C7orf49 Gene
protein-coding GIFtS: 43
GCID: GC07M134777
|
|
chromosome 7 open reading frame 49
| |
Aliases
for C7orf49 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA
Quality score for the ORGUL clustered with this gene is 3
| Aliases |
|---|
| Chromosome 7 Open Reading Frame 491 2 | | MRI1 2 | | FLJ224501 | | FLJ272851 | | MGC52421 | | Modulator Of Retrovirus Infection Homolog2 |
| External Ids: | HGNC: 224321 | Entrez Gene: 789962 | Ensembl: ENSG000001227837 | UniProtKB: Q9BWK53 | | ORGUL members: | |
|---|
| NONCODE:n341328 | |
Export aliases for C7orf49 gene to outside databasesPrevious GC identifers: GC07M134501 GC07M129153
|---|
Summaries
for C7orf49 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: MRI_HUMAN, Q9BWK5Function: May act as a regulator of proteasome (By similarity)
|
Genomic Views
for C7orf49 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000007.13 NC_018918.1 NT_007933.15 NT_079596.2
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the C7orf49 gene promoter:
GR NF-1/L NF-1 AML1a p53 Pax-2 Pax-2a LUN-1 c-Myb GR-alpha
Other transcription factors
Search SABiosciences Chromatin IP Primers for C7orf49
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C7orf49 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 7q33 Ensembl cytogenetic band: 7q33 HGNC cytogenetic band: 7q33C7orf49 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 7 GeneLoc Exon Structure GeneLoc location for GC07M134777: view genomic region
(about GC identifiers)
Start:
|
134,777,115 bp from pter |
End:
|
134,855,547 bp from pter |
Size:
|
78,433 bases |
Orientation:
|
minus strand |
1 alternative location:
| Chr7-,CRA_TCAG 134,194,890-134,199,890 |
|
Proteins
for C7orf49 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: MRI_HUMAN, Q9BWK5 (See
protein sequence)Recommended Name: Modulator of retrovirus infection homolog Size: 157 amino acids; 16829 Da
Subcellular location: Cytoplasm (By similarity)
Sequence caution: Sequence=AAH00168.1; Type=Erroneous initiation;
Secondary accessions: Q6NWZ4 Q6ZNR5Alternative splicing: 3 isoforms: Q9BWK5-1 Q9BWK5-2 Q9BWK5-3 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for C7orf49: NX_Q9BWK5
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9BWK5
C7orf49 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (7 alternative transcripts):
NP_001230678.1 NP_001230680.1 NP_001230681.1 NP_001230682.1 NP_001230683.1 NP_001230684.1 NP_076938.2
ENSEMBL proteins: ENSP00000415192 ENSP00000400024 ENSP00000376823 ENSP00000389941
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005737 | cytoplasm |
IEA | -- |
C7orf49 for ontologies About GeneDecksing
C7orf49 Antibody Products:
Assay Products for C7orf49: |
Protein
Domains /
Families
for C7orf49 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| ProtoNet protein and cluster: Q9BWK5 |
Function
for C7orf49 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: MRI_HUMAN, Q9BWK5Function: May act as a regulator of proteasome (By similarity)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for C7orf49 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for C7orf49 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: C7orf49 (NM_024033) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for C7orf49 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C7orf49 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C7orf49 |
1 GenomeRNAi human phenotype for C7orf49:
|
Pathways & Interactions
for C7orf49 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for C7orf49
|
Drugs & Compounds
for C7orf49 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for C7orf49
Search CenterWatch for drugs/clinical trials and news about C7orf49 / MRI
|
Transcripts
for C7orf49 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for C7orf49 gene (7 alternative transcripts): NM_001243749.1 NM_001243751.1 NM_001243752.1 NM_001243753.1 NM_001243754.1 NM_001243755.1 NM_024033.3 Unigene Cluster for C7orf49: Chromosome 7 open reading frame 49 Hs.521213 [show with all ESTs]Unigene Representative Sequence: NM_00124374913 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000459937(uc003vsg.3 uc003vsh.3) ENST00000464070 ENST00000435834(uc003vsj.3)
ENST00000424142(uc022alz.1 uc022amb.1 uc003vsk.3) ENST00000393114(uc022ama.1)
ENST00000430372(uc003vsm.3 uc003vso.3 uc003vsl.3) ENST00000481410
ENST00000483029 ENST00000472428 ENST00000477820 ENST00000488161 ENST00000487774
ENST00000486115
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for C7orf49 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for C7orf49 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: C7orf49 (NM_024033) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for C7orf49 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C7orf49 |
Additional cDNA sequence: AK026103.1 BC000168.2 BC067350.1 23 DOTS entries: DT.95208627 DT.107104 DT.100029815 DT.446506 DT.97854645 DT.100821173 DT.97810909 DT.97802988 DT.100799308 DT.100821163 DT.121060841 DT.121060787 DT.92005487 DT.409242 DT.92415145 DT.95149953 DT.95158236 DT.100837226 DT.121060558 DT.121060871 DT.95158232 DT.100821157 DT.444226 24/285 AceView cDNA sequences (see all 285): BQ440169 AA906037 BU539869 BC024018 BM789844 BU621670 BE785683 AW167607 CR596076 AK130795 BC000168 BQ949282 BM727569 BQ226755 CB132170 AW515167 AI827176 BC010361 AA954030 AW575793 AW275190 BM977393 AI187313 BM727136
