Aliases for C6orf10 Gene
Aliases for C6orf10 Gene
External Ids for C6orf10 Gene
- HGNC: 13922
- Entrez Gene: 10665
- Ensembl: ENSG00000204296
- UniProtKB: Q5SRN2
Previous GeneCards Identifiers for C6orf10 Gene
- GC06M032287
- GC06M032031
- GC06M032332
- GC06M032368
Summaries for C6orf10 Gene
GeneCards Summary for C6orf10 Gene
C6orf10 (Chromosome 6 Open Reading Frame 10) is a Protein Coding gene.
No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C6orf10 Gene
Genomics for C6orf10 Gene
Regulatory Elements for C6orf10 Gene
Enhancers for C6orf10 Gene
| GeneHancer Identifier | Enhancer Score | Enhancer Sources | Gene-Enhancer Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Gene Targets for Enhancer |
|---|---|---|---|---|---|---|---|---|
| GH06G032432 | 0.9 | ENCODE dbSUPER | 10.8 | -60.1 | -60055 | 0.1 | CTCF ZNF654 TRIM22 JUNB REST RAD21 RFX5 ZNF664 SMC3 | HCG23 C6orf10 HLA-DQB1-AS1 HLA-DQB1 PSMB9 TAP1 HLA-DRA BTNL2 |
| GH06G032528 | 0.9 | ENCODE dbSUPER | 4.2 | -157.9 | -157895 | 2.4 | TBP SMAD5 NR2F1 RELA RFX5 SP1 EGR1 RFXANK POLR2A IKZF1 | HLA-DRB1 HLA-DRB6 HLA-DQA2 HLA-DRB5 HLA-DQA1 HLA-DQB2 HLA-DQB1-AS1 HCG23 C6orf10 GC06M032524 |
| GH06G032369 | 0.7 | ENCODE | 0.7 | +1.3 | 1325 | 2.6 | JUN CEBPB RAD21 EP300 RFX5 JUND MAFF GATA2 STAT3 RCOR1 | HLA-DRB1 HLA-DRB6 HLA-DQA2 RNF5 C4A HLA-DRB5 HLA-DQB2 LOC101929163 ATF6B TNXB |
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around C6orf10 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the C6orf10 gene promoter:
Regulatory Element Products
Genomic Location for C6orf10 Gene
- Chromosome:
- 6
- Start:
- 32,288,526 bp from pter
- End:
- 32,372,114 bp from pter
- Size:
- 83,589 bases
- Orientation:
- Minus strand
Genomic View for C6orf10 Gene
Genes around C6orf10 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 6p21.32 by Ensembl
- 6p21.32 by Entrez Gene
- 6p21.32 by HGNC
C6orf10 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for C6orf10 Gene
Proteins for C6orf10 Gene
-
Protein details for C6orf10 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q5SRN2-CF010_HUMAN
- Recommended name:
- Uncharacterized protein C6orf10
- Protein Accession:
- Q5SRN2
- A2BET1
- A2BET2
- A6NME2
- B0S7R2
- B0S7R3
- E9PMB1
- Q5SPI9
- Q5SPJ0
- Q5SPK9
- Q5SPL0
- Q5SRN3
- Q5TG25
- Q5TG26
- Q8N4B6
Protein attributes for C6orf10 Gene
- Size:
- 563 amino acids
- Molecular mass:
- 61626 Da
- Quaternary structure:
- No Data Available
Protein Expression for C6orf10 Gene
Post-translational modifications for C6orf10 Gene
Other Protein References for C6orf10 Gene
Antibody Products
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-
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Protein Products
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Assay Products
No data available for DME Specific Peptides for C6orf10 Gene
Domains & Families for C6orf10 Gene
Protein Domains for C6orf10 Gene
- ProtoNet:
Suggested Antigen Peptide Sequences for C6orf10 Gene
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Graphical View of Domain Structure for InterPro Entry
No data available for Gene Families and UniProtKB/Swiss-Prot for C6orf10 Gene
Function for C6orf10 Gene
Phenotypes for C6orf10 Gene
- GenomeRNAi human phenotypes for C6orf10:
Animal Model Products
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-
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-
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CRISPR Products
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-
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miRNA Products
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- NM_006781
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-
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- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
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-
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-
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Flow Cytometry Products
No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for C6orf10 Gene
Localization for C6orf10 Gene
Subcellular locations from UniProtKB/Swiss-Prot for C6orf10 Gene
- Membrane; Multi-pass membrane protein.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| extracellular | 2 |
| endoplasmic reticulum | 2 |
| plasma membrane | 1 |
| peroxisome | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IDA | 21630459 |
| GO:0016020 | membrane | IEA | -- |
| GO:0016021 | integral component of membrane | IEA | -- |
Pathways & Interactions for C6orf10 Gene
No data available for Pathways by source and SIGNOR curated interactions for C6orf10 Gene
Transcripts for C6orf10 Gene
mRNA/cDNA for C6orf10 Gene
- (7) REFSEQ mRNAs :
- (4) Additional mRNA sequences :
- (8) Selected AceView cDNA sequences:
- (10) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for C6orf10 Gene
CRISPR Products
-
OriGene CRISPR knockouts for C6orf10
-
Santa Cruz Biotechnology (SCBT) CRISPR for C6orf10
- GenScript: Design CRISPR guide RNA sequences for C6orf10
miRNA Products
- Search ViGene Biosciences for C6orf10
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for C6orf10
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-
ViGene Biosciences ready-to-package AAV shRNAs for C6orf10 gene
Clone Products
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- XM_005275342
- XM_011548190
- XM_011548378
- XM_011548379
- XM_011548380
- XM_011548381
- XM_011548382
- NM_006781
- NM_001286474
- NM_001286475
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for C6orf10
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for C6orf10
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Flow Cytometry Products
Expression for C6orf10 Gene
mRNA differential expression in normal tissues according to GTEx for C6orf10 Gene
This gene is overexpressed in Testis (x51.8).
