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Aliases for C6orf89 Gene

Aliases for C6orf89 Gene

  • Chromosome 6 Open Reading Frame 89 2 3
  • Amfion 3 4
  • BRAP 3 4
  • Bombesin Receptor-Activated Protein C6orf89 3
  • Bombesin Receptor Activated Protein 2

External Ids for C6orf89 Gene

Summaries for C6orf89 Gene

GeneCards Summary for C6orf89 Gene

C6orf89 (Chromosome 6 Open Reading Frame 89) is a Protein Coding gene. Among its related pathways are Ras signaling pathway.

UniProtKB/Swiss-Prot for C6orf89 Gene

  • Exhibits histone deacetylase (HDAC) enhancer properties. May play a role in cell cycle progression and wound repair of bronchial epithelial cells.

Gene Wiki entry for C6orf89 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C6orf89 Gene

Genomics for C6orf89 Gene

Genomic Location for C6orf89 Gene

Start:
36,871,870 bp from pter
End:
36,928,964 bp from pter
Size:
57,095 bases
Orientation:
Plus strand

Genomic View for C6orf89 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for C6orf89 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C6orf89 Gene

Regulatory Elements for C6orf89 Gene

Proteins for C6orf89 Gene

  • Protein details for C6orf89 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6UWU4-CF089_HUMAN
    Recommended name:
    Bombesin receptor-activated protein C6orf89
    Protein Accession:
    Q6UWU4
    Secondary Accessions:
    • B4DTT1
    • F4NAR0
    • F4NAR1
    • Q6ZMG5
    • Q7Z356
    • Q8IZ35

    Protein attributes for C6orf89 Gene

    Size:
    347 amino acids
    Molecular mass:
    39870 Da
    Quaternary structure:
    • Interacts with BRS3.
    SequenceCaution:
    • Sequence=AAH23605.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=CAD98021.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for C6orf89 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for C6orf89 Gene

Proteomics data for C6orf89 Gene at MOPED

Post-translational modifications for C6orf89 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys165 and Lys262

Other Protein References for C6orf89 Gene

No data available for DME Specific Peptides for C6orf89 Gene

Domains for C6orf89 Gene

Protein Domains for C6orf89 Gene

ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C6orf89: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for C6orf89 Gene

Function for C6orf89 Gene

Molecular function for C6orf89 Gene

UniProtKB/Swiss-Prot Function: Exhibits histone deacetylase (HDAC) enhancer properties. May play a role in cell cycle progression and wound repair of bronchial epithelial cells.

Phenotypes for C6orf89 Gene

MGI mutant phenotypes for C6orf89:
inferred from 1 alleles
GenomeRNAi human phenotypes for C6orf89:
genes like me logo Genes that share phenotypes with C6orf89: view

miRNA for C6orf89 Gene

miRTarBase miRNAs that target C6orf89

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targeting and HOMER Transcription for C6orf89 Gene

Localization for C6orf89 Gene

Subcellular locations from UniProtKB/Swiss-Prot for C6orf89 Gene

Isoform 1: Golgi apparatus membrane; Single-pass type II membrane protein. Midbody.
Isoform 2: Cytoplasm. Nucleus, nucleolus. Note=Retained in nucleolar organiser regions (NORs) in mitotic cells.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for C6orf89 Gene COMPARTMENTS Subcellular localization image for C6orf89 gene
Compartment Confidence
golgi apparatus 5
nucleus 5
plasma membrane 5
cytosol 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for C6orf89 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005634 nucleus --
GO:0005730 nucleolus IEA --
GO:0005737 cytoplasm IDA 21857995
GO:0005794 Golgi apparatus --
genes like me logo Genes that share ontologies with C6orf89: view

Pathways for C6orf89 Gene

SuperPathways for C6orf89 Gene

Superpath Contained pathways
1 Ras signaling pathway
genes like me logo Genes that share pathways with C6orf89: view

Pathways by source for C6orf89 Gene

1 KEGG pathway for C6orf89 Gene

Interacting Proteins for C6orf89 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000347322%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: ENSP00000347322 for C6orf89 Gene via STRING

