C6orf25 Gene
protein-coding GIFtS: 51
GCID: GC06P031686
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|
chromosome 6 open reading frame 25
| |
Aliases
for C6orf25 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Chromosome 6 Open Reading Frame 251 2 | | G6b1 2 | | NG311 2 | | Immunoglobulin Receptor2 | | Protein G6b2 |
Export aliases for C6orf25 gene to outside databasesPrevious GC identifers: GC06P031754 GC06P031461 GC06P031795 GC06P031799 GC06P031477 |
Summaries
for C6orf25 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for C6orf25:
This gene is a member of the immunoglobulin (Ig) superfamily and is located in the major histocompatibility complex(MHC) class III region. The protein encoded by this gene is a glycosylated, plasma membrane-bound cell surfacereceptor, but soluble isoforms encoded by some transcript variants have been found in the endoplasmic reticulum andGolgi before being secreted. Multiple transcript variants encoding different isoforms have been found for this gene.(provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: G6B_HUMAN, O95866Function: Inhibits platelet aggregation and activation by agonists such as ADP and collagen-related peptide. Appears tooperate in a calcium-independent manner. Isoform B is a putative inhibitory receptor. Isoform A may be its activatingcounterpart
Gene Wiki entry for C6orf25
|
Genomic Views
for C6orf25 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000006.11 NC_018917.1 NT_007592.15 NT_113891.2 NT_167245.1 NT_167246.1 NT_167247.1 NT_167248.1
- NT_167249.1
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the C6orf25 gene promoter:
Sp1 ITF-2 NF-kappaB1
Other transcription factors
Search SABiosciences Chromatin IP Primers for C6orf25
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C6orf25 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 6p21.33 Ensembl cytogenetic band: 6p21.33 HGNC cytogenetic band: 6p21C6orf25 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 6 GeneLoc Exon Structure GeneLoc location for GC06P031686: view genomic region
(about GC identifiers)
Start:
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31,686,371 bp from pter |
End:
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31,694,491 bp from pter |
Size:
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8,121 bases |
Orientation:
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plus strand |
6 alternative locations:
| Chr6+,ALT_REF_LOCI_4 31,653,709-31,655,400 | Chr6+,ALT_REF_LOCI_2 31,673,784-31,719,452 | Chr6+,ALT_REF_LOCI_5 31,682,267-31,683,957 | | Chr6+,ALT_REF_LOCI_6 31,676,607-31,718,665 | Chr6+,ALT_REF_LOCI_3 31,668,544-31,686,062 | Chr6+,ALT_REF_LOCI_7 31,611,443-31,613,133 | |
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Proteins
for C6orf25 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: G6B_HUMAN, O95866 (See
protein sequence)Recommended Name: Protein G6b precursor Size: 241 amino acids; 26163 Da
Subunit: Interacts with PTPN6 and PTPN11. Binds to heparin
Subcellular location: Isoform E: Endoplasmic reticulum. Golgi apparatus
Subcellular location: Isoform D: Endoplasmic reticulum. Golgi apparatus
Subcellular location: Isoform B: Cell membrane; Single-pass type I membrane protein
Subcellular location: Isoform A: Cell membrane; Single-pass type I membrane protein
Secondary accessions: A2BEZ1 A2BEZ2 A2BEZ3 A2BEZ4 A2BEZ5 B0UXC4 B0UXC7 B0UXC8 B0V024 B0V026 Q14CK2Q96A86 Q96A87 Q96A88 Q96A89 Q96A90 Q96A91Alternative splicing: 7 isoforms: O95866-1 O95866-2 O95866-3 O95866-4 O95866-5 O95866-6 O95866-7 Explore the universe of human proteins at neXtProt for C6orf25: NX_O95866
Post-translational modifications:
All isoforms are N-glycosylated1
Isoform E is O-glycosylated1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_O95866
C6orf25 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (6 alternative transcripts):
NP_079536.2 NP_612116.1 NP_612117.1 NP_612118.1 NP_612119.1 NP_612121.1
ENSEMBL proteins: ENSP00000419306 ENSP00000364968 ENSP00000364963 ENSP00000420355 ENSP00000364967 ENSP00000364962 ENSP00000364972 ENSP00000364964
Human Recombinant Protein Products:
Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table
C6orf25 for ontologies About GeneDecksing
C6orf25 Antibody Products:
Assay Products for C6orf25: |
Protein
Domains /
Families
for C6orf25 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
C6orf25 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry O95866ProtoNet protein and cluster: O95866 1 Blocks protein family: IPB003599 Immunoglobulin subtype
|
Function
for C6orf25 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: G6B_HUMAN, O95866Function: Inhibits platelet aggregation and activation by agonists such as ADP and collagen-related peptide. Appears tooperate in a calcium-independent manner. Isoform B is a putative inhibitory receptor. Isoform A may be its activatingcounterpart
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for C6orf25 (see all 7)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for C6orf25 (see all 6)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C6orf25 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004872 | receptor activity |
-- | -- | | GO:0008201 | heparin binding |
IEA | -- |
C6orf25 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for C6orf25:
|
Pathways & Interactions
for C6orf25 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for C6orf25
STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)
2 Interacting proteins for C6orf25 (O958662, 3 ENSP000003649644) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for C6orf25 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
C6orf25 for compounds About GeneDecksing
 Browse Tocris compounds for C6orf25
4 Novoseek chemical compound relationships for C6orf25 gene About this table
Search CenterWatch for drugs/clinical trials and news about C6orf25 / G6B
|
Transcripts
for C6orf25 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for C6orf25 gene (7 alternative transcripts): NM_025260.3 NM_138272.2 NM_138273.2 NM_138274.2 NM_138275.2 NM_138277.2 NM_138276.1 Unigene Cluster for C6orf25: Chromosome 6 open reading frame 25 Hs.247879 [show with all ESTs]Unigene Representative Sequence: NM_13827711 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000460663 ENST00000480039(uc021yux.1) ENST00000375810 ENST00000375805
