Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

C6orf25 Gene

protein-coding   GIFtS: 52
GCID: GC06P031686

Chromosome 6 Open Reading Frame 25

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Chromosome 6 Open Reading Frame 251 2
G6b2
NG312
Immunoglobulin Receptor2
Protein G6b2

External Ids:    HGNC: 139371   Entrez Gene: 807392   Ensembl: ENSG000002044207   OMIM: 6065205   UniProtKB: O958663   

Export aliases for C6orf25 gene to outside databases

Previous GC identifers: GC06P031754 GC06P031461 GC06P031795 GC06P031799 GC06P031477


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for C6orf25 Gene:
This gene is a member of the immunoglobulin (Ig) superfamily and is located in the major histocompatibility
complex (MHC) class III region. The protein encoded by this gene is a glycosylated, plasma membrane-bound cell
surface receptor, but soluble isoforms encoded by some transcript variants have been found in the endoplasmic
reticulum and Golgi before being secreted. Multiple transcript variants encoding different isoforms have been
found for this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for C6orf25 Gene: 
C6orf25 (chromosome 6 open reading frame 25) is a protein-coding gene. Diseases associated with C6orf25 include x-linked hyper igm syndrome, and gray platelet syndrome. GO annotations related to this gene include heparin binding.

UniProtKB/Swiss-Prot: G6B_HUMAN, O95866
Function: Inhibits platelet aggregation and activation by agonists such as ADP and collagen-related peptide.
Appears to operate in a calcium-independent manner. Isoform B is a putative inhibitory receptor. Isoform A may be
its activating counterpart

Gene Wiki entry for C6orf25 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NC_018917.2  NT_007592.15  NT_113891.2  NT_167245.1  NT_167246.1  NT_167247.1  NT_167248.1  
NT_167249.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the C6orf25 gene promoter:
         Sp1   ITF-2   NF-kappaB1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for C6orf25

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C6orf25


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.33   Ensembl cytogenetic band:  6p21.33   HGNC cytogenetic band: 6p21

C6orf25 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
C6orf25 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P031686:  view genomic region     (about GC identifiers)

Start:
31,686,371 bp from pter      End:
31,694,491 bp from pter
Size:
8,121 bases      Orientation:
plus strand

6 alternative locations:
Chr6+,NT_167249 3,021,938-3,025,304      Chr6+,NT_167247 3,070,804-3,074,170      Chr6+,NT_167246 3,034,010-3,037,377     
Chr6+,NT_167245 2,976,691-2,980,057      Chr6+,NT_113891.2 3,200,738-3,204,104      Chr6+,NT_167248 2,984,751-2,988,117     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: G6B_HUMAN, O95866 (See protein sequence)
Recommended Name: Protein G6b precursor  
Size: 241 amino acids; 26163 Da
Subunit: Interacts with PTPN6 and PTPN11. Binds to heparin
Subcellular location: Isoform E: Endoplasmic reticulum. Golgi apparatus
Subcellular location: Isoform D: Endoplasmic reticulum. Golgi apparatus
Subcellular location: Isoform B: Cell membrane; Single-pass type I membrane protein
Subcellular location: Isoform A: Cell membrane; Single-pass type I membrane protein
Secondary accessions: A2BEZ1 A2BEZ2 A2BEZ3 A2BEZ4 A2BEZ5 B0UXC4 B0UXC7 B0UXC8 B0V024 B0V026
Q14CK2 Q96A86 Q96A87 Q96A88 Q96A89 Q96A90 Q96A91
Alternative splicing: 7 isoforms:  O95866-1   O95866-2   O95866-3   O95866-4   O95866-5   O95866-6   O95866-7   

Explore the universe of human proteins at neXtProt for C6orf25: NX_O95866

Explore proteomics data for C6orf25 at MOPED 

Post-translational modifications:

  • UniProtKB: All isoforms are N-glycosylated
  • UniProtKB: Isoform E is O-glycosylated
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O95866

  • C6orf25 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    C6orf25 Protein Expression
    REFSEQ proteins (6 alternative transcripts): 
    NP_079536.2  NP_612116.1  NP_612117.1  NP_612118.1  NP_612119.1  NP_612121.1  

    ENSEMBL proteins: 
     ENSP00000419306   ENSP00000364968   ENSP00000364963   ENSP00000420355   ENSP00000364967  
     ENSP00000364962   ENSP00000364972   ENSP00000364964  

    Human Recombinant Protein Products for C6orf25: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for C6orf25 (G6b)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for C6orf25
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for C6orf25
    GenScript Custom Purified and Recombinant Proteins Services for C6orf25
    Novus Biologicals C6orf25 Protein
    Novus Biologicals C6orf25 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for C6orf25 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005783endoplasmic reticulum IEA--
    GO:0005794Golgi apparatus IEA--
    GO:0005886plasma membrane IDA11544253
    GO:0016021integral to membrane IEA--

