Aliases for C6orf118 Gene
Aliases for C6orf118 Gene
External Ids for C6orf118 Gene
- HGNC: 21233
- Entrez Gene: 168090
- Ensembl: ENSG00000112539
- UniProtKB: Q5T5N4
Previous GeneCards Identifiers for C6orf118 Gene
- GC06M165526
- GC06M165602
- GC06M165663
- GC06M163154
- GC06M165693
Summaries for C6orf118 Gene
GeneCards Summary for C6orf118 Gene
C6orf118 (Chromosome 6 Open Reading Frame 118) is a Protein Coding gene. GO annotations related to this gene include RNA binding and ribonuclease activity.
No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C6orf118 Gene
Genomics for C6orf118 Gene
Regulatory Elements for C6orf118 Gene
Enhancers for C6orf118 Gene
| GeneHancer Identifier | Enhancer Score | Enhancer Sources | Gene-Enhancer Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Gene Targets for Enhancer |
|---|---|---|---|---|---|---|---|---|
| GH06G165309 | 0.8 | ENCODE | 18.8 | +0.0 | 12 | 1.1 | MXI1 MAX ZIC2 E2F1 ZFHX2 GLIS2 ZNF366 PATZ1 ZNF600 EGR2 | C6orf118 ENSG00000217878 |
| GH06G165230 | 0.5 | ENCODE | 0.2 | +78.0 | 77995 | 1.6 | CTCF ZNF654 SMC3 EP300 RAD21 | C6orf118 ENSG00000217878 |
| GH06G165227 | 0.4 | ENCODE | 0.2 | +81.8 | 81841 | 0.2 | CEBPB | C6orf118 ENSG00000217878 |
| GH06G165181 | 0.5 | ENCODE | 0.1 | +127.5 | 127473 | 1.4 | ZFHX2 FOS NFE2 EGR2 TRIM28 | ENSG00000217878 C6orf118 |
| GH06G165119 | 0.4 | ENCODE | 0.1 | +189.9 | 189881 | 0.2 | NFE2 | ENSG00000217878 C6orf118 |
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around C6orf118 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the C6orf118 gene promoter:
Regulatory Element Products
Genomic Location for C6orf118 Gene
- Chromosome:
- 6
- Start:
- 165,279,664 bp from pter
- End:
- 165,309,647 bp from pter
- Size:
- 29,984 bases
- Orientation:
- Minus strand
Genomic View for C6orf118 Gene
Genes around C6orf118 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 6q27 by Ensembl
- 6q27 by Entrez Gene
- 6q27 by HGNC
C6orf118 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for C6orf118 Gene
Proteins for C6orf118 Gene
-
Protein details for C6orf118 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q5T5N4-CF118_HUMAN
- Recommended name:
- Uncharacterized protein C6orf118
- Protein Accession:
- Q5T5N4
- Q8TC11
Protein attributes for C6orf118 Gene
- Size:
- 469 amino acids
- Molecular mass:
- 53772 Da
- Quaternary structure:
- No Data Available
Protein Expression for C6orf118 Gene
Post-translational modifications for C6orf118 Gene
Other Protein References for C6orf118 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for C6orf118
- Invitrogen Antibodies for C6orf118
- Search GeneTex for Antibodies for C6orf118
Protein Products
-
OriGene Purified Proteins for C6orf118
- Search Origene for MassSpec and Protein Over-expression Lysates for C6orf118
- Origene Custom Protein Services for C6orf118
- Search GeneTex for Proteins for C6orf118
Assay Products
No data available for DME Specific Peptides for C6orf118 Gene
Domains & Families for C6orf118 Gene
Protein Domains for C6orf118 Gene
- InterPro:
- ProtoNet:
Graphical View of Domain Structure for InterPro Entry
No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for C6orf118 Gene
Function for C6orf118 Gene
Phenotypes for C6orf118 Gene
- GenomeRNAi human phenotypes for C6orf118:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for C6orf118
-
-
ViGene Biosciences lentiviral particle packaged cDNA for C6orf118 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for C6orf118 gene
- Search ViGene Biosciences for C6orf118
CRISPR Products
-
OriGene CRISPR knockouts for C6orf118
-
Santa Cruz Biotechnology (SCBT) CRISPR for C6orf118
- GenScript: Design CRISPR guide RNA sequences for C6orf118
miRNA for C6orf118 Gene
- miRTarBase miRNAs that target C6orf118
miRNA Products
- Search ViGene Biosciences for C6orf118
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for C6orf118
- Browse OriGene Inhibitory RNA Products For C6orf118
-
ViGene Biosciences ready-to-package AAV shRNAs for C6orf118 gene
Clone Products
-
OriGene ORF clones in human for C6orf118
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- VectorBuilder custom plasmid, inducible vectors for C6orf118
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for C6orf118
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for C6orf118
-
ViGene Biosciences adenoviral particle packaged cDNA for C6orf118 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for C6orf118 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for C6orf118 gene
Flow Cytometry Products
No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C6orf118 Gene
Localization for C6orf118 Gene
| Compartment | Confidence |
|---|---|
| mitochondrion | 3 |
| nucleus | 2 |
| cytosol | 2 |
| plasma membrane | 1 |
No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for C6orf118 Gene
Pathways & Interactions for C6orf118 Gene
No data available for Pathways by source and SIGNOR curated interactions for C6orf118 Gene
Transcripts for C6orf118 Gene
mRNA/cDNA for C6orf118 Gene
- (9) REFSEQ mRNAs :
- (2) Additional mRNA sequences :
- (17) Selected AceView cDNA sequences:
- (3) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for C6orf118 Gene
CRISPR Products
-
OriGene CRISPR knockouts for C6orf118
-
Santa Cruz Biotechnology (SCBT) CRISPR for C6orf118
- GenScript: Design CRISPR guide RNA sequences for C6orf118
miRNA Products
- Search ViGene Biosciences for C6orf118
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for C6orf118
- Browse OriGene Inhibitory RNA Products For C6orf118
-
ViGene Biosciences ready-to-package AAV shRNAs for C6orf118 gene
Clone Products
-
OriGene ORF clones in human for C6orf118
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for C6orf118
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for C6orf118
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Flow Cytometry Products
| ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b | ^ | 10 | ^ | 11a | · | 11b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | ||||||||||||||||||||||||
| SP2: | |||||||||||||||||||||||||||
| SP3: |
Expression for C6orf118 Gene
mRNA differential expression in normal tissues according to GTEx for C6orf118 Gene
This gene is overexpressed in Testis (x13.5), Pituitary (x6.4), Brain - Caudate (basal ganglia) (x4.7), Fallopian Tube (x4.6), and Brain - Hypothalamus (x4.6).
