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Aliases for C6orf118 Gene

Aliases for C6orf118 Gene

  • Chromosome 6 Open Reading Frame 118 2 3 5
  • Uncharacterized Protein C6orf118 3
  • DJ416F21.2 (Novel Protein) 3
  • DJ416F21.2 3
  • BA85G2.1 3

External Ids for C6orf118 Gene

Previous GeneCards Identifiers for C6orf118 Gene

  • GC06M165526
  • GC06M165602
  • GC06M165663
  • GC06M163154
  • GC06M165693

Summaries for C6orf118 Gene

GeneCards Summary for C6orf118 Gene

C6orf118 (Chromosome 6 Open Reading Frame 118) is a Protein Coding gene. GO annotations related to this gene include RNA binding and ribonuclease activity.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C6orf118 Gene

Genomics for C6orf118 Gene

Regulatory Elements for C6orf118 Gene

Enhancers for C6orf118 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06F165309 0.8 ENCODE 18.8 +0.0 12 1.1 MAX ZIC2 E2F1 ZFHX2 GLIS2 ZNF366 PATZ1 ZNF600 EGR2 ZNF263 C6orf118 ENSG00000217878
GH06F165230 0.5 ENCODE 0.2 +78.0 77995 1.6 CTCF ZNF654 SMC3 RAD21 C6orf118 ENSG00000217878
GH06F165227 0.4 ENCODE 0.2 +81.8 81841 0.2 CEBPB C6orf118 ENSG00000217878
GH06F165181 0.6 ENCODE 0.1 +127.5 127473 1.4 ZFHX2 NFE2 FOS EGR2 SETDB1 TRIM28 ENSG00000217878 C6orf118
GH06F165119 0.4 ENCODE 0.1 +189.9 189881 0.2 NFE2 ENSG00000217878 C6orf118
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around C6orf118 on UCSC Golden Path with GeneCards custom track

Promoters for C6orf118 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001887879 346 1000 TAL1 MAX ZIC2 E2F1 ZFHX2 GLIS2 ZNF366 PATZ1 ZNF600 EGR2

Genomic Location for C6orf118 Gene

165,279,664 bp from pter
165,309,647 bp from pter
29,984 bases
Minus strand

Genomic View for C6orf118 Gene

Genes around C6orf118 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C6orf118 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C6orf118 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C6orf118 Gene

Proteins for C6orf118 Gene

  • Protein details for C6orf118 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Uncharacterized protein C6orf118
    Protein Accession:
    Secondary Accessions:
    • Q8TC11

    Protein attributes for C6orf118 Gene

    469 amino acids
    Molecular mass:
    53772 Da
    Quaternary structure:
    No Data Available

neXtProt entry for C6orf118 Gene

Post-translational modifications for C6orf118 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for C6orf118 Gene

Domains & Families for C6orf118 Gene

Protein Domains for C6orf118 Gene


Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C6orf118: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for C6orf118 Gene

Function for C6orf118 Gene

genes like me logo Genes that share phenotypes with C6orf118: view

Animal Model Products

miRNA for C6orf118 Gene

miRTarBase miRNAs that target C6orf118

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C6orf118 Gene

Localization for C6orf118 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C6orf118 gene
Compartment Confidence
mitochondrion 3
nucleus 2
cytosol 2
plasma membrane 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for C6orf118 Gene

Pathways & Interactions for C6orf118 Gene

SuperPathways for C6orf118 Gene

No Data Available

Interacting Proteins for C6orf118 Gene

Selected Interacting proteins: Q5T5N4-CF118_HUMAN for C6orf118 Gene via IID

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for C6orf118 Gene


No data available for Pathways by source and SIGNOR curated interactions for C6orf118 Gene

Transcripts for C6orf118 Gene

mRNA/cDNA for C6orf118 Gene

Unigene Clusters for C6orf118 Gene

Chromosome 6 open reading frame 118:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for C6orf118 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b
SP1: - - -

Relevant External Links for C6orf118 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for C6orf118 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for C6orf118 Gene

mRNA differential expression in normal tissues according to GTEx for C6orf118 Gene

This gene is overexpressed in Testis (x13.5), Pituitary (x6.4), Brain - Caudate (basal ganglia) (x4.7), Fallopian Tube (x4.6), and Brain - Hypothalamus (x4.6).

Protein differential expression in normal tissues from HIPED for C6orf118 Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (66.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for C6orf118 Gene

Protein tissue co-expression partners for C6orf118 Gene

NURSA nuclear receptor signaling pathways regulating expression of C6orf118 Gene:


SOURCE GeneReport for Unigene cluster for C6orf118 Gene:

genes like me logo Genes that share expression patterns with C6orf118: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for C6orf118 Gene

Orthologs for C6orf118 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C6orf118 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia C6H6orf118 34
  • 98.1 (n)
C6orf118 35
  • 98 (a)
(Canis familiaris)
Mammalia C1H6orf118 34
  • 75.1 (n)
C6orf118 35
  • 62 (a)
(Bos Taurus)
Mammalia C9H6orf118 34
  • 73.29 (n)
MGC134132 35
  • 57 (a)
(Rattus norvegicus)
Mammalia MGC94891 34
  • 69.52 (n)
(Mus musculus)
Mammalia 1700010I14Rik 34 16 35
  • 68.39 (n)
(Monodelphis domestica)
Mammalia C6orf118 35
  • 44 (a)
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 39 (a)
-- 35
  • 38 (a)
(Anolis carolinensis)
Reptilia C6orf118 35
  • 35 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia c6orf118 34
  • 48.34 (n)
Species where no ortholog for C6orf118 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for C6orf118 Gene

Gene Tree for C6orf118 (if available)
Gene Tree for C6orf118 (if available)

Paralogs for C6orf118 Gene

No data available for Paralogs for C6orf118 Gene

Variants for C6orf118 Gene

Sequence variations from dbSNP and Humsavar for C6orf118 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs10080349 -- 165,302,970(+) CTGCA(A/G)GTCTA intron-variant
rs10080753 -- 165,301,248(+) ACCGT(C/T)GTGGC intron-variant
rs10080960 -- 165,301,132(+) CCTTC(A/T)TTTCA intron-variant
rs10081051 -- 165,301,234(+) GAGCC(C/T)CTCAG intron-variant
rs10214718 -- 165,291,525(+) gccag(C/G)gggat intron-variant

Structural Variations from Database of Genomic Variants (DGV) for C6orf118 Gene

Variant ID Type Subtype PubMed ID
esv3571525 CNV loss 25503493
esv3576252 CNV gain 25503493
nsv508438 CNV deletion 20534489
nsv5586 CNV deletion 18451855
nsv605245 CNV gain 21841781
nsv949888 CNV deletion 24416366

Variation tolerance for C6orf118 Gene

Residual Variation Intolerance Score: 95.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.50; 77.63% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C6orf118 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C6orf118 Gene

Disorders for C6orf118 Gene

Relevant External Links for C6orf118

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for C6orf118 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C6orf118 Gene

Publications for C6orf118 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  2. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 3 4 64
  3. Genome-wide interaction studies reveal sex-specific asthma risk alleles. (PMID: 24824216) Myers R.A. … Nicolae D.L. (Hum. Mol. Genet. 2014) 3 64
  4. Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women. (PMID: 22589738) Fox C.S. … Borecki I.B. (PLoS Genet. 2012) 3 64
  5. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 3 64

Products for C6orf118 Gene

Sources for C6orf118 Gene

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