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Aliases for C6orf120 Gene

Aliases for C6orf120 Gene

  • Chromosome 6 Open Reading Frame 120 2 3
  • UPF0669 Protein C6orf120 3
  • BA160E12.4 3

External Ids for C6orf120 Gene

Previous GeneCards Identifiers for C6orf120 Gene

  • GC00U913935
  • GC06U900682
  • GC06P169844
  • GC06P170102
  • GC06P167522

Summaries for C6orf120 Gene

GeneCards Summary for C6orf120 Gene

C6orf120 (Chromosome 6 Open Reading Frame 120) is a Protein Coding gene.

UniProtKB/Swiss-Prot for C6orf120 Gene

  • May be involved in induction of apoptosis in CD4(+) T-cells, but not CD8(+) T-cells or hepatocytes.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C6orf120 Gene

Genomics for C6orf120 Gene

Regulatory Elements for C6orf120 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for C6orf120 Gene

169,702,161 bp from pter
169,706,306 bp from pter
4,146 bases
Plus strand

Genomic View for C6orf120 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for C6orf120 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C6orf120 Gene

Proteins for C6orf120 Gene

  • Protein details for C6orf120 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    UPF0669 protein C6orf120
    Protein Accession:
    Secondary Accessions:
    • B4DHE9
    • E1P5C9

    Protein attributes for C6orf120 Gene

    191 amino acids
    Molecular mass:
    20772 Da
    Quaternary structure:
    No Data Available

neXtProt entry for C6orf120 Gene

Proteomics data for C6orf120 Gene at MOPED

Post-translational modifications for C6orf120 Gene

  • Glycosylation at Asn53
  • Modification sites at PhosphoSitePlus

Other Protein References for C6orf120 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for C6orf120 Gene

Domains for C6orf120 Gene

Protein Domains for C6orf120 Gene


Suggested Antigen Peptide Sequences for C6orf120 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q7Z4R8
  • Belongs to the UPF0669 family.
genes like me logo Genes that share domains with C6orf120: view

No data available for Gene Families for C6orf120 Gene

Function for C6orf120 Gene

Molecular function for C6orf120 Gene

UniProtKB/Swiss-Prot Function: May be involved in induction of apoptosis in CD4(+) T-cells, but not CD8(+) T-cells or hepatocytes.

Animal Model Products

CRISPR Products

miRNA for C6orf120 Gene

miRTarBase miRNAs that target C6orf120

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for C6orf120

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for C6orf120 Gene

Localization for C6orf120 Gene

Subcellular locations from UniProtKB/Swiss-Prot for C6orf120 Gene

Secreted. Note=Secreted by hepatocytes.

Subcellular locations from

Jensen Localization Image for C6orf120 Gene COMPARTMENTS Subcellular localization image for C6orf120 gene
Compartment Confidence
extracellular 5
mitochondrion 2
endoplasmic reticulum 1
lysosome 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for C6orf120 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with C6orf120: view

Pathways for C6orf120 Gene

SuperPathways for C6orf120 Gene

No Data Available

Interacting Proteins for C6orf120 Gene

Gene Ontology (GO) - Biological Process for C6orf120 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process IEA --
genes like me logo Genes that share ontologies with C6orf120: view

No data available for Pathways by source for C6orf120 Gene

Transcripts for C6orf120 Gene

mRNA/cDNA for C6orf120 Gene

(5) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for C6orf120 Gene

Chromosome 6 open reading frame 120:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for C6orf120

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for C6orf120 Gene

No ASD Table

Relevant External Links for C6orf120 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for C6orf120 Gene

mRNA expression in normal human tissues for C6orf120 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for C6orf120 Gene

SOURCE GeneReport for Unigene cluster for C6orf120 Gene Hs.591375

mRNA Expression by UniProt/SwissProt for C6orf120 Gene

Tissue specificity: Mainly expressed in hepatocytes and some weak expression in germinal center cells of lymph nodes.
genes like me logo Genes that share expressions with C6orf120: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for C6orf120 Gene

Orthologs for C6orf120 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C6orf120 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia C6orf120 36
  • 89 (a)
(Bos Taurus)
Mammalia C9H6orf120 35
  • 82.88 (n)
  • 85.79 (a)
C9H6orf120 36
  • 86 (a)
(Canis familiaris)
Mammalia C12H6orf120 35
  • 79.78 (n)
  • 78.69 (a)
C6orf120 36
  • 77 (a)
(Mus musculus)
Mammalia 1600012H06Rik 35
  • 77.17 (n)
  • 76.09 (a)
1600012H06Rik 16
1600012H06Rik 36
  • 76 (a)
(Monodelphis domestica)
Mammalia C6orf120 36
  • 70 (a)
(Rattus norvegicus)
Mammalia LOC100125364 35
  • 76.09 (n)
  • 75.54 (a)
(Gallus gallus)
Aves C3H6ORF120 35
  • 68.12 (n)
  • 71.2 (a)
C3H6ORF120 36
  • 71 (a)
(Anolis carolinensis)
Reptilia C6orf120 36
  • 68 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia c6orf120 35
  • 60.96 (n)
  • 60.77 (a)
(Danio rerio)
Actinopterygii C11H6orf120 36
  • 45 (a)
zgc:77929 35
  • 63.17 (n)
  • 59.12 (a)
Species with no ortholog for C6orf120:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C6orf120 Gene

Gene Tree for C6orf120 (if available)
Gene Tree for C6orf120 (if available)

Paralogs for C6orf120 Gene

No data available for Paralogs for C6orf120 Gene

Variants for C6orf120 Gene

Structural Variations from Database of Genomic Variants (DGV) for C6orf120 Gene

Variant ID Type Subtype PubMed ID
nsv887010 CNV Gain 21882294
nsv830872 CNV Loss 17160897
nsv887011 CNV Loss 21882294

Relevant External Links for C6orf120 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for C6orf120 Gene

Disorders for C6orf120 Gene

No disorders were found for C6orf120 Gene.

No data available for UniProtKB/Swiss-Prot for C6orf120 Gene

Publications for C6orf120 Gene

  1. Role of C6ORF120, an N-glycosylated protein, is implicated in apoptosis of CD4+ T lymphocytes. (PMID: 22340178) Li X. … Wei H.S. (Chin. Med. J. 2011) 2 3 4
  2. A "double adaptor" method for improved shotgun library construction. (PMID: 8619474) Andersson B. … Gibbs R.A. (Anal. Biochem. 1996) 2 3
  3. Large-scale concatenation cDNA sequencing. (PMID: 9110174) Yu W. … Gibbs R.A. (Genome Res. 1997) 2 3
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  5. A genome-wide meta-analysis of six type 1 diabetes cohorts identifies multiple associated loci. (PMID: 21980299) Bradfield J.P. … Hakonarson H. (PLoS Genet. 2011) 3

Products for C6orf120 Gene

Sources for C6orf120 Gene

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