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C6orf211 Gene

protein-coding   GIFtS: 49
GCID: GC06P151773

Chromosome 6 Open Reading Frame 211

  See C6orf211-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Chromosome 6 Open Reading Frame 2111 2
UPF0364 Protein C6orf2112

External Ids:    HGNC: 178721   Entrez Gene: 796242   Ensembl: ENSG000001464767   UniProtKB: Q9H9933   

Export aliases for C6orf211 gene to outside databases

Previous GC identifers: GC06P151728 GC06P151804 GC06P151865 GC06P149335


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for C6orf211 Gene:
C6orf211 (chromosome 6 open reading frame 211) is a protein-coding gene. Diseases associated with C6orf211 include breast cancer susceptibility, and chronic myeloid leukemia.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000006.11  NC_018917.2  NT_025741.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the C6orf211 gene promoter:
         Bach1   ATF-2   STAT5A   Cdc5   NF-AT   AREB6   NF-AT4   NF-AT2   NF-AT3   NF-AT1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidC6orf211 promoter sequence
   Search Chromatin IP Primers for C6orf211

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat C6orf211


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q25.1   Ensembl cytogenetic band:  6q25.1   HGNC cytogenetic band: 6q25.1

C6orf211 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
C6orf211 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P151773:  view genomic region     (about GC identifiers)

Start:
151,773,422 bp from pter      End:
151,791,236 bp from pter
Size:
17,815 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CF211_HUMAN, Q9H993 (See protein sequence)
Recommended Name: UPF0364 protein C6orf211  
Size: 441 amino acids; 51172 Da
Secondary accessions: Q96FC6 Q9UFY5

Explore the universe of human proteins at neXtProt for C6orf211: NX_Q9H993

Explore proteomics data for C6orf211 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See C6orf211 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001273491.1  NP_078849.1  

    ENSEMBL proteins: 
     ENSP00000356263   ENSP00000435882   ENSP00000444121  

    C6orf211 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for C6orf211

     
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    Cloud-Clone Corp. ELISAs for C6orf211
    Cloud-Clone Corp. CLIAs for C6orf211
    Search eBioscience for ELISAs for C6orf211 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR002791 DUF89

    Graphical View of Domain Structure for InterPro Entry Q9H993

    ProtoNet protein and cluster: Q9H993

    1 Blocks protein domain: IPB002791 Protein of unknown function DUF89

    UniProtKB/Swiss-Prot: CF211_HUMAN, Q9H993
    Similarity: Belongs to the UPF0364 family


    Find genes that share domains with C6orf211           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Phenotypes:
         1 GenomeRNAi human phenotype for C6orf211:
     Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for C6orf211
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for C6orf211
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for C6orf211

    miRNA
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    miRTarBase miRNAs that target C6orf211:
    hsa-mir-98-5p (MIRT027761), hsa-mir-128-3p (MIRT022059), hsa-mir-148b-3p (MIRT019465)

    Block miRNA regulation of human, mouse, rat C6orf211 using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate C6orf211:
    hsa-miR-516a-3p hsa-miR-516b*
    SwitchGear 3'UTR luciferase reporter plasmidC6orf211 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for C6orf211
    Predesigned siRNA for gene silencing in human, mouse, rat C6orf211

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for C6orf211

    Clone
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    OriGene ORF clones in mouse, rat for C6orf211
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    GenScript: all cDNA clones in your preferred vector: C6orf211 (NM_024573)
    Browse Sino Biological Human cDNA Clones
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C6orf211


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol2
    mitochondrion1
    nucleus1

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for C6orf211
    Interactions:

        Search GeneGlobe Interaction Network for C6orf211

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for C6orf211 (Q9H9931, 3 ENSP000003562634) via UniProtKB, MINT, STRING, and/or I2D (see all 37)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SAP18O004221, 3, ENSP000003719734EBI-1046033,EBI-1044156 I2D: score=2 STRING: ENSP00000371973
    UBCP0CG483, ENSP000003448184I2D: score=1 STRING: ENSP00000344818
    MAGEA6P433603, ENSP000003291994I2D: score=1 STRING: ENSP00000329199
    ARF6P623303, ENSP000002983164I2D: score=1 STRING: ENSP00000298316
    TLDC1Q6P9B63I2D: score=3 
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for C6orf211 (CF211)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for C6orf211 gene (2 alternative transcripts): 
    NM_001286562.1  NM_024573.2  

    Unigene Cluster for C6orf211:

    Chromosome 6 open reading frame 211
    Hs.15929  [show with all ESTs]
    Unigene Representative Sequence: AK022972
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000367294(uc003qok.1 uc011ees.1) ENST00000494826 ENST00000483931
    ENST00000545879
    miRNA
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    Block miRNA regulation of human, mouse, rat C6orf211 using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate C6orf211:
    hsa-miR-516a-3p hsa-miR-516b*
    SwitchGear 3'UTR luciferase reporter plasmidC6orf211 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for C6orf211
    Predesigned siRNA for gene silencing in human, mouse, rat C6orf211
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    GenScript: all cDNA clones in your preferred vector: C6orf211 (NM_024573)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for C6orf211
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C6orf211
    Primer
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    OriGene qPCR primer pairs and template standards for C6orf211
    OriGene qSTAR qPCR primer pairs in human, mouse for C6orf211
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat C6orf211
      QuantiTect SYBR Green Assays in human, mouse, rat C6orf211
      QuantiFast Probe-based Assays in human, mouse, rat C6orf211

    Additional mRNA sequence: 

    AJ420548.1 AK022972.1 AK298490.1 AK310840.1 AL110241.1 BC011348.1 

    10 DOTS entries:

    DT.113323  DT.100790950  DT.100790952  DT.91767487  DT.121345200  DT.95297949  DT.100790946  DT.121345180 
    DT.95171344  DT.92392145 

