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Aliases for C6orf223 Gene

Aliases for C6orf223 Gene

  • Chromosome 6 Open Reading Frame 223 2 3 5

External Ids for C6orf223 Gene

Previous GeneCards Identifiers for C6orf223 Gene

  • GC06P044077
  • GC06P043690

Summaries for C6orf223 Gene

GeneCards Summary for C6orf223 Gene

C6orf223 (Chromosome 6 Open Reading Frame 223) is a Protein Coding gene.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C6orf223 Gene

Genomics for C6orf223 Gene

Regulatory Elements for C6orf223 Gene

Enhancers for C6orf223 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06G044033 1.9 FANTOM5 Ensembl ENCODE dbSUPER 13 +35.0 35023 3.6 HDGF SIN3A ZNF48 SLC30A9 GLIS2 ZNF143 ZNF207 FOS SP3 SP5 ENSG00000271970 NFKBIE C6orf223 VEGFA CDC5L RPL34P14 RSPH9 SLC29A1 GTPBP2 MAD2L1BP
GH06G043977 1.5 FANTOM5 ENCODE dbSUPER 12.5 -22.9 -22873 1.0 HDGF PKNOX1 WRNIP1 YBX1 ZNF143 JUNB REST TBX21 NBN HMBOX1 C6orf223 RPS2P29 RPL34P14 NFKBIE GC06M043993 LOC105375067
GH06G044028 1 ENCODE dbSUPER 13 +28.9 28923 1.5 HDGF CTCF PKNOX1 ZSCAN4 RARA ZFHX2 ZNF157 SCRT2 FOS EGR2 C6orf223 RSPH9 SLC29A1 GC06P044013 GC06M044069
GH06G044030 0.7 dbSUPER 13 +30.7 30671 0.6 SOX13 DRAP1 FOXA2 RARA POLR2A NCOR1 ADNP HOMEZ SMAD5 FOXA3 C6orf223 RSPH9 SLC29A1 GC06P044013 GC06M044069
GH06G044027 0.6 dbSUPER 13 +27.4 27370 0.9 ZNF664 ZNF146 CEBPB ZNF580 SMAD4 RXRB RARA C6orf223 RSPH9 SLC29A1 GC06P044013 GC06M044069
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around C6orf223 on UCSC Golden Path with GeneCards custom track

Genomic Location for C6orf223 Gene

44,000,580 bp from pter
44,005,958 bp from pter
5,379 bases
Plus strand

Genomic View for C6orf223 Gene

Genes around C6orf223 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C6orf223 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C6orf223 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C6orf223 Gene

Proteins for C6orf223 Gene

  • Protein details for C6orf223 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Uncharacterized protein C6orf223
    Protein Accession:
    Secondary Accessions:
    • E9PB59
    • Q8N575

    Protein attributes for C6orf223 Gene

    242 amino acids
    Molecular mass:
    26113 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH32706.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305};

    Alternative splice isoforms for C6orf223 Gene


neXtProt entry for C6orf223 Gene

Post-translational modifications for C6orf223 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C6orf223 Gene

No data available for DME Specific Peptides for C6orf223 Gene

Domains & Families for C6orf223 Gene

Protein Domains for C6orf223 Gene


Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C6orf223: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for C6orf223 Gene

Function for C6orf223 Gene

Phenotypes for C6orf223 Gene

GenomeRNAi human phenotypes for C6orf223:
genes like me logo Genes that share phenotypes with C6orf223: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C6orf223 Gene

Localization for C6orf223 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for C6orf223 Gene

Pathways & Interactions for C6orf223 Gene

SuperPathways for C6orf223 Gene

No Data Available

Interacting Proteins for C6orf223 Gene

Gene Ontology (GO) - Biological Process for C6orf223 Gene


No data available for Pathways by source and SIGNOR curated interactions for C6orf223 Gene

Drugs & Compounds for C6orf223 Gene

No Compound Related Data Available

Transcripts for C6orf223 Gene

Unigene Clusters for C6orf223 Gene

Chromosome 6 open reading frame 223:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for C6orf223 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3 ^ 4
SP1: - -
SP2: -
SP3: - - -

Relevant External Links for C6orf223 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for C6orf223 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for C6orf223 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for C6orf223 Gene

This gene is overexpressed in Lung (x8.1) and Kidney - Cortex (x4.6).

Protein differential expression in normal tissues from HIPED for C6orf223 Gene

This gene is overexpressed in Neutrophil (45.8) and Pancreas (21.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for C6orf223 Gene

Protein tissue co-expression partners for C6orf223 Gene

NURSA nuclear receptor signaling pathways regulating expression of C6orf223 Gene:


SOURCE GeneReport for Unigene cluster for C6orf223 Gene:

genes like me logo Genes that share expression patterns with C6orf223: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for C6orf223 Gene

Orthologs for C6orf223 Gene

This gene was present in the common ancestor of mammals.

Orthologs for C6orf223 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia C6orf223 35
  • 100 (a)
C6H6orf223 34
  • 99.86 (n)
(Bos Taurus)
Mammalia C23H6orf223 34
  • 72.27 (n)
Species where no ortholog for C6orf223 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for C6orf223 Gene

Gene Tree for C6orf223 (if available)
Gene Tree for C6orf223 (if available)

Paralogs for C6orf223 Gene

No data available for Paralogs for C6orf223 Gene

Variants for C6orf223 Gene

Sequence variations from dbSNP and Humsavar for C6orf223 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1000045326 -- 44,000,362(+) ACATG(A/G)GGGAG intron-variant, upstream-variant-2KB, utr-variant-5-prime
rs1000111831 -- 44,005,347(+) GACTC(C/T)GAGAC intron-variant, upstream-variant-2KB, utr-variant-3-prime
rs1000219982 -- 43,999,966(+) GAGGG(A/T)TGTGT intron-variant, upstream-variant-2KB, utr-variant-5-prime
rs1000240414 -- 44,005,003(+) CTCCA(A/T)CTGGA intron-variant, upstream-variant-2KB, utr-variant-3-prime
rs1001516579 -- 44,001,212(+) GGAGG(G/T)GGGCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for C6orf223 Gene

Variant ID Type Subtype PubMed ID
esv2732001 CNV deletion 23290073
esv2732002 CNV deletion 23290073
nsv462934 CNV loss 19166990
nsv471815 CNV novel sequence insertion 20440878
nsv475668 CNV novel sequence insertion 20440878
nsv475853 CNV novel sequence insertion 20440878
nsv509131 CNV insertion 20534489
nsv603001 CNV loss 21841781

Variation tolerance for C6orf223 Gene

Residual Variation Intolerance Score: 97.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.75; 73.40% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C6orf223 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C6orf223 Gene

Disorders for C6orf223 Gene

Relevant External Links for C6orf223

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for C6orf223 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C6orf223 Gene

Publications for C6orf223 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64
  2. Identification of cis- and trans-acting genetic variants explaining up to half the variation in circulating vascular endothelial growth factor levels. (PMID: 21757650) Debette S. … Seshadri S. (Circ. Res. 2011) 3 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4 64
  4. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 4 64

Products for C6orf223 Gene

Sources for C6orf223 Gene

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