Symbol External ID(s) Details
UBC

Gene Ontology (GO) - Biological Process for C6orf89 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042060 wound healing IDA 21857995
GO:0045787 positive regulation of cell cycle IDA 21857995
GO:0050673 epithelial cell proliferation IDA 21857995
genes like me logo Genes that share ontologies with C6orf89: view

Transcripts for C6orf89 Gene

Unigene Clusters for C6orf89 Gene

Chromosome 6 open reading frame 89:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for C6orf89 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10
SP1: - -
SP2:
SP3:

Relevant External Links for C6orf89 Gene

GeneLoc Exon Structure for
C6orf89
ECgene alternative splicing isoforms for
C6orf89

Expression for C6orf89 Gene

mRNA expression in normal human tissues for C6orf89 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for C6orf89 Gene

SOURCE GeneReport for Unigene cluster for C6orf89 Gene Hs.433381

genes like me logo Genes that share expressions with C6orf89: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for C6orf89 Gene

Orthologs for C6orf89 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C6orf89 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C6H6orf89 35
  • 99.34 (n)
  • 99.15 (a)
C6ORF89 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia C23H6orf89 35
  • 87.32 (n)
  • 84.44 (a)
C6orf89 36
  • 84 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C12H6orf89 35
  • 89.58 (n)
  • 87.78 (a)
C6orf89 36
  • 80 (a)
OneToOne
mouse
(Mus musculus)
Mammalia BC004004 35
  • 85.21 (n)
  • 83.57 (a)
BC004004 16
BC004004 36
  • 83 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia C6orf89 36
  • 67 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia C6orf89 36
  • 56 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia RGD735065 35
  • 85.49 (n)
  • 84.44 (a)
chicken
(Gallus gallus)
Aves C26H6ORF89 35
  • 62.36 (n)
  • 53.54 (a)
C26H6ORF89 36
  • 52 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia C6orf89 36
  • 49 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii C22H6orf89 36
  • 32 (a)
OneToOne
zgc:162255 35
  • 47.4 (n)
  • 35.88 (a)
Species with no ortholog for C6orf89:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C6orf89 Gene

ENSEMBL:
Gene Tree for C6orf89 (if available)
TreeFam:
Gene Tree for C6orf89 (if available)

Paralogs for C6orf89 Gene

No data available for Paralogs for C6orf89 Gene

Variants for C6orf89 Gene

Sequence variations from dbSNP and Humsavar for C6orf89 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs3074 -- 36,924,445(-) AGTTG(C/T)ACACC utr-variant-3-prime
rs8472 -- 36,928,661(+) AGGAG(G/T)CACAG utr-variant-3-prime
rs370450 -- 36,890,104(-) acttg(A/G)aggtg intron-variant
rs449840 -- 36,897,401(-) ataca(A/G)tattt intron-variant
rs517878 -- 36,898,283(+) CTTTT(C/T)TTTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for C6orf89 Gene

Variant ID Type Subtype PubMed ID
esv2651912 CNV Deletion 19546169

Relevant External Links for C6orf89 Gene

HapMap Linkage Disequilibrium report
C6orf89

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C6orf89 Gene

Disorders for C6orf89 Gene

No disorders were found for C6orf89 Gene.

No data available for UniProtKB/Swiss-Prot for C6orf89 Gene

Publications for C6orf89 Gene

  1. Cloning of a novel protein interacting with BRS-3 and its effects in wound repair of bronchial epithelial cells. (PMID: 21857995) Liu H.J. … Qin X.Q. (PLoS ONE 2011) 2 3 4
  2. C6orf89 encodes three distinct HDAC enhancers that function in the nucleolus, the Golgi and the midbody. (PMID: 23460338) Lalioti V.S. … Sandoval I.V. (J. Cell. Physiol. 2013) 2 3 4
  3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4
  4. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 3 4
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4

Products for C6orf89 Gene

Sources for C6orf89 Gene

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