This gene is overexpressed in Pancreas (68.7).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for C6orf10 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of C6orf10 Gene:
C6orf10SOURCE GeneReport for Unigene cluster for C6orf10 Gene:
Hs.567414Evidence on tissue expression from TISSUES for C6orf10 Gene
- Nervous system(4.1)
Primer Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for C6orf10 Gene
Orthologs for C6orf10 Gene
This gene was present in the common ancestor of mammals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | C6orf10 35 |
|
OneToOne | |
| C6H6orf10 34 |
|
||||
| cow (Bos Taurus) |
Mammalia | C6orf10 35 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | C6orf10 35 |
|
OneToOne |
- Species where no ortholog for C6orf10 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- mouse (Mus musculus)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rat (Rattus norvegicus)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Paralogs for C6orf10 Gene
No data available for Paralogs for C6orf10 Gene
Variants for C6orf10 Gene
| SNP ID | Clin | Chr 06 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000007662 | -- | 32,351,023(+) | AGACA(A/C/T)ATATG | intron-variant | |
| rs1000067287 | -- | 32,321,111(+) | CCATG(-/T)TATTT | intron-variant | |
| rs1000078036 | -- | 32,371,552(+) | TCAAT(A/G)AGAGT | intron-variant | |
| rs1000129903 | -- | 32,371,298(+) | TAGGG(C/T)AGTTA | intron-variant | |
| rs1000132775 | -- | 32,334,966(+) | GAGGT(A/G)GAGCT | intron-variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv10404n54 | CNV | loss | 21841781 |
| dgv10463n54 | CNV | loss | 21841781 |
| dgv10472n54 | CNV | loss | 21841781 |
| esv1081136 | CNV | deletion | 17803354 |
| esv2351738 | CNV | deletion | 18987734 |
| esv2569081 | CNV | deletion | 19546169 |
| esv2731826 | CNV | deletion | 23290073 |
| esv2731827 | CNV | deletion | 23290073 |
| esv2731828 | CNV | deletion | 23290073 |
| esv275065 | CNV | loss | 21479260 |
| esv3287273 | CNV | deletion | 24192839 |
| esv3397 | CNV | loss | 18987735 |
| esv3567544 | CNV | deletion | 23714750 |
| esv3608581 | CNV | loss | 21293372 |
| esv3890829 | CNV | loss | 25118596 |
| esv7532 | CNV | loss | 19470904 |
| esv9046 | CNV | loss | 19470904 |
| nsv1073969 | CNV | deletion | 25765185 |
| nsv1112900 | CNV | deletion | 24896259 |
| nsv1126749 | CNV | deletion | 24896259 |
| nsv472192 | CNV | novel sequence insertion | 20440878 |
| nsv479791 | CNV | novel sequence insertion | 20440878 |
| nsv479933 | CNV | novel sequence insertion | 20440878 |
| nsv480054 | CNV | novel sequence insertion | 20440878 |
| nsv830630 | CNV | loss | 17160897 |
| nsv956554 | CNV | deletion | 24416366 |
| nsv981130 | CNV | duplication | 23825009 |
Residual Variation Intolerance Score:
97.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
24.34;
99.63% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for C6orf10 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- C6orf10
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C6orf10 Gene
Disorders for C6orf10 Gene
Relevant External Links for C6orf10
No disorders were found for C6orf10 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C6orf10 Gene
Publications for C6orf10 Gene
- BTL-II: a polymorphic locus with homology to the butyrophilin gene family, located at the border of the major histocompatibility complex class II and class III regions in human and mouse. (PMID: 10803852) Stammers M. … Beck S. (Immunogenetics 2000) 2 3 22 64
- A genome-wide association study in progressive multiple sclerosis. (PMID: 22457343) Martinelli-Boneschi F. … Comi G. (Mult. Scler. 2012) 3 46 64
- Genome-wide association study identifies three new susceptibility loci for adult asthma in the Japanese population. (PMID: 21804548) Hirota T. … Tamari M. (Nat. Genet. 2011) 3 46 64
- Identification of independent risk loci for Graves' disease within the MHC in the Japanese population. (PMID: 21900946) Nakabayashi K. … Shirasawa S. (J. Hum. Genet. 2011) 3 46 64
- Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci. (PMID: 20453842) Stahl E.A. … Plenge R.M. (Nat. Genet. 2010) 3 46 64
Products for C6orf10 Gene
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- VectorBuilder custom plasmid, inducible vectors for C6orf10
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for C6orf10
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for C6orf10 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
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