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Aliases for C7orf31 Gene

Aliases for C7orf31 Gene

  • Chromosome 7 Open Reading Frame 31 2 3 5

External Ids for C7orf31 Gene

Previous GeneCards Identifiers for C7orf31 Gene

  • GC07M024882
  • GC07M024916
  • GC07M024947
  • GC07M025140

Summaries for C7orf31 Gene

GeneCards Summary for C7orf31 Gene

C7orf31 (Chromosome 7 Open Reading Frame 31) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C7orf31 Gene

Genomics for C7orf31 Gene

Regulatory Elements for C7orf31 Gene

Enhancers for C7orf31 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07F024978 0.4 ENCODE 11.3 +200.1 200056 4.6 HDGF PKNOX1 ATF1 CREB3L1 ARID4B SIN3A DMAP1 ZNF48 ZNF2 GLIS2 C7orf31 OSBPL3 SNRPCP19
GH07F026151 1.4 FANTOM5 Ensembl ENCODE 11.2 -975.3 -975313 9.7 HDGF PKNOX1 ARNT CREB3L1 WRNIP1 SIN3A DMAP1 ZNF2 YY1 ZNF766 HNRNPA2B1 SNX10 CBX3 C7orf31 HOXA-AS2 HOXA5 LOC105375304 LOC105375201 NFE2L3 GC07P026176
GH07F025195 0.4 ENCODE 5 -15.7 -15699 1.9 SOX13 ELF3 YY1 ZNF26 SOX5 ZNF280D STAT1 NFIA RNF2 HMG20A NPVF C7orf31 LOC105375191 RPL7AP41
GH07F024819 1.4 FANTOM5 Ensembl ENCODE 2.6 +359.1 359065 3.7 PKNOX1 WRNIP1 ARID4B SIN3A ZNF143 ZNF207 FOS NFYC JUNB REST OSBPL3 DFNA5 C7orf31 SNRPCP19
GH07F024824 1.2 FANTOM5 Ensembl ENCODE 1.7 +349.9 349900 13.1 HDGF PKNOX1 ARNT SIN3A ARID4B DMAP1 ZNF48 ZNF766 GATA2 FOS OSBPL3 DFNA5 C7orf31 SNRPCP19
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around C7orf31 on UCSC Golden Path with GeneCards custom track

Promoters for C7orf31 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000157261 548 1601 HDGF TBP WRNIP1 SIN3A ARID4B ZNF48 RAD21 ZBTB40 YY1 ZNF143

Genomic Location for C7orf31 Gene

Chromosome:
7
Start:
25,125,200 bp from pter
End:
25,180,748 bp from pter
Size:
55,549 bases
Orientation:
Minus strand

Genomic View for C7orf31 Gene

Genes around C7orf31 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C7orf31 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C7orf31 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C7orf31 Gene

Proteins for C7orf31 Gene

  • Protein details for C7orf31 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N865-CG031_HUMAN
    Recommended name:
    Uncharacterized protein C7orf31
    Protein Accession:
    Q8N865
    Secondary Accessions:
    • A4D165
    • Q6MZV8
    • Q6P989
    • Q7LE28
    • Q86XK1
    • Q8N1H5
    • Q96BN4

    Protein attributes for C7orf31 Gene

    Size:
    590 amino acids
    Molecular mass:
    68464 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAP22338.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=BAC05255.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for C7orf31 Gene

Post-translational modifications for C7orf31 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C7orf31 Gene

No data available for DME Specific Peptides for C7orf31 Gene

Domains & Families for C7orf31 Gene

Protein Domains for C7orf31 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C7orf31: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for C7orf31 Gene

Function for C7orf31 Gene

Gene Ontology (GO) - Molecular Function for C7orf31 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with C7orf31: view
genes like me logo Genes that share phenotypes with C7orf31: view

Animal Model Products

miRNA for C7orf31 Gene

miRTarBase miRNAs that target C7orf31

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C7orf31 Gene

Localization for C7orf31 Gene

Subcellular locations from UniProtKB/Swiss-Prot for C7orf31 Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for C7orf31 Gene COMPARTMENTS Subcellular localization image for C7orf31 gene
Compartment Confidence
cytoskeleton 5
cytosol 3
nucleus 3
mitochondrion 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for C7orf31 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005813 centrosome IDA 25074808
GO:0005815 microtubule organizing center IEA --
GO:0005856 cytoskeleton IEA --
genes like me logo Genes that share ontologies with C7orf31: view

