C6orf70 Gene
protein-coding GIFtS: 41
GCID: GC06P170151
|
|
chromosome 6 open reading frame 70
| |
Aliases
for C6orf70 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Chromosome 6 Open Reading Frame 701 2 | | DJ266L20.31 | | FLJ111521 | | Transmembrane Protein C6orf702 |
Export aliases for C6orf70 gene to outside databasesPrevious GC identifers: GC00U914259 GC06P169909 GC06P169969 GC06P167571 |
Summaries
for C6orf70 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for C6orf70 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000006.11 NC_018917.1 NT_025741.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the C6orf70 gene promoter:
Sox5 RP58 AML1a FOXD3 Cdc5 FOXJ2 (long isoform) FOXO4 FOXJ2 RSRFC4
Other transcription factors
Search SABiosciences Chromatin IP Primers for C6orf70
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C6orf70 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 6q27 Ensembl cytogenetic band: 6q27 HGNC cytogenetic band: 6q27C6orf70 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 6 GeneLoc Exon Structure GeneLoc location for GC06P170151: view genomic region
(about GC identifiers)
Start:
|
170,151,718 bp from pter |
End:
|
170,181,680 bp from pter |
Size:
|
29,963 bases |
Orientation:
|
plus strand |
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Proteins
for C6orf70 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CF070_HUMAN, Q5T6L9 (See
protein sequence)Recommended Name: Transmembrane protein C6orf70 Size: 678 amino acids; 77788 Da
Subcellular location: Membrane; Multi-pass membrane protein (Potential)
Sequence caution: Sequence=AAH44812.1; Type=Erroneous termination; Positions=679; Note=Translated as stop;Sequence=BAA91653.1; Type=Erroneous initiation;
Secondary accessions: Q3ZCS8 Q5T6L8 Q9NUT5 Q9NVU2Alternative splicing: 3 isoforms: Q5T6L9-1 Q5T6L9-2 Q5T6L9-3 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for C6orf70: NX_Q5T6L9
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q5T6L9
C6orf70 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_060811.1
ENSEMBL proteins: ENSP00000468722 ENSP00000466474 ENSP00000355734 ENSP00000466679 ENSP00000467582 ENSP00000375945 ENSP00000355735 ENSP00000468124 ENSP00000397661 ENSP00000467665 ENSP00000468240 ENSP00000466335
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016021 | integral to membrane |
IEA | -- |
C6orf70 for ontologies About GeneDecksing
C6orf70 Antibody Products:
Assay Products for C6orf70: |
Protein
Domains /
Families
for C6orf70 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
C6orf70 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q5T6L9ProtoNet protein and cluster: Q5T6L9 |
Function
for C6orf70 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for C6orf70 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for C6orf70
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: C6orf70 (NM_018341) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for C6orf70 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C6orf70 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C6orf70 |
|
Pathways & Interactions
for C6orf70 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for C6orf70
|
Drugs & Compounds
for C6orf70 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for C6orf70
Search CenterWatch for drugs/clinical trials and news about C6orf70 / CF070
|
Transcripts
for C6orf70 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for C6orf70 gene: NM_018341.1 Unigene Cluster for C6orf70: Chromosome 6 open reading frame 70 Hs.47546 [show with all ESTs]Unigene Representative Sequence: NM_01834116 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000592367 ENST00000590711 ENST00000366772(uc010kky.1) ENST00000592745
ENST00000592315 ENST00000392095 ENST00000366773(uc003qxg.1 uc011ehb.1)
ENST00000592580 ENST00000586341 ENST00000418781(uc003qxh.1) ENST00000588437
ENST00000588451 ENST00000590017 ENST00000366771(uc003qxi.1) ENST00000492738
ENST00000477995
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for C6orf70 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for C6orf70
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: C6orf70 (NM_018341) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for C6orf70 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C6orf70 |
Additional cDNA sequence: AK001369.1 AK002014.1 AK021520.1 AK294090.1 BC044812.1 12 DOTS entries: DT.209783 DT.100754682 DT.100754681 DT.91745368 DT.97841109 DT.97841110 DT.102824350 DT.40233433 DT.97801942 DT.121377624 DT.95284955 DT.121377621 24/67 AceView cDNA sequences (see all 67): BE645867 AI270699 BQ447071 AA765149 AI089187 BM715916 AI078788 AI082584 BX119479 AI087800 BQ446447 AI522177 BM909202 AW385335 BQ008434 AK002014 BU633029 BM852869 AK001369 AA610587 BF380791 CA396814 BC044812 BI016164
GeneLoc Exon Structure
5/9 Alternative Splicing Database (ASD) splice patterns (SP) for C6orf70 (see all 9) About this scheme
| ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11a | · | 11b | ^ | 12a | · | 12b | ^ | 13a | · | 13b | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18a | · | 18b | ^ | 19a | · | 19b | ^ |
|---|
|
| SP1: | | | | | | | | | - | | | | | | | | | | | | | | | | - | | | | | | | | - | | | | | | | | | | - | | | | | | | | | | |
| SP2: | | | | | | | | | - | | | | | | | | | | | | | | | | - | | | | | | | | - | | | | | | | | | | | | - | | - | | | | | | |
| SP3: | | | | | | | | | - | | | | | | | | | | | | | | | | - | | | | | | | | - | | | | | | | | | | - | | - | | - | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | - | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | - | | | | | | | | | |
| ExUns: | 20a | · | 20b |
|---|
|
| SP1: | | | | | |
| SP2: | | | | | |
| SP3: | | | | | |
| SP4: | | | | | |
| SP5: | | | | |
ECgene alternative splicing isoforms for C6orf70
|
Expression
for C6orf70 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| C6orf70 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AGTATCAGCA
About this image
See C6orf70 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for C6orf70
SOURCE GeneReport for Unigene cluster: Hs.47546
SABiosciences Custom PCR Arrays for C6orf70
Primer
Products: | | Browse OriGene genome-wide validated SYBR primer pairs
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat C6orf70 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat C6orf70 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat C6orf70 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C6orf70 |
Orthologs
for C6orf70 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for C6orf70 gene from 3/12 species (see all 12) About this table
ENSEMBL Gene Tree for C6orf70 (if available)
TreeFam Gene Tree for C6orf70 (if available) |
Paralogs
for C6orf70 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for C6orf70 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 6 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for C6orf70 (170151718 - 170181680 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for C6orf70
2 CNVs: 94258 99817 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing C6orf70 |
|
Disorders
/ Diseases
for C6orf70 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
C6orf70 for disorders About GeneDecksing
3  diseases for C6orf70: About MalaCardsvisceral leishmaniasis leishmaniasis choroiditis
1 disease from the University of Copenhagen DISEASES database for C6orf70:Visceral leishmaniasis Export disorders for C6orf70 gene to outside databases
|
Publications
for C6orf70 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for C6orf70 gene integrated from 9 sources:
(articles sorted by number of sources associating them with C6orf70) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)2 Mungall A.J.... Beck S. (2003)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Expressed sequence tag analysis of human RPE/choroid for the NEIBank project: over 6000 non-redundant transcripts, novel genes and splice variants. (PubMed id 12107410)1 Wistow G.... Peterson K. (2002)
|
External Searches for C6orf70 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing C6orf70 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing C6orf70 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing C6orf70 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for C6orf70 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for C6orf70 gene:
Search GeneIP for patents involving C6orf70
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for C6orf70 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for C6orf70 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for C6orf70 | | Browse OriGene genome-wide validated SYBR primer pairs | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | Browse OriGene siRNAs | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for C6orf70 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for C6orf70 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for C6orf70 | | OriGene Custom Protein Services for C6orf70 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat C6orf70 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing C6orf70 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C6orf70 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat C6orf70 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat C6orf70 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat C6orf70 |
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 |  |  |  | |
| | | | Search Tocris compounds for C6orf70 |
| |  |  |  |  | | | | |
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 | | | C6orf70 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C6orf70 |
|  |  |  | | | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C6orf70 |
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