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Aliases for C6orf141 Gene

Aliases for C6orf141 Gene

  • Chromosome 6 Open Reading Frame 141 2 3 5

External Ids for C6orf141 Gene

Previous GeneCards Identifiers for C6orf141 Gene

  • GC06P049519
  • GC06P049565
  • GC06P049626
  • GC06P049247

Summaries for C6orf141 Gene

GeneCards Summary for C6orf141 Gene

C6orf141 (Chromosome 6 Open Reading Frame 141) is a Protein Coding gene.

Additional gene information for C6orf141 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C6orf141 Gene

Genomics for C6orf141 Gene

Regulatory Elements for C6orf141 Gene

Enhancers for C6orf141 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06H049569 0.7 ENCODE 17.3 +20.1 20120 1 CTCF FOXA2 L3MBTL2 HLF ZSCAN4 MAX RAD21 POLR2A SMC3 HNF4A C6orf141 CENPQ LOC101927020 CYP2AC1P
GH06H049564 1 FANTOM5 ENCODE 11.2 +15.7 15678 2 JUND POLR2A JUN ZNF169 ETV4 MAX FOS ZNF644 RARA C6orf141 CENPQ LOC101927020 CYP2AC1P
GH06H049645 1.3 FANTOM5 ENCODE 8.1 +96.6 96554 3 PKNOX1 ATF1 ARNT TCF12 ZNF766 GATA2 ELK1 ATF7 CAVIN1 NCOA1 RHAG LOC101927020 LOC101927048 CRISP3 C6orf141 CENPQ CRISP2
GH06H049666 0.9 ENCODE 8.1 +117.0 116957 0 HDAC1 HDGF PKNOX1 ATF1 TBL1XR1 ARNT NFRKB TCF12 ATF7 CREM CRISP3 PGK2 C6orf141 RHAG CRISP2
GH06H049669 0.8 ENCODE 8.1 +118.0 118003 0 ZNF175 CEBPG CTBP1 GATA3 FOSL2 FOS RCOR1 TCF7L2 SMARCE1 CEBPB CRISP3 PGK2 C6orf141 RHAG CRISP2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around C6orf141 on UCSC Golden Path with GeneCards custom track

Promoters for C6orf141 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000197764 1000 2000 PKNOX1 INSM2 SIN3A BMI1 ZNF2 GLIS2 ZNF366 KLF7 EGR2 SP3

Genomic Location for C6orf141 Gene

Chromosome:
6
Start:
49,550,400 bp from pter
End:
49,561,907 bp from pter
Size:
11,508 bases
Orientation:
Plus strand

Genomic View for C6orf141 Gene

Genes around C6orf141 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C6orf141 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C6orf141 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C6orf141 Gene

Proteins for C6orf141 Gene

  • Protein details for C6orf141 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5SZD1-CF141_HUMAN
    Recommended name:
    Uncharacterized protein C6orf141
    Protein Accession:
    Q5SZD1
    Secondary Accessions:
    • A8K1H4
    • Q8N400
    • Q96NQ1

    Protein attributes for C6orf141 Gene

    Size:
    244 amino acids
    Molecular mass:
    26754 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH36917.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

neXtProt entry for C6orf141 Gene

Post-translational modifications for C6orf141 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for C6orf141 Gene

Domains & Families for C6orf141 Gene

Gene Families for C6orf141 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for C6orf141 Gene

ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C6orf141: view

No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for C6orf141 Gene

Function for C6orf141 Gene

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for C6orf141
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C6orf141 Gene

Localization for C6orf141 Gene

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear membrane (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for C6orf141 Gene

Pathways & Interactions for C6orf141 Gene

SuperPathways for C6orf141 Gene

No Data Available

Interacting Proteins for C6orf141 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000431184%0d%0a9606.ENSP00000281172%0d%0a9606.ENSP00000300574%0d%0a
Selected Interacting proteins: ENSP00000431184 Q5SZD1-CF141_HUMAN for C6orf141 Gene via STRING IID

Gene Ontology (GO) - Biological Process for C6orf141 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for C6orf141 Gene

Drugs & Compounds for C6orf141 Gene

No Compound Related Data Available

Transcripts for C6orf141 Gene

Unigene Clusters for C6orf141 Gene

Chromosome 6 open reading frame 141:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for C6orf141
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for C6orf141 Gene

No ASD Table

Relevant External Links for C6orf141 Gene

GeneLoc Exon Structure for
C6orf141
ECgene alternative splicing isoforms for
C6orf141

Expression for C6orf141 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for C6orf141 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for C6orf141 Gene

This gene is overexpressed in Brain - Nucleus accumbens (basal ganglia) (x6.4), Brain - Putamen (basal ganglia) (x6.2), and Brain - Caudate (basal ganglia) (x5.8).

Protein differential expression in normal tissues from HIPED for C6orf141 Gene

This gene is overexpressed in Plasma (56.1) and Heart (12.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for C6orf141 Gene



Protein tissue co-expression partners for C6orf141 Gene

NURSA nuclear receptor signaling pathways regulating expression of C6orf141 Gene:

C6orf141

SOURCE GeneReport for Unigene cluster for C6orf141 Gene:

Hs.722010
genes like me logo Genes that share expression patterns with C6orf141: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for C6orf141 Gene

Orthologs for C6orf141 Gene

This gene was present in the common ancestor of mammals.

Orthologs for C6orf141 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C6H6orf141 33
  • 98.91 (n)
C6orf141 34
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia C23H6orf141 33 34
  • 72.19 (n)
rat
(Rattus norvegicus)
Mammalia LOC688459 33
  • 65.92 (n)
mouse
(Mus musculus)
Mammalia 9130008F23Rik 33 16 34
  • 64.15 (n)
dog
(Canis familiaris)
Mammalia C6orf141 34
  • 47 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia C6orf141 34
  • 38 (a)
OneToOne
Species where no ortholog for C6orf141 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for C6orf141 Gene

ENSEMBL:
Gene Tree for C6orf141 (if available)
TreeFam:
Gene Tree for C6orf141 (if available)

Paralogs for C6orf141 Gene

No data available for Paralogs for C6orf141 Gene

Variants for C6orf141 Gene

Sequence variations from dbSNP and Humsavar for C6orf141 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1000202862 -- 49,548,608(+) GAGTG(C/T)TTAGA upstream-variant-2KB
rs1000265101 -- 49,548,852(+) AATCA(C/T)CCAGG upstream-variant-2KB
rs1000296799 -- 49,560,646(+) ACAGG(C/T)GCCTG downstream-variant-500B, utr-variant-3-prime
rs1000340886 -- 49,561,320(+) TCTCA(A/G)ACTCC downstream-variant-500B
rs1000456891 -- 49,561,028(+) ACCGT(A/C)TCTCT downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for C6orf141 Gene

Variant ID Type Subtype PubMed ID
dgv5960n100 CNV gain 25217958

Variation tolerance for C6orf141 Gene

Gene Damage Index Score: 4.76; 66.58% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C6orf141 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
C6orf141

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C6orf141 Gene

Disorders for C6orf141 Gene

Relevant External Links for C6orf141

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
C6orf141

No disorders were found for C6orf141 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C6orf141 Gene

Publications for C6orf141 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  3. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall AJ … Beck S (Nature 2003) 3 4 60
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  5. Phospho-tyrosine dependent protein-protein interaction network. (PMID: 25814554) Grossmann A … Stelzl U (Molecular systems biology 2015) 3 60

Products for C6orf141 Gene

Sources for C6orf141 Gene

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