA335735 AL042192 CA396632 BM052663 BU844403 BU731859 AI470355 AI049539 BM702980 CR590499 BQ009201 AY358482
GeneLoc Exon Structure
5/7 Alternative Splicing Database (ASD) splice patterns (SP) for C7orf50 (see all 7) About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | · | 4c | · | 4d | ^ | 5 | ^ | 6a | · | 6b | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b | · | 9c | · | 9d |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | - | | | | - | | | | | | | | | | | | | | |
| SP2: | | | | | | | - | | - | | - | | - | | - | | - | | - | | - | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | - | | - | | - | | | | | | | | | | | | | | |
| SP4: | | | | | - | | - | | - | | - | | - | | - | | - | | - | | - | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | - | | - | | - | | - | | - | | - | | - | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for C7orf50
|
Expression
for C7orf50 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| C7orf50 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GGGAGCCCCT
About this image
See C7orf50 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for C7orf50
SOURCE GeneReport for Unigene clusters: Hs.653258 Hs.732316
SABiosciences Custom PCR Arrays for C7orf50
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for C7orf50
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat C7orf50 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat C7orf50 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat C7orf50 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C7orf50 |
Orthologs
for C7orf50 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for C7orf50 gene from 5/18 species (see all 18) About this table
ENSEMBL Gene Tree for C7orf50 (if available)
TreeFam Gene Tree for C7orf50 (if available) |
Paralogs
for C7orf50 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for C7orf50 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 7 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for C7orf50 (1036623 - 1177896 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 16 variations for C7orf50
9 CNVs: 94327 0093 4519 32860 94328 31322 81836 64736 69750
7 Indels: 81833 69749 81835 47208 12896 94326 81834 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing C7orf50 |
|
Disorders
/ Diseases
for C7orf50 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for C7orf50 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for C7orf50 gene, integrated from 9 sources (see all 22):
(articles sorted by number of sources associating them with C7orf50) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)1 Woods N.T....Monteiro A.N. (2012)
- Interactome study suggests multiple cellular functions of hepatoma-derived growth factor (HDGF). (PubMed id 21907836)1 Zhao J....Yang P. (2011)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- Proliferating cell nuclear antigen (PCNA)-associated KIAA0101/PAF15 protein is a cell cycle-regulated anaphase-promoting complex/cyc losome substrate. (PubMed id 21628590)1 Emanuele M.J....Elledge S.J. (2011)
- System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (2011)
- Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (2010)
- Joint influence of small-effect genetic variants on h uman longevity. (PubMed id 20834067)1 Yashin A.I....Ukraintseva S.V. (2010)
- Dynamics of cullin-RING ubiquitin ligase network revea led by systematic quantitative proteomics. (PubMed id 21145461)1 Bennett E.J....Harper J.W. (2010)
|
External Searches for C7orf50 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing C7orf50 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing C7orf50 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing C7orf50 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for C7orf50 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for C7orf50 gene:
Search GeneIP for patents involving C7orf50
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for C7orf50 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for C7orf50 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for C7orf50 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for C7orf50 | | | OriGene Protein Over-expression Lysate for C7orf50 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for C7orf50 | | OriGene 3'-UTR Clone for C7orf50 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for C7orf50 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for C7orf50 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for C7orf50 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for C7orf50 | | OriGene Custom Protein Services for C7orf50 | | | OriGene Custom Immunoassay Development | | |
| |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat C7orf50 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing C7orf50 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C7orf50 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat C7orf50 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat C7orf50 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat C7orf50 |
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 |  |  |  | |
| | | | Search Tocris compounds for C7orf50 |
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 | | | C7orf50 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C7orf50 |
|  |  |  | | | | ThermoFisher Antibodies for C7orf50 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C7orf50 |
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