Free for academic non-profit institutions. Other users need a Commercial license

Aliases for C7 Gene

Aliases for C7 Gene

  • Complement Component 7 2 3

External Ids for C7 Gene

Previous GeneCards Identifiers for C7 Gene

  • GC05P041235
  • GC05P042001
  • GC05P040909
  • GC05P040955
  • GC05P040974

Summaries for C7 Gene

Entrez Gene Summary for C7 Gene

  • C7 is a component of the complement system. It participates in the formation of Membrane Attack Complex (MAC). People with C7 deficiency are prone to bacterial infection. [provided by RefSeq, Jul 2008]

GeneCards Summary for C7 Gene

C7 (Complement Component 7) is a Protein Coding gene. Diseases associated with C7 include c7 deficiency and immunodeficiency due to a late component of complements deficiency. Among its related pathways are Complement and coagulation cascades and Complement and coagulation cascades. An important paralog of this gene is C6.

UniProtKB/Swiss-Prot for C7 Gene

  • Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. C7 serves as a membrane anchor

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C7 Gene

Genomics for C7 Gene

Regulatory Elements for C7 Gene

Genomic Location for C7 Gene

40,909,252 bp from pter
40,982,939 bp from pter
73,688 bases
Plus strand

Genomic View for C7 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for C7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C7 Gene

Proteins for C7 Gene

  • Protein details for C7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Complement component C7
    Protein Accession:
    Secondary Accessions:
    • Q6P3T5
    • Q92489

    Protein attributes for C7 Gene

    843 amino acids
    Molecular mass:
    93518 Da
    Quaternary structure:
    • Monomer or dimer; as a C5b-7 complex it can also form multimeric rosettes. MAC assembly is initiated by protelytic cleavage of C5 into C5a and C5b. C5b binds sequentially C6, C7, C8 and multiple copies of the pore-forming subunit C9

    Three dimensional structures from OCA and Proteopedia for C7 Gene

neXtProt entry for C7 Gene

Proteomics data for C7 Gene at MOPED

Post-translational modifications for C7 Gene

  • C7 has 28 disulfide bridges
  • O- and C-glycosylated. O-glycosylated with core 1 or possibly core 8 glycans.
  • Glycosylation at Trp36, Asn202, Trp503, Trp506, Trp509, Thr696, and Asn754
  • Modification sites at PhosphoSitePlus

Other Protein References for C7 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for C7 Gene

Domains for C7 Gene

Gene Families for C7 Gene


Suggested Antigen Peptide Sequences for C7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • P10643
  • Contains 1 EGF-like domain.
  • Contains 1 LDL-receptor class A domain.
  • Contains 1 MACPF domain.
  • Contains 2 Sushi (CCP/SCR) domains.
  • Contains 2 TSP type-1 domains.
  • Belongs to the complement C6/C7/C8/C9 family.
genes like me logo Genes that share domains with C7: view

Function for C7 Gene

Molecular function for C7 Gene

GENATLAS Biochemistry:
complement component 7,beta-2 globulin,complexing with other late components of the cascade to form the membrane attack complex
UniProtKB/Swiss-Prot Function:
Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. C7 serves as a membrane anchor

Gene Ontology (GO) - Molecular Function for C7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with C7: view

Phenotypes for C7 Gene

genes like me logo Genes that share phenotypes with C7: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for C7 Gene

Localization for C7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for C7 Gene


Subcellular locations from

Jensen Localization Image for C7 Gene COMPARTMENTS Subcellular localization image for C7 gene
Compartment Confidence
extracellular 5
plasma membrane 4
cytosol 1
endoplasmic reticulum 1
lysosome 1

Gene Ontology (GO) - Cellular Components for C7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005579 membrane attack complex IEA --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with C7: view

Pathways for C7 Gene

genes like me logo Genes that share pathways with C7: view

Gene Ontology (GO) - Biological Process for C7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006883 cellular sodium ion homeostasis IEA --
GO:0006956 complement activation TAS 3335508
GO:0006957 complement activation, alternative pathway IEA --
GO:0006958 complement activation, classical pathway IEA --
GO:0019835 cytolysis IEA --
genes like me logo Genes that share ontologies with C7: view

Transcripts for C7 Gene

Unigene Clusters for C7 Gene

Complement component 7:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for C7

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for C7 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15a · 15b ^ 16 ^ 17a · 17b
SP1: - -
SP2: - - - - - -

Relevant External Links for C7 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for C7 Gene

mRNA expression in normal human tissues for C7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for C7 Gene

This gene is overexpressed in Heart - Atrial Appendage (5.8), Ovary (5.6), and Adrenal Gland (4.0).

