C6orf10 Gene
protein-coding GIFtS: 43
GCID: GC06M032261
|
|
chromosome 6 open reading frame 10
| |
Aliases
for C6orf10 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Chromosome 6 Open Reading Frame 101 2 | | TSBP1 2 | | Testis Specific Basic Protein2 | | Uncharacterized Protein C6orf102 |
Export aliases for C6orf10 gene to outside databasesPrevious GC identifers: GC06M032287 GC06M032031 GC06M032332 GC06M032368 |
Summaries
for C6orf10 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Gene Wiki entry for C6orf10
|
Genomic Views
for C6orf10 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000006.11 NC_018917.1 NT_007592.15 NT_113891.2 NT_167244.1 NT_167245.1 NT_167246.1 NT_167247.1
- NT_167248.1 NT_167249.1
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the C6orf10 gene promoter:
NF-1 FOXO3 CUTL1 LCR-F1 FOXO3b FOXJ2 (long isoform) FOXO1a ARP-1 FOXO3a FOXJ2
Other transcription factors
Search SABiosciences Chromatin IP Primers for C6orf10
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C6orf10 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 6p21.3 Ensembl cytogenetic band: 6p21.32 HGNC cytogenetic band: 6p21.32C6orf10 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 6 GeneLoc Exon Structure GeneLoc location for GC06M032261: view genomic region
(about GC identifiers)
Start:
|
32,256,303 bp from pter |
End:
|
32,339,684 bp from pter |
Size:
|
83,382 bases |
Orientation:
|
minus strand |
6/7 alternative locations (see all 7):
| Chr6-,ALT_REF_LOCI_4 32,222,970-32,391,764 | Chr6-,ALT_REF_LOCI_2 32,209,049-32,327,100 | Chr6-,ALT_REF_LOCI_3 32,236,325-32,326,219 | | Chr6-,ALT_REF_LOCI_6 32,218,297-32,332,708 | Chr6-,ALT_REF_LOCI_1 32,295,497-32,358,944 | Chr6-,ALT_REF_LOCI_5 32,281,583-32,330,664 | |
|
Proteins
for C6orf10 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CF010_HUMAN, Q5SRN2 (See
protein sequence)Recommended Name: Uncharacterized protein C6orf10 Size: 563 amino acids; 61626 Da
Subcellular location: Membrane; Multi-pass membrane protein (Potential)
Secondary accessions: A2BET1 A2BET2 A6NME2 B0S7R2 B0S7R3 Q5SPI9 Q5SPJ0 Q5SPK9 Q5SPL0 Q5SRN3 Q5TG25Q5TG26 Q8N4B6Alternative splicing: 2 isoforms: Q5SRN2-1 Q5SRN2-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for C6orf10: NX_Q5SRN2
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q5SRN2
C6orf10 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_006772.3
ENSEMBL proteins: ENSP00000411164 ENSP00000415517 ENSP00000364155 ENSP00000431199 ENSP00000435103 ENSP00000432814 ENSP00000432566 ENSP00000364146
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016021 | integral to membrane |
IEA | -- |
C6orf10 for ontologies About GeneDecksing
C6orf10 Antibody Products:
Assay Products for C6orf10: |
Protein
Domains /
Families
for C6orf10 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| ProtoNet protein and cluster: Q5SRN2 |
Function
for C6orf10 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for C6orf10
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for C6orf10
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): C6orf10 (NM_006443) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for C6orf10 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C6orf10 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C6orf10 |
|
Pathways & Interactions
for C6orf10 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for C6orf10
|
Drugs & Compounds
for C6orf10 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for C6orf10
Search CenterWatch for drugs/clinical trials and news about C6orf10 / CF010
|
Transcripts
for C6orf10 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for C6orf10 gene: NM_006781.3 Unigene Cluster for C6orf10: Chromosome 6 open reading frame 10 Hs.567414 [show with all ESTs]Unigene Representative Sequence: BC0347748 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000442822(uc011dpx.2) ENST00000447241(uc021yvs.1 uc021yvt.1)
ENST00000375015(uc011dpz.2) ENST00000533191(uc021yvu.1 uc021yvv.1)
ENST00000527965 ENST00000532023 ENST00000534588 ENST00000375007
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for C6orf10
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for C6orf10
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): C6orf10 (NM_006443) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for C6orf10 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C6orf10 |
Additional cDNA sequence: AK225742.1 AK302176.1 AK310230.1 BC034774.1 6 DOTS entries: DT.103888 DT.100743472 DT.99996483 DT.100743473 DT.121380749 DT.99961872 8 AceView cDNA sequences: BX113229 BC034774 AI935027 NM_006781 BI826769 BV183550 AA629287 AA936514
GeneLoc Exon Structure
|
Expression
for C6orf10 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| C6orf10 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GATGAAGAAC
About this image
See C6orf10 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for C6orf10
SOURCE GeneReport for Unigene cluster: Hs.567414
SABiosciences Custom PCR Arrays for C6orf10
Primer
Products: | | Browse OriGene genome-wide validated SYBR primer pairs
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat C6orf10 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat C6orf10 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat C6orf10 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C6orf10 |
Orthologs
for C6orf10 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of human and mouse.
