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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

C6orf89 Gene

protein-coding   GIFtS: 41
GCID: GC06P036839

Chromosome 6 Open Reading Frame 89

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Chromosome 6 Open Reading Frame 891 2
Bombesin Receptor Activated Protein1 2
BRAP2 3
amfion2
Bombesin Receptor-Activated Protein C6orf892
Amfion3

External Ids:    HGNC: 211141   Entrez Gene: 2214772   Ensembl: ENSG000001986637   UniProtKB: Q6UWU43   

Export aliases for C6orf89 gene to outside databases

Previous GC identifers: GC06P036842 GC06P036886 GC06P036961 GC06P036571


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for C6orf89 Gene: 
C6orf89 (chromosome 6 open reading frame 89) is a protein-coding gene. Diseases associated with C6orf89 include hepatitis b, and hepatitis.

UniProtKB/Swiss-Prot: CF089_HUMAN, Q6UWU4
Function: Exhibits histone deacetylase (HDAC) enhancer properties. May play a role in cell cycle progression and
wound repair of bronchial epithelial cells

Gene Wiki entry for C6orf89 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NT_007592.15  NC_018917.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the C6orf89 gene promoter:
         TBP   NCX/Ncx   AP-2gamma   Ik-3   c-Ets-1   Pax-3   TFIID   AP-2beta   AP-2alpha   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidC6orf89 promoter sequence
   Search SABiosciences Chromatin IP Primers for C6orf89

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C6orf89


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.2   Ensembl cytogenetic band:  6p21.2   HGNC cytogenetic band: 6p21.31

C6orf89 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
C6orf89 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P036839:  view genomic region     (about GC identifiers)

Start:
36,839,646 bp from pter      End:
36,896,740 bp from pter
Size:
57,095 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CF089_HUMAN, Q6UWU4 (See protein sequence)
Recommended Name: Bombesin receptor-activated protein C6orf89  
Size: 347 amino acids; 39870 Da
Subunit: Interacts with BRS3
Subcellular location: Isoform 1: Golgi apparatus membrane; Single-pass type II membrane protein. Midbody
Subcellular location: Isoform 2: Cytoplasm. Nucleus, nucleolus. Note=Retained in nucleolar organiser regions
(NORs) in mitotic cells
Sequence caution: Sequence=AAH23605.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Sequence=CAD98021.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: B4DTT1 F4NAR0 F4NAR1 Q6ZMG5 Q7Z356 Q8IZ35
Alternative splicing: 2 isoforms:  Q6UWU4-1   Q6UWU4-2   

Explore the universe of human proteins at neXtProt for C6orf89: NX_Q6UWU4

Explore proteomics data for C6orf89 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q6UWU4

  • C6orf89 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    C6orf89 Protein Expression
    REFSEQ proteins: NP_689947.2  
    ENSEMBL proteins: 
     ENSP00000352316   ENSP00000475947   ENSP00000347322   ENSP00000362789   ENSP00000445655  

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    Cloud-Clone Corp. Proteins for C6orf89 

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane IEA--
    GO:0005730nucleolus IEA--
    GO:0005737cytoplasm IDA--
    GO:0005886plasma membrane IDA--
    GO:0016021integral to membrane IEA--

    C6orf89 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ProtoNet protein and cluster: Q6UWU4


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CF089_HUMAN, Q6UWU4
    Function: Exhibits histone deacetylase (HDAC) enhancer properties. May play a role in cell cycle progression and
    wound repair of bronchial epithelial cells

    Phenotypes:
         1 GenomeRNAi human phenotype for C6orf89:

     Decreased circadian period len 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for BC004004):
     normal 

    C6orf89 for phenotypes           About GeneDecksing

    Animal Models:
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for C6orf89 
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for C6orf89

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for C6orf89 (ENSP000003473224) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0042060wound healing IDA--
    GO:0045787positive regulation of cell cycle IDA--
    GO:0050673epithelial cell proliferation IDA--

    C6orf89 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for C6orf89 (CF089)

    Search CenterWatch for drugs/clinical trials and news about C6orf89 / CF089

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for C6orf89 gene: 
    NM_152734.3  

    Unigene Cluster for C6orf89:

    Chromosome 6 open reading frame 89
    Hs.433381  [show with all ESTs]
    Unigene Representative Sequence: NM_152734
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000359359(uc003omv.3 uc003omw.3 uc003omx.3 uc011dtr.2)
    ENST00000480824 ENST00000355190 ENST00000373685 ENST00000510325
    miRNA
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    8/60 QIAGEN miScript miRNA Assays for microRNAs that regulate C6orf89 (see all 60):
    hsa-miR-411* hsa-miR-548j hsa-miR-323-3p hsa-miR-4291 hsa-miR-100* hsa-miR-607 hsa-miR-3938 hsa-miR-642a
    Browse SwitchGear 3'UTR luciferase reporter plasmids
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    Additional mRNA sequence: 

    AJ420498.1 AJ420511.1 AK001957.1 AK025213.1 AK057109.1 AK172780.1 AK300351.1 AK315984.1 
    AL833755.1 BC009380.2 BC021804.1 BC023605.2 BC032796.1 BC050582.1 BC105946.1 BC105947.1 
    BC107489.1 BX538108.1 DQ487761.1 FR832871.1 FR832872.1 

