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Aliases for C6orf106 Gene

Aliases for C6orf106 Gene

  • Chromosome 6 Open Reading Frame 106 2 3 5
  • Uncharacterized Protein C6orf106 3
  • DJ391O22.4 3
  • FP852 3

External Ids for C6orf106 Gene

Previous GeneCards Identifiers for C6orf106 Gene

  • GC06M034601
  • GC06M034663
  • GC06M034278
  • GC06M034689
  • GC06M034899
  • GC06M035237
  • GC06M035732
  • GC06M034815
  • GC06M035575
  • GC06M036290
  • GC06M036659
  • GC06M037012

Summaries for C6orf106 Gene

GeneCards Summary for C6orf106 Gene

C6orf106 (Chromosome 6 Open Reading Frame 106) is a Protein Coding gene. GO annotations related to this gene include ubiquitin binding.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C6orf106 Gene

Genomics for C6orf106 Gene

Regulatory Elements for C6orf106 Gene

Enhancers for C6orf106 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06G034655 1.9 FANTOM5 Ensembl ENCODE dbSUPER 12.8 +39.4 39393 4.0 HDGF PKNOX1 FOXA2 MLX ARNT ZFP64 WRNIP1 ARID4B FEZF1 DMAP1 UHRF1BP1 LEMD2 ENSG00000220643 C6orf106 ENSG00000219023 FANCE RPS10 RPL10A TAF11 HMGA1
GH06G034663 1.9 FANTOM5 Ensembl ENCODE dbSUPER 12.7 +32.4 32402 3.4 HDGF PKNOX1 ATF1 FOXA2 ARNT YY1 ZNF766 ELK1 CAVIN1 JUNB UHRF1BP1 ENSG00000220643 C6orf106 FANCE HMGA1 GC06M037428 RN7SL200P GC06P041046
GH06G034608 1.3 Ensembl ENCODE 11.1 +86.5 86544 2.7 HDGF PKNOX1 FOXA2 MLX CREB3L1 ARNT ZFP64 ZNF2 ZNF143 FOS UHRF1BP1 SPDEF ENSG00000220643 C6orf106 GRM4 ANKS1A TAF11 RPL7P25 GC06P041063
GH06G034373 1.4 FANTOM5 Ensembl ENCODE dbSUPER 10 +322.5 322480 1.6 FEZF1 TBX21 ZNF121 FOSL1 GATA2 POLR2A SCRT2 ZNF600 FOS IKZF2 ENSG00000220643 C6orf106 HMGA1 NUDT3 PIR34626
GH06G034660 1.1 ENCODE dbSUPER 12.7 +35.7 35651 1.5 LEF1 TBL1XR1 ARNT NFRKB TAL1 RELA FOSL1 TCF12 ZNF766 EGR1 ENSG00000220643 C6orf106 RN7SL200P GC06M037428 GC06P041046
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around C6orf106 on UCSC Golden Path with GeneCards custom track

Promoters for C6orf106 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000195977 359 2201 FEZF1 DMAP1 YY1 ZNF548 ZNF263 SP3 TBX21 MEF2D GLIS1 RCOR2

Genomic Location for C6orf106 Gene

Chromosome:
6
Start:
34,587,280 bp from pter
End:
34,696,859 bp from pter
Size:
109,580 bases
Orientation:
Minus strand

Genomic View for C6orf106 Gene

Genes around C6orf106 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C6orf106 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C6orf106 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C6orf106 Gene

Proteins for C6orf106 Gene

  • Protein details for C6orf106 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H6K1-CF106_HUMAN
    Recommended name:
    Uncharacterized protein C6orf106
    Protein Accession:
    Q9H6K1
    Secondary Accessions:
    • B2R8K7
    • Q5VV77
    • Q96MG5
    • Q9BUR9

    Protein attributes for C6orf106 Gene

    Size:
    298 amino acids
    Molecular mass:
    32872 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for C6orf106 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for C6orf106 Gene

Post-translational modifications for C6orf106 Gene

  • Ubiquitination at Lys15, posLast=205205, Lys218, Lys228, posLast=240240, and posLast=287287
  • Modification sites at PhosphoSitePlus

Other Protein References for C6orf106 Gene

No data available for DME Specific Peptides for C6orf106 Gene

Domains & Families for C6orf106 Gene

Protein Domains for C6orf106 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C6orf106: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for C6orf106 Gene

Function for C6orf106 Gene

Gene Ontology (GO) - Molecular Function for C6orf106 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0043130 ubiquitin binding IBA --
genes like me logo Genes that share ontologies with C6orf106: view

Phenotypes for C6orf106 Gene

GenomeRNAi human phenotypes for C6orf106:
genes like me logo Genes that share phenotypes with C6orf106: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C6orf106 Gene

Localization for C6orf106 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C6orf106 gene
Compartment Confidence
nucleus 3
plasma membrane 1
extracellular 1
cytosol 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for C6orf106 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000407 pre-autophagosomal structure IBA --
GO:0005575 cellular_component ND --
GO:0005776 autophagosome IBA --
genes like me logo Genes that share ontologies with C6orf106: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for C6orf106 Gene

Pathways & Interactions for C6orf106 Gene

SuperPathways for C6orf106 Gene

No Data Available

Interacting Proteins for C6orf106 Gene

Gene Ontology (GO) - Biological Process for C6orf106 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
GO:0016236 macroautophagy IBA --
genes like me logo Genes that share ontologies with C6orf106: view

