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Aliases for C7orf49 Gene

Aliases for C7orf49 Gene

  • Chromosome 7 Open Reading Frame 49 2 3
  • MRI 3 4
  • Modulator Of Retrovirus Infection Homolog 3
  • Modulator Of Retrovirus Infection 2

External Ids for C7orf49 Gene

Previous GeneCards Identifiers for C7orf49 Gene

  • GC07M134501
  • GC07M134777
  • GC07M129153

Summaries for C7orf49 Gene

GeneCards Summary for C7orf49 Gene

C7orf49 (Chromosome 7 Open Reading Frame 49) is a Protein Coding gene. Diseases associated with C7orf49 include post-traumatic stress disorder and colorectal cancer.

UniProtKB/Swiss-Prot for C7orf49 Gene

  • May act as a regulator of proteasome.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C7orf49 Gene

Genomics for C7orf49 Gene

Regulatory Elements for C7orf49 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for C7orf49 Gene

Start:
135,092,363 bp from pter
End:
135,170,826 bp from pter
Size:
78,464 bases
Orientation:
Minus strand

Genomic View for C7orf49 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for C7orf49 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C7orf49 Gene

Proteins for C7orf49 Gene

  • Protein details for C7orf49 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BWK5-MRI_HUMAN
    Recommended name:
    Modulator of retrovirus infection homolog
    Protein Accession:
    Q9BWK5
    Secondary Accessions:
    • Q6NWZ4
    • Q6ZNR5

    Protein attributes for C7orf49 Gene

    Size:
    157 amino acids
    Molecular mass:
    16829 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH00168.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for C7orf49 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for C7orf49 Gene

Proteomics data for C7orf49 Gene at MOPED

Post-translational modifications for C7orf49 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for C7orf49 Gene

Domains for C7orf49 Gene

Protein Domains for C7orf49 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C7orf49: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for C7orf49 Gene

Function for C7orf49 Gene

Molecular function for C7orf49 Gene

UniProtKB/Swiss-Prot Function: May act as a regulator of proteasome.

Gene Ontology (GO) - Molecular Function for C7orf49 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with C7orf49: view

Phenotypes for C7orf49 Gene

GenomeRNAi human phenotypes for C7orf49:
genes like me logo Genes that share phenotypes with C7orf49: view

Animal Model Products

CRISPR Products

miRNA for C7orf49 Gene

miRTarBase miRNAs that target C7orf49

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for C7orf49 Gene

Localization for C7orf49 Gene

Subcellular locations from UniProtKB/Swiss-Prot for C7orf49 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for C7orf49 Gene COMPARTMENTS Subcellular localization image for C7orf49 gene
Compartment Confidence
nucleus 3
cytosol 2
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for C7orf49 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with C7orf49: view

Pathways for C7orf49 Gene

SuperPathways for C7orf49 Gene

No Data Available

Interacting Proteins for C7orf49 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000376823%0d%0a9606.ENSP00000288985%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: ENSP00000376823 Q9BWK5-MRI_HUMAN for C7orf49 Gene via STRING UniProtKB

Gene Ontology (GO) - Biological Process for C7orf49 Gene

None

No data available for Pathways by source for C7orf49 Gene

Transcripts for C7orf49 Gene

Unigene Clusters for C7orf49 Gene

Chromosome 7 open reading frame 49:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for C7orf49

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for C7orf49 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c · 2d ^ 3a · 3b ^ 4a · 4b · 4c · 4d · 4e · 4f ^ 5 ^ 6a · 6b · 6c · 6d · 6e · 6f
SP1: - - - - - - - -
SP2: - - - - - - - - - - -
SP3: - - - - - - - - -
SP4: - - - - -
SP5: - - - -
SP6: - -
SP7: - - - -
SP8: - - - - - -
SP9: - - -

Relevant External Links for C7orf49 Gene

GeneLoc Exon Structure for
C7orf49
ECgene alternative splicing isoforms for
C7orf49

Expression for C7orf49 Gene

mRNA expression in normal human tissues for C7orf49 Gene

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for C7orf49 Gene

SOURCE GeneReport for Unigene cluster for C7orf49 Gene Hs.744954

genes like me logo Genes that share expressions with C7orf49: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for C7orf49 Gene

Orthologs for C7orf49 Gene

This gene was present in the common ancestor of mammals.

Orthologs for C7orf49 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C7H7orf49 35
  • 99.36 (n)
  • 99.36 (a)
C7orf49 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia C4H7orf49 35
  • 73.65 (n)
  • 64.19 (a)
C7orf49 36
  • 63 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C16H7orf49 35
  • 73.24 (n)
  • 59.86 (a)
C7orf49 36
  • 34 (a)
OneToOne
mouse
(Mus musculus)
Mammalia 3110062M04Rik 35
  • 70.81 (n)
  • 62.75 (a)
3110062M04Rik 16
3110062M04Rik 36
  • 66 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia C7orf49 36
  • 44 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC500077 35
  • 72.4 (n)
  • 63.06 (a)
Species with no ortholog for C7orf49:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for C7orf49 Gene

ENSEMBL:
Gene Tree for C7orf49 (if available)
TreeFam:
Gene Tree for C7orf49 (if available)

Paralogs for C7orf49 Gene

Selected SIMAP similar genes for C7orf49 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with C7orf49: view

No data available for Paralogs for C7orf49 Gene

Variants for C7orf49 Gene

Sequence variations from dbSNP and Humsavar for C7orf49 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs292505 -- 135,167,680(+) CTAGC(C/T)TCTGC intron-variant
rs292506 -- 135,170,227(+) GCCGC(A/G)GCAAC intron-variant, upstream-variant-2KB
rs292507 -- 135,170,740(+) GCTCC(A/G)GGGTC utr-variant-5-prime, upstream-variant-2KB
rs292508 -- 135,170,881(+) CAGTG(C/G)TAATG upstream-variant-2KB
rs292509 -- 135,171,327(+) ttttt(A/T)aaaaa upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for C7orf49 Gene

Variant ID Type Subtype PubMed ID
nsv527014 CNV Gain 19592680

Relevant External Links for C7orf49 Gene

HapMap Linkage Disequilibrium report
C7orf49

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C7orf49 Gene

Disorders for C7orf49 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (2) Diseases for C7orf49 Gene including...

Search for C7orf49 Gene in MalaCards »

(1) University of Copenhagen DISEASES for C7orf49 Gene

genes like me logo Genes that share disorders with C7orf49: view

No data available for UniProtKB/Swiss-Prot for C7orf49 Gene

Publications for C7orf49 Gene

  1. Isolation, characterization, and genetic complementation of a cellular mutant resistant to retroviral infection. (PMID: 17043244) Agarwal S. … Somia N.V. (Proc. Natl. Acad. Sci. U.S.A. 2006) 2 3
  2. Human chromosome 7: DNA sequence and biology. (PMID: 12690205) Scherer S.W. … Tsui L.-C. (Science 2003) 3 4
  3. Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. (PMID: 15342556) Suzuki Y. … Sugano S. (Genome Res. 2004) 3
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  5. Normalization and subtraction: two approaches to facilitate gene discovery. (PMID: 8889548) Bonaldo M.F. … Soares M.B. (Genome Res. 1996) 3

Products for C7orf49 Gene

Sources for C7orf49 Gene

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