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C6orf201 Gene

protein-coding   GIFtS: 36
GCID: GC06P004079

Chromosome 6 Open Reading Frame 201

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disease database 

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section


Aliases
Chromosome 6 Open Reading Frame 2011 2
dJ1013A10.52
Protein MGC876252
Uncharacterized Protein C6orf2012

External Ids:    HGNC: 216201   Entrez Gene: 4042202   Ensembl: ENSG000001856897   UniProtKB: Q7Z4U53   

Export aliases for C6orf201 gene to outside databases

Previous GC identifiers: GC00U914401 GC06U900580 GC06P004025 GC06P003955


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section


GeneCards Summary for C6orf201 Gene:
C6orf201 (chromosome 6 open reading frame 201) is a protein-coding gene.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

Regulatory elements:
   Regulatory transcription factor binding sites in the C6orf201 gene promoter:
         Tal-1   Pbx1a   NF-kappaB   E47   YY1   FOXL1   SRY   IRF-2   NF-kappaB2   Pax-4a   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for C6orf201

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat C6orf201


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p25.2   Ensembl cytogenetic band:  6p25.2   HGNC cytogenetic band: 6p25.2

C6orf201 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
C6orf201 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P004079:  view genomic region     (about GC identifiers)

Start:
4,079,440 bp from pter      End:
4,131,185 bp from pter
Size:
51,746 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, antibodies-online, and/or GeneTex,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or GeneTex.)
About This Section


UniProtKB/Swiss-Prot: CF201_HUMAN, Q7Z4U5 (See protein sequence)
Recommended Name: Uncharacterized protein C6orf201  
Size: 140 amino acids; 16243 Da
Secondary accessions: A6NLI6 Q6NXN5
Alternative splicing: 2 isoforms:  Q7Z4U5-2   Q7Z4U5-3   (No experimental confirmation available. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay)

Explore the universe of human proteins at neXtProt for C6orf201: NX_Q7Z4U5

Explore proteomics data for C6orf201 at MOPED


See C6orf201 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_001078870.1  
ENSEMBL proteins: 
 ENSP00000420610   ENSP00000419568   ENSP00000420763   ENSP00000417981   ENSP00000330777  
 ENSP00000396912  

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antibodies-online peptides for C6orf201

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GeneTex Antibodies for C6orf201:  
                    C6orf201 Antibodies
antibodies-online antibodies for C6orf201 (15 products) 

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antibodies-online kits for C6orf201 (2 products) 


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GenesLikeMe)
About This Section

1 InterPro protein domain:
 IPR027827 DUF4523

Graphical View of Domain Structure for InterPro Entry Q7Z4U5

ProtoNet protein and cluster: Q7Z4U5


Find genes that share domains with C6orf201           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway, and/or Taconic Biosciences, CRISPR knockouts from OriGene, transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Clones from OriGene, GenScript, Sino Biological, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
About This Section


Phenotypes:
     1 GenomeRNAi human phenotype for C6orf201:
 Increased S DNA content 

Animal Models:
   genOway: Develop your customized and physiologically relevant rodent model for C6orf201

    Search Taconic Biosciences for animal models for C6orf201 

CRISPR Knockouts: 
   OriGene CRISPR knockouts for C6orf201

miRNA
Products:
    
miRTarBase miRNAs that target C6orf201:
hsa-mir-335-5p (MIRT017208)

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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
About This Section


Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
nucleus3
cytosol2

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GenesLikeMe, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
About This Section






    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for C6orf201
Interactions:

    Search GeneGlobe Interaction Network for C6orf201

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, Sets of similar genes according to GenesLikeMe)
About This Section

Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for C6orf201 (CF201)



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
About This Section


REFSEQ mRNAs for C6orf201 gene (5 alternative transcripts): 
NM_001085401.2  NM_206834.1  XM_005249111.2  XM_005249112.2  XM_006715097.1  

9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000380175(uc003mwa.4) ENST00000427996(uc003mvz.4) ENST00000483580
ENST00000451679 ENST00000360378 ENST00000436110(uc011dhw.1 uc003mwb.4)
ENST00000496987 ENST00000333388 ENST00000430835
miRNA
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Selected AceView cDNA sequences (see all 33):

