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C6orf25 Gene

protein-coding   GIFtS: 52
GCID: GC06P031686

Chromosome 6 Open Reading Frame 25

  See C6orf25-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Chromosome 6 Open Reading Frame 251 2
G6b2
NG312
Immunoglobulin Receptor2
Protein G6b2

External Ids:    HGNC: 139371   Entrez Gene: 807392   Ensembl: ENSG000002044207   OMIM: 6065205   UniProtKB: O958663   

Export aliases for C6orf25 gene to outside databases

Previous GC identifers: GC06P031754 GC06P031461 GC06P031795 GC06P031799 GC06P031477


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for C6orf25 Gene:
This gene is a member of the immunoglobulin (Ig) superfamily and is located in the major histocompatibility
complex (MHC) class III region. The protein encoded by this gene is a glycosylated, plasma membrane-bound cell
surface receptor, but soluble isoforms encoded by some transcript variants have been found in the endoplasmic
reticulum and Golgi before being secreted. Multiple transcript variants encoding different isoforms have been
found for this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for C6orf25 Gene:
C6orf25 (chromosome 6 open reading frame 25) is a protein-coding gene. Diseases associated with C6orf25 include gray platelet syndrome, and paraneoplastic pemphigus. GO annotations related to this gene include heparin binding.

UniProtKB/Swiss-Prot: G6B_HUMAN, O95866
Function: Inhibits platelet aggregation and activation by agonists such as ADP and collagen-related peptide.
Appears to operate in a calcium-independent manner. Isoform B is a putative inhibitory receptor. Isoform A may be
its activating counterpart

Gene Wiki entry for C6orf25 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000006.11  NC_018917.2  NT_007592.16  NT_113891.3  NT_167245.2  NT_167246.2  NT_167247.2  NT_167248.2  
NT_167249.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the C6orf25 gene promoter:
         Sp1   ITF-2   NF-kappaB1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for C6orf25

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat C6orf25


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.33   Ensembl cytogenetic band:  6p21.33   HGNC cytogenetic band: 6p21

C6orf25 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
C6orf25 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P031686:  view genomic region     (about GC identifiers)

Start:
31,686,371 bp from pter      End:
31,694,491 bp from pter
Size:
8,121 bases      Orientation:
plus strand

6 alternative locations:
Chr6+,NT_167248 2,984,751-2,988,117      Chr6+,NT_113891.2 3,200,738-3,204,104      Chr6+,NT_167249 3,021,938-3,025,304     
Chr6+,NT_167246 3,034,010-3,037,377      Chr6+,NT_167247 3,070,804-3,074,170      Chr6+,NT_167245 2,976,691-2,980,057     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: G6B_HUMAN, O95866 (See protein sequence)
Recommended Name: Protein G6b precursor  
Size: 241 amino acids; 26163 Da
Subunit: Interacts with PTPN6 and PTPN11. Binds to heparin
Secondary accessions: A2BEZ1 A2BEZ2 A2BEZ3 A2BEZ4 A2BEZ5 B0UXC4 B0UXC7 B0UXC8 B0V024 B0V026
Q14CK2 Q96A86 Q96A87 Q96A88 Q96A89 Q96A90 Q96A91
Alternative splicing: 7 isoforms:  O95866-1   O95866-2   O95866-3   O95866-4   O95866-5   O95866-6   O95866-7   

Explore the universe of human proteins at neXtProt for C6orf25: NX_O95866

Explore proteomics data for C6orf25 at MOPED

Post-translational modifications: 

  • All isoforms are N-glycosylated1
  • Isoform E is O-glycosylated1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See C6orf25 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (6 alternative transcripts): 
    NP_079536.2  NP_612116.1  NP_612117.1  NP_612118.1  NP_612119.1  NP_612121.1  

    ENSEMBL proteins: 
     ENSP00000419306   ENSP00000364968   ENSP00000364963   ENSP00000420355   ENSP00000364967  
     ENSP00000364962   ENSP00000364972   ENSP00000364964  

    C6orf25 Human Recombinant Protein Products:

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    Browse Sino Biological Cell Lysates
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    Cloud-Clone Corp. Proteins for C6orf25

     
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR028070 G6B
     IPR003599 Ig_sub

    Graphical View of Domain Structure for InterPro Entry O95866

    ProtoNet protein and cluster: O95866

    1 Blocks protein domain: IPB003599 Immunoglobulin subtype


    Find genes that share domains with C6orf25           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: G6B_HUMAN, O95866
    Function: Inhibits platelet aggregation and activation by agonists such as ADP and collagen-related peptide.
    Appears to operate in a calcium-independent manner. Isoform B is a putative inhibitory receptor. Isoform A may be
    its activating counterpart

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008201heparin binding IEA--
         
    Find genes that share ontologies with C6orf25           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for C6orf25:
     Synthetic lethal with c-Myc af 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for C6orf25
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       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for C6orf25

    miRNA
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    miRTarBase miRNAs that target C6orf25:
    hsa-mir-335-5p (MIRT017168)

