Aliases for C6orf15 Gene
Aliases for C6orf15 Gene
External Ids for C6orf15 Gene
- HGNC: 13927
- Entrez Gene: 29113
- Ensembl: ENSG00000204542
- OMIM: 611401
- UniProtKB: Q6UXA7
Previous GeneCards Identifiers for C6orf15 Gene
- GC06M031135
- GC06M030849
- GC06M031185
- GC06M031186
Summaries for C6orf15 Gene
GeneCards Summary for C6orf15 Gene
C6orf15 (Chromosome 6 Open Reading Frame 15) is a Protein Coding gene. Diseases associated with C6orf15 include Gastric Body Carcinoma and Posterior Cerebral Artery Infarction. GO annotations related to this gene include heparin binding and fibronectin binding.
No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C6orf15 Gene
Genomics for C6orf15 Gene
Regulatory Elements for C6orf15 Gene
Enhancers for C6orf15 Gene
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around C6orf15 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the C6orf15 gene promoter:
Regulatory Element Products
Genomic Location for C6orf15 Gene
- Chromosome:
- 6
- Start:
- 31,111,223 bp from pter
- End:
- 31,112,559 bp from pter
- Size:
- 1,337 bases
- Orientation:
- Minus strand
Genomic View for C6orf15 Gene
Genes around C6orf15 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 6p21.33 by Ensembl
- 6p21.33 by Entrez Gene
- 6p21.33 by HGNC
C6orf15 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for C6orf15 Gene
Proteins for C6orf15 Gene
-
Protein details for C6orf15 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q6UXA7-CF015_HUMAN
- Recommended name:
- Uncharacterized protein C6orf15
- Protein Accession:
- Q6UXA7
- B0S7V8
- Q0EFA6
- Q2L6G7
- Q5SQ81
- Q86Z05
- Q9UIG3
Protein attributes for C6orf15 Gene
- Size:
- 325 amino acids
- Molecular mass:
- 34195 Da
- Quaternary structure:
-
- Binds to numerous extracellular matrix proteins.
Protein Expression for C6orf15 Gene
Post-translational modifications for C6orf15 Gene
No Post-translational modifications
Other Protein References for C6orf15 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for C6orf15
- Invitrogen Antibodies for C6orf15
- Search GeneTex for Antibodies for C6orf15
Protein Products
-
OriGene Purified Proteins for C6orf15
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- Origene Custom Protein Services for C6orf15
- Novus Biologicals proteins for C6orf15
- Search GeneTex for Proteins for C6orf15
Assay Products
No data available for DME Specific Peptides for C6orf15 Gene
Domains & Families for C6orf15 Gene
Suggested Antigen Peptide Sequences for C6orf15 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for Gene Families and UniProtKB/Swiss-Prot for C6orf15 Gene
Function for C6orf15 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001968 | fibronectin binding | IEA | -- |
| GO:0003674 | molecular_function | ND | -- |
| GO:0005518 | collagen binding | IEA | -- |
| GO:0005539 | glycosaminoglycan binding | IEA | -- |
| GO:0005540 | hyaluronic acid binding | IEA | -- |
Phenotypes for C6orf15 Gene
- MGI mutant phenotypes for C6orf15:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for C6orf15:
Animal Models for C6orf15 Gene
- MGI Knock Outs for C6orf15:
-
- 2300002M23Rik tm1Lex
Animal Model Products
-
Taconic Biosciences Mouse Models for C6orf15
- Cyagen custom Knockout/knockin (KOKI) mouse models for C6orf15
-
-
ViGene Biosciences lentiviral particle packaged cDNA for C6orf15 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for C6orf15 gene
- Search ViGene Biosciences for C6orf15
CRISPR Products
-
OriGene CRISPR knockouts for C6orf15
-
Santa Cruz Biotechnology (SCBT) CRISPR for C6orf15
- GenScript: Design CRISPR guide RNA sequences for C6orf15
miRNA for C6orf15 Gene
- miRTarBase miRNAs that target C6orf15
miRNA Products
- Search ViGene Biosciences for C6orf15
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for C6orf15
- Browse OriGene Inhibitory RNA Products For C6orf15
-
ViGene Biosciences ready-to-package AAV shRNAs for C6orf15 gene
Clone Products
-
OriGene ORF clones in human for C6orf15
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for C6orf15
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for C6orf15
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for C6orf15
-
ViGene Biosciences adenoviral particle packaged cDNA for C6orf15 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for C6orf15 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for C6orf15 gene
Flow Cytometry Products
No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for C6orf15 Gene
Localization for C6orf15 Gene
Subcellular locations from UniProtKB/Swiss-Prot for C6orf15 Gene
- Secreted, extracellular space, extracellular matrix.
