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Aliases for C6orf136 Gene

Aliases for C6orf136 Gene

  • Chromosome 6 Open Reading Frame 136 2 3 5

External Ids for C6orf136 Gene

Previous GeneCards Identifiers for C6orf136 Gene

  • GC06P030385
  • GC06P030721
  • GC06P030722
  • GC06P030614
  • GC06P030414
  • GC06P030648

Summaries for C6orf136 Gene

GeneCards Summary for C6orf136 Gene

C6orf136 (Chromosome 6 Open Reading Frame 136) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C6orf136 Gene

Genomics for C6orf136 Gene

Regulatory Elements for C6orf136 Gene

Enhancers for C6orf136 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around C6orf136 on UCSC Golden Path with GeneCards custom track

Promoters for C6orf136 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around C6orf136 on UCSC Golden Path with GeneCards custom track

Genomic Location for C6orf136 Gene

Chromosome:
6
Start:
30,647,039 bp from pter
End:
30,653,210 bp from pter
Size:
6,172 bases
Orientation:
Plus strand

Genomic View for C6orf136 Gene

Genes around C6orf136 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C6orf136 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C6orf136 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Proteins for C6orf136 Gene

  • Protein details for C6orf136 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5SQH8-CF136_HUMAN
    Recommended name:
    Uncharacterized protein C6orf136
    Protein Accession:
    Q5SQH8
    Secondary Accessions:
    • A9R9P9
    • F8VX15
    • Q5SU01
    • Q6ZSB7
    • Q8TB84

    Protein attributes for C6orf136 Gene

    Size:
    315 amino acids
    Molecular mass:
    35794 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAI17760.2; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI41881.2; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI95540.2; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI95541.2; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for C6orf136 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for C6orf136 Gene

Proteomics data for C6orf136 Gene at MOPED

Post-translational modifications for C6orf136 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for C6orf136 Gene

Domains & Families for C6orf136 Gene

Protein Domains for C6orf136 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C6orf136: view

No data available for Gene Families and UniProtKB/Swiss-Prot for C6orf136 Gene

Function for C6orf136 Gene

Phenotypes for C6orf136 Gene

genes like me logo Genes that share phenotypes with C6orf136: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for C6orf136 Gene

Localization for C6orf136 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for C6orf136 Gene COMPARTMENTS Subcellular localization image for C6orf136 gene
Compartment Confidence
cytosol 2
mitochondrion 2
nucleus 1

Gene Ontology (GO) - Cellular Components for C6orf136 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA --
genes like me logo Genes that share ontologies with C6orf136: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for C6orf136 Gene

Pathways & Interactions for C6orf136 Gene

SuperPathways for C6orf136 Gene

No Data Available

Interacting Proteins for C6orf136 Gene

Selected Interacting proteins: Q5SQH8-CF136_HUMAN for C6orf136 Gene via MINT I2D

Gene Ontology (GO) - Biological Process for C6orf136 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for C6orf136 Gene

Drugs & Compounds for C6orf136 Gene

No Compound Related Data Available

Transcripts for C6orf136 Gene

Unigene Clusters for C6orf136 Gene

Chromosome 6 open reading frame 136:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for C6orf136 Gene

No ASD Table

Relevant External Links for C6orf136 Gene

GeneLoc Exon Structure for
C6orf136
ECgene alternative splicing isoforms for
C6orf136

Expression for C6orf136 Gene

mRNA expression in normal human tissues for C6orf136 Gene

Protein differential expression in normal tissues from HIPED for C6orf136 Gene

This gene is overexpressed in Frontal cortex (19.3), Retina (11.5), Salivary gland (10.3), and Heart (7.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for C6orf136 Gene



SOURCE GeneReport for Unigene cluster for C6orf136 Gene Hs.591787

genes like me logo Genes that share expression patterns with C6orf136: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for C6orf136 Gene

Orthologs for C6orf136 Gene

This gene was present in the common ancestor of animals.

Orthologs for C6orf136 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia C23H6orf136 35
  • 88.64 (n)
  • 89.17 (a)
C6orf136 36
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C12H6orf136 35
  • 89.1 (n)
  • 88.78 (a)
C6orf136 36
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia 2310061I04Rik 35
  • 83.23 (n)
  • 79.94 (a)
2310061I04Rik 16
2310061I04Rik 36
  • 79 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia C6H6orf136 35
  • 99.37 (n)
  • 100 (a)
C6orf136 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia RGD1302996 35
  • 81.83 (n)
  • 78.71 (a)
oppossum
(Monodelphis domestica)
Mammalia C6orf136 36
  • 74 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia C6orf136 36
  • 49 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia C6orf136 36
  • 48 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia c6orf136 35
  • 50.72 (n)
  • 47.84 (a)
zebrafish
(Danio rerio)
Actinopterygii C19H6orf136 36
  • 27 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG16787 36
  • 26 (a)
OneToOne
Species with no ortholog for C6orf136:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C6orf136 Gene

ENSEMBL:
Gene Tree for C6orf136 (if available)
TreeFam:
Gene Tree for C6orf136 (if available)

Paralogs for C6orf136 Gene

No data available for Paralogs for C6orf136 Gene

Variants for C6orf136 Gene

Sequence variations from dbSNP and Humsavar for C6orf136 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs5875269 -- 30,652,240(+) CCTGT(-/CACACACA)CACAC intron-variant
rs6899862 -- 30,652,107(+) gtgtg(C/G)tggta intron-variant
rs6900113 -- 30,652,455(+) aggat(C/T)gttaa intron-variant
rs9501480 -- 30,651,954(+) actca(A/C)atact intron-variant
rs11557269 -- 30,651,429(+) CCGCA(A/C/G/T)AAAGA reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for C6orf136 Gene

Variant ID Type Subtype PubMed ID
esv2731791 CNV Deletion 23290073
nsv884086 CNV Gain 21882294
esv2670269 CNV Deletion 23128226
nsv830626 CNV Loss 17160897
dgv6526n71 CNV Loss 21882294

Variation tolerance for C6orf136 Gene

Residual Variation Intolerance Score: 53.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.52; 55.48% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for C6orf136 Gene

Disorders for C6orf136 Gene

Relevant External Links for C6orf136

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
C6orf136

No disorders were found for C6orf136 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C6orf136 Gene

Publications for C6orf136 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 67
  2. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
  3. FOXM1 induces a global methylation signature that mimics the cancer epigenome in head and neck squamous cell carcinoma. (PMID: 22461910) Teh M.T. … Hutchison I.L. (PLoS ONE 2012) 3
  4. A directed protein interaction network for investigating intracellular signal transduction. (PMID: 21900206) Vinayagam A. … Wanker E.E. (Sci Signal 2011) 3
  5. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 3

Products for C6orf136 Gene

Sources for C6orf136 Gene

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