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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

C6orf89 Gene

protein-coding GIFtS: 43
GCID: GC06P036839

chromosome 6 open reading frame 89

Explore 2 diseases affiliated with
C6orf89 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Chromosome 6 Open Reading Frame 89¹ ²
FLJ25357¹
Amfion³
Bombesin Receptor-Activated Protein C6orf89²
Amfion³
BRAP³

External Ids:	HGNC: 21114¹	Entrez Gene: 221477²	Ensembl: ENSG00000198663⁷	UniProtKB: Q6UWU4³

Export aliases for C6orf89 gene to outside databases

Previous GC identifers: GC06P036842 GC06P036886 GC06P036961 GC06P036571

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: CF089_HUMAN, Q6UWU4

Function: May play a role in cell cycle progression and wound repair of bronchial epithelial cells

Gene Wiki entry for C6orf89

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000006.11 NC_018917.1 NT_007592.15

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the C6orf89 gene promoter:
TBP NCX/Ncx AP-2gamma Ik-3 c-Ets-1 Pax-3 TFIID AP-2beta AP-2alpha AP-2alphaA
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: C6orf89 promoter sequence

Search SABiosciences Chromatin IP Primers for C6orf89

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C6orf89

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.2 Ensembl cytogenetic band: 6p21.2 HGNC cytogenetic band: 6p21.31

C6orf89 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
C6orf89 gene location

GeneLoc information about chromosome 6 GeneLoc Exon Structure

GeneLoc location for GC06P036839: view genomic region (about GC identifiers)

Start:	36,839,646 bp from pter	End:	36,896,740 bp from pter
Size:	57,095 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CF089_HUMAN, Q6UWU4 (See protein sequence)

Recommended Name: Bombesin receptor-activated protein C6orf89

Size: 347 amino acids; 39870 Da

Subunit: Interacts with BRS3

Subcellular location: Membrane; Single-pass membrane protein. Cytoplasm

Sequence caution: Sequence=AAH23605.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;

Sequence=CAD98021.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;

Secondary accessions: B4DTT1 F4NAR0 F4NAR1 Q6ZMG5 Q7Z356 Q8IZ35

Alternative splicing: 2 isoforms: Q6UWU4-1 Q6UWU4-2

Explore the universe of human proteins at neXtProt for C6orf89: NX_Q6UWU4

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q6UWU4

C6orf89 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_689947.2

ENSEMBL proteins:

ENSP00000352316 ENSP00000347322 ENSP00000362789 ENSP00000387562 ENSP00000445655

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	Uscn Proteins for C6orf89

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	IDA	--
GO:0005886	plasma membrane	IDA	--
GO:0016021	integral to membrane	IEA	--

C6orf89 for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ProtoNet protein and cluster: Q6UWU4

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: CF089_HUMAN, Q6UWU4

Function: May play a role in cell cycle progression and wound repair of bronchial epithelial cells

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In Situ Assay
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1 GenomeRNAi human phenotype for C6orf89:

Decreased circadian period len

Animal Models:
1 MGI mutant phenotype (inferred from 1 allele) (MGI details for BC004004):

normal

C6orf89 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for C6orf89

STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

1 Interacting protein for C6orf89 (ENSP00000347322⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
UBC	ENSP00000344818⁴	STRING: ENSP00000344818

About this table

Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0042060	wound healing	IDA	--
GO:0045787	positive regulation of cell cycle	IDA	--
GO:0050673	epithelial cell proliferation	IDA	--

C6orf89 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for C6orf89
Search CenterWatch for drugs/clinical trials and news about C6orf89 / CF089

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
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About This Section

REFSEQ mRNAs for C6orf89 gene:

NM_152734.3

Unigene Cluster for C6orf89:

Chromosome 6 open reading frame 89

Hs.433381 [show with all ESTs]

Unigene Representative Sequence: NM_152734

6 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000359359(uc003omv.3 uc003omw.3 uc003omx.3 uc011dtr.2)

ENST00000480824 ENST00000355190 ENST00000373685 ENST00000416621 ENST00000510325

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Additional cDNA sequence:

AJ420498.1 AJ420511.1 AK001957.1 AK025213.1 AK057109.1 AK172780.1 AK300351.1 AK315984.1

AL833755.1 BC009380.2 BC021804.1 BC023605.2 BC032796.1 BC050582.1 BC105946.1 BC105947.1

BC107489.1 BX538108.1 DQ487761.1 FR832871.1 FR832872.1

14 DOTS entries:

DT.95248037 DT.112746 DT.75115772 DT.112396 DT.121337697 DT.100824896 DT.113683 DT.95267645

DT.121337695 DT.95248047 DT.100028595 DT.121337742 DT.121337737 DT.97778516

24/444 AceView cDNA sequences (see all 444):

BQ214602 BM783106 BM764655 BG032074 BM681644 BI826624 AI300054 BM983149

AA399414 AI955724 AW848185 BE645987 BM764928 BM970466 BQ057057 BM727176

AI868079 AW591601 AL520781 BU620451 BM765184 BM811524 BM449776 BX384937

GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for C6orf89 About this scheme

