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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

C6orf15 Gene

protein-coding GIFtS: 43
GCID: GC06M031079

chromosome 6 open reading frame 15

Explore 7 diseases affiliated with
C6orf15 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Chromosome 6 Open Reading Frame 15¹ ²
STG¹ ² ³
Taste Bud-Specific Protein²
Uncharacterized Protein C6orf15²
Protein STG³

External Ids:	HGNC: 13927¹	Entrez Gene: 29113²	Ensembl: ENSG00000204542⁷	OMIM: 611401⁵	UniProtKB: Q6UXA7³

Export aliases for C6orf15 gene to outside databases

Previous GC identifers: GC06M031135 GC06M030849 GC06M031185 GC06M031186

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000006.11 NC_018917.1 NT_007592.15 NT_113891.2 NT_167245.1 NT_167246.1 NT_167247.1 NT_167248.1

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the C6orf15 gene promoter:
Max MyoD MIF-1 ITF-2 TGIF Tal-1beta E47 c-Myc
Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids

Search SABiosciences Chromatin IP Primers for C6orf15

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C6orf15

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.3 Ensembl cytogenetic band: 6p21.33 HGNC cytogenetic band: 6p21

C6orf15 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
C6orf15 gene location

GeneLoc information about chromosome 6 GeneLoc Exon Structure

GeneLoc location for GC06M031079: view genomic region (about GC identifiers)

Start:	31,079,000 bp from pter	End:	31,080,336 bp from pter
Size:	1,337 bases	Orientation:	minus strand

5 alternative locations:

Chr6-,ALT_REF_LOCI_4 31,047,005-31,048,337	Chr6-,ALT_REF_LOCI_5 31,072,348-31,073,680	Chr6-,ALT_REF_LOCI_3 31,072,775-31,085,145
Chr6-,ALT_REF_LOCI_2 31,071,500-31,112,020	Chr6-,ALT_REF_LOCI_6 31,071,421-31,108,334

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
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About This Section

UniProtKB/Swiss-Prot: CF015_HUMAN, Q6UXA7 (See protein sequence)

Recommended Name: Uncharacterized protein C6orf15 precursor

Size: 325 amino acids; 34195 Da

Subunit: Binds to numerous extracellular matrix proteins (By similarity)

Subcellular location: Secreted, extracellular space, extracellular matrix (By similarity)

Secondary accessions: B0S7V8 Q0EFA6 Q2L6G7 Q5SQ81 Q86Z05 Q9UIG3

Explore the universe of human proteins at neXtProt for C6orf15: NX_Q6UXA7

C6orf15 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_054789.2

ENSEMBL proteins:

ENSP00000259870

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	Uscn Proteins for C6orf15

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005575	cellular_component	ND	--
GO:0005614	interstitial matrix	IEA	--
GO:0031012	extracellular matrix	--	--

C6orf15 for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

C6orf15 for domains About GeneDecksing

1 InterPro domain/family:

IPR026135 C6orf15

Graphical View of Domain Structure for InterPro Entry Q6UXA7

ProtoNet protein and cluster: Q6UXA7

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

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In Situ Assay
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Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001968	fibronectin binding	IEA	--
GO:0003674	molecular_function	ND	--
GO:0005518	collagen binding	--	--
GO:0005539	glycosaminoglycan binding	--	--
GO:0005540	hyaluronic acid binding	IEA	--

C6orf15 for ontologies           About GeneDecksing

Animal Models:
     Mouse knock-out 2300002M23Rik^tm1Lex for C6orf15
     1 MGI phenotypic allele

for 2300002M23Rik (no phenotypes)

C6orf15 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for C6orf15

3 Interacting proteins for C6orf15 (Q6UXA7³) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ST8SIA2	Q92186³	I2D: score=1
SV2B	Q7L1I2³	I2D: score=1
SYT1	P21579³	I2D: score=1

About this table

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0008150	biological_process	ND	--
GO:0030198	extracellular matrix organization	IEA	--

C6orf15 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for C6orf15
Search CenterWatch for drugs/clinical trials and news about C6orf15 / CF015

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
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About This Section

REFSEQ mRNAs for C6orf15 gene:

NM_014070.2

Unigene Cluster for C6orf15:

Chromosome 6 open reading frame 15

Hs.272214 [show with all ESTs]

Unigene Representative Sequence: AY358438

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000259870(uc003nsk.1)

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Additional cDNA sequence:

AB031481.1 AY358438.1

1 DOTS entry:

DT.97820461

4 AceView cDNA sequences:

NM_014070 AY358438 AB031481 CD625156

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

C6orf15 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

About this image

C6orf15 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Blimp1- mVenus and stella-ECFP genetically modified stem cells (Embryonic Stem Cell)

Early Embryo, Inner Cell Mass

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See C6orf15 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for C6orf15

SOURCE GeneReport for Unigene cluster: Hs.272214

UniProtKB/Swiss-Prot: CF015_HUMAN, Q6UXA7

Tissue specificity: Expressed in skin and tonsils

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In Situ
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of human and mouse.

