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Aliases for C6orf106 Gene

Aliases for C6orf106 Gene

  • Chromosome 6 Open Reading Frame 106 2 3 5
  • DJ391O22.4 3
  • FP852 3

External Ids for C6orf106 Gene

Previous GeneCards Identifiers for C6orf106 Gene

  • GC06M034601
  • GC06M034663
  • GC06M034278
  • GC06M034689
  • GC06M034899
  • GC06M035237
  • GC06M035732
  • GC06M034815
  • GC06M035575

Summaries for C6orf106 Gene

GeneCards Summary for C6orf106 Gene

C6orf106 (Chromosome 6 Open Reading Frame 106) is a Protein Coding gene. GO annotations related to this gene include ubiquitin binding.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C6orf106 Gene

Genomics for C6orf106 Gene

Regulatory Elements for C6orf106 Gene

Enhancers for C6orf106 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around C6orf106 on UCSC Golden Path with GeneCards custom track

Promoters for C6orf106 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around C6orf106 on UCSC Golden Path with GeneCards custom track

Genomic Location for C6orf106 Gene

Chromosome:
6
Start:
34,587,280 bp from pter
End:
34,696,859 bp from pter
Size:
109,580 bases
Orientation:
Minus strand

Genomic View for C6orf106 Gene

Genes around C6orf106 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C6orf106 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C6orf106 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C6orf106 Gene

Proteins for C6orf106 Gene

  • Protein details for C6orf106 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H6K1-CF106_HUMAN
    Recommended name:
    Uncharacterized protein C6orf106
    Protein Accession:
    Q9H6K1
    Secondary Accessions:
    • B2R8K7
    • Q5VV77
    • Q96MG5
    • Q9BUR9

    Protein attributes for C6orf106 Gene

    Size:
    298 amino acids
    Molecular mass:
    32872 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for C6orf106 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for C6orf106 Gene

Proteomics data for C6orf106 Gene at MOPED

Post-translational modifications for C6orf106 Gene

  • Ubiquitination at Lys 15, Lys 205, Lys 218, Lys 228, Lys 240, and Lys 287
  • Modification sites at PhosphoSitePlus

Other Protein References for C6orf106 Gene

No data available for DME Specific Peptides for C6orf106 Gene

Domains & Families for C6orf106 Gene

Protein Domains for C6orf106 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C6orf106: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for C6orf106 Gene

Function for C6orf106 Gene

Phenotypes for C6orf106 Gene

GenomeRNAi human phenotypes for C6orf106:
genes like me logo Genes that share phenotypes with C6orf106: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C6orf106 Gene

Localization for C6orf106 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for C6orf106 Gene COMPARTMENTS Subcellular localization image for C6orf106 gene
Compartment Confidence
nucleus 3
vacuole 3
cytosol 1
extracellular 1
golgi apparatus 1
plasma membrane 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for C6orf106 Gene

Pathways & Interactions for C6orf106 Gene

SuperPathways for C6orf106 Gene

No Data Available

Interacting Proteins for C6orf106 Gene

Gene Ontology (GO) - Biological Process for C6orf106 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for C6orf106 Gene

Drugs & Compounds for C6orf106 Gene

No Compound Related Data Available

Transcripts for C6orf106 Gene

Unigene Clusters for C6orf106 Gene

Chromosome 6 open reading frame 106:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for C6orf106 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8
SP1: - - -
SP2: -
SP3: -
SP4: - - -
SP5: - - -
SP6:

Relevant External Links for C6orf106 Gene

GeneLoc Exon Structure for
C6orf106
ECgene alternative splicing isoforms for
C6orf106

Expression for C6orf106 Gene

mRNA expression in normal human tissues for C6orf106 Gene

mRNA differential expression in normal tissues according to GTEx for C6orf106 Gene

This gene is overexpressed in Muscle - Skeletal (x4.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for C6orf106 Gene



SOURCE GeneReport for Unigene cluster for C6orf106 Gene Hs.643498

genes like me logo Genes that share expression patterns with C6orf106: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for C6orf106 Gene

Orthologs for C6orf106 Gene

This gene was present in the common ancestor of animals.

