Aliases for C6orf141 Gene
External Ids for C6orf141 Gene
- HGNC: 21351
- Entrez Gene: 135398
- Ensembl: ENSG00000197261
- UniProtKB: Q5SZD1
Previous GeneCards Identifiers for C6orf141 Gene
- GC06P049519
- GC06P049565
- GC06P049626
- GC06P049247
Summaries for C6orf141 Gene
GeneCards Summary for C6orf141 Gene
C6orf141 (Chromosome 6 Open Reading Frame 141) is a Protein Coding gene.
No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C6orf141 Gene
Genomics for C6orf141 Gene
Regulatory Elements for C6orf141 Gene
Enhancers for C6orf141 Gene
| GeneHancer Identifier | Enhancer Score | Enhancer Sources | Gene-Enhancer Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Gene Targets for Enhancer |
|---|---|---|---|---|---|---|---|---|
| GH06G049564 | 1.2 | FANTOM5 ENCODE | 11.2 | +15.7 | 15678 | 2.4 | CTCF YBX3 TAF1 JUN MAX ZNF384 ZNF644 ZNF2 ZBTB40 RARA | C6orf141 CENPQ LOC101927020 CYP2AC1P |
| GH06G049569 | 0.7 | ENCODE | 17.3 | +20.1 | 20120 | 1.2 | CTCF FOXA2 TAF1 L3MBTL2 HLF ZSCAN4 CEBPB MAX RAD21 FOXA1 | C6orf141 CENPQ LOC101927020 CYP2AC1P |
| GH06G049645 | 1.3 | FANTOM5 ENCODE | 8.1 | +96.6 | 96554 | 3.4 | PKNOX1 ATF1 CREB3L1 ARNT E2F7 TCF12 ZNF766 ELK1 GATA2 KLF13 | RHAG LOC101927020 LOC101927048 CRISP3 C6orf141 CENPQ CRISP2 |
| GH06G049666 | 0.9 | ENCODE | 8.1 | +117.0 | 116957 | 0.9 | HDAC1 HDGF PKNOX1 ATF1 TBL1XR1 ARNT NFRKB TCF12 ELK1 CREM | CRISP3 PGK2 C6orf141 RHAG CRISP2 |
| GH06G049669 | 0.8 | ENCODE | 8.1 | +118.0 | 118003 | 0.2 | BRD4 GTF2E2 ZNF175 CEBPG ZNF644 RAD21 CTBP1 GATA3 FOSL2 FOS | CRISP3 PGK2 C6orf141 RHAG CRISP2 |
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around C6orf141 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Location for C6orf141 Gene
- Chromosome:
- 6
- Start:
- 49,550,400 bp from pter
- End:
- 49,561,907 bp from pter
- Size:
- 11,508 bases
- Orientation:
- Plus strand
Genomic View for C6orf141 Gene
Genes around C6orf141 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 6p12.3 by Ensembl
- 6p12.3 by Entrez Gene
- 6p12.3 by HGNC
C6orf141 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for C6orf141 Gene
Proteins for C6orf141 Gene
-
Protein details for C6orf141 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q5SZD1-CF141_HUMAN
- Recommended name:
- Uncharacterized protein C6orf141
- Protein Accession:
- Q5SZD1
- A8K1H4
- Q8N400
- Q96NQ1
Protein attributes for C6orf141 Gene
- Size:
- 244 amino acids
- Molecular mass:
- 26754 Da
- Quaternary structure:
- No Data Available
- SequenceCaution:
-
- Sequence=AAH36917.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};
Protein Expression for C6orf141 Gene
Post-translational modifications for C6orf141 Gene
Other Protein References for C6orf141 Gene
Antibody Products
- Novus Biologicals Antibodies for C6orf141
-
Abcam antibodies for C6orf141
- Invitrogen Antibodies for C6orf141
- Search GeneTex for Antibodies for C6orf141
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for C6orf141
- Origene Custom Protein Services for C6orf141
- Novus Biologicals proteins for C6orf141
- Search GeneTex for Proteins for C6orf141
Assay Products
No data available for DME Specific Peptides for C6orf141 Gene
Domains & Families for C6orf141 Gene
Protein Domains for C6orf141 Gene
- ProtoNet:
Graphical View of Domain Structure for InterPro Entry
No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for C6orf141 Gene
Function for C6orf141 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for C6orf141
-
-
ViGene Biosciences lentiviral particle packaged cDNA for C6orf141 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for C6orf141 gene
- Search ViGene Biosciences for C6orf141
CRISPR Products
-
OriGene CRISPR knockouts for C6orf141
-
Santa Cruz Biotechnology (SCBT) CRISPR for C6orf141
- GenScript: Design CRISPR guide RNA sequences for C6orf141
miRNA for C6orf141 Gene
- miRTarBase miRNAs that target C6orf141
-
- hsa-mir-335-5p (MIRT018292)
- hsa-mir-665 (MIRT690036)
- hsa-mir-6771-5p (MIRT690037)
- hsa-mir-4449 (MIRT690038)
- hsa-mir-6762-3p (MIRT690039)
- hsa-mir-3622b-5p (MIRT690040)
- hsa-mir-7160-5p (MIRT690041)
- hsa-mir-423-3p (MIRT690042)
- hsa-mir-4722-5p (MIRT690043)
- hsa-mir-6884-5p (MIRT690044)
- hsa-mir-485-5p (MIRT690045)
- hsa-mir-1827 (MIRT690046)
- hsa-mir-4649-3p (MIRT690047)
- hsa-mir-6746-5p (MIRT690048)
- hsa-mir-4768-3p (MIRT690049)
- hsa-mir-4478 (MIRT690050)
- hsa-mir-4419b (MIRT690051)
- hsa-mir-3929 (MIRT690052)
- hsa-mir-940 (MIRT690053)
- hsa-mir-6893-5p (MIRT690054)
- hsa-mir-6808-5p (MIRT690055)
- hsa-mir-5197-5p (MIRT690056)
miRNA Products
- Search ViGene Biosciences for C6orf141
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for C6orf141
- Browse OriGene Inhibitory RNA Products For C6orf141
-
ViGene Biosciences ready-to-package AAV shRNAs for C6orf141 gene
Clone Products
-
OriGene ORF clones in human for C6orf141
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- VectorBuilder custom plasmid, inducible vectors for C6orf141
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for C6orf141
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for C6orf141
-
ViGene Biosciences adenoviral particle packaged cDNA for C6orf141 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for C6orf141 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for C6orf141 gene
Flow Cytometry Products
No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C6orf141 Gene
Localization for C6orf141 Gene
