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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

C6orf15 Gene

protein-coding   GIFtS: 43
GCID: GC06M031079

Chromosome 6 Open Reading Frame 15

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Chromosome 6 Open Reading Frame 151 2
STG2 3
Taste Bud-Specific Protein2
Uncharacterized Protein C6orf152
Protein STG3

External Ids:    HGNC: 139271   Entrez Gene: 291132   Ensembl: ENSG000002045427   OMIM: 6114015   UniProtKB: Q6UXA73   

Export aliases for C6orf15 gene to outside databases

Previous GC identifers: GC06M031135 GC06M030849 GC06M031185 GC06M031186


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for C6orf15 Gene: 
C6orf15 (chromosome 6 open reading frame 15) is a protein-coding gene. Diseases associated with C6orf15 include pthirus pubis infestation, and follicular lymphoma. GO annotations related to this gene include hyaluronic acid binding and molecular_function.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NC_018917.2  NT_007592.15  NT_113891.2  NT_167245.1  NT_167246.1  NT_167247.1  NT_167248.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the C6orf15 gene promoter:
         Max   MyoD   MIF-1   ITF-2   TGIF   Tal-1beta   E47   c-Myc   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for C6orf15

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C6orf15


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.3   Ensembl cytogenetic band:  6p21.33   HGNC cytogenetic band: 6p21

C6orf15 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
C6orf15 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M031079:  view genomic region     (about GC identifiers)

Start:
31,079,000 bp from pter      End:
31,080,336 bp from pter
Size:
1,337 bases      Orientation:
minus strand

5 alternative locations:
Chr6-,NT_167245 2,376,172-2,377,504      Chr6-,NT_167248 2,374,818-2,376,150      Chr6-,NT_113891.2 2,593,704-2,595,036     
Chr6-,NT_167246 2,427,346-2,428,678      Chr6-,NT_167247 2,460,925-2,462,257     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CF015_HUMAN, Q6UXA7 (See protein sequence)
Recommended Name: Uncharacterized protein C6orf15 precursor  
Size: 325 amino acids; 34195 Da
Subunit: Binds to numerous extracellular matrix proteins (By similarity)
Subcellular location: Secreted, extracellular space, extracellular matrix (By similarity)
Secondary accessions: B0S7V8 Q0EFA6 Q2L6G7 Q5SQ81 Q86Z05 Q9UIG3

Explore the universe of human proteins at neXtProt for C6orf15: NX_Q6UXA7

Explore proteomics data for C6orf15 at MOPED 

C6orf15 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

C6orf15 Protein Expression

REFSEQ proteins: NP_054789.2  
ENSEMBL proteins: 
 ENSP00000259870  

Human Recombinant Protein Products for C6orf15: 
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Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005575cellular_component ND--
GO:0005614interstitial matrix IEA--
GO:0031012extracellular matrix ----

C6orf15 for ontologies           About GeneDecksing



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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
1 InterPro protein domain:
 IPR026135 C6orf15

Graphical View of Domain Structure for InterPro Entry Q6UXA7

ProtoNet protein and cluster: Q6UXA7


C6orf15 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

     Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0001968fibronectin binding IEA--
GO:0003674molecular_function ND--
GO:0005518collagen binding ----
GO:0005539glycosaminoglycan binding ----
GO:0005540hyaluronic acid binding IEA--
     
C6orf15 for ontologies           About GeneDecksing


Phenotypes:
     1 MGI phenotypic allele for 2300002M23Rik (no phenotypes)

C6orf15 for phenotypes           About GeneDecksing

Animal Models:
     MGI mouse knock-out 2300002M23Riktm1Lex for C6orf15

   inGenious Targeting Laboratory - Custom generated mouse model solutions for C6orf15 
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miRNA
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SwitchGear 3'UTR luciferase reporter plasmidC6orf15 3' UTR sequence
Inhib. RNA
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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section



Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for C6orf15

3 Interacting proteins for C6orf15 (Q6UXA73) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
ST8SIA2Q921863I2D: score=1 
SV2BQ7L1I23I2D: score=1 
SYT1P215793I2D: score=1 
About this table

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0008150biological_process ND--
GO:0030198extracellular matrix organization IEA--

C6orf15 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for C6orf15 (CF015)

Search CenterWatch for drugs/clinical trials and news about C6orf15 / CF015

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for C6orf15 gene: 
NM_014070.2  

Unigene Cluster for C6orf15:

Chromosome 6 open reading frame 15
Hs.272214  [show with all ESTs]
Unigene Representative Sequence: AY358438
1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000259870(uc003nsk.1)
miRNA
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2 QIAGEN miScript miRNA Assays for microRNAs that regulate C6orf15:
hsa-miR-650 hsa-miR-3612
SwitchGear 3'UTR luciferase reporter plasmidC6orf15 3' UTR sequence
Inhib. RNA
Products:
     
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Clone
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OriGene ORF clones in mouse, rat for C6orf15
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GenScript: all cDNA clones in your preferred vector: C6orf15 (NM_014070)
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Primer
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  QIAGEN QuantiFast Probe-based Assays in human, mouse, rat C6orf15

Additional mRNA sequence: 

AB031481.1 AY358438.1 

1 DOTS entry:

DT.97820461 

4 AceView cDNA sequences:

AB031481 NM_014070 AY358438 CD625156 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

C6orf15 expression in normal human tissues (normalized intensities)      C6orf15 embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
C6orf15 Expression
About this image


C6orf15 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database 
 5/3 selected tissues (see all 3) fully expand
 
 Breast (Uncategorized)
         Human Mammary Epithelial Cells (HMEpiC)   
 
 Inner Cell Mass (Early Embryonic Tissues)
         Blimp1- mVenus and stella-ECFP genetically modified stem cells
 
 Epithelium
         Human Mammary Epithelial Cells (HMEpiC)   

See C6orf15 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for C6orf15

SOURCE GeneReport for Unigene cluster: Hs.272214

UniProtKB/Swiss-Prot: CF015_HUMAN, Q6UXA7
Tissue specificity: Expressed in skin and tonsils

    SABiosciences Custom PCR Arrays for C6orf15
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QIAGEN QuantiFast Probe-based Assays in human, mouse, rat C6orf15
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C6orf15

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of human and mouse.