    C6orf25 for ontologies           About GeneDecksing



    C6orf25 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for C6orf25
    GenScript Custom Superior Antibodies Services for C6orf25
    Novus Biologicals C6orf25 Antibodies
    Abcam antibodies for C6orf25
    Cloud-Clone Corp. Antibodies for C6orf25 
    ThermoFisher Antibodies for C6orf25
    LSBio Antibodies in human, mouse, rat for C6orf25 

    Assay Products for C6orf25: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for C6orf25
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for C6orf25
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for C6orf25 
    Cloud-Clone Corp. CLIAs for C6orf25


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR003599 Ig_sub

    Graphical View of Domain Structure for InterPro Entry O95866

    ProtoNet protein and cluster: O95866

    1 Blocks protein domain: IPB003599 Immunoglobulin subtype


    C6orf25 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: G6B_HUMAN, O95866
    Function: Inhibits platelet aggregation and activation by agonists such as ADP and collagen-related peptide.
    Appears to operate in a calcium-independent manner. Isoform B is a putative inhibitory receptor. Isoform A may be
    its activating counterpart

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008201heparin binding IEA--
         
    C6orf25 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for C6orf25:
     Synthetic lethal with c-Myc af 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for C6orf25 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for C6orf25

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for C6orf25 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for C6orf25 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat C6orf25
    4 QIAGEN miScript miRNA Assays for microRNAs that regulate C6orf25:
    hsa-miR-3678-3p hsa-miR-3116 hsa-miR-147 hsa-miR-3160-3p
    SwitchGear 3'UTR luciferase reporter plasmidC6orf25 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for C6orf25
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat C6orf25

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for C6orf25
    Sirion Biotech Customized adenovirus for overexpression of C6orf25

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for C6orf25 (see all 23)
    OriGene ORF clones in mouse, rat for C6orf25
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 6): C6orf25 (NM_138273)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for C6orf25
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C6orf25
    Sirion Biotech Customized lentivirus for stable overexpression of C6orf25 
                         Customized lentivirus expression plasmids for stable overexpression of C6orf25 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for C6orf25
    Search LifeMap BioReagents cell lines for C6orf25
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C6orf25


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for C6orf25

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for C6orf25 (O958662, 3 ENSP000003649644) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PTPN11Q061242, 3, ENSP000003409444MINT-8035965 I2D: score=3 STRING: ENSP00000340944
    PTPN6P293502, 3, ENSP000003915924MINT-8035954 I2D: score=3 STRING: ENSP00000391592
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    C6orf25 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for C6orf25 (G6B)

    4 Novoseek inferred chemical compound relationships for C6orf25 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 27.6 5 18684881 (1), 11544253 (1), 9103201 (1)
    sphingosine 26.5 1 15693752 (1)
    lipid 0 1 20140224 (1)
    calcium 0 1 15693752 (1)

    Search CenterWatch for drugs/clinical trials and news about C6orf25 / G6B

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for C6orf25 gene (7 alternative transcripts): 
    NM_025260.3  NM_138272.2  NM_138273.2  NM_138274.2  NM_138275.2  NM_138277.2  NM_138276.1  

    Unigene Cluster for C6orf25:

    Chromosome 6 open reading frame 25
    Hs.247879  [show with all ESTs]
    Unigene Representative Sequence: NM_138277
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000460663 ENST00000480039(uc021yux.1) ENST00000375810 ENST00000375805
    ENST00000485548 ENST00000375809(uc011doc.2 uc003nwk.3 uc011dod.2 uc003nwn.3 uc011doe.2 uc003nwo.3)
    ENST00000466312 ENST00000375804 ENST00000375814 ENST00000471545 ENST00000375806

    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat C6orf25
    4 QIAGEN miScript miRNA Assays for microRNAs that regulate C6orf25:
    hsa-miR-3678-3p hsa-miR-3116 hsa-miR-147 hsa-miR-3160-3p
    SwitchGear 3'UTR luciferase reporter plasmidC6orf25 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for C6orf25
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat C6orf25
    Clone
    Products:
         
    OriGene clones in human, mouse for C6orf25 (see all 23)
    OriGene ORF clones in mouse, rat for C6orf25
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 6): C6orf25 (NM_138273)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for C6orf25
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C6orf25
    Sirion Biotech Customized lentivirus for stable overexpression of C6orf25 
                         Customized lentivirus expression plasmids for stable overexpression of C6orf25 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for C6orf25
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat C6orf25
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat C6orf25
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat C6orf25

    Additional mRNA sequence: 

