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Aliases for C6orf222 Gene

Aliases for C6orf222 Gene

  • Chromosome 6 Open Reading Frame 222 2 3 5

External Ids for C6orf222 Gene

Previous GeneCards Identifiers for C6orf222 Gene

  • GC06M036393
  • GC06M036283
  • GC06M036002
  • GC06M036432
  • GC06M036434
  • GC06M036677

Summaries for C6orf222 Gene

GeneCards Summary for C6orf222 Gene

C6orf222 (Chromosome 6 Open Reading Frame 222) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C6orf222 Gene

Genomics for C6orf222 Gene

Regulatory Elements for C6orf222 Gene

Enhancers for C6orf222 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06F036357 1.2 FANTOM5 Ensembl ENCODE 13.3 -21.6 -21550 1.4 HDGF TBP PKNOX1 TBL1XR1 WRNIP1 BMI1 ZBTB40 RFX5 GATA2 EGR1 C6orf222 LOC105375037 ETV7 MAPK13 KCTD20 PXT1 PNPLA1 CPNE5 PIR35042
GH06F036360 1.3 Ensembl ENCODE 13.3 -23.7 -23674 1.1 ELF3 TBP ARID4B ZNF48 RAD21 SLC30A9 SCRT2 ZNF143 ETV6 CREM C6orf222 LOC105375037 ETV7 KCTD20 PXT1 PNPLA1 PIR35042
GH06F036364 1.1 Ensembl ENCODE 13.2 -28.3 -28318 1.5 BCOR MAZ MCM3 RNF2 ZMYM3 UBTF RELA JUND POLR2A SMARCA4 C6orf222 ETV7 LOC105375037 MAPK13 KCTD20 PXT1 BRPF3 LOC102723648 PNPLA1 SLC26A8
GH06F036362 0.5 Ensembl 13.2 -26.2 -26207 0.8 CTCF RNF2 NFYC MAX CEBPB CEBPG POLR2A ZBTB33 MYC C6orf222 ETV7 LOC105375037 KCTD20 PXT1 PNPLA1 PIR35042
GH06F036302 0.8 Ensembl ENCODE 12.2 +34.4 34377 0.8 ARNT WRNIP1 ARID4B ZNF2 ZNF143 DEK MIER2 REST TBX21 PPARG C6orf222 PNPLA1 MAPK13 RAB44 SLC26A8 ENSG00000219023 LOC105375036
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around C6orf222 on UCSC Golden Path with GeneCards custom track

Genomic Location for C6orf222 Gene

36,315,757 bp from pter
36,336,977 bp from pter
21,221 bases
Minus strand

Genomic View for C6orf222 Gene

Genes around C6orf222 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C6orf222 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C6orf222 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C6orf222 Gene

Proteins for C6orf222 Gene

  • Protein details for C6orf222 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Uncharacterized protein C6orf222
    Protein Accession:
    Secondary Accessions:
    • B2RTY8

    Protein attributes for C6orf222 Gene

    652 amino acids
    Molecular mass:
    71930 Da
    Quaternary structure:
    No Data Available

neXtProt entry for C6orf222 Gene

Post-translational modifications for C6orf222 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C6orf222 Gene

No data available for DME Specific Peptides for C6orf222 Gene

Domains & Families for C6orf222 Gene

Protein Domains for C6orf222 Gene


Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C6orf222: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for C6orf222 Gene

Function for C6orf222 Gene

Phenotypes for C6orf222 Gene

GenomeRNAi human phenotypes for C6orf222:
genes like me logo Genes that share phenotypes with C6orf222: view

Animal Model Products

miRNA for C6orf222 Gene

miRTarBase miRNAs that target C6orf222

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C6orf222 Gene

Localization for C6orf222 Gene

Subcellular locations from

Jensen Localization Image for C6orf222 Gene COMPARTMENTS Subcellular localization image for C6orf222 gene
Compartment Confidence
nucleus 3
cytosol 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for C6orf222 Gene