Orthologs for C6orf15 gene from 1/6 species (see all 6)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia 2300002M23Rik1 , 5 RIKEN cDNA 2300002M23 gene1, 5 63.97(n)1
50.16(a)1
  17 (18.70 cM)5
695421  NM_175148.31  NP_780357.11 
 355674505 


ENSEMBL Gene Tree for C6orf15 (if available)
TreeFam Gene Tree for C6orf15 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
  --

(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/121 SNPs in C6orf15 are shown (see all 121)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 6 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1884030151,2
--31078543(+) GCCTGC/TAAGGG 1 -- int10--------
rs1926397491,2
--31078548(+) TAAGGC/GAGGAG 1 -- int10--------
rs1128419531,2
C--31078553(+) GAGGAG/AGTCGA 1 -- int11Minor allele frequency- A:0.50CSA 2
rs12650581,2
C,F,A--31078557(-) TACATC/TGACCT 1 -- int110Minor allele frequency- T:0.49MN WA NA CSA EA 552
rs1830328041,2
--31078558(+) GGTCGA/GTGTAC 1 -- int10--------
rs12650571,2
C,F,A--31078615(-) TGTCTA/GCGCTT 1 -- int112Minor allele frequency- G:0.40MN NA WA CSA EA 556
rs1875649411,2
--31078620(+) TAGACA/GTTGCG 1 -- int10--------
rs1388249341,2
--31078621(+) AGACAG/TTGCGA 1 -- int10--------
rs12650561,2
C,F,A,H--31078650(-) TGCAAT/CTCACA 1 -- int116Minor allele frequency- C:0.47MN NS EA NA WA CSA 930
rs1163993181,2
C,F--31078664(+) AATCCT/CGTCCA 1 -- int12Minor allele frequency- C:0.03WA EA 238

HapMap Linkage Disequilibrium report for C6orf15 (31079000 - 31080336 bp)

Structural Variations
     Database of Genomic Variants (DGV) 5 variations for C6orf15:    About this table     
Variant IDTypeSubtypePubMed ID
esv2731791CNV Deletion23290073
nsv428140CNV Gain+Loss18775914
esv690CNV CNV17122850
dgv1919e1CNV Complex17122850
dgv1918e1CNV Complex17122850


Human Gene Mutation Database (HGMD): C6orf15
SABiosciences Cancer Mutation PCR Assays
SeqTarget long-range PCR primers for resequencing C6orf15
DNA2.0 Custom Variant and Variant Library Synthesis for C6orf15

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
OMIM gene information: 611401    OMIM disorders: --

9 diseases for C6orf15:    About MalaCards
pthirus pubis infestation    follicular lymphoma    aphasia    tonsillitis
hypothyroidism    systemic lupus erythematosus    psoriasis    graves' disease
lupus erythematosus


C6orf15 for disorders           About GeneDecksing

Genetic Association Database (GAD): C6orf15
Human Genome Epidemiology (HuGE) Navigator: C6orf15 (5 documents)

Export disorders for C6orf15 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for C6orf15 gene, integrated from 9 sources (see all 18):
(articles sorted by number of sources associating them with C6orf15)
    Utopia: connect your pdf to the dynamic
world of online information

  1. STG does not associate with psoriasis in the Swedish population. (PubMed id 15217361)1, 2 Sanchez F.... Staehle M. (2004)
  2. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
  3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
  4. Association analysis using refined microsatellite markers localizes a susceptibility locus for psoriasis vulgaris within a 111 kb segment telomeric to the HLA-C gene. (PubMed id 10545595)1, 2 Oka A....Inoko H. (1999)
  5. GWAS of blood cell traits identifies novel associated loci and epistatic interactions in Caucasian and African-American children. (PubMed id 23263863)1 Li J....Sleiman P.M. (2013)
  6. A genome-wide integrative genomic study localizes gene tic factors influencing antibodies against Epstein-Barr virus nuclear antigen 1 (EBNA-1). (PubMed id 23326239)1 Rubicz R....Goring H.H. (2013)
  7. Novel associations for hypothyroidism include known au toimmune risk loci. (PubMed id 22493691)1 Eriksson N....Do C.B. (2012)
  8. Multiple loci are associated with white blood cell phe notypes. (PubMed id 21738480)1 Nalls M.A....Ganesh S.K. (2011)
  9. A genome-wide association study identifies two new ris k loci for Graves' disease. (PubMed id 21841780)1 Chu X....Song H.D. (2011)
  10. Genome-wide association study identifies variants in the MHC class I, IL10, and IL23R-IL12RB2 regions associated with BehAset's disea se. (PubMed id 20622878)4 Remmers E.F....GA1l A. (2010)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 29113 HGNC: 13927 AceView: C6orf15 Ensembl:ENSG00000204542 euGenes: HUgn29113
ECgene: C6orf15 H-InvDB: C6orf15

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for C6orf15 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for C6orf15 gene:
Search GeneIP for patents involving C6orf15

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
About This Section

 
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GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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