Protein differential expression in normal tissues for C7 Gene

This gene is overexpressed in Serum (19.6), Plasma (14.2), and Synovial fluid (12.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for C7 Gene

SOURCE GeneReport for Unigene cluster for C7 Gene Hs.78065

genes like me logo Genes that share expressions with C7: view

Expression partners for C7 Gene

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for C7 Gene

Orthologs for C7 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C7 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia C7 35
  • 84.13 (n)
  • 79.93 (a)
C7 36
  • 80 (a)
(Canis familiaris)
Mammalia C7 35
  • 84.37 (n)
  • 81.43 (a)
C7 36
  • 79 (a)
(Mus musculus)
Mammalia C7 35
  • 79.23 (n)
  • 73.96 (a)
C7 16
C7 36
  • 74 (a)
(Pan troglodytes)
Mammalia C7 35
  • 99.41 (n)
  • 99.05 (a)
C7 36
  • 99 (a)
(Rattus norvegicus)
Mammalia C7 35
  • 81.77 (n)
  • 79.57 (a)
(Monodelphis domestica)
Mammalia C7 36
  • 64 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 61 (a)
-- 36
  • 60 (a)
(Gallus gallus)
Aves C7 35
  • 66.34 (n)
  • 60.19 (a)
C7 36
  • 59 (a)
(Anolis carolinensis)
Reptilia C7 36
  • 56 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia c7 35
  • 62.24 (n)
  • 56.51 (a)
Str.11855 35
(Danio rerio)
Actinopterygii c7b 35
  • 54.16 (n)
  • 46.05 (a)
C7 (2 of 2) 36
  • 44 (a)
c7a 36
  • 40 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11577 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 29 (a)
-- 36
  • 28 (a)
-- 36
  • 25 (a)
-- 36
  • 23 (a)
-- 36
  • 24 (a)
-- 36
  • 23 (a)
Species with no ortholog for C7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C7 Gene

Gene Tree for C7 (if available)
Gene Tree for C7 (if available)

Paralogs for C7 Gene

Paralogs for C7 Gene

Selected SIMAP similar genes for C7 Gene using alignment to 3 proteins: Pseudogenes for C7 Gene

genes like me logo Genes that share paralogs with C7: view

Variants for C7 Gene

Sequence variations from dbSNP and Humsavar for C7 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs8264 -- 40,982,678(+) TCCCT(A/G)TTCTG utr-variant-3-prime
rs14190 -- 40,982,875(+) CTGGT(A/G)AATAT utr-variant-3-prime
rs178927 -- 40,934,256(-) TCCTT(A/T)ATCTG intron-variant
rs178928 -- 40,917,191(-) catac(A/C)aaatg intron-variant
rs178929 -- 40,924,108(-) atagg(C/T)agaag intron-variant

Structural Variations from Database of Genomic Variants (DGV) for C7 Gene

Variant ID Type Subtype PubMed ID
nsv881467 CNV Loss 21882294
dgv1797e1 CNV Complex 17122850
nsv823055 CNV Loss 20364138
esv35077 CNV Loss 17911159
nsv830268 CNV Gain 17160897
nsv880796 CNV Gain 21882294
nsv823056 CNV Loss 20364138
esv1534008 CNV Insertion 17803354
nsv507248 CNV Insertion 20534489
nsv823057 CNV Loss 20364138
esv2676304 CNV Deletion 23128226
esv1086081 CNV Insertion 17803354

Relevant External Links for C7 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)
Locus Specific Mutation Databases (LSDB)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C7 Gene

Disorders for C7 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for C7 Gene in MalaCards »

(2) Diseases for C7 Gene including...

(1) OMIM Diseases for C7 Gene (217070)


  • Complement component 7 deficiency (C7D) [MIM:610102]: A rare defect of the complement classical pathway associated with susceptibility to severe recurrent infections, predominantly by Neisseria gonorrhoeae or Neisseria meningitidis. {ECO:0000269 PubMed:8871666, ECO:0000269 PubMed:9218625, ECO:0000269 PubMed:9856499}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.

Genatlas disease for C7 Gene


Relevant External Links for C7

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with C7: view

No data available for University of Copenhagen DISEASES and Novoseek inferred disease relationships for C7 Gene

Publications for C7 Gene

  1. Solution structure of factor I-like modules from complement C7 reveals a pair of follistatin domains in compact pseudosymmetric arrangement. (PMID: 19419965) Phelan M.M. … Bramham J. (J. Biol. Chem. 2009) 3 4 23
  2. Complement factor 7 gene mutations in relation to meningococcal infection and clinical recurrence of meningococcal disease. (PMID: 19931914) Kuijpers T.W. … de Boer M. (Mol. Immunol. 2010) 3 23
  3. Structure of the human C7 gene and comparison with the C6, C8A, C8B and C9 genes. (PMID: 7730625) Hobart M.J. … DiScipio R.G. (J. Immunol. 1995) 3 4
  4. Molecular bases of C7 deficiency: three different defects. (PMID: 9218625) Fernie B.A. … Hobart M.J. (J. Immunol. 1997) 3 4
  5. Complement C7 deficiency: seven further molecular defects and their associated marker haplotypes. (PMID: 9856499) Fernie B.A. … Hobart M.J. (Hum. Genet. 1998) 3 4

Products for C7 Gene

Sources for C7 Gene

Back to Top