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Aliases for C6orf25 Gene

Aliases for C6orf25 Gene

  • Chromosome 6 Open Reading Frame 25 2 3
  • G6B 3 4
  • Immunoglobulin Receptor 3
  • Protein G6b 3
  • NG31 3

External Ids for C6orf25 Gene

Previous GeneCards Identifiers for C6orf25 Gene

  • GC06P031754
  • GC06P031461
  • GC06P031795
  • GC06P031799
  • GC06P031686
  • GC06P031477

Summaries for C6orf25 Gene

Entrez Gene Summary for C6orf25 Gene

  • This gene is a member of the immunoglobulin (Ig) superfamily and is located in the major histocompatibility complex (MHC) class III region. The protein encoded by this gene is a glycosylated, plasma membrane-bound cell surface receptor, but soluble isoforms encoded by some transcript variants have been found in the endoplasmic reticulum and Golgi before being secreted. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for C6orf25 Gene

C6orf25 (Chromosome 6 Open Reading Frame 25) is a Protein Coding gene. Diseases associated with C6orf25 include gray platelet syndrome and paraneoplastic pemphigus. GO annotations related to this gene include heparin binding.

UniProtKB/Swiss-Prot for C6orf25 Gene

  • Inhibits platelet aggregation and activation by agonists such as ADP and collagen-related peptide. Appears to operate in a calcium-independent manner. Isoform B is a putative inhibitory receptor. Isoform A may be its activating counterpart.

Gene Wiki entry for C6orf25 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C6orf25 Gene

Genomics for C6orf25 Gene

Regulatory Elements for C6orf25 Gene

Transcription factor binding sites by QIAGEN in the C6orf25 gene promoter:

Genomic Location for C6orf25 Gene

Start:
31,718,594 bp from pter
End:
31,726,714 bp from pter
Size:
8,121 bases
Orientation:
Plus strand

Genomic View for C6orf25 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for C6orf25 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Proteins for C6orf25 Gene

  • Protein details for C6orf25 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95866-G6B_HUMAN
    Recommended name:
    Protein G6b
    Protein Accession:
    O95866
    Secondary Accessions:
    • A2BEZ1
    • A2BEZ2
    • A2BEZ3
    • A2BEZ4
    • A2BEZ5
    • B0UXC4
    • B0UXC7
    • B0UXC8
    • B0V024
    • B0V026
    • Q14CK2
    • Q96A86
    • Q96A87
    • Q96A88
    • Q96A89
    • Q96A90
    • Q96A91

    Protein attributes for C6orf25 Gene

    Size:
    241 amino acids
    Molecular mass:
    26163 Da
    Quaternary structure:
    • Interacts with PTPN6 and PTPN11. Binds to heparin.

    Alternative splice isoforms for C6orf25 Gene

neXtProt entry for C6orf25 Gene

Proteomics data for C6orf25 Gene at MOPED

Post-translational modifications for C6orf25 Gene

No data available for DME Specific Peptides for C6orf25 Gene

Domains for C6orf25 Gene

Protein Domains for C6orf25 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for C6orf25 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C6orf25: view

No data available for Gene Families and UniProtKB/Swiss-Prot for C6orf25 Gene

Function for C6orf25 Gene

Molecular function for C6orf25 Gene

UniProtKB/Swiss-Prot Function: Inhibits platelet aggregation and activation by agonists such as ADP and collagen-related peptide. Appears to operate in a calcium-independent manner. Isoform B is a putative inhibitory receptor. Isoform A may be its activating counterpart.

Gene Ontology (GO) - Molecular Function for C6orf25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008201 heparin binding IEA --
genes like me logo Genes that share ontologies with C6orf25: view

Phenotypes for C6orf25 Gene

GenomeRNAi human phenotypes for C6orf25:
genes like me logo Genes that share phenotypes with C6orf25: view

miRNA for C6orf25 Gene

miRTarBase miRNAs that target C6orf25

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for C6orf25 Gene

Localization for C6orf25 Gene

Subcellular locations from UniProtKB/Swiss-Prot for C6orf25 Gene

Isoform E: Endoplasmic reticulum. Golgi apparatus.
Isoform D: Endoplasmic reticulum. Golgi apparatus.
Isoform B: Cell membrane; Single-pass type I membrane protein.
Isoform A: Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for C6orf25 Gene COMPARTMENTS Subcellular localization image for C6orf25 gene
Compartment Confidence
endoplasmic reticulum 5
golgi apparatus 5
plasma membrane 5
extracellular 3
lysosome 1

Gene Ontology (GO) - Cellular Components for C6orf25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IEA --
GO:0005794 Golgi apparatus IEA --
GO:0005886 plasma membrane IDA 11544253
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with C6orf25: view

Pathways for C6orf25 Gene

SuperPathways for C6orf25 Gene

No Data Available

Interacting Proteins for C6orf25 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000364964%0d%0a9606.ENSP00000340944%0d%0a9606.ENSP00000391592%0d%0a
Selected Interacting proteins: O95866-G6B_HUMAN ENSP00000364964 for C6orf25 Gene via MINT STRING I2D

Gene Ontology (GO) - Biological Process for C6orf25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007229 integrin-mediated signaling pathway IEA --
GO:0007596 blood coagulation IEA --
GO:0030220 platelet formation IEA --
GO:0035855 megakaryocyte development IEA --
genes like me logo Genes that share ontologies with C6orf25: view