GeneLoc Exon Structure
5/9 Alternative Splicing Database (ASD) splice patterns (SP) for C7orf49 (see all 9) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2a | · | 2b | · | 2c | · | 2d | ^ | 3a | · | 3b | ^ | 4a | · | 4b | · | 4c | · | 4d | · | 4e | · | 4f | ^ | 5 | ^ | 6a | · | 6b | · | 6c | · | 6d | · | 6e | · | 6f |
|---|
|
| SP1: | | | | | | | | | - | | - | | - | | - | | - | | - | | | | | | | | | | - | | - | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | - | | - | | - | | - | | - | | - | | | | - | | - | | - | | - | | - | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | - | | - | | - | | - | | - | | - | | | | | | | | - | | - | | - | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | - | | - | | - | | | | | | | | | | - | | - | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | - | | - | | - | | - | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for C7orf49
|
Expression
for C7orf49 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| C7orf49 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TCTCTGCCTC
About this image
See C7orf49 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for C7orf49
SOURCE GeneReport for Unigene cluster: Hs.521213
SABiosciences Custom PCR Arrays for C7orf49
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for C7orf49
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat C7orf49 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat C7orf49 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat C7orf49 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C7orf49 |
Orthologs
for C7orf49 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of human and mouse.
Orthologs for C7orf49 gene from 1/6 species (see all 6) About this table
ENSEMBL Gene Tree for C7orf49 (if available)
TreeFam Gene Tree for C7orf49 (if available) |
Paralogs
for C7orf49 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for C7orf49 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 7 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for C7orf49 (134777115 - 134855547 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for C7orf49: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing C7orf49 |
|
Disorders
/ Diseases
for C7orf49 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
C7orf49 for disorders About GeneDecksing
2  diseases for C7orf49: About MalaCardscerebellar disease liver lymphoma
1 disease from the University of Copenhagen DISEASES database for C7orf49:post-traumatic stress disorder Export disorders for C7orf49 gene to outside databases
|
Publications
for C7orf49 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for C7orf49 gene integrated from 9 sources:
(articles sorted by number of sources associating them with C7orf49) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Isolation, characterization, and genetic complementation of a cellular mutant resistant to retroviral infection. (PubMed id 17043244)1, 3 Agarwal S....Somia N.V. (2006)
- Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)1, 2 Scherer S.W.... Tsui L.-C. (2003)
- The consensus coding sequences of human breast and colorectal cancers. (PubMed id 16959974)2 Sjoeblom T.... Velculescu V.E. (2006)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. (PubMed id 15342556)1 Suzuki Y.... Sugano S. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548)1 Bonaldo M.F.... Soares M.B. (1996)
|
External Searches for C7orf49 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing C7orf49 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing C7orf49 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing C7orf49 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for C7orf49 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for C7orf49 gene:
Search GeneIP for patents involving C7orf49
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for C7orf49 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for C7orf49 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for C7orf49 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for C7orf49 | | | OriGene Protein Over-expression Lysate for C7orf49 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for C7orf49 | | OriGene 3'-UTR Clone for C7orf49 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for C7orf49 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for C7orf49 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat C7orf49 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing C7orf49 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C7orf49 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat C7orf49 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat C7orf49 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat C7orf49 |
| |
 |  |  |  | |
| | | | Search Tocris compounds for C7orf49 |
| |  |  |  |  | | | | |
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 | | | C7orf49 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C7orf49 |
|  |  |  | | | | Search ThermoFisher Antibodies for C7orf49 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C7orf49 |
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