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C7orf26 Gene

protein-coding   GIFtS: 46
GCID: GC07P006658

Chromosome 7 Open Reading Frame 26

  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Chromosome 7 Open Reading Frame 261 2
Uncharacterized Protein C7orf262

External Ids:    HGNC: 217021   Entrez Gene: 790342   Ensembl: ENSG000001465767   UniProtKB: Q96N113   

Export aliases for C7orf26 gene to outside databases

Previous GC identifers: GC07P006339 GC07P006374 GC07P006403 GC07P006596 GC07P006630 GC07P006635 GC07P006640 GC07P006644


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for C7orf26 Gene:
C7orf26 (chromosome 7 open reading frame 26) is a protein-coding gene. Diseases associated with C7orf26 include malaria.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000007.14  NT_007819.18  NC_018918.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the C7orf26 gene promoter:
         C/EBPbeta   AML1a   p300   Olf-1   Lmo2   AP-4   Tal-1beta   E47   AREB6   HFH-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): C7orf26 promoter sequence
   Search Chromatin IP Primers for C7orf26

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat C7orf26


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7p22.1   Ensembl cytogenetic band:  7p22.1   HGNC cytogenetic band: 7p22.1

C7orf26 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
C7orf26 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P006658:  view genomic region     (about GC identifiers)

Start:
6,629,648 bp from pter      End:
6,648,357 bp from pter
Size:
18,710 bases      Orientation:
plus strand

1 alternative location:
Chr7+,CRA_TCAG 6,676,974-6,695,409     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: CG026_HUMAN, Q96N11 (See protein sequence)
Recommended Name: Uncharacterized protein C7orf26  
Size: 449 amino acids; 50047 Da
Secondary accessions: Q9BQ43
Alternative splicing: 2 isoforms:  Q96N11-1   Q96N11-2   

Explore the universe of human proteins at neXtProt for C7orf26: NX_Q96N11

Explore proteomics data for C7orf26 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See C7orf26 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_076972.2  
    ENSEMBL proteins: 
     ENSP00000340220   ENSP00000351974   ENSP00000390166   ENSP00000396194  

    C7orf26 Human Recombinant Protein Products:

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    LSBio Antibodies in human, mouse, rat for C7orf26

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    Cloud-Clone Corp. ELISAs for C7orf26
    Cloud-Clone Corp. CLIAs for C7orf26


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR027844 DUF4507

    Graphical View of Domain Structure for InterPro Entry Q96N11

    ProtoNet protein and cluster: Q96N11


    C7orf26 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Phenotypes:
         2 GenomeRNAi human phenotypes for C7orf26:
     Increased gamma-H2AX phosphory  Increased number of cells in m 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for C7orf26
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for C7orf26
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for C7orf26

    miRNA
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    miRTarBase miRNAs that target C7orf26:
    hsa-mir-193b-3p (MIRT041344)

    Block miRNA regulation of human, mouse, rat C7orf26 using miScript Target Protectors
    6 qRT-PCR Assays for microRNAs that regulate C7orf26:
    hsa-miR-124 hsa-miR-506 hsa-miR-32* hsa-miR-488 hsa-miR-4282 hsa-miR-452
    SwitchGear 3'UTR luciferase reporter plasmidC7orf26 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for C7orf26
    Predesigned siRNA for gene silencing in human, mouse, rat C7orf26

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for C7orf26

    Clone
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    OriGene clones in human, mouse for C7orf26 (see all 6)
    OriGene ORF clones in mouse, rat for C7orf26
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: C7orf26 (NM_024067)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for C7orf26
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C7orf26

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for C7orf26 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C7orf26


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol2
    nucleus2
    plasma membrane2
    peroxisome1

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for C7orf26
    Interactions:

        Search GeneGlobe Interaction Network for C7orf26

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    Selected Interacting proteins for C7orf26 (Q96N112, 3 ENSP000003402204) via UniProtKB, MINT, STRING, and/or I2D (see all 10)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    INTS5Q6P9B93, ENSP000003278894I2D: score=1 STRING: ENSP00000327889
    INTS1Q8N2013, ENSP000003857224I2D: score=1 STRING: ENSP00000385722
    INTS3Q68E013, ENSP000003186414I2D: score=1 STRING: ENSP00000318641
    INTS6Q9UL033, ENSP000003102604I2D: score=1 STRING: ENSP00000310260
    INTS10Q9NVR23I2D: score=5 
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for C7orf26 (CG026)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for C7orf26 gene: 
    NM_024067.2  

    Unigene Cluster for C7orf26:

    Chromosome 7 open reading frame 26
    Hs.487511  [show with all ESTs]
    Unigene Representative Sequence: BM558459
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000344417(uc003sqo.1) ENST00000359073(uc003sqp.1) ENST00000472693
    ENST00000477298 ENST00000445375 ENST00000440409
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat C7orf26 using miScript Target Protectors
    6 qRT-PCR Assays for microRNAs that regulate C7orf26:
    hsa-miR-124 hsa-miR-506 hsa-miR-32* hsa-miR-488 hsa-miR-4282 hsa-miR-452
    SwitchGear 3'UTR luciferase reporter plasmidC7orf26 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for C7orf26
    Predesigned siRNA for gene silencing in human, mouse, rat C7orf26
    Clone
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    OriGene clones in human, mouse for C7orf26 (see all 6)
    OriGene ORF clones in mouse, rat for C7orf26
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: C7orf26 (NM_024067)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for C7orf26
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C7orf26
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for C7orf26
    OriGene qSTAR qPCR primer pairs in human, mouse for C7orf26
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat C7orf26
      QuantiTect SYBR Green Assays in human, mouse, rat C7orf26
      QuantiFast Probe-based Assays in human, mouse, rat C7orf26

    Additional mRNA sequence: 

    AK056149.1 BC001076.2 BC005121.1 BC113910.1 

    7 DOTS entries:

    DT.212541  DT.121049094  DT.95270673  DT.95270672  DT.99928854  DT.102819872  DT.92423933 

    Selected AceView cDNA sequences (see all 363):

    BM705739 BM713080 CB112519 CR591069 CB150696 CK299594 CD674200 T25508 
    BE885343 AA916429 BM473024 Z41394 AW304031 CK823414 AA283047 AA613892 
    CB215726 AY359090 CR609834 BQ185277 BQ925460 BU737547 AI014772 CA454040 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for C7orf26 (see all 10)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b · 5c · 5d · 5e ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c
    SP1:                    -                 -                       -     -     -                 -           -     -     -     -                     
    SP2:                                      -                                                     -           -     -     -     -                     
    SP3:                                                                                            -           -                 -                     
    SP4:                                                                                            -           -     -           -                     
    SP5:                                                                                            -           -     -                                 


    ECgene alternative splicing isoforms for C7orf26

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    C7orf26 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CAGATTGGAT
    C7orf26 Expression
    About this image

    C7orf26 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    C7orf26 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.487511
        Custom PCR Arrays for C7orf26
    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C7orf26

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for C7orf26 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia E130309D02Rik1 , 5 RIKEN cDNA E130309D02 gene1, 5 88.1(n)1
    94.87(a)1
      5 (82.07 cM)5
    2318681  NM_172726.41  NP_766314.31 
     1433011955 
    chicken
    (Gallus gallus)
    Aves C7ORF261 chromosome 14 open reading frame, human C7orf26 79.36(n)
    88.42(a)
      416658  XM_414955.4  XP_414955.3 
    lizard
    (Anolis carolinensis)
    Reptilia C7orf266
    chromosome 7 open reading frame 26
    70(a)
    1 ↔ 1
    AAWZ02036670(4787-9741)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC691652 hypothetical protein MGC69165 71.61(n)    BC056130.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc564092 hypothetical protein MGC56409 74.03(n)   393295  BC052107.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG52741 CG5274 46.33(n)
    36(a)
      40257  NM_140965.3  NP_649222.1 


    ENSEMBL Gene Tree for C7orf26 (if available)
    TreeFam Gene Tree for C7orf26 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for C7orf26 (see all 574)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs38135131,2
    C,F--6629137(-) GTCATG/CTCTCC 1 -- us2k110Minor allele frequency- C:0.31NA WA CSA EA 370
    rs2021309121,2
    C--6629295(+) CATCT-/CCCCCG 1 -- us2k10--------
    rs607423751,2
    C,F--6629402(+) CCCCCA/CATTCT 1 -- us2k17Minor allele frequency- C:0.35NA WA CSA EA 365
    rs133121801,2
    C,F,H--6629444(+) CGGCAG/TCTCTG 1 -- us2k119Minor allele frequency- T:0.34NS EA NA WA 2340
    rs791951421,2
    C--6629492(+) ACGGAA/GCGGGC 1 -- us2k10--------
    rs1827392521,2
    C--6629543(+) CTGGGA/CCCGCG 1 -- us2k10--------
    rs1384402961,2
    C,F--6629944(+) CTGCGC/TCGCGA 2 R syn12Minor allele frequency- T:0.00NA EU 3195
    rs133124441,2
    C--6630000(+) CTTCAA/C/GCAGCC 3 N T S mis1 ese32NA 4
    rs1466068111,2
    C,F--6630046(+) GGCCCC/GGTGGA 2 P syn12Minor allele frequency- G:0.00NA EU 4051
    rs780647411,2
    C,F--6630103(+) CAGCCC/TAAGGT 2 P syn11Minor allele frequency- T:0.02NA 2316

    HapMap Linkage Disequilibrium report for C7orf26 (6629648 - 6648357 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for C7orf26 (see all 13):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2733933CNV Deletion23290073
    esv2733932CNV Deletion23290073
    nsv436904CNV Insertion17901297
    dgv7149n71CNV Loss21882294
    dgv7150n71CNV Loss21882294
    nsv830895CNV Loss17160897
    dgv7148n71CNV Loss21882294
    dgv7147n71CNV Loss21882294
    nsv515978CNV Loss19592680
    nsv508444CNV Loss20534489

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing C7orf26
    DNA2.0 Custom Variant and Variant Library Synthesis for C7orf26

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    1 disease for C7orf26:    
    About MalaCards
    malaria


    C7orf26 for disorders           About GeneDecksing


    Export disorders for C7orf26 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for C7orf26 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with C7orf26)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    3. Interactome study suggests multiple cellular functions of hepatoma-derived growth factor (HDGF). (PubMed id 21907836)1 Zhao J....Yang P. (J Proteomics 2011)
    4. Streamlined analysis schema for high-throughput identification of endogenous protein complexes. (PubMed id 20133760)1 Malovannaya A....Qin J. (Proc. Natl. Acad. Sci. U.S.A. 2010)
    5. A human protein-protein interaction network: a resource for annotating the proteome. (PubMed id 16169070)1 Stelzl U.... Wanker E.E. (Cell 2005)
    6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 79034 HGNC: 21702 AceView: ZDHHC4andC7orf26 Ensembl:ENSG00000146576 euGenes: HUgn79034
    ECgene: C7orf26 H-InvDB: C7orf26

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for C7orf26 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for C7orf26 gene:
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