C6orf57 Gene
protein-coding GIFtS: 40
GCID: GC06P071333
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chromosome 6 open reading frame 57
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Aliases
for C6orf57 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Chromosome 6 Open Reading Frame 571 2 | | UPF0369 Protein C6orf572 |
Export aliases for C6orf57 gene to outside databasesPrevious GC identifers: GC06P071226 GC06P071272 GC06P068474 |
Summaries
for C6orf57 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for C6orf57 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000006.11 NC_018917.1 NT_007299.13
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the C6orf57 gene promoter:
Nkx3-1 GR NCX/Ncx GR-beta Nkx3-1 v1 AREB6 FOXJ2 (long isoform) FOXJ2 GR-alpha En-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for C6orf57
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C6orf57 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 6q13 Ensembl cytogenetic band: 6q13 HGNC cytogenetic band: 6q12C6orf57 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 6 GeneLoc Exon Structure GeneLoc location for GC06P071333: view genomic region
(about GC identifiers)
Start:
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71,276,620 bp from pter |
End:
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71,299,272 bp from pter |
Size:
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22,653 bases |
Orientation:
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plus strand |
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Proteins
for C6orf57 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CF057_HUMAN, Q5VUM1 (See
protein sequence)Recommended Name: UPF0369 protein C6orf57 precursor Size: 108 amino acids; 12213 Da
Subcellular location: Secreted (Potential)
Secondary accessions: E1P532Explore the universe of human proteins at neXtProt for C6orf57: NX_Q5VUM1
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q5VUM1
C6orf57 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_660310.2
ENSEMBL proteins: ENSP00000359505
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005576 | extracellular region |
IEA | -- | | GO:0005739 | mitochondrion |
IEA | -- |
C6orf57 for ontologies About GeneDecksing
C6orf57 Antibody Products:
Assay Products for C6orf57: |
Protein
Domains /
Families
for C6orf57 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
C6orf57 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q5VUM1ProtoNet protein and cluster: Q5VUM1 1 Blocks protein family: IPB012875 Protein of unknown function DUF1674
UniProtKB/Swiss-Prot: CF057_HUMAN, Q5VUM1Similarity: Belongs to the UPF0369 family |
Function
for C6orf57 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for C6orf57 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for C6orf57 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: C6orf57 (NM_145267) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for C6orf57 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C6orf57 |
1 GenomeRNAi human phenotype for C6orf57:
|
Pathways & Interactions
for C6orf57 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for C6orf57
|
Drugs & Compounds
for C6orf57 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for C6orf57
Search CenterWatch for drugs/clinical trials and news about C6orf57 / CF057
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Transcripts
for C6orf57 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for C6orf57 gene: NM_145267.2 Unigene Cluster for C6orf57: Chromosome 6 open reading frame 57 Hs.418495 [show with all ESTs]Unigene Representative Sequence: BU5981522 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000468640 ENST00000370474(uc003pfq.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for C6orf57 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for C6orf57 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: C6orf57 (NM_145267) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for C6orf57 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C6orf57 |
Additional cDNA sequence: BC018085.1 BC104649.1 4 DOTS entries: DT.95368296 DT.92419498 DT.100741951 DT.75197566 24/42 AceView cDNA sequences (see all 42): BM142334 AI950532 AW054719 CK820153 AI383596 BM685163 AI089178 BM142223 AW195530 AI347649 BC018085 NM_145267 AA532643 AI300847 BX115326 AI344488 AI769717 AA553900 BM932161 BG703280 AA741040 AI038324 CF597237 AI347478
GeneLoc Exon Structure
3 Alternative Splicing Database (ASD) splice patterns (SP) for C6orf57 About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 |
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| SP1: | | | | | | | | | - | | | | |
| SP2: | | | | | - | | | | | | | | |
| SP3: | | | | | - | | | | - | | | |
ECgene alternative splicing isoforms for C6orf57
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Expression
for C6orf57 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| C6orf57 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ACCCCATCGA
About this image
See C6orf57 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for C6orf57
SOURCE GeneReport for Unigene cluster: Hs.418495
SABiosciences Custom PCR Arrays for C6orf57
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for C6orf57
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat C6orf57 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat C6orf57 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat C6orf57 |
Orthologs
for C6orf57 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for C6orf57 gene from 8/19 species (see all 19) About this table
ENSEMBL Gene Tree for C6orf57 (if available)
TreeFam Gene Tree for C6orf57 (if available) |
Paralogs
for C6orf57 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for C6orf57 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 6 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for C6orf57 (71276620 - 71299272 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for C6orf57: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing C6orf57 |
|
Disorders
/ Diseases
for C6orf57 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 C6orf57 for disorders About MalaCards
C6orf57 for disorders About GeneDecksing
Human Genome Epidemiology (HuGE) Navigator: C6orf57 (1 document)
Export disorders for C6orf57 gene to outside databases
|
Publications
for C6orf57 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for C6orf57 gene integrated from 9 sources:
(articles sorted by number of sources associating them with C6orf57) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
- Transferability of type 2 diabetes implicated loci in multi-ethnic cohorts from Southeast Asia. (PubMed id 21490949)1 Sim X....Tai E.S. (2011)
- Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1 Hendrickson S.L....O'Brien S.J. (2010)
- hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
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External Searches for C6orf57 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing C6orf57 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing C6orf57 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing C6orf57 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for C6orf57 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for C6orf57 gene:
Search GeneIP for patents involving C6orf57
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for C6orf57 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for C6orf57 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for C6orf57 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for C6orf57 | | | OriGene Protein Over-expression Lysate for C6orf57 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for C6orf57 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for C6orf57 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for C6orf57 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for C6orf57 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat C6orf57 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing C6orf57 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C6orf57 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat C6orf57 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat C6orf57 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat C6orf57 |
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| | | | Search Tocris compounds for C6orf57 |
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 | | | C6orf57 Proteins, Antibodies, CLIAs, and ELISAs |
| | | |  |  |  | | | | Search ThermoFisher Antibodies for C6orf57 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C6orf57 |
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