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Aliases for C6orf222 Gene

Aliases for C6orf222 Gene

  • Chromosome 6 Open Reading Frame 222 2 3 5

External Ids for C6orf222 Gene

Previous GeneCards Identifiers for C6orf222 Gene

  • GC06M036393
  • GC06M036283
  • GC06M036002
  • GC06M036432
  • GC06M036434
  • GC06M036677
  • GC06M037029
  • GC06M037379

Summaries for C6orf222 Gene

GeneCards Summary for C6orf222 Gene

C6orf222 (Chromosome 6 Open Reading Frame 222) is a Protein Coding gene.

Additional gene information for C6orf222 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C6orf222 Gene

Genomics for C6orf222 Gene

Regulatory Elements for C6orf222 Gene

Enhancers for C6orf222 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06H036357 1.7 FANTOM5 Ensembl ENCODE dbSUPER 13.3 -21.6 -21551 1 HDGF PKNOX1 TBL1XR1 BMI1 BATF RFX5 GATA2 ATF7 RUNX3 CREM C6orf222 LOC105375037 ETV7 FGD2 MAPK13 PXT1 KCTD20 PNPLA1 CPNE5 PIR35042
GH06H036422 1.9 FANTOM5 Ensembl ENCODE dbSUPER 10.8 -86.6 -86553 1 MLX ARID4B SIN3A ZNF2 YY1 ZNF766 ZNF143 ZNF207 FOS DEK ETV7 KCTD20 LOC105375037 C6orf222 STK38 PI16 MAPK13 PXT1 SRSF3 CDKN1A
GH06H036360 1.4 Ensembl ENCODE dbSUPER 13.3 -23.7 -23674 1 ELF3 RB1 ARID4B RAD21 RFX5 SLC30A9 SCRT2 ZNF143 ATF7 RUNX3 C6orf222 LOC105375037 ETV7 PXT1 KCTD20 PNPLA1 PIR35042
GH06H036364 1.2 Ensembl ENCODE dbSUPER 13.3 -28.3 -28318 1 BCOR ZNF687 MAZ ZMYM3 RELA ZNF217 EED IKZF1 NBN MLLT1 C6orf222 LOC105375037 ETV7 MAPK13 PXT1 KCTD20 BRPF3 LOC102723648 PNPLA1 SLC26A8
GH06H036302 1.3 Ensembl ENCODE 12.2 +34.3 34277 0 ARNT ARID4B ZNF2 ZNF143 ATF7 RUNX3 DEK ZC3H11A REST MIER2 C6orf222 PNPLA1 MAPK13 RAB44 SLC26A8 ENSG00000219023 LOC105375036
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around C6orf222 on UCSC Golden Path with GeneCards custom track

Genomic Location for C6orf222 Gene

Chromosome:
6
Start:
36,315,757 bp from pter
End:
36,336,977 bp from pter
Size:
21,221 bases
Orientation:
Minus strand

Genomic View for C6orf222 Gene

Genes around C6orf222 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C6orf222 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C6orf222 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C6orf222 Gene

Proteins for C6orf222 Gene

  • Protein details for C6orf222 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P0C671-CF222_HUMAN
    Recommended name:
    Uncharacterized protein C6orf222
    Protein Accession:
    P0C671
    Secondary Accessions:
    • B2RTY8

    Protein attributes for C6orf222 Gene

    Size:
    652 amino acids
    Molecular mass:
    71930 Da
    Quaternary structure:
    No Data Available

neXtProt entry for C6orf222 Gene

Post-translational modifications for C6orf222 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C6orf222 Gene

No data available for DME Specific Peptides for C6orf222 Gene

Domains & Families for C6orf222 Gene

Gene Families for C6orf222 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for C6orf222 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C6orf222: view

No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for C6orf222 Gene

Function for C6orf222 Gene

Phenotypes for C6orf222 Gene

GenomeRNAi human phenotypes for C6orf222:
genes like me logo Genes that share phenotypes with C6orf222: view

Animal Model Products

CRISPR Products

miRNA for C6orf222 Gene

miRTarBase miRNAs that target C6orf222

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for C6orf222
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C6orf222 Gene

Localization for C6orf222 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C6orf222 gene
Compartment Confidence
nucleus 3
cytosol 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for C6orf222 Gene