Orthologs for C6orf106 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia C12H6orf106 35
  • 97.02 (n)
  • 98.97 (a)
C6orf106 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia D17Wsu92e 35
  • 94.39 (n)
  • 97.25 (a)
D17Wsu92e 16
D17Wsu92e 36
  • 97 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia LOC463186 35
  • 100 (n)
  • 100 (a)
C6ORF106 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia C6ORF106 36
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia C6orf106 36
  • 94 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia C6orf106 36
  • 81 (a)
OneToOne
chicken
(Gallus gallus)
Aves C26H6ORF106 35
  • 86.71 (n)
  • 93.81 (a)
C26H6ORF106 36
  • 94 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia C6orf106 36
  • 94 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia c6orf106 35
  • 72.9 (n)
  • 80.94 (a)
zebrafish
(Danio rerio)
Actinopterygii zgc:101577 35
  • 76.6 (n)
  • 81.56 (a)
C6H6orf106 36
  • 81 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000469 35
  • 50.89 (n)
  • 40.43 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG5445 36
  • 20 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea C36E6.2 36
  • 26 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5611 36
  • 35 (a)
OneToOne
Species with no ortholog for C6orf106:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for C6orf106 Gene

ENSEMBL:
Gene Tree for C6orf106 (if available)
TreeFam:
Gene Tree for C6orf106 (if available)

Paralogs for C6orf106 Gene

Pseudogenes.org Pseudogenes for C6orf106 Gene

genes like me logo Genes that share paralogs with C6orf106: view

No data available for Paralogs for C6orf106 Gene

Variants for C6orf106 Gene

Sequence variations from dbSNP and Humsavar for C6orf106 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1046318 -- 34,587,567(-) TCAAT(C/T)TGAGC utr-variant-3-prime
rs1139976 -- 34,588,219(-) GAACA(A/C)ACCAT utr-variant-3-prime
rs1201872 -- 34,587,932(-) ACCAC(C/T)TGCGT utr-variant-3-prime
rs5875506 -- 34,674,882(+) GGTGA(-/G)GATCC intron-variant
rs6457784 -- 34,612,967(+) gaacc(C/T)gggag intron-variant

Structural Variations from Database of Genomic Variants (DGV) for C6orf106 Gene

Variant ID Type Subtype PubMed ID
dgv1938e1 CNV Complex 17122850
dgv6831n71 CNV Gain 21882294
nsv516578 CNV Loss 19592680
nsv885792 CNV Gain 21882294
nsv823667 CNV Gain 20364138
nsv818410 CNV Gain 17921354
nsv830640 CNV Loss 17160897
esv988873 CNV Deletion 20482838
nsv885794 CNV Gain 21882294
nsv7888 CNV Loss 18304495
esv2665867 CNV Deletion 23128226
esv1078185 CNV Insertion 17803354
nsv5255 CNV Loss 18451855

Variation tolerance for C6orf106 Gene

Residual Variation Intolerance Score: 34.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.36; 7.92% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C6orf106 Gene

Human Gene Mutation Database (HGMD)
C6orf106

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C6orf106 Gene

Disorders for C6orf106 Gene

Relevant External Links for C6orf106

Genetic Association Database (GAD)
C6orf106
Human Genome Epidemiology (HuGE) Navigator
C6orf106
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
C6orf106

No disorders were found for C6orf106 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C6orf106 Gene

Publications for C6orf106 Gene

  1. Meta-analysis of genome-wide scans for human adult stature identifies novel Loci and associations with measures of skeletal frame size. (PMID: 19343178) Soranzo N. … Deloukas P. (PLoS Genet. 2009) 3 48 67
  2. C6orf106 enhances NSCLC cell invasion by upregulating vimentin, and downregulating E-cadherin and P120ctn. (PMID: 25736925) Zhang X. … Wang E. (Tumour Biol. 2015) 3
  3. A novel biomarker C6orf106 promotes the malignant progression of breast cancer. (PMID: 25953261) Jiang G. … Wang E. (Tumour Biol. 2015) 3
  4. A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning. (PMID: 26673895) KA+rlA+ K. … GAPrlich D. (Elife 2015) 3
  5. The MEKK1 PHD ubiquitinates TAB1 to activate MAPKs in response to cytokines. (PMID: 25260751) Charlaftis N. … Gallagher E. (EMBO J. 2014) 3

Products for C6orf106 Gene

Sources for C6orf106 Gene

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