This gene is overexpressed in Bone marrow mesenchymal stem cell (66.7).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for C6orf118 Gene
NURSA nuclear receptor signaling pathways regulating expression of C6orf118 Gene:
C6orf118SOURCE GeneReport for Unigene cluster for C6orf118 Gene:
Hs.144734Primer Products
-
OriGene qPCR primer pairs and template standards for C6orf118
-
OriGene qPCR primer pairs for C6orf118
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for C6orf118 Gene
Orthologs for C6orf118 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | C6H6orf118 34 |
|
||
| C6orf118 35 |
|
OneToOne | |||
| dog (Canis familiaris) |
Mammalia | C1H6orf118 34 |
|
||
| C6orf118 35 |
|
OneToOne | |||
| cow (Bos Taurus) |
Mammalia | C9H6orf118 34 |
|
||
| MGC134132 35 |
|
OneToOne | |||
| rat (Rattus norvegicus) |
Mammalia | MGC94891 34 |
|
||
| mouse (Mus musculus) |
Mammalia | 1700010I14Rik 34 16 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | C6orf118 35 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 35 |
|
OneToMany | |
| -- 35 |
|
OneToMany | |||
| lizard (Anolis carolinensis) |
Reptilia | C6orf118 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | c6orf118 34 |
|
- Species where no ortholog for C6orf118 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Paralogs for C6orf118 Gene
No data available for Paralogs for C6orf118 Gene
Variants for C6orf118 Gene
| SNP ID | Clin | Chr 06 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000010632 | -- | 165,293,819(+) | TTTTA(C/T)ACTCA | intron-variant | |
| rs1000105542 | -- | 165,310,893(+) | GTCCT(G/T)CCCAA | intron-variant, upstream-variant-2KB | |
| rs1000183716 | -- | 165,280,785(+) | GCCAT(A/G)TTGAG | intron-variant | |
| rs1000214994 | -- | 165,281,080(+) | TAAAC(A/C)AATGA | intron-variant | |
| rs1000359142 | -- | 165,286,443(+) | ATCAT(C/G)CTGGT | intron-variant |
Residual Variation Intolerance Score:
95.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
6.50;
77.63% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for C6orf118 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- C6orf118
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C6orf118 Gene
Disorders for C6orf118 Gene
Relevant External Links for C6orf118
- Atlas of Genetics and Cytogenetics in Oncology and Haematology:
- C6orf118
No disorders were found for C6orf118 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C6orf118 Gene
Publications for C6orf118 Gene
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
- The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 3 4 64
- Genome-wide interaction studies reveal sex-specific asthma risk alleles. (PMID: 24824216) Myers R.A. … Nicolae D.L. (Hum. Mol. Genet. 2014) 3 64
- Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women. (PMID: 22589738) Fox C.S. … Borecki I.B. (PLoS Genet. 2012) 3 64
- Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 3 64
Products for C6orf118 Gene
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- OriGene Purified Proteins for C6orf118
- Search Origene for MassSpec and Protein Over-expression Lysates for C6orf118
- Origene Custom Protein Services for C6orf118
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for C6orf118
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- OriGene qPCR primer pairs and template standards for C6orf118
- OriGene qPCR primer pairs for C6orf118
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- GenScript: Design CRISPR guide RNA sequences for C6orf118
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- Novus Biologicals Antibodies for C6orf118
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- ViGene Biosciences adenoviral particle packaged cDNA for C6orf118 gene
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- Search ViGene Biosciences for C6orf118
- Horizon Cell Lines for C6orf118
- Cyagen custom Knockout/knockin (KOKI) mouse models for C6orf118
- VectorBuilder custom plasmid, inducible vectors for C6orf118
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for C6orf118
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for C6orf118 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
- (121) SIGNOR
- (122) diseasecard
- (123) NIH Rare Diseases
- (124) Orphanet
- (125) UMLS
- (126) GTR
- (127) Disease Ontology
- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
- (131) CDC
- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer