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Aliases for C7orf25 Gene

Aliases for C7orf25 Gene

  • Chromosome 7 Open Reading Frame 25 2 3 5

External Ids for C7orf25 Gene

Previous GeneCards Identifiers for C7orf25 Gene

  • GC07M042655
  • GC07M042689
  • GC07M042722
  • GC07M042915
  • GC07M042833
  • GC07M042948

Summaries for C7orf25 Gene

GeneCards Summary for C7orf25 Gene

C7orf25 (Chromosome 7 Open Reading Frame 25) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C7orf25 Gene

Genomics for C7orf25 Gene

Regulatory Elements for C7orf25 Gene

Enhancers for C7orf25 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07F042886 1.8 FANTOM5 Ensembl ENCODE 40.4 +24.0 24004 3.4 ARID4B FEZF1 DMAP1 ZNF48 ZNF2 YY1 ZNF121 GLIS2 ZNF302 SP3 C7orf25 GC07M042892 ENSG00000231539
GH07F042911 1.1 ENCODE 46.8 +0.1 113 2.3 HDGF CREB3L1 MLX ARID4B SIN3A DMAP1 YY1 SLC30A9 ZNF207 ZNF143 C7orf25 MRPL32 PSMA2 ENSG00000261019
GH07F042930 1.1 ENCODE 43 -19.8 -19831 3.7 HDGF PKNOX1 CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 YY1 ZNF766 ZNF207 C7orf25 MRPL32 PSMA2 ENSG00000256646 LOC105375252
GH07F042913 0.8 FANTOM5 ENCODE 44.3 -2.1 -2121 1.4 ZNF121 POLR2A JUN C7orf25 MRPL32 LOC105375252
GH07F042940 1 Ensembl ENCODE 27.8 -29.1 -29078 0.9 CTCF CBX3 WRNIP1 MAX ZNF2 RAD21 SCRT2 ZNF143 SMC3 ZNF652 C7orf25 MRPL32 PSMA2 LOC105375253
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around C7orf25 on UCSC Golden Path with GeneCards custom track

Promoters for C7orf25 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001559397 605 1801 HDGF CREB3L1 MLX ARID4B SIN3A DMAP1 YY1 SLC30A9 ZNF207 ZNF143

Genomic Location for C7orf25 Gene

Chromosome:
7
Start:
42,908,726 bp from pter
End:
42,912,305 bp from pter
Size:
3,580 bases
Orientation:
Minus strand

Genomic View for C7orf25 Gene

Genes around C7orf25 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C7orf25 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C7orf25 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C7orf25 Gene

Proteins for C7orf25 Gene

  • Protein details for C7orf25 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BPX7-CG025_HUMAN
    Recommended name:
    UPF0415 protein C7orf25
    Protein Accession:
    Q9BPX7
    Secondary Accessions:
    • A4D1V2
    • J3KR36
    • Q9H779

    Protein attributes for C7orf25 Gene

    Size:
    421 amino acids
    Molecular mass:
    46451 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for C7orf25 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for C7orf25 Gene

Post-translational modifications for C7orf25 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for C7orf25 Gene

Domains & Families for C7orf25 Gene

Protein Domains for C7orf25 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for C7orf25 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BPX7

UniProtKB/Swiss-Prot:

CG025_HUMAN :
  • Belongs to the UPF0415 family.
Family:
  • Belongs to the UPF0415 family.
genes like me logo Genes that share domains with C7orf25: view

No data available for Gene Families for C7orf25 Gene

Function for C7orf25 Gene

Gene Ontology (GO) - Molecular Function for C7orf25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with C7orf25: view

Phenotypes for C7orf25 Gene

genes like me logo Genes that share phenotypes with C7orf25: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for C7orf25 Gene

Localization for C7orf25 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C7orf25 gene
Compartment Confidence
cytosol 4
nucleus 3

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for C7orf25 Gene

Pathways & Interactions for C7orf25 Gene

SuperPathways for C7orf25 Gene

No Data Available

Gene Ontology (GO) - Biological Process for C7orf25 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for C7orf25 Gene

Transcripts for C7orf25 Gene

Unigene Clusters for C7orf25 Gene

Chromosome 7 open reading frame 25:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for C7orf25 Gene