    AJ292259.1 AJ292260.1 AJ292261.1 AJ292262.1 AJ292263.1 AJ292265.1 AK092392.1 BC113719.1 
    BC113721.1 BC143850.1 BX647860.1 

    8 DOTS entries:

    DT.95301631  DT.121311108  DT.91670895  DT.95368866  DT.95368864  DT.95368865  DT.100055534  DT.95368863 

    24/39 AceView cDNA sequences (see all 39):

    BX644924 AX747518 BX397581 AK092392 AJ292265 NM_138276 AJ292261 BX389558 
    NM_138272 AI190741 BX503538 NM_138277 BX503539 NM_025260 NM_138273 AJ292260 
    AJ292262 BU681844 AJ292259 AJ292264 BX647860 BI911004 AJ292263 AI065057 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    C6orf25 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCGCCTGCCC
    C6orf25 Expression
    About this image


    See C6orf25 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for C6orf25

    SOURCE GeneReport for Unigene cluster: Hs.247879

    UniProtKB/Swiss-Prot: G6B_HUMAN, O95866
    Tissue specificity: Expressed in a restricted set of hematopoietic cell lines including the erythroleukemia cell
    line K-562 and the T-cell leukemia cell lines MOLT-4 and Jurkat. Not detected in the monocyte-like cell line
    U-937, the B-cell-like cell line Raji, the fibroblast cell lines TK and HeLa, or the natural killer cell lines
    NKL, NK 62 and YT. Expressed in platelets

        SABiosciences Custom PCR Arrays for C6orf25
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for C6orf25
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat C6orf25
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat C6orf25
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat C6orf25
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C6orf25

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of human and mouse.

    Orthologs for C6orf25 gene from 1/6 species (see all 6)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia G6b5
    AU0238711
    G6B protein5
    expressed sequence AU0238711
    77.92(n)1
    73.84(a)1
      17 (18.59 cM)5
    1067221  NM_001191012.11  NP_001177941.11 
     350644375 


    ENSEMBL Gene Tree for C6orf25 (if available)
    TreeFam Gene Tree for C6orf25 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for C6orf25 gene
    1 SIMAP similar gene for C6orf25 using alignment to 5 protein entries:     B0UXC5_HUMAN (see all proteins):
    G6B

    C6orf25 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/115 SNPs in C6orf25 are shown (see all 115)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs709902661,2
    C--31476714(+) ATTAG-/TCAG  
            
    GTGTG
    6 -- us2k11Minor allele frequency- TCAG:0.00NA 2
    rs1453331921,2
    C,F--31606403(+) TAAGGG/ACTTTC 6 -- us2k11Minor allele frequency- A:0.00NA 4550
    rs1836185681,2
    C--31606413(+) CATGGC/TGAGGG 6 -- us2k10--------
    rs2004035081,2
    C--31606435(+) GTGGCA/GACCAC 6 -- us2k11Minor allele frequency- G:0.00EU 1305
    rs1426949901,2
    C--31606676(+) AATGCC/TATTGT 6 -- us2k10--------
    rs8052921,2
    C,F,A,H--31606963(-) GCAGGC/TATTGG 6 -- us2k142Minor allele frequency- T:0.35NS EA NA MN WA CSA 5518
    rs1476405331,2
    C--31607060(+) CAGGTC/TTGCTA 6 -- us2k10--------
    rs559325441,2
    C--31607310(+) AGGCCA/GGGTGT 6 -- us2k10--------
    rs1446054461,2
    --31607323(+) TGGCTC/TACACC 6 -- us2k10--------
    rs1860956011,2
    --31607534(+) TGAGTC/TGAGAT 6 -- us2k10--------

    HapMap Linkage Disequilibrium report for C6orf25 (31686371 - 31694491 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for C6orf25:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv884425CNV Loss21882294
    nsv884418CNV Gain21882294

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing C6orf25
    DNA2.0 Custom Variant and Variant Library Synthesis for C6orf25

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 606520    OMIM disorders: --

    20/30 diseases for C6orf25 (see all 30):    About MalaCards
    x-linked hyper igm syndrome    gray platelet syndrome    hairy cell leukemia    intestinal disease
    paraneoplastic pemphigus    cryoglobulinemia    follicular lymphoma    b-cell chronic lymphocytic leukemia
    mastocytosis    chronic lymphocytic leukemia    pemphigus    kaposi's sarcoma
    lupus erythematosus    t-cell leukemia    systemic lupus erythematosus    non-hodgkin lymphoma
    hodgkin's lymphoma    glomerulonephritis    choriocarcinoma    rheumatoid arthritis


    C6orf25 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    9 Novoseek inferred disease relationships for C6orf25 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    lymphoma b-cell 31.4 1 16618777 (1)
    somatic mutations 30.3 1 1642656 (1)
    autoimmunity 14.6 1 12223069 (1)
    rheumatoid arthritis 13.5 1 10736104 (1)
    lymphoma non-hodgkins 9.35 1 11071657 (1)
    lupus erythematosus systemic 8.18 2 11604589 (1), 16504824 (1)
    lymphoma 3.61 3 15671532 (1), 7709821 (1), 9814592 (1)
    necrosis 0 1 20032102 (1)
    tumors 0 6 16618777 (1), 14989784 (1), 7709821 (1), 8988839 (1) (see all 6)

    Human Genome Epidemiology (HuGE) Navigator: C6orf25 (6 documents)

    Export disorders for C6orf25 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for C6orf25 gene, integrated from 9 sources (see all 112):
    (articles sorted by number of sources associating them with C6orf25)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. G6b, a novel immunoglobulin superfamily member encoded in the human major histocompatibility complex, interacts with SHP-1 and SHP-2. (PubMed id 11544253)1, 2, 3, 9 de Vet E.C....Campbell R.D. (2001)
    2. The novel inhibitory receptor G6B is expressed on the surface of platelets and attenuates platelet function in vitro. (PubMed id 17311996)1, 2 Newland S.A.... Campbell D.R. (2007)
    3. The cell surface receptor G6b, a member of the immunoglobulin superfamily, binds heparin. (PubMed id 15848171)1, 2 de Vet E.C.... Campbell R.D. (2005)
    4. Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse. (PubMed id 14656967)1, 2 Xie T.... Hood L. (2003)
    5. Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PubMed id 12665801)1, 2 Gevaert K.... Vandekerckhove J. (2003)
    6. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
    7. Genes encoding three new members of the leukocyte antigen 6 superfamily and a novel member of Ig superfamily, together with genes encoding the regulatory nuclear chloride ion channel protein (hRNCC) and an N omega-N omega-dimethylarginine dimethylaminohydrolase homologue, are found in a 30-kb segment of the MHC class III region. (PubMed id 10384126)1, 3 Ribas G.... Campbell R.D. (1999)
    8. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1 Bailey S.D....Anand S. (2010)
    9. Several loci in the HLA class III region are associated with T1D risk after adjusting for DRB1-DQB1. (PubMed id 19143814)1 Valdes A.M. and Thomson G. (2009)
    10. Gene-centric association signals for lipids and apoli poproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 80739 HGNC: 13937 AceView: C6orf25 Ensembl:ENSG00000204420 euGenes: HUgn80739
    ECgene: C6orf25 H-InvDB: C6orf25

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for C6orf25 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for C6orf25 gene:
    Search GeneIP for patents involving C6orf25

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Recombinant/Natural Proteins for C6orf25 (G6b)  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for C6orf25  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for C6orf25  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for C6orf25  
     OriGene qSTAR qPCR primer pairs in human, mouse for C6orf25   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for C6orf25   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for C6orf25   OriGene Custom Protein Services for C6orf25  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat C6orf25
     QIAGEN SeqTarget long-range PCR primers for resequencing C6orf25
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C6orf25
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat C6orf25
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat C6orf25
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat C6orf25
     GenScript Custom Purified and Recombinant Proteins Services for C6orf25 GenScript cDNA clones with any tag delivered in your preferred vector for C6orf25
     GenScript Custom Assay Services for C6orf25 GenScript Custom Superior Antibodies Services for C6orf25
     GenScript Custom overexpressing Cell Line Services for C6orf25 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in C6orf25 promoter
     Search Chromatin IP Primers for C6orf25
     RT2 qPCR Primer Assay in human, mouse, rat C6orf25
     GNC Network for C6orf25
     SABiosciences Custom PCR Arrays for C6orf25
     Search Tocris compounds for C6orf25 (G6B)
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     C6orf25 antibodies
     C6orf25 proteins
     C6orf25 lysates
     Antibodies for C6orf25
     See all of Abcam's Antibodies, Kits and Proteins for C6orf25
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for C6orf25
     Antibodies for C6orf25
     ELISAs for C6orf25
     CLIAs for C6orf25
     Search LifeMap BioReagents cell lines for C6orf25
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C6orf25
     SwitchGear 3'UTR luciferase reporter plasmids for C6orf25
     Browse SwitchGear Promoter luciferase reporter plasmids for C6orf25
     ThermoFisher Antibodies for C6orf25
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C6orf25
     inGenious Targeting Laboratory - Custom generated mouse model solutions for C6orf25
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for C6orf25
    Customized:
     lentivirus for stable overexpression of C6orf25
     lentivirus expression plasmids for stable overexpression of C6orf25
     adenovirus for overexpression of C6orf25
     LSBio Antibodies in human, mouse, rat for C6orf25
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      C6orf25 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4