    14 DOTS entries:

    DT.95248037  DT.112746  DT.75115772  DT.112396  DT.121337697  DT.100824896  DT.113683  DT.95267645 
    DT.121337695  DT.95248047  DT.100028595  DT.121337742  DT.121337737  DT.97778516 

    24/444 AceView cDNA sequences (see all 444):

    AW015191 BM727176 BC021804 BM449776 AK025213 AI955715 AI401083 BQ057057 
    AI565150 AI399788 BQ636849 AI653926 CA392779 BM983149 BM917800 AL119182 
    BP368793 AI041827 CD108104 AI421723 CB125244 BX384937 BE836045 BU182707 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for C6orf89    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10
    SP1:              -                       -                           
    SP2:                                                                  
    SP3:                                                                  


    ECgene alternative splicing isoforms for C6orf89

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    C6orf89 expression in normal human tissues (normalized intensities)      C6orf89 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    C6orf89 Expression
    About this image


    C6orf89 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/3 selected tissues (see all 3) fully expand
     
     Testis (Reproductive System)
             sperm   
     
     Ovary (Reproductive System)
             Primary Oocyte Primary Follicle
     
     Gonad
             Primary Oocyte Primary Follicle

    See C6orf89 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for C6orf89

    SOURCE GeneReport for Unigene cluster: Hs.433381
        SABiosciences Custom PCR Arrays for C6orf89
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C6orf89

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for C6orf89 gene from 4/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia BC0040041 , 5 cDNA sequence BC0040041, 5 85.3(n)1
    83.57(a)1
      17 (15.17 cM)5
    807481  NM_030561.31  NP_085038.31 
     292687885 
    chicken
    (Gallus gallus)
    Aves C26H6orf891 chromosome 26 open reading frame, human C6orf89 62.46(n)
    53.54(a)
      419817  NM_001012548.1  NP_001012566.1 
    lizard
    (Anolis carolinensis)
    Reptilia C6ORF896
    Uncharacterized protein
    49(a)
    1 ↔ 1
    4(123598638-123626900)
    zebrafish
    (Danio rerio)
    Actinopterygii zgc:1622551 zgc:162255 47.36(n)
    36.36(a)
      100037321  NM_001089477.1  NP_001082946.1 


    ENSEMBL Gene Tree for C6orf89 (if available)
    TreeFam Gene Tree for C6orf89 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1079 SNPs in C6orf89 are shown (see all 1079)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1381263551,2
    --36851642(+) AATTCC/TCCTTT 1 -- us2k10--------
    rs69128911,2
    C,F,A,H--36851764(+) cgggcG/Ttgatg 1 -- us2k17Minor allele frequency- T:0.29NA WA EA 366
    rs69130471,2
    C,F,A,H--36851830(+) gtcagG/Aagttt 1 -- us2k12Minor allele frequency- A:0.50NA 4
    rs1874098761,2
    C--36851831(+) TCAGGA/GGTTTG 1 -- us2k10--------
    rs1441406081,2
    --36851906(+) GGTGGC/TAGGTG 1 -- us2k10--------
    rs1918273701,2
    --36851996(+) TCGCCA/GCTGCA 1 -- us2k10--------
    rs770071681,2
    C--36852213(+) CGCCCA/GATAAT 1 -- us2k10--------
    rs1809699291,2
    --36852251(+) TATTCG/TCTCAA 1 -- us2k10--------
    rs1161133371,2
    F--36852293(+) ACAACG/ATCAAA 1 -- us2k11Minor allele frequency- A:0.02WA 118
    rs1119635211,2
    F--36852322(+) AATAAG/CAAAAA 1 -- us2k12Minor allele frequency- C:0.50CSA 4

    HapMap Linkage Disequilibrium report for C6orf89 (36839646 - 36896740 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for C6orf89:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2651912CNV Deletion19546169

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    2 diseases for C6orf89:    About MalaCards
    hepatitis b    hepatitis


    C6orf89 for disorders           About GeneDecksing


    Export disorders for C6orf89 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for C6orf89 gene, integrated from 9 sources (see all 16):
    (articles sorted by number of sources associating them with C6orf89)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. C6orf89 encodes three distinct HDAC enhancers that function in the nucleolus, the Golgi and the midbody. (PubMed id 23460338)1, 2, 3 Lalioti V.S....Sandoval I.V. (2013)
    2. Cloning of a novel protein interacting with BRS-3 and its effects in wound repair of bronchial epithelial cells. (PubMed id 21857995)1, 2, 3 Liu H.J.... Qin X.Q. (2011)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
    6. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
    7. Role of bombesin receptor activated protein in the ant igen presentation by human bronchial epithelial cells. (PubMed id 22930588)1 Qu X....Qin X.Q. (2013)
    8. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    9. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    10. Screening and cloning for proteins transactivated by the PS1TP5 protein of hepatitis B virus: a suppression subtractive hybridization study. (PubMed id 17461456)1 Zhang J.K.... Mao Y. (2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 221477 HGNC: 21114 AceView: C6orf89 Ensembl:ENSG00000198663 euGenes: HUgn221477
    ECgene: C6orf89 H-InvDB: C6orf89

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for C6orf89 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for C6orf89 gene:
    Search GeneIP for patents involving C6orf89

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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