Free for academic non-profit institutions. Other users need a Commercial license

Aliases for C6orf226 Gene

Aliases for C6orf226 Gene

  • Chromosome 6 Open Reading Frame 226 2 3 5

External Ids for C6orf226 Gene

Previous GeneCards Identifiers for C6orf226 Gene

  • GC06M042965
  • GC06M042858
  • GC06M042575

Summaries for C6orf226 Gene

GeneCards Summary for C6orf226 Gene

C6orf226 (Chromosome 6 Open Reading Frame 226) is a Protein Coding gene.

Additional gene information for C6orf226 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C6orf226 Gene

Genomics for C6orf226 Gene

Regulatory Elements for C6orf226 Gene

Enhancers for C6orf226 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06H042769 1.8 FANTOM5 Ensembl ENCODE dbSUPER 6.2 +119.4 119403 2 HDGF PKNOX1 ZNF143 ZNF207 ATF7 ETV6 RUNX3 CREM IKZF2 SMARCA5 TBCC CUL7 RPL7L1 CUL9 ABCC10 TRERF1 C6orf226 PRPH2 BICRAL GNMT
GH06H042877 1.2 Ensembl ENCODE 8.3 +13.2 13204 1 ELF3 TBP ARID4B DMAP1 DNMT3B ZNF2 RAD21 RARA RFX5 YY1 PEX6 C6orf226 RPL7L1 LOC401261
GH06H042878 1.2 ENCODE 8.3 +10.7 10736 2 HDGF FOXA2 MLX ARNT ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 ABCC10 ZNF318 POLH CUL7 GTPBP2 BICRAL RPS2P29 PEX6 RPL34P14 RRP36
GH06H042889 1.1 ENCODE 8.7 +0.2 167 2 HNRNPUL1 HDGF PKNOX1 ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 POLH ZNF318 RPS2P29 POLR1C XPO5 GTPBP2 UBR2 BICRAL RPL7L1 RPL24P4
GH06H042913 0.6 dbSUPER 11.3 -24.6 -24564 3 ZNF157 ZNF629 ATF7 REPIN1 RUNX3 ATF2 RPL7L1 ENSG00000231113 PPP2R5D PEX6 C6orf226 KLHDC3 MEA1 RNU6-890P CUL9 PTCRA
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around C6orf226 on UCSC Golden Path with GeneCards custom track

Promoters for C6orf226 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000197059 16 1201 HNRNPUL1 HDGF ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF143

Genomic Location for C6orf226 Gene

Chromosome:
6
Start:
42,890,265 bp from pter
End:
42,890,816 bp from pter
Size:
552 bases
Orientation:
Minus strand

Genomic View for C6orf226 Gene

Genes around C6orf226 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C6orf226 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C6orf226 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C6orf226 Gene

Proteins for C6orf226 Gene

  • Protein details for C6orf226 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5I0X4-CF226_HUMAN
    Recommended name:
    Uncharacterized protein C6orf226
    Protein Accession:
    Q5I0X4

    Protein attributes for C6orf226 Gene

    Size:
    101 amino acids
    Molecular mass:
    10566 Da
    Quaternary structure:
    No Data Available

neXtProt entry for C6orf226 Gene

Post-translational modifications for C6orf226 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C6orf226 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for C6orf226 Gene

Domains & Families for C6orf226 Gene

Gene Families for C6orf226 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for C6orf226 Gene

ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C6orf226: view

No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for C6orf226 Gene

Function for C6orf226 Gene

Phenotypes From GWAS Catalog for C6orf226 Gene

Gene Ontology (GO) - Molecular Function for C6orf226 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with C6orf226: view

Phenotypes for C6orf226 Gene

GenomeRNAi human phenotypes for C6orf226:
genes like me logo Genes that share phenotypes with C6orf226: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for C6orf226
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for C6orf226 Gene

Localization for C6orf226 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C6orf226 gene
Compartment Confidence
extracellular 3
nucleus 2
mitochondrion 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear speckles (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for C6orf226 Gene

Pathways & Interactions for C6orf226 Gene

SuperPathways for C6orf226 Gene

No Data Available

Gene Ontology (GO) - Biological Process for C6orf226 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for C6orf226 Gene

Drugs & Compounds for C6orf226 Gene

No Compound Related Data Available

Transcripts for C6orf226 Gene

mRNA/cDNA for C6orf226 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(37) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for C6orf226 Gene

Chromosome 6 open reading frame 226:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for C6orf226
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for C6orf226 Gene

No ASD Table

Relevant External Links for C6orf226 Gene

GeneLoc Exon Structure for
C6orf226
ECgene alternative splicing isoforms for
C6orf226

Expression for C6orf226 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for C6orf226 Gene

NURSA nuclear receptor signaling pathways regulating expression of C6orf226 Gene:

C6orf226

SOURCE GeneReport for Unigene cluster for C6orf226 Gene:

Hs.571098
genes like me logo Genes that share expression patterns with C6orf226: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for C6orf226 Gene

Orthologs for C6orf226 Gene

This gene was present in the common ancestor of human and mouse.

Orthologs for C6orf226 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C6H6orf226 33
  • 96.97 (n)
C6orf226 34
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia 2310039H08Rik 34
  • 46 (a)
OneToOne
Species where no ortholog for C6orf226 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for C6orf226 Gene

ENSEMBL:
Gene Tree for C6orf226 (if available)
TreeFam:
Gene Tree for C6orf226 (if available)

Paralogs for C6orf226 Gene

No data available for Paralogs for C6orf226 Gene

Variants for C6orf226 Gene

Sequence variations from dbSNP and Humsavar for C6orf226 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1000382508 -- 42,892,536(+) ACCTA(A/G)TCTTG upstream-variant-2KB
rs1002628128 -- 42,890,939(+) ACAAC(A/T)CTGAC upstream-variant-2KB
rs1003223887 -- 42,889,812(+) GTTGA(C/T)GAAAA intron-variant, nc-transcript-variant, utr-variant-3-prime
rs1004055453 -- 42,890,707(+) CTGGA(C/G)CAGCT reference, missense
rs1004986807 -- 42,891,007(+) CAACG(G/T)ACGCG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for C6orf226 Gene

Variant ID Type Subtype PubMed ID
esv3576145 CNV gain 25503493
nsv1017398 CNV gain 25217958
nsv830651 CNV loss 17160897

Variation tolerance for C6orf226 Gene

Residual Variation Intolerance Score: 83.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.18; 39.41% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C6orf226 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
C6orf226

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C6orf226 Gene

Disorders for C6orf226 Gene

Relevant External Links for C6orf226

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
C6orf226

No disorders were found for C6orf226 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C6orf226 Gene

Publications for C6orf226 Gene

  1. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 60
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 60
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 60
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 60

Products for C6orf226 Gene

Sources for C6orf226 Gene

Content
Loading form....