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Aliases for C6orf226 Gene

Aliases for C6orf226 Gene

  • Chromosome 6 Open Reading Frame 226 2 3 5

External Ids for C6orf226 Gene

Previous GeneCards Identifiers for C6orf226 Gene

  • GC06M042965
  • GC06M042575

Summaries for C6orf226 Gene

GeneCards Summary for C6orf226 Gene

C6orf226 (Chromosome 6 Open Reading Frame 226) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C6orf226 Gene

Genomics for C6orf226 Gene

Regulatory Elements for C6orf226 Gene

Enhancers for C6orf226 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06F042927 0.5 ENCODE 11.3 -40.0 -39973 5.6 CREB3L1 MLX ZFP64 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC PEX6 CUL9 CUL7 POLH PPP2R5D RRP36 RPL24P4 C6orf226 KLHDC3 MEA1
GH06F043113 1.1 FANTOM5 Ensembl ENCODE 11.2 -224.6 -224603 4.7 HDGF ATF1 PKNOX1 ARNT CREB3L1 FEZF1 ZNF48 ZNF2 ZNF121 ELK1 CUL7 CUL9 DNPH1 C6orf226 POLH RPS2P29 PEX6 PTK7 PIR51341 SRF
GH06F042020 1.3 FANTOM5 Ensembl ENCODE 11.1 +863.8 863820 12.0 HDGF PKNOX1 ARNT CREB3L1 WRNIP1 SIN3A ZNF143 FOS KLF13 ZNF263 PRICKLE4 MED20 TAF8 CCND3 TREML2 USP49 FRS3 C6orf226 ENSG00000207371 BYSL
GH06F042016 1.4 Ensembl ENCODE 11.1 +873.8 873753 2.0 PKNOX1 ATF1 ARNT CREB3L1 ELK1 GATA2 FOS KDM4B JUNB NCOA1 TREML2 C6orf226 PRICKLE4 GC06M042019 LOC105375059 RNU6-761P
GH06F042312 1.6 FANTOM5 Ensembl ENCODE 11.1 +575.4 575361 6.7 ATF1 SIN3A ZNF121 GLIS2 GATA2 FOS JUNB MEF2D MAFF SMARCA4 CUL9 USP49 C6orf226 GUCA1B GLTSCR1L BYSL TRERF1 LOC105375061 GC06M042412
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around C6orf226 on UCSC Golden Path with GeneCards custom track

Promoters for C6orf226 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001216922 16 1601 HDGF WRNIP1 ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF143

Genomic Location for C6orf226 Gene

Chromosome:
6
Start:
42,890,265 bp from pter
End:
42,890,816 bp from pter
Size:
552 bases
Orientation:
Minus strand

Genomic View for C6orf226 Gene

Genes around C6orf226 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C6orf226 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C6orf226 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C6orf226 Gene

Proteins for C6orf226 Gene

  • Protein details for C6orf226 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5I0X4-CF226_HUMAN
    Recommended name:
    Uncharacterized protein C6orf226
    Protein Accession:
    Q5I0X4

    Protein attributes for C6orf226 Gene

    Size:
    101 amino acids
    Molecular mass:
    10566 Da
    Quaternary structure:
    No Data Available

neXtProt entry for C6orf226 Gene

Post-translational modifications for C6orf226 Gene

No Post-translational modifications

Other Protein References for C6orf226 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for C6orf226 Gene

Domains & Families for C6orf226 Gene

Protein Domains for C6orf226 Gene

ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C6orf226: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for C6orf226 Gene

Function for C6orf226 Gene

Gene Ontology (GO) - Molecular Function for C6orf226 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with C6orf226: view

Phenotypes for C6orf226 Gene

GenomeRNAi human phenotypes for C6orf226:
genes like me logo Genes that share phenotypes with C6orf226: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for C6orf226 Gene

Localization for C6orf226 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for C6orf226 Gene COMPARTMENTS Subcellular localization image for C6orf226 gene
Compartment Confidence
extracellular 3
nucleus 2
cytosol 1
mitochondrion 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for C6orf226 Gene

Pathways & Interactions for C6orf226 Gene

SuperPathways for C6orf226 Gene

No Data Available

Gene Ontology (GO) - Biological Process for C6orf226 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for C6orf226 Gene

Transcripts for C6orf226 Gene

mRNA/cDNA for C6orf226 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(37) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for C6orf226 Gene

Chromosome 6 open reading frame 226:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for C6orf226 Gene

No ASD Table

Relevant External Links for C6orf226 Gene

GeneLoc Exon Structure for
C6orf226
ECgene alternative splicing isoforms for
C6orf226

Expression for C6orf226 Gene

mRNA expression in normal human tissues for C6orf226 Gene

NURSA nuclear receptor signaling pathways regulating expression of C6orf226 Gene:

C6orf226

SOURCE GeneReport for Unigene cluster for C6orf226 Gene:

Hs.571098
genes like me logo Genes that share expression patterns with C6orf226: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for C6orf226 Gene

Orthologs for C6orf226 Gene

This gene was present in the common ancestor of human and mouse.

Orthologs for C6orf226 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C6H6orf226 34
  • 96.97 (n)
C6orf226 35
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia 2310039H08Rik 35
  • 46 (a)
OneToOne
Species where no ortholog for C6orf226 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for C6orf226 Gene

ENSEMBL:
Gene Tree for C6orf226 (if available)
TreeFam:
Gene Tree for C6orf226 (if available)

Paralogs for C6orf226 Gene

No data available for Paralogs for C6orf226 Gene

Variants for C6orf226 Gene

Sequence variations from dbSNP and Humsavar for C6orf226 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1056055 -- 42,889,781(+) GAGCA(A/C)ACTGC intron-variant, nc-transcript-variant, utr-variant-3-prime
rs111715080 -- 42,892,805(+) AATAC(-/A)AAAAA upstream-variant-2KB
rs112414831 -- 42,891,596(+) CCACC(A/G)CACCC upstream-variant-2KB
rs112948882 -- 42,889,913(+) GTACC(A/G)TGACA downstream-variant-500B
rs113588316 -- 42,891,504(+) TTTCA(C/T)CATGT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for C6orf226 Gene

Variant ID Type Subtype PubMed ID
esv3576145 CNV gain 25503493
nsv1017398 CNV gain 25217958
nsv830651 CNV loss 17160897

Variation tolerance for C6orf226 Gene

Residual Variation Intolerance Score: 83.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.18; 39.41% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C6orf226 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
C6orf226

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C6orf226 Gene

Disorders for C6orf226 Gene

Relevant External Links for C6orf226

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
C6orf226

No disorders were found for C6orf226 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C6orf226 Gene

Publications for C6orf226 Gene

  1. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  2. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4 64
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 64

Products for C6orf226 Gene

Sources for C6orf226 Gene

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