C6orf106 Gene
protein-coding GIFtS: 47
GCID: GC06M034899
|
|
chromosome 6 open reading frame 106
| |
Aliases
for C6orf106 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Chromosome 6 Open Reading Frame 1061 2 | | DJ391O22.41 | | FLJ221951 | | FP8522 | | Uncharacterized Protein C6orf1062 |
Export aliases for C6orf106 gene to outside databasesPrevious GC identifers: GC06M034601 GC06M034663 GC06M034278 GC06M034689 |
Summaries
for C6orf106 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for C6orf106 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000006.11 NC_018917.1 NT_007592.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the C6orf106 gene promoter:
Max1 p53 ATF-2 HNF-4alpha2 STAT5A C/EBPalpha HNF-4alpha1 CREB CRE-BP1 NF-kappaB1
Other transcription factors
Search SABiosciences Chromatin IP Primers for C6orf106
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C6orf106 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 6p21.31 Ensembl cytogenetic band: 6p21.31 HGNC cytogenetic band: 6p21.31C6orf106 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 6 GeneLoc Exon Structure GeneLoc location for GC06M034899: view genomic region
(about GC identifiers)
Start:
|
34,555,065 bp from pter |
End:
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34,664,636 bp from pter |
Size:
|
109,572 bases |
Orientation:
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minus strand |
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Proteins
for C6orf106 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CF106_HUMAN, Q9H6K1 (See
protein sequence)Recommended Name: Uncharacterized protein C6orf106 Size: 298 amino acids; 32872 Da
Secondary accessions: B2R8K7 Q5VV77 Q96MG5 Q9BUR9Alternative splicing: 2 isoforms: Q9H6K1-1 Q9H6K1-2 Explore the universe of human proteins at neXtProt for C6orf106: NX_Q9H6K1
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9H6K1
C6orf106 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_073595.2 NP_077270.1
ENSEMBL proteins: ENSP00000363135 ENSP00000363138 ENSP00000363133
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005575 | cellular_component |
ND | -- |
C6orf106 for ontologies About GeneDecksing
C6orf106 Antibody Products:
Assay Products for C6orf106: |
Protein
Domains /
Families
for C6orf106 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
C6orf106 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q9H6K1ProtoNet protein and cluster: Q9H6K1 |
Function
for C6orf106 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for C6orf106 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for C6orf106 (see all 4)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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Synthesis Service for C6orf106 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C6orf106 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C6orf106 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003674 | molecular_function |
ND | -- |
C6orf106 for ontologies About GeneDecksing
|
Pathways & Interactions
for C6orf106 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for C6orf106
STRING Interaction
Network Preview (showing 3 interactants - click image to see more details)
5 Interacting proteins for C6orf106 (Q9H6K13 ENSP000003631354) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008150 | biological_process |
ND | -- |
C6orf106 for ontologies About GeneDecksing
|
Drugs & Compounds
for C6orf106 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for C6orf106
Search CenterWatch for drugs/clinical trials and news about C6orf106 / CF106
|
Transcripts
for C6orf106 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for C6orf106 gene (2 alternative transcripts): NM_022758.4 NM_024294.2 Unigene Cluster for C6orf106: Chromosome 6 open reading frame 106 Hs.643498 [show with all ESTs]Unigene Representative Sequence: NM_0242943 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000374023(uc003ojr.2) ENST00000374026(uc003ojs.2) ENST00000374021
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for C6orf106 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for C6orf106 (see all 4)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): C6orf106 (NM_022758) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for C6orf106 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C6orf106 |
Additional cDNA sequence: AF052106.1 AF370387.1 AK025848.1 AK056964.1 AK313410.1 BC002328.1 BC010143.2 BC010184.1 BC013241.1 BC071885.1 BC075810.1 BC107732.1 20 DOTS entries: DT.95263974 DT.101954771 DT.97790845 DT.121358688 DT.95341998 DT.315335 DT.100793717 DT.121358621 DT.121359021 DT.95341996 DT.121358984 DT.95263976 DT.92448842 DT.97825516 DT.121358609 DT.121358612 DT.121358670 DT.40132725 DT.40274976 DT.97835143 24/401 AceView cDNA sequences (see all 401): CD251885 CR593696 BQ129348 BQ014885 BF115182 BI910503 BU857277 BQ901181 AK025848 BE727547 AI677935 AW192449 BU742818 BE884510 BU195587 AA782326 BC013241 CN480919 BU194590 AW264235 AW673200 AF052106 BU620574 NM_022758
GeneLoc Exon Structure
5/6 Alternative Splicing Database (ASD) splice patterns (SP) for C6orf106 (see all 6) About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7 | ^ | 8 |
|---|
|
| SP1: | | | | | - | | | | - | | | | | | | | - | | | | |
| SP2: | | | | | | | | | - | | | | | | | | | | | | |
| SP3: | | | | | - | | | | | | | | | | | | | | | | |
| SP4: | | | | | - | | | | - | | - | | | | | | | | | | |
| SP5: | | | | | | | | | - | | - | | | | | | - | | | |
ECgene alternative splicing isoforms for C6orf106
|
Expression
for C6orf106 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| C6orf106 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GTGCCTAGGA
About this image
See C6orf106 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for C6orf106
SOURCE GeneReport for Unigene cluster: Hs.643498
SABiosciences Custom PCR Arrays for C6orf106
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for C6orf106
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat C6orf106 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat C6orf106 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat C6orf106 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C6orf106 |
Orthologs
for C6orf106 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for C6orf106 gene from 6/17 species (see all 17) About this table
ENSEMBL Gene Tree for C6orf106 (if available)
TreeFam Gene Tree for C6orf106 (if available) |
Paralogs
for C6orf106 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for C6orf106 gene
C6orf106 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for C6orf106
PGOHUM00000240829
|
Genomic Variants
for C6orf106 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 6 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for C6orf106 (34555065 - 34664636 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for C6orf106
3 CNVs: 9528 3605 32800 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing C6orf106 |
|
Disorders
/ Diseases
for C6orf106 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
C6orf106 for disorders About GeneDecksing
OMIM gene information: 612217
OMIM disorders: --
5  diseases for C6orf106: About MalaCardsdown syndrome critical region pediatric crohns disease down syndrome crohn's disease
breast cancer
Human Genome Epidemiology (HuGE) Navigator: C6orf106 (3 documents)
Export disorders for C6orf106 gene to outside databases
|
Publications
for C6orf106 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for C6orf106 gene, integrated from 9 sources (see all 27):
(articles sorted by number of sources associating them with C6orf106) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
- Proteome-wide identification of ubiquitylation sites b y conjugation of engineered lysine-less ubiquitin. (PubMed id 22053931)1 Oshikawa K....Nakayama K.I. (2012)
- Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (2011)
- Ubiquitin ligase substrate identification through qua ntitative proteomics at both the protein and peptide levels. (PubMed id 21987572)1 Lee K.A....Doedens J.R. (2011)
- Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
|
External Searches for C6orf106 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing C6orf106 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing C6orf106 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing C6orf106 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for C6orf106 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for C6orf106 gene:
Search GeneIP for patents involving C6orf106
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for C6orf106 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for C6orf106 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for C6orf106 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for C6orf106 | | | OriGene Protein Over-expression Lysate for C6orf106 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for C6orf106 | | OriGene 3'-UTR Clone for C6orf106 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for C6orf106 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for C6orf106 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat C6orf106 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing C6orf106 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C6orf106 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat C6orf106 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat C6orf106 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat C6orf106 |
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 | | | C6orf106 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C6orf106 |
|  |  |  | | | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C6orf106 |
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