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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

C6orf118 Gene

protein-coding   GIFtS: 39
GCID: GC06M165693

chromosome 6 open reading frame 118
  Search for C6orf118
in
MalaCards
our new
 Human Malady Compendium 
Biological research products
for C6orf118    

Aliases
for C6orf118 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Chromosome 6 Open Reading Frame 1181 2
BA85G2.11
MGC238841
DJ416F21.21
DJ416F21.2 (Novel Protein)2
Uncharacterized Protein C6orf1182

External Ids:    HGNC: 212331   Entrez Gene: 1680902   Ensembl: ENSG000001125397   UniProtKB: Q5T5N43   

Export aliases for C6orf118 gene to outside databases

Previous GC identifers: GC06M165526 GC06M165602 GC06M165663 GC06M163154


Summaries
for C6orf118 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
  --

Genomic Views
for C6orf118 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NC_018917.1  NT_025741.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the C6orf118 gene promoter:
         POU3F2 (N-Oct-5a)   POU3F2 (N-Oct-5b)   Nkx2-5   POU3F2   FOXL1   HNF-1A   CREB   HNF-1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for C6orf118

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C6orf118


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q27   Ensembl cytogenetic band:  6q27   HGNC cytogenetic band: 6q27

C6orf118 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
C6orf118 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M165693:  view genomic region     (about GC identifiers)

Start:
 165,693,153 bp from pter      End:
 165,723,111 bp from pter
Size:
 29,959 bases      Orientation:
 minus strand

Proteins
for C6orf118 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: CF118_HUMAN, Q5T5N4 (See protein sequence)
Recommended Name: Uncharacterized protein C6orf118  
Size: 469 amino acids; 53772 Da
Secondary accessions: Q8TC11

Explore the universe of human proteins at neXtProt for C6orf118: NX_Q5T5N4

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q5T5N4

    • C6orf118 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_659417.2  
    ENSEMBL proteins: 
     ENSP00000230301   ENSP00000439288  

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    Protein Domains /
    Families
    for C6orf118 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ProtoNet protein and cluster: Q5T5N4


    Function
    for C6orf118 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    miRNA
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    Pathways & Interactions
    for C6orf118 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for C6orf118

    Drugs & Compounds
    for C6orf118 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for C6orf118
    Search CenterWatch for drugs/clinical trials and news about C6orf118 / CF118 

    Transcripts
    for C6orf118 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
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    About This Section
    REFSEQ mRNAs for C6orf118 gene: 
    NM_144980.3  

    Unigene Cluster for C6orf118:

    Chromosome 6 open reading frame 118
    Hs.144734  [show with all ESTs]
    Unigene Representative Sequence: NM_144980
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000494696 ENST00000230301(uc003qum.4) ENST00000491176 ENST00000543069(uc011egi.1)


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    Inhib. RNA
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    Additional cDNA sequence: 

    AK302358.1 BC026278.1 

    4 DOTS entries:

    DT.205734  DT.86844051  DT.121376831  DT.121376832 

    17 AceView cDNA sequences:

    AI799083 CB242288 BX104603 BC026278 NM_144980 BU678768 AA417005 AI192015 
    AI798754 AI807196 BM968092 BI545688 BG548434 AA417192 AA993942 BG703279 
    AW572810 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for C6orf118    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b
    SP1:        -                                               -           -               
    SP2:                                                                                    
    SP3:                                                                                    


    ECgene alternative splicing isoforms for C6orf118

    Expression
    for C6orf118 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    C6orf118 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: ATTAGTTTCT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    C6orf118 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Posterior foregut-like cells (A scalable, suspensi...)
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See C6orf118 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for C6orf118

    SOURCE GeneReport for Unigene cluster: Hs.144734
        SABiosciences Custom PCR Arrays for C6orf118
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    In Situ
    Assay Products:     
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    Orthologs
    for C6orf118 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for C6orf118 gene from 2/9 species (see all 9)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia 1700010I14Rik1 , 5 RIKEN cDNA 1700010I14 gene1, 5 67.98(n)1
    59.03(a)1    		   17 (5.53 cM)5
    669311  NM_025851.31  NP_080127.21 
     89883335 
    lizard
    (Anolis carolinensis)    		 Reptilia C6orf1186
    		 --
    		 35(a)
    		 1 ↔ 1
    		 GL343461.1(128311-151136)


    ENSEMBL Gene Tree for C6orf118 (if available)
    TreeFam Gene Tree for C6orf118 (if available) 

    Paralogs
    for C6orf118 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    		  --

    Genomic Variants
    for C6orf118 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/628 NCBI SNPs in C6orf118 are shown (see all 628)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 6 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs58816411,2
    		C,--163165133(+) TTAAC-/AATATT 1 -- int12Minor allele frequency- A:0.25NA 4
    rs19776121,2
    		C,A,H,--165692704(-) CTGACT/CTCAAG 1 -- int14Minor allele frequency- C:0.14NA CSA 7
    rs1429867361,2
    		--165692762(+) AAAATA/GCAAAA 1 -- int10--------
    rs1508331531,2
    		--165692768(+) CAAAAG/TTAGCT 1 -- int10--------
    rs1812301161,2
    		--165692789(+) GCACAC/TACCTG 1 -- int10--------
    rs1396103111,2
    		--165692843(+) TGAACC/TGAGGA 1 -- int10--------
    rs1139486981,2
    		--165692877(+) ATCATA/GCCATT 1 -- int11Minor allele frequency- G:0.00CSA 1
    rs1392611211,2
    		--165692888(+) GCACTC/TCAGCC 1 -- int10--------
    rs1850077041,2
    		--165692965(+) CAAGCA/TTGCGT 1 -- int10--------
    rs1882866321,2
    		--165692966(+) AAGCTA/TGCGTT 1 -- int10--------

    HapMap Linkage Disequilibrium report for C6orf118 (165693153 - 165723111 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 4 variations for C6orf118
         4 CNVs: 36487 36486 36485 36484

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    Disorders / Diseases
    for C6orf118 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    		   --

    Publications
    for C6orf118 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for C6orf118 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with C6orf118)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    2. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
    3. Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women. (PubMed id 22589738)1 Fox C.S....Borecki I.B. (2012)
    4. Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    6. Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548)1 Bonaldo M.F.... Soares M.B. (1996)

    External Searches for C6orf118 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing C6orf118 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 168090 HGNC: 21233 AceView: C6orf118 Ensembl:ENSG00000112539 euGenes: HUgn168090
    ECgene: C6orf118 H-InvDB: C6orf118

    Other Databases showing C6orf118 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing C6orf118 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for C6orf118 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for C6orf118 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for C6orf118 gene:
    Search GeneIP for patents involving C6orf118

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for C6orf118 gene

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    About This Section

     
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