ExUns:	1	^	2	^	3	^	4	^	5	^	6	^	7a	·	7b	^	8	^	9	^	10
SP1:					-								-
SP2:
SP3:

ECgene alternative splicing isoforms for C6orf89

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

C6orf89 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

About this image

C6orf89 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Ovary

Primary Follicle

Primary Oocyte

Female Gametocytes, Germ Cells

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See C6orf89 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for C6orf89

SOURCE GeneReport for Unigene cluster: Hs.433381

SABiosciences Custom PCR Arrays for C6orf89

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for C6orf89 gene from 4/10 species (see all 10) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	BC004004^{1 , 5}	cDNA sequence BC004004^{1, 5}	85.3(n)¹ 83.57(a)¹		17 (15.17 cM)⁵ 80748¹ NM_030561.3¹ NP_085038.3¹ 29268788⁵
chicken (Gallus gallus)	Aves	C26H6orf89¹	chromosome 26 open reading frame, human C6orf89	62.46(n) 53.54(a)		419817 NM_001012548.1 NP_001012566.1
lizard (Anolis carolinensis)	Reptilia	C6orf89⁶	--	75(a)	1 ↔ 1	4(123604735-123605737)
zebrafish (Danio rerio)	Actinopterygii	zgc:162255¹	zgc:162255	47.36(n) 36.36(a)		100037321 NM_001089477.1 NP_001082946.1

ENSEMBL Gene Tree for C6orf89 (if available)
TreeFam Gene Tree for C6orf89 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 6 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs138126355^1,2		--	36851642(+)	`AATTCC/TCCTTT`	1	--	us2k¹		0	--	--	--	--
rs6912891^1,2	C,F,A,H,	--	36851764(+)	`CGGGCG/TTGATG`	1	--	us2k¹		7		NA WA EA	366
rs6913047^1,2	C,F,A,H,	--	36851830(+)	`GTCAGG/AAGTTT`	1	--	us2k¹		2		NA	4
rs187409876^1,2		--	36851831(+)	`TCAGGA/GGTTTG`	1	--	us2k¹		0	--	--	--	--
rs144140608^1,2		--	36851906(+)	`GGTGGC/TAGGTG`	1	--	us2k¹		0	--	--	--	--
rs191827370^1,2		--	36851996(+)	`TCGCCA/GCTGCA`	1	--	us2k¹		0	--	--	--	--
rs77007168^1,2	C	--	36852213(+)	`CGCCCA/GATAAT`	1	--	us2k¹		0	--	--	--	--
rs180969929^1,2		--	36852251(+)	`TATTCG/TCTCAA`	1	--	us2k¹		0	--	--	--	--
rs116113337^1,2	F,	--	36852293(+)	`ACAACG/ATCAAA`	1	--	us2k¹		1		WA	118
rs111963521^1,2	F,	--	36852322(+)	`AATAAG/CAAAAA`	1	--	us2k¹		2		CSA	4

HapMap Linkage Disequilibrium report for C6orf89 (36839646 - 36896740 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for C6orf89
1 CNV: 99505

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

C6orf89 for disorders About GeneDecksing

2 diseases for C6orf89: About MalaCards

hepatitis b hepatitis

Export disorders for C6orf89 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for C6orf89 gene, integrated from 9 sources (see all 15):
(articles sorted by number of sources associating them with C6orf89)

Utopia: connect your pdf to the dynamic
world of online information

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)^{1, 2} Mungall A.J.... Beck S. (2003)
The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)^{1, 2} Clark H.F.... Gray A.M. (2003)
Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)¹ Kim W....Gygi S.P. (2011)
A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)¹ Wagner S.A....Choudhary C. (2011)
Cloning of a novel protein interacting with BRS-3 and its effects in wound repair of bronchial epithelial cells. (PubMed id 21857995)² Liu H.J.... Qin X.Q. (2011)
Screening and cloning for proteins transactivated by the PS1TP5 protein of hepatitis B virus: a suppression subtractive hybridization study. (PubMed id 17461456)¹ Zhang J.K.... Mao Y. (2007)
The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)² Bechtel S.... Schupp I. (2007)
The LIFEdb database in 2006. (PubMed id 16381901)¹ Mehrle A....Wiemann S. (2006)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 221477	HGNC: 21114	AceView: C6orf89	Ensembl:ENSG00000198663	euGenes: HUgn221477
ECgene: C6orf89	H-InvDB: C6orf89

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for C6orf89	Pharmacogenomics, SNPs, Pathways

Intellectual Property for C6orf89 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for C6orf89 gene:
Search GeneIP for patents involving C6orf89

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
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About This Section


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GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes C6orf89 gene at Home site.

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C6orf89 Gene

chromosome 6 open reading frame 89

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C6orf89 Gene

chromosome 6 open reading frame 89

Aliasesfor C6orf89 gene

Summariesfor C6orf89 gene

Genomic Viewsfor C6orf89 gene

Proteinsfor C6orf89 gene

Protein Domains /Familiesfor C6orf89 gene

Functionfor C6orf89 gene

Pathways & Interactionsfor C6orf89 gene

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External Searches for C6orf89 gene

Genome Databases showing C6orf89 gene

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for C6orf89 gene

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for C6orf89 gene

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