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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

C6orf201 Gene

protein-coding   GIFtS: 37
GCID: GC06P004079

chromosome 6 open reading frame 201
  Search for C6orf201
in
MalaCards
our new
 Human Malady Compendium 
Biological research products
for C6orf201    

Aliases
for C6orf201 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Chromosome 6 Open Reading Frame 2011 2
DJ1013A10.51
Protein MGC876252
Uncharacterized Protein C6orf2012

External Ids:    HGNC: 216201   Entrez Gene: 4042202   Ensembl: ENSG000001856897   UniProtKB: Q7Z4U53   

Export aliases for C6orf201 gene to outside databases

Previous GC identifers: GC00U914401 GC06U900580 GC06P004025 GC06P003955


Summaries
for C6orf201 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
  --

Genomic Views
for C6orf201 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NC_018917.1  NT_007592.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the C6orf201 gene promoter:
         Tal-1   Pbx1a   NF-kappaB   E47   YY1   FOXL1   SRY   IRF-2   NF-kappaB2   Pax-4a   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for C6orf201

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C6orf201


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p25.2   Ensembl cytogenetic band:  6p25.2   HGNC cytogenetic band: 6p25.2

C6orf201 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
C6orf201 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P004079:  view genomic region     (about GC identifiers)

Start:
 4,079,440 bp from pter      End:
 4,131,185 bp from pter
Size:
 51,746 bases      Orientation:
 plus strand

Proteins
for C6orf201 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: CF201_HUMAN, Q7Z4U5 (See protein sequence)
Recommended Name: Uncharacterized protein C6orf201  
Size: 140 amino acids; 16243 Da
Secondary accessions: A6NLI6 Q6NXN5
Alternative splicing: 2 isoforms:  Q7Z4U5-2   Q7Z4U5-3   (No experimental confirmation available. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay)

Explore the universe of human proteins at neXtProt for C6orf201: NX_Q7Z4U5

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q7Z4U5

    • C6orf201 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_001078870.1  
    ENSEMBL proteins: 
     ENSP00000420610   ENSP00000419568   ENSP00000420763   ENSP00000417981   ENSP00000330777  
     ENSP00000396912  

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    Protein Domains /
    Families
    for C6orf201 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ProtoNet protein and cluster: Q7Z4U5


    Function
    for C6orf201 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    miRNA
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    1 GenomeRNAi human phenotype for C6orf201:
     Increased S DNA content 


    Pathways & Interactions
    for C6orf201 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for C6orf201

    Drugs & Compounds
    for C6orf201 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for C6orf201
    Search CenterWatch for drugs/clinical trials and news about C6orf201 / CF201 

    Transcripts
    for C6orf201 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    About This Section
    REFSEQ mRNAs for C6orf201 gene (2 alternative transcripts): 
    NM_206834.1  NM_001085401.2  

    Unigene Cluster for C6orf201:

    Chromosome 6 open reading frame 201
    Hs.716731  [show with all ESTs]
    Unigene Representative Sequence: AK124114
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000380175(uc003mwa.4) ENST00000427996(uc003mvz.4) ENST00000483580
    ENST00000451679 ENST00000360378 ENST00000436110(uc011dhw.1 uc003mwb.4)
    ENST00000496987 ENST00000333388 ENST00000430835

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    Additional cDNA sequence: 

    AF429972.1 AK124114.1 AK301893.1 BC047663.1 

    3 DOTS entries:

    DT.452723  DT.99942807  DT.95353692 

    24/33 AceView cDNA sequences (see all 33):

    AI217226 AA412669 AA442456 AA436648 AA399269 AA815401 BU561413 BI829193 
    BC066986 AI018748 AI025290 AA405276 AF429972 AI203473 BC047663 BM172284 
    NM_206834 AI653280 BM919709 AA412241 AI028745 AA813227 BC040916 AK124114 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for C6orf201    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b
    SP1:                                -                                 
    SP2:                                                                  
    SP3:                                -     -     -     -               
    SP4:                                -     -                           


    ECgene alternative splicing isoforms for C6orf201

    Expression
    for C6orf201 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    C6orf201 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AAAGCTGTAT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See C6orf201 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for C6orf201

    SOURCE GeneReport for Unigene cluster: Hs.716731
        SABiosciences Custom PCR Arrays for C6orf201
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    In Situ
    Assay Products:     
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    Orthologs
    for C6orf201 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for C6orf201 gene from 2/5 species (see all 5)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia 4933417A18Rik1 , 5 RIKEN cDNA 4933417A18 gene1, 5 65.41(n)1
    54.89(a)1    		   13 (14.22 cM)5
    667611  NM_025750.31  NP_080026.21 
     349244095 
    lizard
    (Anolis carolinensis)    		 Reptilia C6orf2016
    		 --
    		 20(a)
    		 1 ↔ 1
    		 GL343209.1(465468-468837)


    ENSEMBL Gene Tree for C6orf201 (if available)
    TreeFam Gene Tree for C6orf201 (if available) 

    Paralogs
    for C6orf201 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    		  --

    Genomic Variants
    for C6orf201 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/594 NCBI SNPs in C6orf201 are shown (see all 594)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 6 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1425626841,2
    		C,--4081537(+) TAATT-/TTTA  
                TTTAT     		1 -- int10--------
    rs1865705561,2
    		--4081611(+) CGGCTC/TACTGC 1 -- int10--------
    rs1463505101,2
    		--4081702(+) CACCAC/TGCCCG 1 -- int10--------
    rs1910235671,2
    		--4081839(+) CTGAGC/GTCAGC 1 -- int10--------
    rs1837360161,2
    		--4082031(+) TTATGC/TGTGCT 1 -- int10--------
    rs1882659751,2
    		--4082117(+) TTTCTC/GTTCAT 1 -- int10--------
    rs795724501,2
    		F,--4082139(+) TTATTT/GCAGAA 1 -- int11Minor allele frequency- G:0.03EA 120
    rs1905721241,2
    		--4082176(+) GTCCTC/TGTGAG 1 -- int10--------
    rs117558771,2
    		C,F,A,H,--4082177(+) TCCTTG/CTGAGA 1 -- int128Minor allele frequency- C:0.35NS EA NA WA CSA 2953
    rs2000854931,2
    		--4082214(+) GATTC-/TTTTTT 1 -- int10--------

    HapMap Linkage Disequilibrium report for C6orf201 (4079440 - 4131185 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 2 variations for C6orf201
         2 CNVs: 5390 5389

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    Disorders / Diseases
    for C6orf201 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    		   --

    Publications
    for C6orf201 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for C6orf201 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with C6orf201)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
    2. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    4. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)2 Mungall A.J.... Beck S. (2003)
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    6. Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)

    External Searches for C6orf201 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing C6orf201 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 404220 HGNC: 21620 AceView: C6orf201 Ensembl:ENSG00000185689 euGenes: HUgn404220
    ECgene: C6orf201 H-InvDB: C6orf201

    Other Databases showing C6orf201 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing C6orf201 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for C6orf201 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for C6orf201 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for C6orf201 gene:
    Search GeneIP for patents involving C6orf201

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for C6orf201 gene

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    About This Section

     
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