No ASD Table

Relevant External Links for C7orf25 Gene

GeneLoc Exon Structure for
C7orf25
ECgene alternative splicing isoforms for
C7orf25

Expression for C7orf25 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for C7orf25 Gene

Protein differential expression in normal tissues from HIPED for C7orf25 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (36.4), Spleen (7.5), and Skin (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for C7orf25 Gene



NURSA nuclear receptor signaling pathways regulating expression of C7orf25 Gene:

C7orf25

SOURCE GeneReport for Unigene cluster for C7orf25 Gene:

Hs.698120
genes like me logo Genes that share expression patterns with C7orf25: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for C7orf25 Gene

Orthologs for C7orf25 Gene

This gene was present in the common ancestor of animals.

Orthologs for C7orf25 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C7orf25 35
  • 100 (a)
OneToOne
C7H7orf25 34
  • 99.72 (n)
cow
(Bos Taurus)
Mammalia C7orf25 35
  • 98 (a)
OneToOne
C4H7orf25 34
  • 91.84 (n)
dog
(Canis familiaris)
Mammalia C7orf25 35
  • 97 (a)
OneToOne
C18H7orf25 34
  • 93.03 (n)
rat
(Rattus norvegicus)
Mammalia RGD1308147 34
  • 88.36 (n)
mouse
(Mus musculus)
Mammalia AW209491 34 16 35
  • 88.12 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia C7orf25 35
  • 86 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia C7orf25 35
  • 72 (a)
OneToOne
chicken
(Gallus gallus)
Aves C7orf25 35
  • 81 (a)
OneToOne
C2H7ORF25 34
  • 74.07 (n)
lizard
(Anolis carolinensis)
Reptilia C7orf25 35
  • 79 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia c7orf25 34
  • 73.73 (n)
Str.14994 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.10096 34
zebrafish
(Danio rerio)
Actinopterygii C2H7orf25 35
  • 71 (a)
OneToOne
zgc:55781 34
  • 66.42 (n)
Dr.207 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5893 34
fruit fly
(Drosophila melanogaster)
Insecta CG42553 34 35
  • 47.82 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004537 34
  • 45.67 (n)
worm
(Caenorhabditis elegans)
Secernentea F33G12.3 34 35
  • 43.11 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 42 (a)
OneToOne
Species where no ortholog for C7orf25 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for C7orf25 Gene

ENSEMBL:
Gene Tree for C7orf25 (if available)
TreeFam:
Gene Tree for C7orf25 (if available)

Paralogs for C7orf25 Gene

No data available for Paralogs for C7orf25 Gene

Variants for C7orf25 Gene

Sequence variations from dbSNP and Humsavar for C7orf25 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs1048423 -- 42,909,502(-) TCTTT(A/G)TCTCT utr-variant-3-prime
rs1048434 -- 42,909,439(-) TCTAT(C/T)AAACT utr-variant-3-prime
rs10534667 -- 42,914,219(+) CACTT(-/TG)TGAGT upstream-variant-2KB
rs112097397 -- 42,909,157(+) GACTG(A/C)ACCTG downstream-variant-500B
rs112503165 -- 42,914,685(+) CTATT(C/T)TGAAA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for C7orf25 Gene

Variant ID Type Subtype PubMed ID
nsv606715 CNV gain 21841781
nsv830979 CNV gain 17160897

Variation tolerance for C7orf25 Gene

Residual Variation Intolerance Score: 21.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.17; 39.30% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C7orf25 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
C7orf25

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C7orf25 Gene

Disorders for C7orf25 Gene

Relevant External Links for C7orf25

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
C7orf25

No disorders were found for C7orf25 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C7orf25 Gene

Publications for C7orf25 Gene

  1. MxA interacts with and is modified by the SUMOylation machinery. (PMID: 25447205) Brantis-de-Carvalho C.E. … Valentini S.R. (Exp. Cell Res. 2015) 3 64
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3 64
  4. A directed protein interaction network for investigating intracellular signal transduction. (PMID: 21900206) Vinayagam A. … Wanker E.E. (Sci Signal 2011) 3 64
  5. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 3 64

Products for C7orf25 Gene

Sources for C7orf25 Gene

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