    Block miRNA regulation of human, mouse, rat C6orf25 using miScript Target Protectors
    4 qRT-PCR Assays for microRNAs that regulate C6orf25:
    hsa-miR-3678-3p hsa-miR-3116 hsa-miR-147 hsa-miR-3160-3p
    SwitchGear 3'UTR luciferase reporter plasmidC6orf25 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    G6B_HUMAN, O95866: Isoform E: Endoplasmic reticulum. Golgi apparatus
    G6B_HUMAN, O95866: Isoform D: Endoplasmic reticulum. Golgi apparatus
    G6B_HUMAN, O95866: Isoform B: Cell membrane; Single-pass type I membrane protein
    G6B_HUMAN, O95866: Isoform A: Cell membrane; Single-pass type I membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    golgi apparatus5
    plasma membrane5
    extracellular3
    lysosome1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005783endoplasmic reticulum IEA--
    GO:0005794Golgi apparatus IEA--
    GO:0005886plasma membrane IDA11544253
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with C6orf25           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for C6orf25
    Interactions:

        GeneGlobe Interaction Network for C6orf25

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for C6orf25 (O958662, 3 ENSP000003649644) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PTPN11Q061242, 3, ENSP000003409444MINT-8035965 I2D: score=3 STRING: ENSP00000340944
    PTPN6P293502, 3, ENSP000003915924MINT-8035954 I2D: score=3 STRING: ENSP00000391592
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for C6orf25 (G6B)

    4 Novoseek inferred chemical compound relationships for C6orf25 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 27.6 5 18684881 (1), 11544253 (1), 9103201 (1)
    sphingosine 26.5 1 15693752 (1)
    lipid 0 1 20140224 (1)
    calcium 0 1 15693752 (1)



    Find genes that share compounds with C6orf25           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for C6orf25 gene (7 alternative transcripts): 
    NM_025260.3  NM_138272.2  NM_138273.2  NM_138274.2  NM_138275.2  NM_138277.2  NM_138276.1  

    Unigene Cluster for C6orf25:

    Chromosome 6 open reading frame 25
    Hs.247879  [show with all ESTs]
    Unigene Representative Sequence: NM_138277
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000460663 ENST00000480039(uc021yux.1) ENST00000375810 ENST00000375805
    ENST00000485548 ENST00000375809(uc011doc.2 uc003nwk.3 uc011dod.2 uc003nwn.3 uc011doe.2 uc003nwo.3)
    ENST00000466312 ENST00000375804 ENST00000375814 ENST00000471545 ENST00000375806

    miRNA
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    4 qRT-PCR Assays for microRNAs that regulate C6orf25:
    hsa-miR-3678-3p hsa-miR-3116 hsa-miR-147 hsa-miR-3160-3p
    SwitchGear 3'UTR luciferase reporter plasmidC6orf25 3' UTR sequence
    Inhib. RNA
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      QuantiTect SYBR Green Assays in human, mouse, rat C6orf25
      QuantiFast Probe-based Assays in human, mouse, rat C6orf25

    Additional mRNA sequence: 

    AJ292259.1 AJ292260.1 AJ292261.1 AJ292262.1 AJ292263.1 AJ292265.1 AK092392.1 BC113719.1 
    BC113721.1 BC143850.1 BX647860.1 

    8 DOTS entries:

    DT.95301631  DT.121311108  DT.91670895  DT.95368866  DT.95368864  DT.95368865  DT.100055534  DT.95368863 

    Selected AceView cDNA sequences (see all 39):

    AX747518 AK092392 BX397581 BX644924 AJ292259 NM_138272 AJ292262 BX503539 
    AJ292263 BX389558 BI911004 AJ292265 NM_138276 BX389560 AI065057 AJ292261 
    BU681844 NM_138275 BX647860 NM_025260 BX503538 AI190741 NM_138273 AJ292264 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    C6orf25 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCGCCTGCCC
    C6orf25 Expression
    About this image

    C6orf25 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    C6orf25 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.247879

    UniProtKB/Swiss-Prot: G6B_HUMAN, O95866
    Tissue specificity: Expressed in a restricted set of hematopoietic cell lines including the erythroleukemia cell
    line K-562 and the T-cell leukemia cell lines MOLT-4 and Jurkat. Not detected in the monocyte-like cell line
    U-937, the B-cell-like cell line Raji, the fibroblast cell lines TK and HeLa, or the natural killer cell lines
    NKL, NK 62 and YT. Expressed in platelets

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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and mouse.

