Free for academic non-profit institutions. Other users need a Commercial license

Aliases for C7orf43 Gene

Aliases for C7orf43 Gene

  • Chromosome 7 Open Reading Frame 43 2 3 5

External Ids for C7orf43 Gene

Previous GeneCards Identifiers for C7orf43 Gene

  • GC07M099589
  • GC07M099752
  • GC07M094387

Summaries for C7orf43 Gene

GeneCards Summary for C7orf43 Gene

C7orf43 (Chromosome 7 Open Reading Frame 43) is a Protein Coding gene.

Gene Wiki entry for C7orf43 Gene

Additional gene information for C7orf43 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C7orf43 Gene

Genomics for C7orf43 Gene

Regulatory Elements for C7orf43 Gene

Enhancers for C7orf43 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07H100343 1.8 FANTOM5 Ensembl ENCODE dbSUPER 21.8 -186.3 -186311 2 HDGF PKNOX1 ATF1 ARNT SIN3A FEZF1 GLI4 ZNF2 TCF12 GLIS2 PILRA C7orf43 MBLAC1 ZCWPW1 MEPCE FAM200A LAMTOR4 ENSG00000241357 GPC2 GAL3ST4
GH07H100364 1.9 FANTOM5 Ensembl ENCODE dbSUPER 12.2 -212.2 -212248 12 HDGF PKNOX1 ATF1 YBX1 ZBTB7B ZNF121 ZNF143 ZNF207 ATF7 RUNX3 PILRA ZCWPW1 MEPCE MOSPD3 LAMTOR4 C7orf43 PVRIG ENSG00000241357 STAG3 GIGYF1
GH07H100538 2 FANTOM5 Ensembl ENCODE dbSUPER 11 -385.9 -385893 12 MLX DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC SSRP1 GLIS1 RCOR2 SAP25 SRRT MEPCE PPP1R35 ZSCAN25 GIGYF1 AP4M1 PCOLCE-AS1 FBXO24 LRCH4
GH07H099692 1.9 FANTOM5 Ensembl ENCODE dbSUPER 11.3 +464.5 464473 2 HDGF PKNOX1 FOXA2 MLX ARID4B DMAP1 YY1 SLC30A9 ZNF766 CBX5 PDAP1 PTCD1 C7orf43 CYP3A5 SAP25 ZSCAN25 TMEM225B CYP3A43 CYP3A4 AZGP1
GH07H101136 1.6 Ensembl ENCODE dbSUPER 11.3 -980.5 -980518 4 HDGF PKNOX1 MLX ARNT ARID4B FEZF1 ZNF2 ZBTB7B ZNF766 ZNF143 GIGYF1 STAG3L5P SRRT PCOLCE C7orf43 NAT16 PCOLCE-AS1 GNB2 MOSPD3 SAP25
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around C7orf43 on UCSC Golden Path with GeneCards custom track

Promoters for C7orf43 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000215750 121 1201 HDGF FOXA2 PKNOX1 ARNT ZFP64 ARID4B SIN3A DMAP1 YBX1 ZNF766

Genomic Location for C7orf43 Gene

Chromosome:
7
Start:
100,154,420 bp from pter
End:
100,158,721 bp from pter
Size:
4,302 bases
Orientation:
Minus strand

Genomic View for C7orf43 Gene

Genes around C7orf43 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C7orf43 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C7orf43 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C7orf43 Gene

Proteins for C7orf43 Gene

  • Protein details for C7orf43 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WVR3-CG043_HUMAN
    Recommended name:
    Uncharacterized protein C7orf43
    Protein Accession:
    Q8WVR3
    Secondary Accessions:
    • A4D2A9
    • D6W5U4
    • Q9BQJ1
    • Q9BUB6
    • Q9NV47

    Protein attributes for C7orf43 Gene

    Size:
    580 amino acids
    Molecular mass:
    62597 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAB66490.1; Type=Frameshift; Positions=539; Evidence={ECO:0000305};

    Alternative splice isoforms for C7orf43 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for C7orf43 Gene

Post-translational modifications for C7orf43 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C7orf43 Gene

No data available for DME Specific Peptides for C7orf43 Gene

Domains & Families for C7orf43 Gene

Gene Families for C7orf43 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for C7orf43 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for C7orf43 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C7orf43: view

No data available for UniProtKB/Swiss-Prot for C7orf43 Gene

Function for C7orf43 Gene

Phenotypes From GWAS Catalog for C7orf43 Gene

genes like me logo Genes that share phenotypes with C7orf43: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for C7orf43
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C7orf43 Gene

Localization for C7orf43 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C7orf43 gene
Compartment Confidence
plasma membrane 5
cytoskeleton 5
nucleus 2
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Microtubule organizing center (4)
  • Vesicles (4)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for C7orf43 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005815 microtubule organizing center IDA --
GO:0005886 plasma membrane IDA --
GO:0043231 intracellular membrane-bounded organelle IDA --
genes like me logo Genes that share ontologies with C7orf43: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for C7orf43 Gene