Pathways & Interactions for C6orf222 Gene

SuperPathways for C6orf222 Gene

No Data Available

Interacting Proteins for C6orf222 Gene

Gene Ontology (GO) - Biological Process for C6orf222 Gene


No data available for Pathways by source and SIGNOR curated interactions for C6orf222 Gene

Transcripts for C6orf222 Gene

mRNA/cDNA for C6orf222 Gene

(4) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(6) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for C6orf222 Gene

Chromosome 6 open reading frame 222:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for C6orf222 Gene

No ASD Table

Relevant External Links for C6orf222 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for C6orf222 Gene

mRNA expression in normal human tissues for C6orf222 Gene

mRNA differential expression in normal tissues according to GTEx for C6orf222 Gene

This gene is overexpressed in Small Intestine - Terminal Ileum (x20.4), Colon - Transverse (x10.2), Stomach (x10.0), and Pancreas (x4.6).

Protein differential expression in normal tissues from HIPED for C6orf222 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (61.3) and Platelet (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for C6orf222 Gene

Protein tissue co-expression partners for C6orf222 Gene

NURSA nuclear receptor signaling pathways regulating expression of C6orf222 Gene:


SOURCE GeneReport for Unigene cluster for C6orf222 Gene:

genes like me logo Genes that share expression patterns with C6orf222: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for C6orf222 Gene

Orthologs for C6orf222 Gene

This gene was present in the common ancestor of mammals.

Orthologs for C6orf222 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia C6H6orf222 34
  • 99.13 (n)
C6orf222 35
  • 98 (a)
(Canis familiaris)
Mammalia C12H6orf222 34
  • 76.38 (n)
C6orf222 35
  • 59 (a)
(Bos Taurus)
Mammalia C23H6orf222 34
  • 76.25 (n)
C6orf222 35
  • 59 (a)
(Mus musculus)
Mammalia 4930539E08Rik 34 16 35
  • 66.61 (n)
(Rattus norvegicus)
Mammalia LOC689561 34
  • 65.29 (n)
Species where no ortholog for C6orf222 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for C6orf222 Gene

Gene Tree for C6orf222 (if available)
Gene Tree for C6orf222 (if available)

Paralogs for C6orf222 Gene

No data available for Paralogs for C6orf222 Gene

Variants for C6orf222 Gene

Sequence variations from dbSNP and Humsavar for C6orf222 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs193920980 Uncertain significance 36,323,317(-) GCCAT(C/T)GGCCC reference, missense
rs1015059 -- 36,327,885(-) AGCCA(A/G)ACAAT intron-variant
rs10456083 -- 36,323,831(+) CCTGT(C/T)TCTAC intron-variant
rs10456439 -- 36,320,968(+) CTGGC(A/G)TTTTC intron-variant
rs10625892 -- 36,338,399(+) AAGAA(-/AGAA)GGAAA upstream-variant-2KB

Variation tolerance for C6orf222 Gene

Residual Variation Intolerance Score: 93.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.50; 91.08% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C6orf222 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for C6orf222 Gene

Disorders for C6orf222 Gene

Relevant External Links for C6orf222

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for C6orf222 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C6orf222 Gene

Publications for C6orf222 Gene

  1. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 3 4 64
  2. Uncovering global SUMOylation signaling networks in a site-specific manner. (PMID: 25218447) Hendriks I.A. … Vertegaal A.C. (Nat. Struct. Mol. Biol. 2014) 4 64
  3. A quantitative atlas of mitotic phosphorylation. (PMID: 18669648) Dephoure N. … Gygi S.P. (Proc. Natl. Acad. Sci. U.S.A. 2008) 4 64
  4. The full-ORF clone resource of the German cDNA consortium. (PMID: 17974005) Bechtel S. … Schupp I. (BMC Genomics 2007) 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4 64

Products for C6orf222 Gene

Sources for C6orf222 Gene

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