Pathways & Interactions for C6orf222 Gene

SuperPathways for C6orf222 Gene

No Data Available

Interacting Proteins for C6orf222 Gene

Gene Ontology (GO) - Biological Process for C6orf222 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for C6orf222 Gene

Drugs & Compounds for C6orf222 Gene

No Compound Related Data Available

Transcripts for C6orf222 Gene

mRNA/cDNA for C6orf222 Gene

(4) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(6) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for C6orf222 Gene

Chromosome 6 open reading frame 222:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for C6orf222
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for C6orf222 Gene

No ASD Table

Relevant External Links for C6orf222 Gene

GeneLoc Exon Structure for
C6orf222
ECgene alternative splicing isoforms for
C6orf222

Expression for C6orf222 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for C6orf222 Gene

mRNA differential expression in normal tissues according to GTEx for C6orf222 Gene

This gene is overexpressed in Small Intestine - Terminal Ileum (x20.4), Colon - Transverse (x10.2), Stomach (x10.0), and Pancreas (x4.6).

Protein differential expression in normal tissues from HIPED for C6orf222 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (61.3) and Platelet (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for C6orf222 Gene



Protein tissue co-expression partners for C6orf222 Gene

NURSA nuclear receptor signaling pathways regulating expression of C6orf222 Gene:

C6orf222

SOURCE GeneReport for Unigene cluster for C6orf222 Gene:

Hs.162104
genes like me logo Genes that share expression patterns with C6orf222: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for C6orf222 Gene

Orthologs for C6orf222 Gene

This gene was present in the common ancestor of mammals.

Orthologs for C6orf222 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C6H6orf222 33
  • 99.13 (n)
C6orf222 34
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C12H6orf222 33
  • 76.38 (n)
C6orf222 34
  • 59 (a)
OneToOne
cow
(Bos Taurus)
Mammalia C23H6orf222 33
  • 76.25 (n)
C6orf222 34
  • 59 (a)
OneToOne
mouse
(Mus musculus)
Mammalia 4930539E08Rik 33 16 34
  • 66.61 (n)
rat
(Rattus norvegicus)
Mammalia LOC689561 33
  • 65.29 (n)
Species where no ortholog for C6orf222 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for C6orf222 Gene

ENSEMBL:
Gene Tree for C6orf222 (if available)
TreeFam:
Gene Tree for C6orf222 (if available)

Paralogs for C6orf222 Gene

No data available for Paralogs for C6orf222 Gene

Variants for C6orf222 Gene

Sequence variations from dbSNP and Humsavar for C6orf222 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs193920980 Uncertain significance 36,323,317(-) GCCAT(C/T)GGCCC reference, missense
rs1000135192 -- 36,338,824(+) AGGCC(C/G)TGTGT upstream-variant-2KB
rs1000248396 -- 36,326,806(+) GGGAA(A/G)GCTCT intron-variant
rs1000512093 -- 36,315,837(+) ACATA(C/G)CAAAT utr-variant-3-prime
rs1000640586 -- 36,321,973(+) GTAGG(G/T)CATCC intron-variant

Variation tolerance for C6orf222 Gene

Residual Variation Intolerance Score: 93.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.50; 91.08% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C6orf222 Gene

Human Gene Mutation Database (HGMD)
C6orf222
SNPedia medical, phenotypic, and genealogical associations of SNPs for
C6orf222

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for C6orf222 Gene

Disorders for C6orf222 Gene

Relevant External Links for C6orf222

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
C6orf222

No disorders were found for C6orf222 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C6orf222 Gene

Publications for C6orf222 Gene

  1. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall AJ … Beck S (Nature 2003) 3 4 60
  2. Uncovering global SUMOylation signaling networks in a site-specific manner. (PMID: 25218447) Hendriks IA … Vertegaal AC (Nature structural & molecular biology 2014) 4 60
  3. A quantitative atlas of mitotic phosphorylation. (PMID: 18669648) Dephoure N … Gygi SP (Proceedings of the National Academy of Sciences of the United States of America 2008) 4 60
  4. The full-ORF clone resource of the German cDNA Consortium. (PMID: 17974005) Bechtel S … Schupp I (BMC genomics 2007) 4 60
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 60

Products for C6orf222 Gene

Sources for C6orf222 Gene

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