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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

C6orf120 Gene

protein-coding   GIFtS: 37
GCID: GC06P170102

chromosome 6 open reading frame 120
  Search for C6orf120
in
MalaCards
our new
 Human Malady Compendium 
Biological research products
for C6orf120    

Aliases
for C6orf120 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Chromosome 6 Open Reading Frame 1201 2
BA160E12.41
UPF0669 Protein C6orf1202

External Ids:    HGNC: 212471   Entrez Gene: 3872632   Ensembl: ENSG000001851277   UniProtKB: Q7Z4R83   

Export aliases for C6orf120 gene to outside databases

Previous GC identifers: GC00U913935 GC06U900682 GC06P169844 GC06P167522


Summaries
for C6orf120 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: CF120_HUMAN, Q7Z4R8
Function: May be involved in induction of apoptosis in CD4(+) T-cells, but not CD8(+) T-cells or hepatocytes




Genomic Views
for C6orf120 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NC_018917.1  NT_025741.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the C6orf120 gene promoter:
         Nkx3-1   Sox5   Nkx3-1 v4   p300   Nkx3-1 v1   HNF-1A   Nkx3-1 v2   POU2F1   POU2F1a   Nkx3-1 v3   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for C6orf120

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C6orf120


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q27   Ensembl cytogenetic band:  6q27   HGNC cytogenetic band: 6q27

C6orf120 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
C6orf120 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P170102:  view genomic region     (about GC identifiers)

Start:
 170,102,233 bp from pter      End:
 170,106,402 bp from pter
Size:
 4,170 bases      Orientation:
 plus strand

Proteins
for C6orf120 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: CF120_HUMAN, Q7Z4R8 (See protein sequence)
Recommended Name: UPF0669 protein C6orf120 precursor  
Size: 191 amino acids; 20772 Da
Subcellular location: Secreted. Note=Secreted by hepatocytes
Secondary accessions: B4DHE9 E1P5C9

Explore the universe of human proteins at neXtProt for C6orf120: NX_Q7Z4R8

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q7Z4R8

    • C6orf120 Protein expression data from MOPED and PaxDb:    About this image 
    C6orf120 Protein Expression
    REFSEQ proteins: NP_001025034.1  
    ENSEMBL proteins: 
     ENSP00000390806   ENSP00000346931  

    Human Recombinant Protein Products for C6orf120: 
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    Uscn Proteins for C6orf120

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--

    C6orf120 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for C6orf120

    Protein Domains /
    Families
    for C6orf120 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ProtoNet protein and cluster: Q7Z4R8

    UniProtKB/Swiss-Prot: CF120_HUMAN, Q7Z4R8
    Similarity: Belongs to the UPF0669 family


    Function
    for C6orf120 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CF120_HUMAN, Q7Z4R8
    Function: May be involved in induction of apoptosis in CD4(+) T-cells, but not CD8(+) T-cells or hepatocytes

    Animal Models:

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    Inhib. RNA
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    Pathways & Interactions
    for C6orf120 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for C6orf120

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006915apoptotic process IEA--

    C6orf120 for ontologies           About GeneDecksing



    Drugs & Compounds
    for C6orf120 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for C6orf120
    Search CenterWatch for drugs/clinical trials and news about C6orf120 / CF120 

    Transcripts
    for C6orf120 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
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    About This Section
    REFSEQ mRNAs for C6orf120 gene: 
    NM_001029863.1  

    Unigene Clusters for C6orf120:

    Chromosome 6 open reading frame 120
    Hs.591375  [show with all ESTs], Hs.694601
    Unigene Representative Sequences: BC051700, AK295962
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000439249(uc011egx.2) ENST00000332290(uc003qxb.3)

    miRNA
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    8/55 QIAGEN miScript miRNA Assays for microRNAs that regulate C6orf120 (see all 55):
    hsa-miR-548j hsa-miR-2052 hsa-miR-429 hsa-miR-199a-3p hsa-miR-3651 hsa-miR-106a hsa-miR-513a-5p hsa-miR-128
    SwitchGear 3'UTR luciferase reporter plasmid: C6orf120 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for C6orf120 (see all 4)
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    Clone
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    Additional cDNA sequence: AK295962.1 