No data available for Pathways by source and SIGNOR curated interactions for C6orf106 Gene

Drugs & Compounds for C6orf106 Gene

No Compound Related Data Available

Transcripts for C6orf106 Gene

Unigene Clusters for C6orf106 Gene

Chromosome 6 open reading frame 106:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for C6orf106 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8
SP1: - - -
SP2: -
SP3: -
SP4: - - -
SP5: - - -
SP6:

Relevant External Links for C6orf106 Gene

GeneLoc Exon Structure for
C6orf106
ECgene alternative splicing isoforms for
C6orf106

Expression for C6orf106 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for C6orf106 Gene

mRNA differential expression in normal tissues according to GTEx for C6orf106 Gene

This gene is overexpressed in Muscle - Skeletal (x4.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for C6orf106 Gene



NURSA nuclear receptor signaling pathways regulating expression of C6orf106 Gene:

C6orf106

SOURCE GeneReport for Unigene cluster for C6orf106 Gene:

Hs.643498

Evidence on tissue expression from TISSUES for C6orf106 Gene

  • Muscle(4.3)
  • Nervous system(4)
  • Eye(2.7)
  • Skin(2.2)
genes like me logo Genes that share expression patterns with C6orf106: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for C6orf106 Gene

Orthologs for C6orf106 Gene

This gene was present in the common ancestor of animals.

Orthologs for C6orf106 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC463186 34
  • 100 (n)
C6ORF106 35
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C6orf106 35
  • 99 (a)
OneToOne
C12H6orf106 34
  • 97.02 (n)
cow
(Bos Taurus)
Mammalia C6ORF106 35
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia D17Wsu92e 34 16 35
  • 94.39 (n)
oppossum
(Monodelphis domestica)
Mammalia C6orf106 35
  • 94 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia C6orf106 35
  • 81 (a)
OneToOne
chicken
(Gallus gallus)
Aves C26H6ORF106 34 35
  • 86.71 (n)
lizard
(Anolis carolinensis)
Reptilia C6orf106 35
  • 94 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia c6orf106 34
  • 72.9 (n)
zebrafish
(Danio rerio)
Actinopterygii C6H6orf106 35
  • 81 (a)
OneToOne
zgc:101577 34
  • 76.6 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000469 34
  • 50.89 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG5445 35
  • 20 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea C36E6.2 35
  • 26 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5611 35
  • 35 (a)
OneToOne
Species where no ortholog for C6orf106 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for C6orf106 Gene

ENSEMBL:
Gene Tree for C6orf106 (if available)
TreeFam:
Gene Tree for C6orf106 (if available)

Paralogs for C6orf106 Gene

Pseudogenes.org Pseudogenes for C6orf106 Gene

genes like me logo Genes that share paralogs with C6orf106: view

No data available for Paralogs for C6orf106 Gene

Variants for C6orf106 Gene

Sequence variations from dbSNP and Humsavar for C6orf106 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1000018719 -- 34,635,586(+) GAGGG(A/G)GGGAG intron-variant
rs1000030053 -- 34,631,426(+) GGGTT(A/C)AAGCC intron-variant
rs1000046463 -- 34,644,728(+) AGGGG(C/G)AGGGA intron-variant
rs1000099588 -- 34,604,543(+) TGTTC(A/G)TCTTC intron-variant
rs1000103682 -- 34,622,657(+) AGGAA(C/T)GTAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for C6orf106 Gene

Variant ID Type Subtype PubMed ID
dgv5954n100 CNV gain 25217958
esv1078185 CNV insertion 17803354
esv2665867 CNV deletion 23128226
esv2759418 CNV gain 17122850
esv2763967 CNV gain 21179565
esv3608664 CNV gain 21293372
esv3608665 CNV gain 21293372
esv3608666 CNV loss 21293372
esv988873 CNV deletion 20482838
nsv1033534 CNV gain 25217958
nsv516578 CNV loss 19592680
nsv5255 CNV deletion 18451855
nsv7888 CNV loss 18304495
nsv818410 CNV gain 17921354
nsv823667 CNV gain 20364138
nsv830640 CNV loss 17160897
nsv981134 CNV duplication 23825009

Variation tolerance for C6orf106 Gene

Residual Variation Intolerance Score: 34.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.36; 7.92% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C6orf106 Gene

Human Gene Mutation Database (HGMD)
C6orf106
SNPedia medical, phenotypic, and genealogical associations of SNPs for
C6orf106

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C6orf106 Gene

Disorders for C6orf106 Gene

Relevant External Links for C6orf106

Genetic Association Database (GAD)
C6orf106
Human Genome Epidemiology (HuGE) Navigator
C6orf106
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
C6orf106

No disorders were found for C6orf106 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C6orf106 Gene

Publications for C6orf106 Gene

  1. C6orf106 enhances NSCLC cell invasion by upregulating vimentin, and downregulating E-cadherin and P120ctn. (PMID: 25736925) Zhang X. … Wang E. (Tumour Biol. 2015) 2 3 64
  2. Meta-analysis of genome-wide scans for human adult stature identifies novel Loci and associations with measures of skeletal frame size. (PMID: 19343178) Soranzo N. … Deloukas P. (PLoS Genet. 2009) 3 46 64
  3. Genome-wide association analysis identifies 20 loci that influence adult height. (PMID: 18391952) Weedon M.N. … Frayling T.M. (Nat. Genet. 2008) 3 46 64
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for C6orf106 Gene

Sources for C6orf106 Gene

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