No data available for Pathways by source for C6orf25 Gene

Compounds for C6orf25 Gene

(4) Novoseek inferred chemical compound relationships for C6orf25 Gene

Compound -log(P) Hits PubMed IDs
tyrosine 27.6 3
sphingosine 26.5 1
lipid 0 1
calcium 0 1
genes like me logo Genes that share compounds with C6orf25: view

Transcripts for C6orf25 Gene

Unigene Clusters for C6orf25 Gene

Chromosome 6 open reading frame 25:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for C6orf25 Gene

No ASD Table

Relevant External Links for C6orf25 Gene

GeneLoc Exon Structure for
C6orf25
ECgene alternative splicing isoforms for
C6orf25

Expression for C6orf25 Gene

mRNA expression in normal human tissues for C6orf25 Gene

mRNA differential expression in normal tissues according to GTEx for C6orf25 Gene

This gene is overexpressed in Whole Blood (22.3), Skin - Sun Exposed (Lower leg) (6.0), and Skin - Not Sun Exposed (Suprapubic) (5.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for C6orf25 Gene

SOURCE GeneReport for Unigene cluster for C6orf25 Gene Hs.247879

mRNA Expression by UniProt/SwissProt for C6orf25 Gene

O95866-G6B_HUMAN
Tissue specificity: Expressed in a restricted set of hematopoietic cell lines including the erythroleukemia cell line K-562 and the T-cell leukemia cell lines MOLT-4 and Jurkat. Not detected in the monocyte-like cell line U-937, the B-cell-like cell line Raji, the fibroblast cell lines TK and HeLa, or the natural killer cell lines NKL, NK 62 and YT. Expressed in platelets.
genes like me logo Genes that share expressions with C6orf25: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for C6orf25 Gene

Orthologs for C6orf25 Gene

This gene was present in the common ancestor of mammals.

Orthologs for C6orf25 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C6H6orf25 35
  • 99.59 (n)
  • 99.17 (a)
C6orf25 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia C6ORF25 36
  • 62 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C12H6orf25 35
  • 81.68 (n)
  • 80.2 (a)
C6orf25 36
  • 75 (a)
OneToOne
mouse
(Mus musculus)
Mammalia AU023871 36
  • 71 (a)
OneToOne
G6b 35
  • 77.92 (n)
  • 73.84 (a)
G6b 16
oppossum
(Monodelphis domestica)
Mammalia C6orf25 36
  • 56 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia G6b 35
  • 77.87 (n)
  • 73.71 (a)
Species with no ortholog for C6orf25:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for C6orf25 Gene

ENSEMBL:
Gene Tree for C6orf25 (if available)
TreeFam:
Gene Tree for C6orf25 (if available)

Paralogs for C6orf25 Gene

Selected SIMAP similar genes for C6orf25 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with C6orf25: view

No data available for Paralogs for C6orf25 Gene

Variants for C6orf25 Gene

Sequence variations from dbSNP and Humsavar for C6orf25 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs407283 -- 31,725,193(-) CCAGT(C/T)TAGCA utr-variant-3-prime
rs453098 -- 31,723,880(-) GAGTC(C/T)CCCGC synonymous-codon, reference
rs805306 -- 31,724,386(-) ACCAG(C/T)CAGCG intron-variant
rs4947252 -- 31,723,889(+) TCGGG(A/C)ACTTT synonymous-codon, reference
rs11575845 -- 31,724,609(+) CGATT(C/G)GACCA reference, missense, intron-variant

Structural Variations from Database of Genomic Variants (DGV) for C6orf25 Gene

Variant ID Type Subtype PubMed ID
nsv884418 CNV Gain 21882294
nsv884425 CNV Loss 21882294

Relevant External Links for C6orf25 Gene

HapMap Linkage Disequilibrium report
C6orf25

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C6orf25 Gene

Disorders for C6orf25 Gene

(9) Novoseek inferred disease relationships for C6orf25 Gene

Disease -log(P) Hits PubMed IDs
lymphoma b-cell 31.4 1
somatic mutations 30.3 1
autoimmunity 14.6 1
rheumatoid arthritis 13.5 1
lymphoma non-hodgkins 9.35 1

Relevant External Links for C6orf25

Human Genome Epidemiology (HuGE) Navigator
C6orf25
genes like me logo Genes that share disorders with C6orf25: view

No data available for UniProtKB/Swiss-Prot for C6orf25 Gene

Publications for C6orf25 Gene

  1. G6b, a novel immunoglobulin superfamily member encoded in the human major histocompatibility complex, interacts with SHP-1 and SHP-2. (PMID: 11544253) de Vet E.C.M. … Campbell R.D. (J. Biol. Chem. 2001) 2 3 4 23
  2. Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PMID: 12665801) Gevaert K. … Vandekerckhove J. (Nat. Biotechnol. 2003) 3 4
  3. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 3 4
  4. Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse. (PMID: 14656967) Xie T. … Hood L. (Genome Res. 2003) 3 4
  5. Genes encoding three new members of the leukocyte antigen 6 superfamily and a novel member of Ig superfamily, together with genes encoding the regulatory nuclear chloride ion channel protein (hRNCC) and an N omega-N omega-dimethylarginine dimethylaminohydrolase homologue, are found in a 30-kb segment of the MHC class III region. (PMID: 10384126) Ribas G. … Campbell R.D. (J. Immunol. 1999) 2 3

Products for C6orf25 Gene

Sources for C6orf25 Gene

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