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Aliases for C7orf31 Gene

Aliases for C7orf31 Gene

  • Chromosome 7 Open Reading Frame 31 2 3 5

External Ids for C7orf31 Gene

Previous GeneCards Identifiers for C7orf31 Gene

  • GC07M024882
  • GC07M024916
  • GC07M024947
  • GC07M025140

Summaries for C7orf31 Gene

GeneCards Summary for C7orf31 Gene

C7orf31 (Chromosome 7 Open Reading Frame 31) is a Protein Coding gene.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C7orf31 Gene

Genomics for C7orf31 Gene

Regulatory Elements for C7orf31 Gene

Enhancers for C7orf31 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07G024819 1.9 FANTOM5 Ensembl ENCODE dbSUPER 2.6 +359.1 359065 3.7 PKNOX1 ARNT WRNIP1 ARID4B SIN3A ZNF766 ZNF143 ZNF207 FOS NFYC OSBPL3 DFNA5 C7orf31 SNRPCP19
GH07G025195 0.8 ENCODE 5 -15.7 -15699 1.9 ELF3 SOX13 FOXA2 MAX ZNF384 RAD21 YY1 ZNF26 SOX5 STAT1 NPVF C7orf31 LOC105375191 RPL7AP41
GH07G024824 1.8 FANTOM5 Ensembl ENCODE dbSUPER 1.7 +351.1 351064 10.8 FOXA2 PKNOX1 ARNT SIN3A ARID4B DMAP1 ZNF48 TCF12 ZNF766 GATA2 OSBPL3 DFNA5 C7orf31 SNRPCP19
GH07G024786 1.6 FANTOM5 Ensembl ENCODE 1.7 +393.7 393709 1.7 FOXA2 CREB3L1 MLX ARID4B DMAP1 ZNF48 FOS SP5 KAT8 ZNF592 DFNA5 C7orf31 SNRPCP19
GH07G024753 1.6 FANTOM5 ENCODE dbSUPER 1.3 +424.5 424506 4.7 HDGF PKNOX1 FOXA2 ARNT SIN3A DMAP1 YY1 FOS SP3 JUNB DFNA5 MPP6 C7orf31 PIR41431
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around C7orf31 on UCSC Golden Path with GeneCards custom track

Promoters for C7orf31 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000209668 448 1400 HDGF TBP RB1 WRNIP1 SIN3A ARID4B ZNF48 RAD21 ZBTB40 YY1

Genomic Location for C7orf31 Gene

25,125,200 bp from pter
25,180,748 bp from pter
55,549 bases
Minus strand

Genomic View for C7orf31 Gene

Genes around C7orf31 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C7orf31 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C7orf31 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C7orf31 Gene

Proteins for C7orf31 Gene

  • Protein details for C7orf31 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Uncharacterized protein C7orf31
    Protein Accession:
    Secondary Accessions:
    • A4D165
    • Q6MZV8
    • Q6P989
    • Q7LE28
    • Q86XK1
    • Q8N1H5
    • Q96BN4

    Protein attributes for C7orf31 Gene

    590 amino acids
    Molecular mass:
    68464 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAP22338.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=BAC05255.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for C7orf31 Gene

Post-translational modifications for C7orf31 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C7orf31 Gene

No data available for DME Specific Peptides for C7orf31 Gene

Domains & Families for C7orf31 Gene

Protein Domains for C7orf31 Gene


Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C7orf31: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for C7orf31 Gene

Function for C7orf31 Gene

Gene Ontology (GO) - Molecular Function for C7orf31 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with C7orf31: view
genes like me logo Genes that share phenotypes with C7orf31: view

Animal Model Products

CRISPR Products

miRNA for C7orf31 Gene

miRTarBase miRNAs that target C7orf31

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C7orf31 Gene

Localization for C7orf31 Gene

Subcellular locations from UniProtKB/Swiss-Prot for C7orf31 Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C7orf31 gene
Compartment Confidence
cytoskeleton 5
nucleus 3
cytosol 3
mitochondrion 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for C7orf31 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005813 centrosome IDA 25074808
GO:0005815 microtubule organizing center IEA --
GO:0005856 cytoskeleton IEA --
genes like me logo Genes that share ontologies with C7orf31: view