Pathways & Interactions for C7orf31 Gene

SuperPathways for C7orf31 Gene

No Data Available

Interacting Proteins for C7orf31 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000283905%0d%0a9606.ENSP00000287777%0d%0a
Selected Interacting proteins: ENSP00000283905 Q8N865-CG031_HUMAN for C7orf31 Gene via STRING UniProtKB IID

Gene Ontology (GO) - Biological Process for C7orf31 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for C7orf31 Gene

Transcripts for C7orf31 Gene

Unigene Clusters for C7orf31 Gene

Chromosome 7 open reading frame 31:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for C7orf31 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11
SP1: - - - -
SP2: - -
SP3: - -
SP4: - - -
SP5: -

Relevant External Links for C7orf31 Gene

GeneLoc Exon Structure for
C7orf31
ECgene alternative splicing isoforms for
C7orf31

Expression for C7orf31 Gene

mRNA expression in normal human tissues for C7orf31 Gene

mRNA differential expression in normal tissues according to GTEx for C7orf31 Gene

This gene is overexpressed in Testis (x13.2).

Protein differential expression in normal tissues from HIPED for C7orf31 Gene

This gene is overexpressed in Testis (68.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for C7orf31 Gene



Protein tissue co-expression partners for C7orf31 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of C7orf31 Gene:

C7orf31

SOURCE GeneReport for Unigene cluster for C7orf31 Gene:

Hs.122055
genes like me logo Genes that share expression patterns with C7orf31: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for C7orf31 Gene

Orthologs for C7orf31 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C7orf31 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C7H7orf31 34
  • 99.04 (n)
C7orf31 35
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C14H7orf31 34
  • 88.11 (n)
C7orf31 35
  • 84 (a)
OneToOne
cow
(Bos Taurus)
Mammalia C4H7orf31 34
  • 86.82 (n)
C7orf31 35
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia 4921507P07Rik 34 16 35
  • 79.76 (n)
rat
(Rattus norvegicus)
Mammalia LOC500124 34
  • 78.97 (n)
oppossum
(Monodelphis domestica)
Mammalia C7orf31 35
  • 52 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia C7orf31 35
  • 52 (a)
OneToOne
chicken
(Gallus gallus)
Aves C2H7ORF31 34
  • 54.42 (n)
C7orf31 35
  • 44 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia C7orf31 35
  • 30 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100497526 34
  • 51.15 (n)
Species where no ortholog for C7orf31 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for C7orf31 Gene

ENSEMBL:
Gene Tree for C7orf31 (if available)
TreeFam:
Gene Tree for C7orf31 (if available)

Paralogs for C7orf31 Gene

No data available for Paralogs for C7orf31 Gene

Variants for C7orf31 Gene

Sequence variations from dbSNP and Humsavar for C7orf31 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs10156062 -- 25,163,576(+) CATGG(C/T)GGCAG intron-variant
rs10227016 -- 25,177,408(+) aaccc(A/G)ggagg intron-variant
rs10227123 -- 25,177,493(+) aaaaa(A/C)caaaa intron-variant
rs10236740 -- 25,146,713(+) ATTTA(C/G)GTTTG intron-variant
rs10237157 -- 25,167,634(+) TATTT(C/T)TTTTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for C7orf31 Gene

Variant ID Type Subtype PubMed ID
esv3612592 CNV loss 21293372
nsv510075 OTHER sequence alteration 20534489
nsv606424 CNV gain 21841781
nsv7393 OTHER inversion 18451855

Variation tolerance for C7orf31 Gene

Residual Variation Intolerance Score: 97.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 16.81; 97.91% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C7orf31 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
C7orf31

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C7orf31 Gene

Disorders for C7orf31 Gene

Relevant External Links for C7orf31

Genetic Association Database (GAD)
C7orf31
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
C7orf31

No disorders were found for C7orf31 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C7orf31 Gene

Publications for C7orf31 Gene

  1. Proteomic analysis of mammalian sperm cells identifies new components of the centrosome. (PMID: 25074808) Firat-Karalar E.N. … Stearns T. (J. Cell Sci. 2014) 2 3 4 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier L.W. … Wilson R.K. (Nature 2003) 3 4 64
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3 64

Products for C7orf31 Gene

Sources for C7orf31 Gene

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