    8 DOTS entries:

    DT.455377  DT.97847413  DT.91707560  DT.95275392  DT.95266906  DT.100815536  DT.91758075  DT.100815537 

    GeneLoc Exon Structure


    Expression
    for C6orf120 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    C6orf120 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CTGCCTCAAT
    C6orf120 Expression
    About this image

    C6orf120 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table

    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    Head MesenchymeHead MesenchymeHead Mesenchyme
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See C6orf120 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for C6orf120

    SOURCE GeneReport for Unigene clusters: Hs.591375 Hs.694601

    UniProtKB/Swiss-Prot: CF120_HUMAN, Q7Z4R8
    Tissue specificity: Mainly expressed in hepatocytes and some weak expression in germinal center cells of lymph nodes

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    In Situ
    Assay Products:     
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    Orthologs
    for C6orf120 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for C6orf120 gene from 4/11 species (see all 11)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia 1600012H06Rik1 , 5 RIKEN cDNA 1600012H06 gene1, 5 77.17(n)1
    76.09(a)1    		   17 (8.95 cM)5
    679121  NM_001083880.11  NP_001077349.11 
     149431845 
    chicken
    (Gallus gallus)    		 Aves C3H6orf1201 chromosome 3 open reading frame, human C6orf120 68.12(n)
    71.2(a)    		   421557  NM_001031065.1  NP_001026236.1 
    lizard
    (Anolis carolinensis)    		 Reptilia C6orf1206
    		 --
    		 67(a)
    		 1 ↔ 1
    		 5(798066-798629)
    zebrafish
    (Danio rerio)    		 Actinopterygii zgc:779291 zgc:77929 63.17(n)
    59.12(a)    		   402944  NM_205647.1  NP_991210.1 


    ENSEMBL Gene Tree for C6orf120 (if available)
    TreeFam Gene Tree for C6orf120 (if available) 

    Paralogs
    for C6orf120 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    		  --

    Genomic Variants
    for C6orf120 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 2 variations for C6orf120
         2 CNVs: 94258 81775
    SABiosciences Cancer Mutation PCR Assays
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    DNA2.0 Custom Variant and Variant Library Synthesis for C6orf120

    Disorders / Diseases
    for C6orf120 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    		   --

    Publications
    for C6orf120 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for C6orf120 gene, integrated from 9 sources (see all 11):
    (articles sorted by number of sources associating them with C6orf120)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Role of C6ORF120, an N-glycosylated protein, is implicated in apoptosis of CD4+ T lymphocytes. (PubMed id 22340178)1, 2, 3 Li X.... Wei H.S. (2011)
    2. Large-scale concatenation cDNA sequencing. (PubMed id 9110174)1, 3 Yu W.... Gibbs R.A. (1997)
    3. A "double adaptor" method for improved shotgun library construction. (PubMed id 8619474)1, 3 Andersson B.... Gibbs R.A. (1996)
    4. A genome-wide meta-analysis of six type 1 diabetes coh orts identifies multiple associated loci. (PubMed id 21980299)1 Bradfield J.P....Hakonarson H. (2011)
    5. Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry. (PubMed id 19159218)2 Chen R.... Zou H. (2009)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
    8. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)2 Mungall A.J.... Beck S. (2003)
    9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    10. Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)

    External Searches for C6orf120 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing C6orf120 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 387263 HGNC: 21247 Ensembl:ENSG00000185127 euGenes: HUgn387263 ECgene: C6orf120
    H-InvDB: C6orf120

    Other Databases showing C6orf120 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing C6orf120 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for C6orf120 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for C6orf120 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for C6orf120 gene:
    Search GeneIP for patents involving C6orf120

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

     
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