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Aliases for C6orf132 Gene

Aliases for C6orf132 Gene

  • Chromosome 6 Open Reading Frame 132 2 3 5
  • Uncharacterized Protein C6orf132 3
  • BA7K24.2 3

External Ids for C6orf132 Gene

Previous GeneCards Identifiers for C6orf132 Gene

  • GC00U914215
  • GC06U900651
  • GC06M042185
  • GC06M042202
  • GC06M041786

Summaries for C6orf132 Gene

GeneCards Summary for C6orf132 Gene

C6orf132 (Chromosome 6 Open Reading Frame 132) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C6orf132 Gene

Genomics for C6orf132 Gene

Regulatory Elements for C6orf132 Gene

Enhancers for C6orf132 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06F042115 1.4 Ensembl ENCODE 18.4 +22.2 22167 10.1 HDGF PKNOX1 ARNT CREB3L1 ARID4B SIN3A DMAP1 ZNF207 FOS ZNF263 C6orf132 TREML2 ENSG00000214732 GUCA1A GUCA1B MED20 ENSG00000207371 BYSL ENSG00000206977 ENSG00000261068
GH06F042097 1.3 Ensembl ENCODE 18.1 +40.1 40117 11.2 HDGF CREB3L1 MLX ARID4B SIN3A SLC30A9 ZNF143 FOS KLF13 DEK C6orf132 ENSG00000214732 GUCA1A GUCA1B ENSG00000261068 FRS3 PRICKLE4 MED20 ENSG00000207371 BYSL
GH06F042112 1 Ensembl ENCODE 16.9 +29.3 29262 2.8 ZFHX2 GATA3 SCRT2 TRIM24 FOS TCF7L2 EGR2 SCRT1 ZNF362 HLF C6orf132 ENSG00000214732 GUCA1A GUCA1B MED20 ENSG00000207371 BYSL ENSG00000261068 GC06P042135
GH06F042223 1.3 Ensembl ENCODE 10.2 -83.8 -83825 5.9 PKNOX1 ARID4B SIN3A FEZF1 ZNF766 FOS SP3 ZHX2 JUNB REST MRPS10 GUCA1B ENSG00000214732 GUCA1A C6orf132 PIR36094
GH06F042087 1 Ensembl ENCODE 11.3 +54.8 54776 0.8 ESRRA PKNOX1 JUN KLF17 MAX CTBP1 RCOR1 FOS SMARCC1 SP3 GUCA1A ENSG00000214732 C6orf132 GUCA1B MED20 ENSG00000207371 BYSL ENSG00000261068 TAF8
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around C6orf132 on UCSC Golden Path with GeneCards custom track

Promoters for C6orf132 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001216741 877 2201 PKNOX1 ZFP64 ZNF48 ZNF121 GLIS2 KLF7 FOS SP3 MIER3 GLIS1

Genomic Location for C6orf132 Gene

Chromosome:
6
Start:
42,101,118 bp from pter
End:
42,142,977 bp from pter
Size:
41,860 bases
Orientation:
Minus strand

Genomic View for C6orf132 Gene

Genes around C6orf132 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C6orf132 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C6orf132 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C6orf132 Gene

Proteins for C6orf132 Gene

  • Protein details for C6orf132 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5T0Z8-CF132_HUMAN
    Recommended name:
    Uncharacterized protein C6orf132
    Protein Accession:
    Q5T0Z8
    Secondary Accessions:
    • A6NI05

    Protein attributes for C6orf132 Gene

    Size:
    1188 amino acids
    Molecular mass:
    124034 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BE791477; Type=Frameshift; Positions=Several; Evidence={ECO:0000305}; Sequence=BU857282; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in the N-terminal part.; Evidence={ECO:0000305}; Sequence=BU857282; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in the C-terminal part.; Evidence={ECO:0000305}; Sequence=CAI16783.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI19541.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for C6orf132 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for C6orf132 Gene

Post-translational modifications for C6orf132 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C6orf132 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for C6orf132 Gene

Domains & Families for C6orf132 Gene

Protein Domains for C6orf132 Gene

ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C6orf132: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for C6orf132 Gene

Function for C6orf132 Gene

genes like me logo Genes that share phenotypes with C6orf132: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C6orf132 Gene

Localization for C6orf132 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C6orf132 gene
Compartment Confidence
cytosol 3
mitochondrion 2
nucleus 2
golgi apparatus 2
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for C6orf132 Gene