AA399269 AA442456 AA412669 AI217226 AA436648 BM919709 BC040916 AA412241 
BM172284 AA405276 AK124114 AI028745 AA815401 NM_206834 AI203473 AA813227 
BC047663 AI653280 BG721721 AI018748 BI829193 BC066986 AI025290 BU561413 

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for C6orf201    About this scheme

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b
SP1:                                -                                 
SP2:                                                                  
SP3:                                -     -     -     -               
SP4:                                -     -                           


ECgene alternative splicing isoforms for C6orf201

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GenesLikeMe, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

C6orf201 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: AAAGCTGTAT
C6orf201 Expression
About this image

C6orf201 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

C6orf201 Protein Expression
    Custom PCR Arrays for C6orf201
Primer
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In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C6orf201

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section


This gene was present in the common ancestor of chordates.

Orthologs for C6orf201 gene from Selected species (see all 7)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia 4933417A18Rik1 , 5 RIKEN cDNA 4933417A18 gene1, 5 64.51(n)1
53.24(a)1
  13 (14.22 cM)5
667611  NM_025750.31  NP_080026.21 
 349244095 
lizard
(Anolis carolinensis)
Reptilia C6orf2016
chromosome 6 open reading frame 201
18(a)
1 ↔ 1
GL343209.1(465468-468837)


ENSEMBL Gene Tree for C6orf201 (if available)
TreeFam Gene Tree for C6orf201 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68,Sets of similar genes according to GenesLikeMe)
About This Section

  --

(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and 4UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
About This Section


Selected SNPs for C6orf201 (see all 728)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 6 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1425626841,2
C--4081537(+) TAATT-/TTTA  
        
TTTAT
1 -- int10--------
rs1865705561,2
--4081611(+) CGGCTC/TACTGC 1 -- int10--------
rs1463505101,2
--4081702(+) CACCAC/TGCCCG 1 -- int10--------
rs1910235671,2
--4081839(+) CTGAGC/GTCAGC 1 -- int10--------
rs1837360161,2
--4082031(+) TTATGC/TGTGCT 1 -- int10--------
rs1882659751,2
--4082117(+) TTTCTC/GTTCAT 1 -- int10--------
rs795724501,2
C,F--4082139(+) TTATTT/GCAGAA 1 -- int11Minor allele frequency- G:0.03EA 120
rs1905721241,2
--4082176(+) GTCCTC/TGTGAG 1 -- int10--------
rs117558771,2
C,F,A,H--4082177(+) TCCTTG/CTGAGA 1 -- int128Minor allele frequency- C:0.35NS EA NA WA CSA 2953
rs2000854931,2
C--4082214(+) AGATT-/TTTTTT 1 -- int10--------

HapMap Linkage Disequilibrium report for C6orf201 (4079440 - 4131185 bp)

Structural Variations
     Database of Genomic Variants (DGV) 2 variations for C6orf201:    About this table    
Variant IDTypeSubtypePubMed ID
esv2422231CNV Deletion17116639
esv2422457CNV Deletion17116639

Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing C6orf201

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB, Sets of similar genes according to GenesLikeMe)
About This Section

  --

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section


PubMed articles for C6orf201 gene integrated from 10 sources:
(articles sorted by number of sources associating them with C6orf201)

  1. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (J. Biol. Chem. 2011)
  2. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (Genomics 2007)
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  4. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)2 Mungall A.J.... Beck S. (Nature 2003)
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
  6. (PubMed id )2 

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 404220 HGNC: 21620 AceView: C6orf201 Ensembl:ENSG00000185689 euGenes: HUgn404220
ECgene: C6orf201 H-InvDB: C6orf201

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for C6orf201 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for C6orf201 gene:
Search GeneIP for patents involving C6orf201

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, GeneTex, and/or others, Clones from OriGene, GenScript, Sino Biological, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from genOway and/or Taconic Biosciences,
CRISPR knockouts from OriGene)
About This Section


 
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The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science
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