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Aliases for C6orf89 Gene

Aliases for C6orf89 Gene

  • Chromosome 6 Open Reading Frame 89 2 3 5
  • Amfion 2 3 4
  • BRAP 3 4
  • Bombesin Receptor-Activated Protein C6orf89 3
  • Bombesin Receptor Activated Protein 2

External Ids for C6orf89 Gene

Previous GeneCards Identifiers for C6orf89 Gene

  • GC06P036842
  • GC06P036886
  • GC06P036961
  • GC06P036571
  • GC06P036839
  • GC06P037045
  • GC06P037078
  • GC06P037798
  • GC06P038420
  • GC06P039010

Summaries for C6orf89 Gene

GeneCards Summary for C6orf89 Gene

C6orf89 (Chromosome 6 Open Reading Frame 89) is a Protein Coding gene.

UniProtKB/Swiss-Prot for C6orf89 Gene

  • Exhibits histone deacetylase (HDAC) enhancer properties (PubMed:23460338). May play a role in cell cycle progression and wound repair of bronchial epithelial cells (PubMed:21857995).

Gene Wiki entry for C6orf89 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C6orf89 Gene

Genomics for C6orf89 Gene

Regulatory Elements for C6orf89 Gene

Enhancers for C6orf89 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06G036820 1.9 FANTOM5 Ensembl ENCODE dbSUPER 18.7 -47.2 -47164 8.8 HDGF PKNOX1 ARNT FEZF1 DMAP1 ZNF766 FOS ZNF263 SP3 JUNB PPIL1 C6orf89 MTCH1 COX6A1P2 FGD2 CPNE5 MAPK14 GC06P041064
GH06G036906 1.4 ENCODE dbSUPER 22.6 +35.7 35653 1.7 CREB3L1 ZFP64 DMAP1 YBX1 YY1 ZNF143 SP3 NFYC TBX21 MEF2D C6orf89 PPIL1 FGD2 CMTR1 RAB44 CPNE5 PIR40408 GC06P040146 GC06P040339 PIR55478
GH06G036848 1.5 Ensembl ENCODE dbSUPER 18.8 -22.9 -22914 1.3 HDGF PKNOX1 ATF1 ARID4B SIN3A TCF12 ZNF766 GATA2 KLF13 SP5 PPIL1 C6orf89 RAB44 MTCH1 CPNE5 GC06M037869
GH06G037133 2.1 FANTOM5 Ensembl ENCODE dbSUPER 9.4 +266.5 266524 9.7 CREB3L1 MLX ZFP64 DMAP1 FEZF1 YY1 SLC30A9 ZNF263 SP3 NFYC PIM1 COX6A1P2 TBC1D22B FGD2 PPIL1 RAB44 C6orf89 PI16 GC06P041050
GH06G037124 2 FANTOM5 Ensembl ENCODE dbSUPER 9.6 +256.6 256641 8.6 HDGF FOXA2 PKNOX1 CREB3L1 MLX ARNT ARID4B DMAP1 FEZF1 ZNF2 CMTR1 PIM1 COX6A1P2 FGD2 MTCH1 C6orf89 RAB44 MDGA1 PPIL1 GC06P041050
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around C6orf89 on UCSC Golden Path with GeneCards custom track

Genomic Location for C6orf89 Gene

Chromosome:
6
Start:
36,871,846 bp from pter
End:
36,928,964 bp from pter
Size:
57,119 bases
Orientation:
Plus strand

Genomic View for C6orf89 Gene

Genes around C6orf89 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C6orf89 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C6orf89 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C6orf89 Gene

Proteins for C6orf89 Gene

  • Protein details for C6orf89 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6UWU4-CF089_HUMAN
    Recommended name:
    Bombesin receptor-activated protein C6orf89
    Protein Accession:
    Q6UWU4
    Secondary Accessions:
    • B4DTT1
    • B7Z9L9
    • F4NAR0
    • F4NAR1
    • Q5TDC5
    • Q6ZMG5
    • Q7Z356
    • Q8IZ35

