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Aliases for C6orf99 Gene

Aliases for C6orf99 Gene

  • Chromosome 6 Open Reading Frame 99 2 3 5

External Ids for C6orf99 Gene

Previous GeneCards Identifiers for C6orf99 Gene

  • GC00U914191
  • GC06U900640
  • GC06P159211
  • GC06P159290
  • GC06P156780

Summaries for C6orf99 Gene

GeneCards Summary for C6orf99 Gene

C6orf99 (Chromosome 6 Open Reading Frame 99) is a Protein Coding gene.

Additional gene information for C6orf99 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C6orf99 Gene

Genomics for C6orf99 Gene

GeneHancer (GH) Regulatory Elements for C6orf99 Gene

Promoters and enhancers for C6orf99 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06I158866 Promoter/Enhancer 1.8 Ensembl ENCODE dbSUPER 550.8 -1.0 -956 4.6 HDGF PKNOX1 CLOCK SMAD1 ARNT SIN3A ZNF2 IRF4 POLR2B ZNF766 C6orf99 WTAP DYNLT1 EZR GC06M158870 GC06M158871 OSTCP1
GH06I158923 Enhancer 1 Ensembl ENCODE 10.2 +54.3 54336 1.5 HDAC1 ATF1 PKNOX1 INSM2 KLF17 FEZF1 ZNF2 EGR1 EGR2 CEBPB C6orf99 RSPH3 LOC442272 RNU6-293P
GH06I159031 Enhancer 1 FANTOM5 Ensembl dbSUPER 4.5 +162.8 162800 2.5 NR2F1 ETV6 NR2F6 IKZF2 ATF2 RSPH3 TAGAP C6orf99 GC06P159017 LOC105378083
GH06I158995 Enhancer 0.8 Ensembl ENCODE 5.4 +125.7 125685 1.1 CBFB JUNB BATF IRF4 FOSL1 IKZF1 FOS FOSL2 MAFK RUNX3 RSPH3 C6orf99 LOC105378083
GH06I159001 Enhancer 0.8 Ensembl ENCODE 4.6 +133.0 132989 1.8 HLF MAX CEBPB GABPA RFX5 JUND POLR2A MYNN PRDM1 GC06P159001 RSPH3 C6orf99 LOC105378083 GC06P159017
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around C6orf99 on UCSC Golden Path with GeneCards custom track

Genomic Locations for C6orf99 Gene

Genomic Locations for C6orf99 Gene
chr6:158,869,855-158,918,005
(GRCh38/hg38)
Size:
48,151 bases
Orientation:
Plus strand
chr6:159,290,971-159,331,385
(GRCh37/hg19)

Genomic View for C6orf99 Gene

Genes around C6orf99 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C6orf99 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C6orf99 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C6orf99 Gene

Proteins for C6orf99 Gene

  • Protein details for C6orf99 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q4VX62-CF099_HUMAN
    Recommended name:
    Putative uncharacterized protein C6orf99
    Protein Accession:
    Q4VX62
    Secondary Accessions:
    • Q4VX61

    Protein attributes for C6orf99 Gene

    Size:
    202 amino acids
    Molecular mass:
    22766 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for C6orf99 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for C6orf99 Gene

Post-translational modifications for C6orf99 Gene

No Post-translational modifications

No data available for DME Specific Peptides for C6orf99 Gene

Domains & Families for C6orf99 Gene

Protein Domains for C6orf99 Gene

ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C6orf99: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for C6orf99 Gene

Function for C6orf99 Gene

Phenotypes From GWAS Catalog for C6orf99 Gene

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for C6orf99 Gene

Localization for C6orf99 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C6orf99 gene
Compartment Confidence
extracellular 2
nucleus 2
cytosol 2
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for C6orf99 Gene

Pathways & Interactions for C6orf99 Gene

SuperPathways for C6orf99 Gene

No Data Available

Interacting Proteins for C6orf99 Gene

Gene Ontology (GO) - Biological Process for C6orf99 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for C6orf99 Gene

Drugs & Compounds for C6orf99 Gene

No Compound Related Data Available

Transcripts for C6orf99 Gene

mRNA/cDNA for C6orf99 Gene

(12) REFSEQ mRNAs :
(0) Additional mRNA sequences :
-
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for C6orf99 Gene

Chromosome 6 open reading frame 99:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for C6orf99 Gene

No ASD Table

Relevant External Links for C6orf99 Gene

GeneLoc Exon Structure for
C6orf99
ECgene alternative splicing isoforms for
C6orf99

Expression for C6orf99 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for C6orf99 Gene

mRNA differential expression in normal tissues according to GTEx for C6orf99 Gene

This gene is overexpressed in Testis (x45.8).

NURSA nuclear receptor signaling pathways regulating expression of C6orf99 Gene:

C6orf99

SOURCE GeneReport for Unigene cluster for C6orf99 Gene:

Hs.32804
genes like me logo Genes that share expression patterns with C6orf99: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for C6orf99 Gene

Orthologs for C6orf99 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for C6orf99 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C6H6orf99 33
  • 96.94 (n)
C6orf99 34
  • 57 (a)
OneToOne
Species where no ortholog for C6orf99 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for C6orf99 Gene

ENSEMBL:
Gene Tree for C6orf99 (if available)
TreeFam:
Gene Tree for C6orf99 (if available)

Paralogs for C6orf99 Gene

No data available for Paralogs for C6orf99 Gene

Variants for C6orf99 Gene

Sequence variations from dbSNP and Humsavar for C6orf99 Gene

SNP ID Clin Chr 06 pos Variation AA Info Type
rs1000119652 -- 158,916,185(+) C/T genic_downstream_transcript_variant, intron_variant
rs1000126220 -- 158,882,574(+) T/C genic_upstream_transcript_variant, intron_variant
rs1000215350 -- 158,876,664(+) G/A genic_upstream_transcript_variant, intron_variant
rs1000226732 -- 158,877,449(+) T/C genic_upstream_transcript_variant, intron_variant
rs1000330177 -- 158,899,031(+) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for C6orf99 Gene

Variant ID Type Subtype PubMed ID
dgv1073n67 CNV loss 20364138
dgv1074n67 CNV loss 20364138
esv2677655 CNV deletion 23128226
esv2733019 CNV deletion 23290073
esv3611406 CNV loss 21293372
esv3611407 CNV loss 21293372
nsv442017 CNV gain+loss 18776908
nsv527528 CNV loss 19592680

Variation tolerance for C6orf99 Gene

Gene Damage Index Score: 0.58; 12.52% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for C6orf99 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
C6orf99

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C6orf99 Gene

Disorders for C6orf99 Gene

Additional Disease Information for C6orf99

No disorders were found for C6orf99 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C6orf99 Gene

Publications for C6orf99 Gene

  1. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall AJ … Beck S (Nature 2003) 3 4 58

Products for C6orf99 Gene

Sources for C6orf99 Gene

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