| Compartment | Confidence |
|---|---|
| extracellular | 4 |
| golgi apparatus | 2 |
| peroxisome | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005575 | cellular_component | ND | -- |
| GO:0005576 | extracellular region | IEA | -- |
| GO:0005578 | proteinaceous extracellular matrix | IEA | -- |
| GO:0005614 | interstitial matrix | IEA | -- |
Pathways & Interactions for C6orf15 Gene
No Data Available
Interacting Proteins for C6orf15 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0008150 | biological_process | ND | -- |
| GO:0030198 | extracellular matrix organization | IEA | -- |
No data available for Pathways by source and SIGNOR curated interactions for C6orf15 Gene
Transcripts for C6orf15 Gene
mRNA/cDNA for C6orf15 Gene
- (1) REFSEQ mRNAs :
- (2) Additional mRNA sequences :
- (4) Selected AceView cDNA sequences:
- (1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for C6orf15 Gene
CRISPR Products
-
OriGene CRISPR knockouts for C6orf15
-
Santa Cruz Biotechnology (SCBT) CRISPR for C6orf15
- GenScript: Design CRISPR guide RNA sequences for C6orf15
miRNA Products
- Search ViGene Biosciences for C6orf15
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for C6orf15
- Browse OriGene Inhibitory RNA Products For C6orf15
-
ViGene Biosciences ready-to-package AAV shRNAs for C6orf15 gene
Clone Products
-
OriGene ORF clones in human for C6orf15
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for C6orf15
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for C6orf15
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Flow Cytometry Products
Expression for C6orf15 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Inner Cell Mass (Early Embryonic Tissues)
-
Epidermis (Integumentary System)
mRNA differential expression in normal tissues according to GTEx for C6orf15 Gene
This gene is overexpressed in Skin - Sun Exposed (Lower leg) (x23.3), Skin - Not Sun Exposed (Suprapubic) (x13.5), Cervix - Endocervix (x4.6), and Vagina (x4.5).
This gene is overexpressed in Milk (69.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for C6orf15 Gene
NURSA nuclear receptor signaling pathways regulating expression of C6orf15 Gene:
C6orf15SOURCE GeneReport for Unigene cluster for C6orf15 Gene:
Hs.272214mRNA Expression by UniProt/SwissProt for C6orf15 Gene:
Q6UXA7-CF015_HUMAN
Tissue specificity:
Expressed in skin and tonsils.
Evidence on tissue expression from TISSUES for C6orf15 Gene
- Skin(4.1)
- Nervous system(2.5)
Primer Products
-
OriGene qPCR primer pairs for C6orf15
No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for C6orf15 Gene
Orthologs for C6orf15 Gene
This gene was present in the common ancestor of mammals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | C6H6orf15 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | C12H6orf15 34 |
|
||
| C6ORF15 35 |
|
OneToOne | |||
| cow (Bos Taurus) |
Mammalia | C23H6orf15 34 |
|
||
| C6orf15 35 |
|
OneToOne | |||
| rat (Rattus norvegicus) |
Mammalia | RGD1562885 34 |
|
||
| mouse (Mus musculus) |
Mammalia | 2300002M23Rik 34 16 35 |
|
- Species where no ortholog for C6orf15 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Paralogs for C6orf15 Gene
No data available for Paralogs for C6orf15 Gene
Variants for C6orf15 Gene
| SNP ID | Clin | Chr 06 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1002033998 | -- | 31,113,456(+) | GAATA(A/G)TCCAT | upstream-variant-2KB | |
| rs1003765652 | -- | 31,114,460(+) | TAAGT(C/T)GCATG | upstream-variant-2KB | |
| rs1003858589 | -- | 31,114,414(+) | GCGGG(A/G)ACTTC | upstream-variant-2KB | |
| rs1004570788 | -- | 31,111,154(+) | ACAGA(C/T)TCACT | downstream-variant-500B | |
| rs1004878611 | -- | 31,113,115(+) | ACTAA(C/T)TCCTG | upstream-variant-2KB |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2731791 | CNV | deletion | 23290073 |
| esv2759414 | CNV | gain+loss | 17122850 |
| esv3411275 | CNV | duplication | 20981092 |
| nsv1033227 | CNV | gain | 25217958 |
| nsv1074389 | CNV | deletion | 25765185 |
| nsv1122126 | CNV | deletion | 24896259 |
| nsv1144137 | CNV | deletion | 24896259 |
| nsv428140 | CNV | gain+loss | 18775914 |
| nsv601264 | CNV | loss | 21841781 |
| nsv601481 | CNV | loss | 21841781 |
| nsv601489 | CNV | loss | 21841781 |
| nsv601490 | CNV | gain | 21841781 |
Residual Variation Intolerance Score:
86% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
7.08;
80.42% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for C6orf15 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C6orf15 Gene
Disorders for C6orf15 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| gastric body carcinoma |
|
|
| posterior cerebral artery infarction |
|
|
| toxic diffuse goiter |
|
|
| avoidant personality disorder |
|
|
Search C6orf15 in MalaCards
View complete list of genes associated with diseases
Relevant External Links for C6orf15
No data available for UniProtKB/Swiss-Prot and Genatlas for C6orf15 Gene
Publications for C6orf15 Gene
- STG does not associate with psoriasis in the Swedish population. (PMID: 15217361) Sanchez F. … Staehle M. (Exp. Dermatol. 2004) 2 3 4 64
- The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4 64
- The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 3 4 64
- Association analysis using refined microsatellite markers localizes a susceptibility locus for psoriasis vulgaris within a 111kb segment telomeric to the HLA-C gene. (PMID: 10545595) Oka A. … Inoko H. (Hum. Mol. Genet. 1999) 3 4 64
- GWAS of blood cell traits identifies novel associated loci and epistatic interactions in Caucasian and African-American children. (PMID: 23263863) Li J. … Sleiman P.M. (Hum. Mol. Genet. 2013) 3 64
Products for C6orf15 Gene
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- Humanized Mice
- ViGene Biosciences adenoviral particle packaged cDNA for C6orf15 gene
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- Horizon Cell Lines for C6orf15
- Cyagen custom Knockout/knockin (KOKI) mouse models for C6orf15
- VectorBuilder custom plasmid, inducible vectors for C6orf15
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for C6orf15
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for C6orf15 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
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- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
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- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
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- (115) ProteomicsDB
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- (154) TISSUES
- (155) Gene ORGANizer