Pathways & Interactions for C7orf31 Gene

SuperPathways for C7orf31 Gene

No Data Available

Interacting Proteins for C7orf31 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000283905 Q8N865-CG031_HUMAN for C7orf31 Gene via STRING UniProtKB IID

Gene Ontology (GO) - Biological Process for C7orf31 Gene


No data available for Pathways by source and SIGNOR curated interactions for C7orf31 Gene

Drugs & Compounds for C7orf31 Gene

No Compound Related Data Available

Transcripts for C7orf31 Gene

Unigene Clusters for C7orf31 Gene

Chromosome 7 open reading frame 31:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for C7orf31 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11
SP1: - - - -
SP2: - -
SP3: - -
SP4: - - -
SP5: -

Relevant External Links for C7orf31 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for C7orf31 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for C7orf31 Gene

mRNA differential expression in normal tissues according to GTEx for C7orf31 Gene

This gene is overexpressed in Testis (x13.2).

Protein differential expression in normal tissues from HIPED for C7orf31 Gene

This gene is overexpressed in Testis (68.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for C7orf31 Gene

Protein tissue co-expression partners for C7orf31 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of C7orf31 Gene:


SOURCE GeneReport for Unigene cluster for C7orf31 Gene:


Evidence on tissue expression from TISSUES for C7orf31 Gene

  • Intestine(4.1)
  • Kidney(4.1)
  • Spleen(4.1)
  • Stomach(4.1)
genes like me logo Genes that share expression patterns with C7orf31: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for C7orf31 Gene

Orthologs for C7orf31 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C7orf31 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia C7H7orf31 34
  • 99.04 (n)
C7orf31 35
  • 98 (a)
(Canis familiaris)
Mammalia C14H7orf31 34
  • 88.11 (n)
C7orf31 35
  • 84 (a)
(Bos Taurus)
Mammalia C4H7orf31 34
  • 86.82 (n)
C7orf31 35
  • 84 (a)
(Mus musculus)
Mammalia 4921507P07Rik 34 16 35
  • 79.76 (n)
(Rattus norvegicus)
Mammalia LOC500124 34
  • 78.97 (n)
(Monodelphis domestica)
Mammalia C7orf31 35
  • 52 (a)
(Ornithorhynchus anatinus)
Mammalia C7orf31 35
  • 52 (a)
(Gallus gallus)
Aves C2H7ORF31 34
  • 54.42 (n)
C7orf31 35
  • 44 (a)
(Anolis carolinensis)
Reptilia C7orf31 35
  • 30 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100497526 34
  • 51.15 (n)
Species where no ortholog for C7orf31 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for C7orf31 Gene

Gene Tree for C7orf31 (if available)
Gene Tree for C7orf31 (if available)

Paralogs for C7orf31 Gene

No data available for Paralogs for C7orf31 Gene

Variants for C7orf31 Gene

Sequence variations from dbSNP and Humsavar for C7orf31 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs1000072293 -- 25,153,837(+) GCCAG(A/T)ATACT intron-variant
rs1000079702 -- 25,142,410(+) AAACT(C/T)ACCCA intron-variant
rs1000253027 -- 25,177,793(+) TTTTC(A/C)TTGTA intron-variant
rs1000263458 -- 25,137,449(+) CTGCC(A/G)TAATG intron-variant
rs1000350479 -- 25,182,008(+) CTACT(A/G)ACCAA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for C7orf31 Gene

Variant ID Type Subtype PubMed ID
esv3612592 CNV loss 21293372
nsv510075 OTHER sequence alteration 20534489
nsv606424 CNV gain 21841781
nsv7393 OTHER inversion 18451855

Variation tolerance for C7orf31 Gene

Residual Variation Intolerance Score: 97.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 16.81; 97.91% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C7orf31 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C7orf31 Gene

Disorders for C7orf31 Gene

Relevant External Links for C7orf31

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for C7orf31 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C7orf31 Gene

Publications for C7orf31 Gene

  1. Proteomic analysis of mammalian sperm cells identifies new components of the centrosome. (PMID: 25074808) Firat-Karalar E.N. … Stearns T. (J. Cell Sci. 2014) 2 3 4 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier L.W. … Wilson R.K. (Nature 2003) 3 4 64
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3 64

Products for C7orf31 Gene

Sources for C7orf31 Gene

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