Orthologs for C6orf15 gene from 1/6 species (see all 6) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	2300002M23Rik^{1 , 5}	RIKEN cDNA 2300002M23 gene^{1, 5}	63.97(n)¹ 50.16(a)¹		17 (18.70 cM)⁵ 69542¹ NM_175148.3¹ NP_780357.1¹ 35567450⁵

ENSEMBL Gene Tree for C6orf15 (if available)
TreeFam Gene Tree for C6orf15 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 6 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs188403015^1,2		--	31078543(+)	`GCCTGC/TAAGGG`	1	--	int¹		0	--	--	--	--
rs192639749^1,2		--	31078548(+)	`TAAGGC/GAGGAG`	1	--	int¹		0	--	--	--	--
rs112841953^1,2		--	31078553(+)	`GAGGAG/AGTCGA`	1	--	int¹		1		CSA	2
rs1265058^1,2	C,F,A,	--	31078557(-)	`TACATC/TGACCT`	1	--	int¹		10		MN WA NA CSA EA	552
rs183032804^1,2		--	31078558(+)	`GGTCGA/GTGTAC`	1	--	int¹		0	--	--	--	--
rs1265057^1,2	C,F,A,	--	31078615(-)	`TGTCTA/GCGCTT`	1	--	int¹		12		MN NA WA CSA EA	556
rs187564941^1,2		--	31078620(+)	`TAGACA/GTTGCG`	1	--	int¹		0	--	--	--	--
rs138824934^1,2		--	31078621(+)	`AGACAG/TTGCGA`	1	--	int¹		0	--	--	--	--
rs1265056^1,2	C,F,A,H,	--	31078650(-)	`TGCAAT/CTCACA`	1	--	int¹		16		MN NS EA NA WA CSA	930
rs116399318^1,2	F,	--	31078664(+)	`AATCCT/CGTCCA`	1	--	int¹		2		WA EA	238

HapMap Linkage Disequilibrium report for C6orf15 (31079000 - 31080336 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for C6orf15
1 CNV: 3601
Human Gene Mutation Database (HGMD): C6orf15

SABiosciences Cancer Mutation PCR Assays

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

C6orf15 for disorders           About GeneDecksing

OMIM gene information: 611401    OMIM disorders: --

7 diseases for C6orf15:    About MalaCards

pthirus pubis infestation systemic lupus erythematosus lupus erythematosus aphasia

follicular lymphoma tonsillitis psoriasis

Human Genome Epidemiology (HuGE) Navigator: C6orf15 (5 documents)

Export disorders for C6orf15 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for C6orf15 gene, integrated from 9 sources (see all 13):
(articles sorted by number of sources associating them with C6orf15)

Utopia: connect your pdf to the dynamic
world of online information

STG does not associate with psoriasis in the Swedish population. (PubMed id 15217361)^{1, 2} Sanchez F.... Staehle M. (2004)
The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)^{1, 2} Mungall A.J.... Beck S. (2003)
The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)^{1, 2} Clark H.F.... Gray A.M. (2003)
Association analysis using refined microsatellite markers localizes a susceptibility locus for psoriasis vulgaris within a 111 kb segment telomeric to the HLA-C gene. (PubMed id 10545595)^{1, 2} Oka A....Inoko H. (1999)
Novel associations for hypothyroidism include known au toimmune risk loci. (PubMed id 22493691)¹ Eriksson N....Do C.B. (2012)
A genome-wide association study identifies two new ris k loci for Graves' disease. (PubMed id 21841780)¹ Chu X....Song H.D. (2011)
Genome-wide association study of follicular lymphoma identifies a risk locus at 6p21.32. (PubMed id 20639881)¹ Conde L....Skibola C.F. (2010)
Genetic variants at 6p21.33 are associated with susce ptibility to follicular lymphoma. (PubMed id 19620980)¹ Skibola C.F....Brown K.M. (2009)
High-density SNP screening of the major histocompatib ility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions. (PubMed id 19851445)¹ Barcellos L.F....Criswell L.A. (2009)
Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)¹ Barbe L....Andersson-Svahn H. (2008)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 29113	HGNC: 13927	AceView: C6orf15	Ensembl:ENSG00000204542	euGenes: HUgn29113
ECgene: C6orf15	H-InvDB: C6orf15

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for C6orf15	Pharmacogenomics, SNPs, Pathways

Intellectual Property for C6orf15 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for C6orf15 gene:
Search GeneIP for patents involving C6orf15

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
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About This Section


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GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes C6orf15 gene at Home site.

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C6orf15 Gene

chromosome 6 open reading frame 15

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C6orf15 Gene

chromosome 6 open reading frame 15

Aliasesfor C6orf15 gene

Summariesfor C6orf15 gene

Genomic Viewsfor C6orf15 gene

Proteinsfor C6orf15 gene

Protein Domains /Familiesfor C6orf15 gene

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Genome Databases showing C6orf15 gene

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