    Protein attributes for C6orf89 Gene

    Size:
    347 amino acids
    Molecular mass:
    39870 Da
    Quaternary structure:
    • Homodimer (PubMed:23460338). Interacts with BRS3 (PubMed:21857995). Interacts (via N-terminus) with SIN3B (PubMed:23460338).
    Miscellaneous:
    • Named amfion, after the 4 Amfion heroes in Greek mythology and their deeds in different locations within the mother land.
    SequenceCaution:
    • Sequence=AAH23605.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=CAD98021.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for C6orf89 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for C6orf89 Gene

Post-translational modifications for C6orf89 Gene

No data available for DME Specific Peptides for C6orf89 Gene

Domains & Families for C6orf89 Gene

Protein Domains for C6orf89 Gene

ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C6orf89: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for C6orf89 Gene

Function for C6orf89 Gene

Molecular function for C6orf89 Gene

UniProtKB/Swiss-Prot Function:
Exhibits histone deacetylase (HDAC) enhancer properties (PubMed:23460338). May play a role in cell cycle progression and wound repair of bronchial epithelial cells (PubMed:21857995).

Gene Ontology (GO) - Molecular Function for C6orf89 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 23460338
genes like me logo Genes that share ontologies with C6orf89: view
genes like me logo Genes that share phenotypes with C6orf89: view

Animal Model Products

  • Taconic Biosciences Mouse Models for C6orf89

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C6orf89 Gene

Localization for C6orf89 Gene

Subcellular locations from UniProtKB/Swiss-Prot for C6orf89 Gene

Isoform 1: Golgi apparatus membrane; Single-pass type II membrane protein. Midbody.
Isoform 2: Golgi apparatus membrane; Single-pass type II membrane protein. Midbody.
Isoform 3: Cytoplasm. Nucleus, nucleolus. Note=Retained in nucleolar organiser regions (NORs) in mitotic cells (PubMed:23460338). {ECO:0000269 PubMed:23460338}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C6orf89 gene
Compartment Confidence
plasma membrane 5
nucleus 5
golgi apparatus 5
cytosol 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for C6orf89 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IDA 23460338
GO:0005634 nucleus IEA --
GO:0005730 nucleolus IEA --
GO:0005737 cytoplasm IDA,IEA 21857995
GO:0005794 Golgi apparatus IEA --
genes like me logo Genes that share ontologies with C6orf89: view

Pathways & Interactions for C6orf89 Gene

SuperPathways for C6orf89 Gene

No Data Available

Interacting Proteins for C6orf89 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000347322%0d%0a9606.ENSP00000330389%0d%0a
Selected Interacting proteins: Q6UWU4-CF089_HUMAN ENSP00000347322 for C6orf89 Gene via IID STRING

Gene Ontology (GO) - Biological Process for C6orf89 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042060 wound healing IDA 21857995
GO:0045787 positive regulation of cell cycle IDA 21857995
GO:0050673 epithelial cell proliferation IDA 21857995
GO:1901727 positive regulation of histone deacetylase activity IDA 23460338
genes like me logo Genes that share ontologies with C6orf89: view

No data available for Pathways by source and SIGNOR curated interactions for C6orf89 Gene

Drugs & Compounds for C6orf89 Gene

No Compound Related Data Available

Transcripts for C6orf89 Gene

Unigene Clusters for C6orf89 Gene

Chromosome 6 open reading frame 89:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for C6orf89 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10
SP1: - -
SP2:
SP3:

Relevant External Links for C6orf89 Gene

GeneLoc Exon Structure for
C6orf89
ECgene alternative splicing isoforms for
C6orf89

Expression for C6orf89 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for C6orf89 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for C6orf89 Gene