Orthologs for C6orf10 gene from 1/2 species (see all 2) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
175 |
testis specific basic protein |
-- |
|
syntenic - |
ENSEMBL Gene Tree for C6orf10 (if available)
TreeFam Gene Tree for C6orf10 (if available) |
Paralogs
for C6orf10 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for C6orf10 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 6 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for C6orf10 (32256303 - 32339684 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 7 variations for C6orf10
2 CNVs: 62498 99491
5 Indels: 28275 42961 47099 40851 62497 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing C6orf10 |
|
Disorders
/ Diseases
for C6orf10 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
C6orf10 for disorders About GeneDecksing
7  diseases for C6orf10: About MalaCardssystemic lupus erythematosus lupus erythematosus rheumatoid arthritis multiple sclerosis
vitiligo arthritis psoriasis
Human Genome Epidemiology (HuGE) Navigator: C6orf10 (14 documents)
Export disorders for C6orf10 gene to outside databases
|
Publications
for C6orf10 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for C6orf10 gene, integrated from 9 sources (see all 28):
(articles sorted by number of sources associating them with C6orf10) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- BTL-II: a polymorphic locus with homology to the butyrophilin gene family, located at the border of the major histocompatibility complex class II and class III regions in human and mouse. (PubMed id 10803852)1, 3, 9 Stammers M.... Beck S. (2000)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
- A genome-wide association study in progressive multipl e sclerosis. (PubMed id 22457343)1 Martinelli-Boneschi F....Comi G. (2012)
- Genetic associations for activated partial thromboplas tin time and prothrombin time, their gene expression profiles, and risk of coron ary artery disease. (PubMed id 22703881)1 Tang W....Folsom A.R. (2012)
- Genome-wide association study in Han Chinese identifie s four new susceptibility loci for coronary artery disease. (PubMed id 22751097)1 Lu X....Gu D. (2012)
- Functional dissection of lysine deacetylases reveals t hat HDAC1 and p300 regulate AMPK. (PubMed id 22318606)1 Lin Y.Y....Boeke J.D. (2012)
- Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women. (PubMed id 22589738)1 Fox C.S....Borecki I.B. (2012)
- Genome-wide association study identifies three new sus ceptibility loci for adult asthma in the Japanese population. (PubMed id 21804548)1 Hirota T....Tamari M. (2011)
- Genome-wide analysis identifies a quantitative trait locus in the MHC class II region associated with generalized vitiligo age of on set. (PubMed id 21326295)1 Jin Y....Spritz R.A. (2011)
|
External Searches for C6orf10 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing C6orf10 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing C6orf10 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing C6orf10 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for C6orf10 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for C6orf10 gene:
Search GeneIP for patents involving C6orf10
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for C6orf10 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for C6orf10 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for C6orf10 | | Browse OriGene genome-wide validated SYBR primer pairs | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for C6orf10 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for C6orf10 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for C6orf10 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for C6orf10 | | OriGene Custom Protein Services for C6orf10 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat C6orf10 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing C6orf10 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C6orf10 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat C6orf10 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat C6orf10 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat C6orf10 |
| |
 |  |  |  | |
| | | | Search Tocris compounds for C6orf10 |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | C6orf10 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C6orf10 |
|  |  |  | | | | Search ThermoFisher Antibodies for C6orf10 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C6orf10 |
|
|
|
|