Pathways & Interactions for C7orf43 Gene

SuperPathways for C7orf43 Gene

No Data Available

Interacting Proteins for C7orf43 Gene

Gene Ontology (GO) - Biological Process for C7orf43 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for C7orf43 Gene

Drugs & Compounds for C7orf43 Gene

No Compound Related Data Available

Transcripts for C7orf43 Gene

Unigene Clusters for C7orf43 Gene

Chromosome 7 open reading frame 43:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for C7orf43
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for C7orf43 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10a · 10b · 10c ^ 11a · 11b · 11c ^ 12a · 12b ^ 13
SP1: - - - - -
SP2: - - - -
SP3: - - -
SP4: -
SP5: -
SP6: - -
SP7:
SP8:

Relevant External Links for C7orf43 Gene

GeneLoc Exon Structure for
C7orf43
ECgene alternative splicing isoforms for
C7orf43

Expression for C7orf43 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for C7orf43 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for C7orf43 Gene

This gene is overexpressed in Whole Blood (x5.2).

Protein differential expression in normal tissues from HIPED for C7orf43 Gene

This gene is overexpressed in Cervix (45.9) and Peripheral blood mononuclear cells (10.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for C7orf43 Gene



Protein tissue co-expression partners for C7orf43 Gene

NURSA nuclear receptor signaling pathways regulating expression of C7orf43 Gene:

C7orf43

SOURCE GeneReport for Unigene cluster for C7orf43 Gene:

Hs.533139

Evidence on tissue expression from TISSUES for C7orf43 Gene

  • Skin(4.3)
  • Nervous system(4.2)
  • Liver(4.1)
genes like me logo Genes that share expression patterns with C7orf43: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for C7orf43 Gene

Orthologs for C7orf43 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C7orf43 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C7ORF43 34
  • 100 (a)
OneToOne
C7H7orf43 33
  • 99.28 (n)
cow
(Bos Taurus)
Mammalia C7orf43 34
  • 98 (a)
OneToOne
C25H7orf43 33
  • 93.05 (n)
dog
(Canis familiaris)
Mammalia C7orf43 34
  • 97 (a)
OneToOne
C6H7orf43 33
  • 92.53 (n)
rat
(Rattus norvegicus)
Mammalia RGD1305455 33
  • 91.15 (n)
oppossum
(Monodelphis domestica)
Mammalia C7orf43 34
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia BC037034 33 16 34 34
  • 90.98 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia C7orf43 34
  • 89 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia c7orf43 33
  • 66.67 (n)
Str.19426 33
zebrafish
(Danio rerio)
Actinopterygii LOC100003958 33
  • 65.12 (n)
C7H7orf43 34
  • 63 (a)
OneToOne
Species where no ortholog for C7orf43 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C7orf43 Gene

ENSEMBL:
Gene Tree for C7orf43 (if available)
TreeFam:
Gene Tree for C7orf43 (if available)

Paralogs for C7orf43 Gene

No data available for Paralogs for C7orf43 Gene

Variants for C7orf43 Gene

Sequence variations from dbSNP and Humsavar for C7orf43 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs1000062003 -- 100,158,472(+) GAAGT(-/A)CATCG intron-variant, upstream-variant-2KB, reference, frameshift-variant
rs1000622990 -- 100,159,645(+) AACCT(G/T)GGAGG upstream-variant-2KB, utr-variant-3-prime
rs1001224117 -- 100,154,797(+) AGGAA(C/T)TCGGG utr-variant-3-prime
rs1001296171 -- 100,154,924(+) GGCAT(C/T)CCAGG utr-variant-3-prime
rs1002225274 -- 100,156,135(+) GAAGT(A/G)GAGTT intron-variant, downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for C7orf43 Gene

Variant ID Type Subtype PubMed ID
esv2734888 CNV deletion 23290073
nsv428180 CNV gain 18775914
nsv469687 CNV loss 16826518
nsv607931 CNV loss 21841781

Variation tolerance for C7orf43 Gene

Residual Variation Intolerance Score: 15.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.17; 23.68% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C7orf43 Gene

Human Gene Mutation Database (HGMD)
C7orf43
SNPedia medical, phenotypic, and genealogical associations of SNPs for
C7orf43

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C7orf43 Gene

Disorders for C7orf43 Gene

Relevant External Links for C7orf43

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
C7orf43

No disorders were found for C7orf43 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C7orf43 Gene

Publications for C7orf43 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  3. Human chromosome 7: DNA sequence and biology. (PMID: 12690205) Scherer SW … Tsui LC (Science (New York, N.Y.) 2003) 3 4 60
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 60
  5. Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S … Poustka A (Genome research 2001) 3 4 60

Products for C7orf43 Gene

Sources for C7orf43 Gene

Content
Loading form....