Pathways & Interactions for C6orf132 Gene

SuperPathways for C6orf132 Gene

No Data Available

Interacting Proteins for C6orf132 Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000341368%0d%0a9606.ENSP00000441929%0d%0a9606.ENSP00000216492%0d%0a9606.ENSP00000341551%0d%0a
Selected Interacting proteins: ENSP00000341368 for C6orf132 Gene via STRING

Gene Ontology (GO) - Biological Process for C6orf132 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for C6orf132 Gene

Transcripts for C6orf132 Gene

mRNA/cDNA for C6orf132 Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for C6orf132 Gene

Chromosome 6 open reading frame 132:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for C6orf132 Gene

No ASD Table

Relevant External Links for C6orf132 Gene

GeneLoc Exon Structure for
C6orf132
ECgene alternative splicing isoforms for
C6orf132

Expression for C6orf132 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for C6orf132 Gene

mRNA differential expression in normal tissues according to GTEx for C6orf132 Gene

This gene is overexpressed in Esophagus - Mucosa (x13.8), Skin - Sun Exposed (Lower leg) (x6.3), Skin - Not Sun Exposed (Suprapubic) (x6.0), and Vagina (x4.5).

Protein differential expression in normal tissues from HIPED for C6orf132 Gene

This gene is overexpressed in Cervix (34.2), Bone (12.9), and Hair follicle (10.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for C6orf132 Gene



NURSA nuclear receptor signaling pathways regulating expression of C6orf132 Gene:

C6orf132

SOURCE GeneReport for Unigene cluster for C6orf132 Gene:

Hs.444277
genes like me logo Genes that share expression patterns with C6orf132: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for C6orf132 Gene

Orthologs for C6orf132 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C6orf132 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C6H6orf132 34
  • 98.89 (n)
C6orf132 35
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C6orf132 35
  • 71 (a)
OneToOne
mouse
(Mus musculus)
Mammalia AI661453 35
  • 65 (a)
OneToOne
cow
(Bos Taurus)
Mammalia C6orf132 35
  • 57 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia C6orf132 35
  • 53 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia C6orf132 35
  • 26 (a)
OneToOne
chicken
(Gallus gallus)
Aves C6orf132 35
  • 34 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia C6orf132 35
  • 47 (a)
OneToOne
Species where no ortholog for C6orf132 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for C6orf132 Gene

ENSEMBL:
Gene Tree for C6orf132 (if available)
TreeFam:
Gene Tree for C6orf132 (if available)

Paralogs for C6orf132 Gene

No data available for Paralogs for C6orf132 Gene

Variants for C6orf132 Gene

Sequence variations from dbSNP and Humsavar for C6orf132 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs10456114 -- 42,117,641(+) CAAGT(C/G)ccggg intron-variant
rs10456115 -- 42,118,501(+) ACATT(C/T)TCAGG intron-variant
rs10456507 -- 42,116,408(+) AAACC(A/C)AGCTG intron-variant
rs10456508 -- 42,117,660(+) ctcac(C/G)cctgt intron-variant
rs10456509 -- 42,118,762(+) TTCCT(C/T)GTCCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for C6orf132 Gene

Variant ID Type Subtype PubMed ID
nsv830649 CNV loss 17160897
esv2658537 CNV deletion 23128226
dgv753n27 CNV loss 19166990
dgv10639n54 CNV loss 21841781

Variation tolerance for C6orf132 Gene

Gene Damage Index Score: 8.73; 86.61% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C6orf132 Gene

Human Gene Mutation Database (HGMD)
C6orf132
SNPedia medical, phenotypic, and genealogical associations of SNPs for
C6orf132

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C6orf132 Gene

Disorders for C6orf132 Gene

Relevant External Links for C6orf132

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
C6orf132

No disorders were found for C6orf132 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C6orf132 Gene

Publications for C6orf132 Gene

  1. Genome-wide association study combining pathway analysis for typical sporadic amyotrophic lateral sclerosis in Chinese Han populations. (PMID: 24529757) Xie T. … Xu R. (Neurobiol. Aging 2014) 3 64
  2. Immunoaffinity enrichment and mass spectrometry analysis of protein methylation. (PMID: 24129315) Guo A. … Comb M.J. (Mol. Cell. Proteomics 2014) 4 64
  3. Initial characterization of the human central proteome. (PMID: 21269460) Burkard T.R. … Colinge J. (BMC Syst. Biol. 2011) 4 64
  4. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PMID: 21406692) Rigbolt K.T. … Blagoev B. (Sci. Signal. 2011) 4 64
  5. Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PMID: 20068231) Olsen J.V. … Mann M. (Sci. Signal. 2010) 4 64

Products for C6orf132 Gene

Sources for C6orf132 Gene

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