ENST00000485548 ENST00000375809(uc011doc.2 uc003nwk.3 uc011dod.2 uc003nwn.3 uc011doe.2 uc003nwo.3)
ENST00000466312 ENST00000375804 ENST00000375814 ENST00000471545 ENST00000375806
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for C6orf25 (see all 7)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for C6orf25 (see all 6)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 6): C6orf25 (NM_138273) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for C6orf25 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C6orf25 |
Additional cDNA sequence: AJ292259.1 AJ292260.1 AJ292261.1 AJ292262.1 AJ292263.1 AJ292265.1 AK092392.1 BC113719.1 BC113721.1 BC143850.1 BX647860.1 8 DOTS entries: DT.95301631 DT.121311108 DT.91670895 DT.95368866 DT.95368864 DT.95368865 DT.100055534 DT.95368863 24/39 AceView cDNA sequences (see all 39): BX397581 BX644924 AX747518 AK092392 AJ292261 NM_138276 AJ292262 BX503539 AI190741 NM_138274 BX389560 NM_138273 NM_138277 BX389558 NM_138275 AJ292265 BI911004 BX503538 AJ292264 BU681844 NM_138272 AJ292260 AJ292263 NM_025260
GeneLoc Exon Structure
|
Expression
for C6orf25 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| C6orf25 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GCGCCTGCCC
About this image
See C6orf25 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for C6orf25
SOURCE GeneReport for Unigene cluster: Hs.247879
UniProtKB/Swiss-Prot: G6B_HUMAN, O95866Tissue specificity: Expressed in a restricted set of hematopoietic cell lines including the erythroleukemia cell lineK-562 and the T-cell leukemia cell lines MOLT-4 and Jurkat. Not detected in the monocyte-like cell line U-937, theB-cell-like cell line Raji, the fibroblast cell lines TK and HeLa, or the natural killer cell lines NKL, NK 62 and YT.Expressed in platelets
SABiosciences Custom PCR Arrays for C6orf25
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for C6orf25
Browse OriGene validated miRNA SYBR primer pairs
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Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C6orf25 |
Orthologs
for C6orf25 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of human and mouse.
Orthologs for C6orf25 gene from 1/5 species (see all 5) About this table
ENSEMBL Gene Tree for C6orf25 (if available)
TreeFam Gene Tree for C6orf25 (if available) |
Paralogs
for C6orf25 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for C6orf25 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 6 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for C6orf25 (31686371 - 31694491 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for C6orf25: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing C6orf25 |
|
Disorders
/ Diseases
for C6orf25 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
C6orf25 for disorders About GeneDecksing
OMIM gene information: 606520
OMIM disorders: --
20/28  diseases for C6orf25 (see all 28): About MalaCardsgray platelet syndrome non-hodgkin lymphoma lupus erythematosus b-cell lymphomas
hairy cell leukemia systemic lupus erythematosus hodgkin's lymphoma rheumatoid arthritis
chronic lymphocytic leukemia lymphocytic leukemia follicular lymphoma kaposi's sarcoma
cryoglobulinemia intestinal disease mastocytosis pemphigus
t-cell leukemia hepatitis c hepatitis b arthritis
9 Novoseek disease relationships for C6orf25 gene About this table
Human Genome Epidemiology (HuGE) Navigator: C6orf25 (6 documents)
Export disorders for C6orf25 gene to outside databases
|
Publications
for C6orf25 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for C6orf25 gene, integrated from 9 sources (see all 112):
(articles sorted by number of sources associating them with C6orf25) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- G6b, a novel immunoglobulin superfamily member encoded in the human major histocompatibility complex, interacts with SHP-1 and SHP-2. (PubMed id 11544253)1, 2, 3, 9 de Vet E.C....Campbell R.D. (2001)
- The novel inhibitory receptor G6B is expressed on the surface of platelets and attenuates platelet function in vitro. (PubMed id 17311996)1, 2 Newland S.A.... Campbell D.R. (2007)
- The cell surface receptor G6b, a member of the immunoglobulin superfamily, binds heparin. (PubMed id 15848171)1, 2 de Vet E.C.... Campbell R.D. (2005)
- Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse. (PubMed id 14656967)1, 2 Xie T.... Hood L. (2003)
- Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PubMed id 12665801)1, 2 Gevaert K.... Vandekerckhove J. (2003)
- The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
- Genes encoding three new members of the leukocyte antigen 6 superfamily and a novel member of Ig superfamily, together with genes encoding the regulatory nuclear chloride ion channel protein (hRNCC) and an N omega-N omega-dimethylarginine dimethylaminohydrolase homologue, are found in a 30-kb segment of the MHC class III region. (PubMed id 10384126)1, 3 Ribas G.... Campbell R.D. (1999)
- Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1 Bailey S.D....Anand S. (2010)
- Several loci in the HLA class III region are associated with T1D risk after adjusting for DRB1-DQB1. (PubMed id 19143814)1 Valdes A.M. and Thomson G. (2009)
- Gene-centric association signals for lipids and apoli poproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (2009)
|
External Searches for C6orf25 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing C6orf25 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing C6orf25 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing C6orf25 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for C6orf25 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for C6orf25 gene:
Search GeneIP for patents involving C6orf25
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for C6orf25 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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| |
 |  |  |  | |
| | | | Search Tocris compounds for C6orf25 |
| |  |  |  |  | | | | |
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 | | | C6orf25 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C6orf25 |
|  |  |  | | | | ThermoFisher Antibodies for C6orf25 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C6orf25 |
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