This gene is overexpressed in Bone (40.7), Peripheral blood mononuclear cells (10.3), and Testis (7.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for C6orf89 Gene



Protein tissue co-expression partners for C6orf89 Gene

NURSA nuclear receptor signaling pathways regulating expression of C6orf89 Gene:

C6orf89

SOURCE GeneReport for Unigene cluster for C6orf89 Gene:

Hs.433381

Evidence on tissue expression from TISSUES for C6orf89 Gene

  • Nervous system(4.4)
  • Muscle(4.3)
  • Intestine(4.2)
  • Lung(2.1)
  • Skin(2.1)
genes like me logo Genes that share expression patterns with C6orf89: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for C6orf89 Gene

Orthologs for C6orf89 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C6orf89 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C6H6orf89 34
  • 99.34 (n)
C6ORF89 35
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C12H6orf89 34
  • 89.58 (n)
C6orf89 35
  • 80 (a)
OneToOne
cow
(Bos Taurus)
Mammalia C23H6orf89 34
  • 87.32 (n)
C6orf89 35
  • 84 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia RGD735065 34
  • 85.49 (n)
mouse
(Mus musculus)
Mammalia BC004004 34 16 35
  • 85.21 (n)
oppossum
(Monodelphis domestica)
Mammalia C6orf89 35
  • 67 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia C6orf89 35
  • 56 (a)
OneToOne
chicken
(Gallus gallus)
Aves C26H6ORF89 34 35
  • 62.36 (n)
lizard
(Anolis carolinensis)
Reptilia C6orf89 35
  • 49 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii zgc:162255 34
  • 47.4 (n)
C22H6orf89 35
  • 32 (a)
OneToOne
Species where no ortholog for C6orf89 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C6orf89 Gene

ENSEMBL:
Gene Tree for C6orf89 (if available)
TreeFam:
Gene Tree for C6orf89 (if available)

Paralogs for C6orf89 Gene

No data available for Paralogs for C6orf89 Gene

Variants for C6orf89 Gene

Sequence variations from dbSNP and Humsavar for C6orf89 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1000028008 -- 36,919,673(+) TCTGT(C/G)GCCAT reference, synonymous-codon
rs1000081906 -- 36,839,044(+) TCCTC(A/G)ATGCA intron-variant
rs1000084206 -- 36,926,421(+) CCAGC(G/T)ACACA utr-variant-3-prime
rs1000115008 -- 36,860,852(+) GTATT(A/G)TTGTT intron-variant
rs1000120339 -- 36,882,942(+) CACCT(C/T)GTTAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for C6orf89 Gene

Variant ID Type Subtype PubMed ID
esv2651912 CNV deletion 19546169
nsv1015689 CNV gain 25217958

Variation tolerance for C6orf89 Gene

Residual Variation Intolerance Score: 37.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.66; 31.82% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C6orf89 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
C6orf89

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C6orf89 Gene

Disorders for C6orf89 Gene

Relevant External Links for C6orf89

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
C6orf89

No disorders were found for C6orf89 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C6orf89 Gene

Publications for C6orf89 Gene

  1. C6orf89 encodes three distinct HDAC enhancers that function in the nucleolus, the Golgi and the midbody. (PMID: 23460338) Lalioti V.S. … Sandoval I.V. (J. Cell. Physiol. 2013) 2 3 4 64
  2. Cloning of a novel protein interacting with BRS-3 and its effects in wound repair of bronchial epithelial cells. (PMID: 21857995) Liu H.J. … Qin X.Q. (PLoS ONE 2011) 2 3 4 64
  3. Bombesin Receptor-Activated Protein (BRAP) Modulates NF-I_B Activation in Bronchial Epithelial Cells by Enhancing HDAC Activity. (PMID: 26460487) Liu Y. … Qu X. (J. Cell. Biochem. 2015) 2 3 64
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for C6orf89 Gene

Sources for C6orf89 Gene

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