    Selected AceView cDNA sequences (see all 179):

    BE049580 BE463863 NM_024573 CR610148 AA570163 BU522045 AW969586 AA337784 
    AL554573 AI478450 BX103314 BG370221 AA569809 AW516237 AI139489 AV660902 
    AU133079 CA419811 BU688980 CB851341 AK022972 AI418802 BF796914 Z30310 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for C6orf211    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b
    SP1:                          -                 -           -               
    SP2:                          -     -           -           -               
    SP3:                          -                                             
    SP4:                          -     -           -                           
    SP5:                                                                        


    ECgene alternative splicing isoforms for C6orf211

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    C6orf211 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAATAATAGC
    C6orf211 Expression
    About this image


    C6orf211 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Cerebral Cortex
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Ovary (Reproductive System)
             Oviduct
     
     Pancreas (Endocrine System)
             Islets of Langerhans
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
    C6orf211 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    C6orf211 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.15929
        Custom PCR Arrays for C6orf211
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C6orf211

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for C6orf211 gene from Selected species (see all 21)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia 1700052N19Rik1 , 5 RIKEN cDNA 1700052N19 gene1, 5 79.35(n)1
    77.45(a)1
      10 (2.06 cM)5
    734191  NM_024261.21  NP_077223.21 
     44324675 
    chicken
    (Gallus gallus)
    Aves C6ORF2111 chromosome 3 open reading frame, human C6orf211 72.25(n)
    68.4(a)
      421637  XM_419676.4  XP_419676.4 
    lizard
    (Anolis carolinensis)
    Reptilia C6orf2116
    chromosome 6 open reading frame 211
    64(a)
    1 ↔ 1
    GL343259.1(1172645-1179288)
    African clawed frog
    (Xenopus laevis)
    Amphibia BG347785.12   -- 83.74(n)    BG347785.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc:1108161 zgc:110816 61.07(n)
    57.47(a)
      541518  NM_001014331.2  NP_001014353.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG114741 CG11474 45.77(n)
    35.57(a)
      37514  NM_137790.3  NP_611634.1 
    worm
    (Caenorhabditis elegans)
    Secernentea F31D4.21 F31D4.2 50.83(n)
    39.19(a)
      180370  NM_075624.6  NP_508025.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes (YMR027W)4
    YMR027W1
    Putative protein of unknown function; green fluorescent more4
    YMR027W1
    46.78(n)1
    35.02(a)1
      13(325877-327289)4
    8550421, 4  NP_013740.11, 4 


    ENSEMBL Gene Tree for C6orf211 (if available)
    TreeFam Gene Tree for C6orf211 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for C6orf211 (see all 324)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1845958371,2
    --151775498(+) GCTTCC/TATGAC 1 -- int10--------
    rs1477020531,2
    C--151775533(+) CTTATA/GTCTTA 1 -- int10--------
    rs1889137551,2
    --151775661(+) TATATA/CTTGCA 1 -- int10--------
    rs1819307071,2
    --151775822(+) TGTTAA/CTTTCT 1 -- int10--------
    rs69251151,2
    C,H--151775836(+) CAGAAA/GCATAA 1 -- int14Minor allele frequency- G:0.00NS EA 414
    rs1856693271,2
    --151775857(+) TTGAAA/GGTATC 1 -- int10--------
    rs1171576511,2
    C,F--151775920(+) TTAAGG/ATAATA 1 -- int11Minor allele frequency- A:0.02NA 120
    rs1893304391,2
    C--151776077(+) GACTTA/CGTCAA 1 -- int10--------
    rs170812621,2
    C,F,H--151776164(+) AATTTG/TAGATC 1 -- int120Minor allele frequency- T:0.12NA NS EA WA CSA 2224
    rs1151475351,2
    F--151776172(+) ATCTTG/CAGTCC 1 -- int11Minor allele frequency- C:0.01WA 118

    HapMap Linkage Disequilibrium report for C6orf211 (151773422 - 151791236 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for C6orf211: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing C6orf211
    DNA2.0 Custom Variant and Variant Library Synthesis for C6orf211

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    2 diseases for C6orf211:    
    About MalaCards
    breast cancer susceptibility    chronic myeloid leukemia


    Find genes that share disorders with C6orf211           About GenesLikeMe

    Genetic Association Database (GAD): C6orf211
    Human Genome Epidemiology (HuGE) Navigator: C6orf211 (1 document)

    Export disorders for C6orf211 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for C6orf211 gene, integrated from 10 sources (see all 16):
    (articles sorted by number of sources associating them with C6orf211)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    3. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (Nature 2003)
    4. N-terminal acetylome analyses and functional insights of the N- terminal acetyltransferase NatB. (PubMed id 22814378)2 Van Damme P....Aldabe R. (Proc. Natl. Acad. Sci. U.S.A. 2012)
    5. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    6. ESR1 is co-expressed with closely adjacent uncharacterised genes spanning a breast cancer susceptibility locus at 6q25.1. (PubMed id 21552322)1 Dunbier A.K....Dowsett M. (PLoS Genet. 2011)
    7. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    8. A genome-wide association study identifies novel loci associated with susceptibility to chronic myeloid leukemia. (PubMed id 21540461)1 Kim D.H....Lipton J.H. (Blood 2011)
    9. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)
    10. Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. (PubMed id 19413330)2 Gauci S....Mohammed S. (Anal. Chem. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 79624 HGNC: 17872 AceView: C6orf211 Ensembl:ENSG00000146476 euGenes: HUgn79624
    ECgene: C6orf211 H-InvDB: C6orf211

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for C6orf211 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for C6orf211 gene:
    Search GeneIP for patents involving C6orf211

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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