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Aliases for C7orf43 Gene

Aliases for C7orf43 Gene

  • Chromosome 7 Open Reading Frame 43 2 3 5

External Ids for C7orf43 Gene

Previous GeneCards Identifiers for C7orf43 Gene

  • GC07M099589
  • GC07M099752
  • GC07M094387

Summaries for C7orf43 Gene

GeneCards Summary for C7orf43 Gene

C7orf43 (Chromosome 7 Open Reading Frame 43) is a Protein Coding gene.

Gene Wiki entry for C7orf43 Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C7orf43 Gene

Genomics for C7orf43 Gene

Regulatory Elements for C7orf43 Gene

Enhancers for C7orf43 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around C7orf43 on UCSC Golden Path with GeneCards custom track

Promoters for C7orf43 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around C7orf43 on UCSC Golden Path with GeneCards custom track

Genomic Location for C7orf43 Gene

Chromosome:
7
Start:
100,154,420 bp from pter
End:
100,158,721 bp from pter
Size:
4,302 bases
Orientation:
Minus strand

Genomic View for C7orf43 Gene

Genes around C7orf43 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C7orf43 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C7orf43 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C7orf43 Gene

Proteins for C7orf43 Gene

  • Protein details for C7orf43 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WVR3-CG043_HUMAN
    Recommended name:
    Uncharacterized protein C7orf43
    Protein Accession:
    Q8WVR3
    Secondary Accessions:
    • A4D2A9
    • D6W5U4
    • Q9BQJ1
    • Q9BUB6
    • Q9NV47

    Protein attributes for C7orf43 Gene

    Size:
    580 amino acids
    Molecular mass:
    62597 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAB66490.1; Type=Frameshift; Positions=539; Evidence={ECO:0000305};

    Alternative splice isoforms for C7orf43 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for C7orf43 Gene

Proteomics data for C7orf43 Gene at MOPED

Post-translational modifications for C7orf43 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for C7orf43 Gene

Domains & Families for C7orf43 Gene

Protein Domains for C7orf43 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for C7orf43 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C7orf43: view

No data available for Gene Families and UniProtKB/Swiss-Prot for C7orf43 Gene

Function for C7orf43 Gene

genes like me logo Genes that share phenotypes with C7orf43: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C7orf43 Gene

Localization for C7orf43 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for C7orf43 Gene COMPARTMENTS Subcellular localization image for C7orf43 gene
Compartment Confidence
cytoskeleton 2
cytosol 2
nucleus 2
plasma membrane 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for C7orf43 Gene

Pathways & Interactions for C7orf43 Gene

SuperPathways for C7orf43 Gene

No Data Available

Interacting Proteins for C7orf43 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000324741%0d%0a9606.ENSP00000363478%0d%0a9606.ENSP00000249883%0d%0a
Selected Interacting proteins: Q8WVR3-CG043_HUMAN ENSP00000324741 for C7orf43 Gene via MINT STRING I2D

Gene Ontology (GO) - Biological Process for C7orf43 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for C7orf43 Gene

Drugs & Compounds for C7orf43 Gene

No Compound Related Data Available

Transcripts for C7orf43 Gene

Unigene Clusters for C7orf43 Gene

Chromosome 7 open reading frame 43:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for C7orf43 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10a · 10b · 10c ^ 11a · 11b · 11c ^ 12a · 12b ^ 13
SP1: - - - - -
SP2: - - - -
SP3: - - -
SP4: -
SP5: -
SP6: - -
SP7:
SP8:

Relevant External Links for C7orf43 Gene

GeneLoc Exon Structure for
C7orf43
ECgene alternative splicing isoforms for
C7orf43

Expression for C7orf43 Gene

mRNA expression in normal human tissues for C7orf43 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for C7orf43 Gene

This gene is overexpressed in Whole Blood (x5.2).

Protein differential expression in normal tissues from HIPED for C7orf43 Gene

This gene is overexpressed in Cervix (45.9) and Peripheral blood mononuclear cells (10.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for C7orf43 Gene



SOURCE GeneReport for Unigene cluster for C7orf43 Gene Hs.533139

genes like me logo Genes that share expression patterns with C7orf43: view

Protein tissue co-expression partners for C7orf43 Gene

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for C7orf43 Gene

Orthologs for C7orf43 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C7orf43 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia C25H7orf43 35
  • 93.05 (n)
  • 97.76 (a)
C7orf43 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C6H7orf43 35
  • 92.53 (n)
  • 97.41 (a)
C7orf43 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia BC037034 35
  • 90.98 (n)
  • 96.38 (a)
BC037034 16
BC037034 36
  • 96 (a)
OneToMany
BC037034 36
  • 96 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia C7H7orf43 35
  • 99.28 (n)
  • 99.41 (a)
C7ORF43 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia RGD1305455 35
  • 91.15 (n)
  • 96.55 (a)
oppossum
(Monodelphis domestica)
Mammalia C7orf43 36
  • 91 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia C7orf43 36
  • 89 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia c7orf43 35
  • 66.67 (n)
  • 64.91 (a)
Str.19426 35
zebrafish
(Danio rerio)
Actinopterygii LOC100003958 35
  • 65.12 (n)
  • 70.8 (a)
C7H7orf43 36
  • 63 (a)
OneToOne
Species with no ortholog for C7orf43:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C7orf43 Gene

ENSEMBL:
Gene Tree for C7orf43 (if available)
TreeFam:
Gene Tree for C7orf43 (if available)

Paralogs for C7orf43 Gene

No data available for Paralogs for C7orf43 Gene

Variants for C7orf43 Gene

Sequence variations from dbSNP and Humsavar for C7orf43 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
VAR_050817 -
rs1045937 -- 100,154,713(-) TGGTT(C/T)TGAGT utr-variant-3-prime
rs2272337 -- 100,155,498(-) CTGGG(C/T)CCTGG intron-variant
rs34325124 -- 100,158,683(+) CCGGA(A/T)CCGGG utr-variant-5-prime
rs55839153 -- 100,154,943(+) AGCCC(A/G)GGAGC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for C7orf43 Gene

Variant ID Type Subtype PubMed ID
nsv469687 CNV Loss 16826518
esv2734888 CNV Deletion 23290073
nsv428180 CNV Gain 18775914
nsv888773 CNV Loss 21882294

Variation tolerance for C7orf43 Gene

Residual Variation Intolerance Score: 15.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.17; 23.68% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C7orf43 Gene

Human Gene Mutation Database (HGMD)
C7orf43

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C7orf43 Gene

Disorders for C7orf43 Gene

Relevant External Links for C7orf43

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
C7orf43

No disorders were found for C7orf43 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C7orf43 Gene

Publications for C7orf43 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 67
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions. (PMID: 24255178) Couzens A.L. … Gingras A.C. (Sci Signal 2013) 3
  5. The LIFEdb database in 2006. (PMID: 16381901) Mehrle A. … Wiemann S. (Nucleic Acids Res. 2006) 3

Products for C7orf43 Gene

Sources for C7orf43 Gene

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