    Orthologs for C6orf25 gene from Selected species (see all 6)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia G6b1 , 5 G6B protein5
    immunoreceptor tyrosine-based inhibitory motif (ITIM) more1
    77.92(n)1
    73.84(a)1
      17 (18.59 cM)5
    1067221  NM_001191012.11  NP_001177941.11 
     350644375 


    ENSEMBL Gene Tree for C6orf25 (if available)
    TreeFam Gene Tree for C6orf25 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for C6orf25 gene
    1 SIMAP similar gene for C6orf25 using alignment to 3 protein entries:     B0V023_HUMAN (see all proteins):
    G6B

    Find genes that share paralogs with C6orf25           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for C6orf25 (see all 115)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs709902661,2
    C--31476714(+) ATTAG-/TCAG  
            
    GTGTG
    6 -- us2k11Minor allele frequency- TCAG:0.00NA 2
    rs1453331921,2
    C,F--31606403(+) TAAGGG/ACTTTC 6 -- us2k11Minor allele frequency- A:0.00NA 4550
    rs1836185681,2
    C--31606413(+) CATGGC/TGAGGG 6 -- us2k10--------
    rs2004035081,2
    C--31606435(+) GTGGCA/GACCAC 6 -- us2k11Minor allele frequency- G:0.00EU 1305
    rs1426949901,2
    C--31606676(+) AATGCC/TATTGT 6 -- us2k10--------
    rs8052921,2
    C,F,A,H--31606963(-) GCAGGC/TATTGG 6 -- us2k142Minor allele frequency- T:0.35NS EA NA MN WA CSA 5518
    rs1476405331,2
    C--31607060(+) CAGGTC/TTGCTA 6 -- us2k10--------
    rs559325441,2
    C--31607310(+) AGGCCA/GGGTGT 6 -- us2k10--------
    rs1446054461,2
    --31607323(+) TGGCTC/TACACC 6 -- us2k10--------
    rs1860956011,2
    --31607534(+) TGAGTC/TGAGAT 6 -- us2k10--------

    HapMap Linkage Disequilibrium report for C6orf25 (31686371 - 31694491 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for C6orf25:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv884425CNV Loss21882294
    nsv884418CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing C6orf25
    DNA2.0 Custom Variant and Variant Library Synthesis for C6orf25

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 606520    OMIM disorders: --

    3 diseases for C6orf25:    
    About MalaCards
    gray platelet syndrome    paraneoplastic pemphigus    intestinal disease


    Find genes that share disorders with C6orf25           About GenesLikeMe

    9 Novoseek inferred disease relationships for C6orf25 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    lymphoma b-cell 31.4 1 16618777 (1)
    somatic mutations 30.3 1 1642656 (1)
    autoimmunity 14.6 1 12223069 (1)
    rheumatoid arthritis 13.5 1 10736104 (1)
    lymphoma non-hodgkins 9.35 1 11071657 (1)
    lupus erythematosus systemic 8.18 2 11604589 (1), 16504824 (1)
    lymphoma 3.61 3 15671532 (1), 7709821 (1), 9814592 (1)
    necrosis 0 1 20032102 (1)
    tumors 0 6 16618777 (1), 14989784 (1), 7709821 (1), 8988839 (1) (see all 6)

    Human Genome Epidemiology (HuGE) Navigator: C6orf25 (6 documents)

    Export disorders for C6orf25 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for C6orf25 gene, integrated from 10 sources (see all 112):
    (articles sorted by number of sources associating them with C6orf25)
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    1. G6b, a novel immunoglobulin superfamily member encoded in the human major histocompatibility complex, interacts with SHP-1 and SHP-2. (PubMed id 11544253)1, 2, 3, 9 de Vet E.C.M.... Campbell R.D. (J. Biol. Chem. 2001)
    2. The novel inhibitory receptor G6B is expressed on the surface of platelets and attenuates platelet function in vitro. (PubMed id 17311996)1, 2 Newland S.A.... Campbell D.R. (Blood 2007)
    3. The cell surface receptor G6b, a member of the immunoglobulin superfamily, binds heparin. (PubMed id 15848171)1, 2 de Vet E.C.... Campbell R.D. (FEBS Lett. 2005)
    4. Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse. (PubMed id 14656967)1, 2 Xie T.... Hood L. (Genome Res. 2003)
    5. Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PubMed id 12665801)1, 2 Gevaert K.... Vandekerckhove J. (Nat. Biotechnol. 2003)
    6. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (Nature 2003)
    7. Genes encoding three new members of the leukocyte antigen 6 superfamily and a novel member of Ig superfamily, together with genes encoding the regulatory nuclear chloride ion channel protein (hRNCC) and an N omega-N omega-dimethylarginine dimethylaminohydrolase homologue, are found in a 30-kb segment of the MHC class III region. (PubMed id 10384126)1, 3 Ribas G.... Campbell R.D. (J. Immunol. 1999)
    8. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1 Bailey S.D....Anand S. (Diabetes Care 2010)
    9. Several loci in the HLA class III region are associated with T1D risk after adjusting for DRB1-DQB1. (PubMed id 19143814)1 Valdes A.M. and Thomson G. (amp 2009)
    10. Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (Am. J. Hum. Genet. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 80739 HGNC: 13937 AceView: C6orf25 Ensembl:ENSG00000204420 euGenes: HUgn80739
    ECgene: C6orf25 H-InvDB: C6orf25

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for C6orf25 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for C6orf25 gene:
    Search GeneIP for patents involving C6orf25

    GeneCards and IP:
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