No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for C6orf141 Gene
Pathways & Interactions for C6orf141 Gene
No Data Available
Interacting Proteins for C6orf141 Gene
No data available for Pathways by source and SIGNOR curated interactions for C6orf141 Gene
Transcripts for C6orf141 Gene
mRNA/cDNA for C6orf141 Gene
- (12) REFSEQ mRNAs :
- (1) Additional mRNA sequences :
- (20) Selected AceView cDNA sequences:
- (7) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for C6orf141 Gene
- Chromosome 6 open reading frame 141:
- Representative Sequences:
CRISPR Products
-
OriGene CRISPR knockouts for C6orf141
-
Santa Cruz Biotechnology (SCBT) CRISPR for C6orf141
- GenScript: Design CRISPR guide RNA sequences for C6orf141
miRNA Products
- Search ViGene Biosciences for C6orf141
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for C6orf141
- Browse OriGene Inhibitory RNA Products For C6orf141
-
ViGene Biosciences ready-to-package AAV shRNAs for C6orf141 gene
Clone Products
-
OriGene ORF clones in human for C6orf141
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for C6orf141
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for C6orf141
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Flow Cytometry Products
Expression for C6orf141 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Brain (Nervous System)
-
Blood (Hematopoietic System)
- Hematopoietic Stem Cells Hematopoietic Bone Marrow
- Neurons
-
Testis (Reproductive System)
mRNA differential expression in normal tissues according to GTEx for C6orf141 Gene
This gene is overexpressed in Brain - Nucleus accumbens (basal ganglia) (x6.4), Brain - Putamen (basal ganglia) (x6.2), and Brain - Caudate (basal ganglia) (x5.8).
This gene is overexpressed in Plasma (56.1) and Heart (12.9).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for C6orf141 Gene
NURSA nuclear receptor signaling pathways regulating expression of C6orf141 Gene:
C6orf141SOURCE GeneReport for Unigene cluster for C6orf141 Gene:
Hs.722010Primer Products
-
OriGene qPCR primer pairs for C6orf141
No data available for mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for C6orf141 Gene
Orthologs for C6orf141 Gene
This gene was present in the common ancestor of mammals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | C6H6orf141 34 |
|
||
| C6orf141 35 |
|
OneToOne | |||
| cow (Bos Taurus) |
Mammalia | C23H6orf141 34 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | LOC688459 34 |
|
||
| mouse (Mus musculus) |
Mammalia | 9130008F23Rik 34 16 35 |
|
||
| dog (Canis familiaris) |
Mammalia | C6orf141 35 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | C6orf141 35 |
|
OneToOne |
- Species where no ortholog for C6orf141 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Paralogs for C6orf141 Gene
No data available for Paralogs for C6orf141 Gene
Variants for C6orf141 Gene
| SNP ID | Clin | Chr 06 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000202862 | -- | 49,548,608(+) | GAGTG(C/T)TTAGA | upstream-variant-2KB | |
| rs1000265101 | -- | 49,548,852(+) | AATCA(C/T)CCAGG | upstream-variant-2KB | |
| rs1000296799 | -- | 49,560,646(+) | ACAGG(C/T)GCCTG | downstream-variant-500B, utr-variant-3-prime | |
| rs1000340886 | -- | 49,561,320(+) | TCTCA(A/G)ACTCC | downstream-variant-500B | |
| rs1000456891 | -- | 49,561,028(+) | ACCGT(A/C)TCTCT | downstream-variant-500B |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv5960n100 | CNV | gain | 25217958 |
Gene Damage Index Score:
4.76;
66.58% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for C6orf141 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- C6orf141
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C6orf141 Gene
Disorders for C6orf141 Gene
Relevant External Links for C6orf141
- Atlas of Genetics and Cytogenetics in Oncology and Haematology:
- C6orf141
No disorders were found for C6orf141 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C6orf141 Gene
Publications for C6orf141 Gene
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
- The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 3 4 64
- Phospho-tyrosine dependent protein-protein interaction network. (PMID: 25814554) Grossmann A. … Stelzl U. (Mol. Syst. Biol. 2015) 3 64
- Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. (PMID: 15146197) Brandenberger R. … Stanton L.W. (Nat. Biotechnol. 2004) 3 64
Products for C6orf141 Gene
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- OriGene qPCR primer pairs for C6orf141
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- Novus Biologicals Antibodies for C6orf141
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- ViGene Biosciences adenoviral particle packaged cDNA for C6orf141 gene
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- Horizon Cell Lines for C6orf141
- Cyagen custom Knockout/knockin (KOKI) mouse models for C6orf141
- VectorBuilder custom plasmid, inducible vectors for C6orf141
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for C6orf141
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for C6orf141 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
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- (122) diseasecard
- (123) NIH Rare Diseases
- (124) Orphanet
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- (127) Disease Ontology
- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
- (131) CDC
- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer