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Aliases for C6orf10 Gene

Aliases for C6orf10 Gene

  • Chromosome 6 Open Reading Frame 10 2 3 5
  • Testis Specific Basic Protein 2 3
  • Uncharacterized Protein C6orf10 3
  • TSBP 3

External Ids for C6orf10 Gene

Previous GeneCards Identifiers for C6orf10 Gene

  • GC06M032287
  • GC06M032031
  • GC06M032332
  • GC06M032368

Summaries for C6orf10 Gene

GeneCards Summary for C6orf10 Gene

C6orf10 (Chromosome 6 Open Reading Frame 10) is a Protein Coding gene.

Gene Wiki entry for C6orf10 Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C6orf10 Gene

Genomics for C6orf10 Gene

Regulatory Elements for C6orf10 Gene

Enhancers for C6orf10 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06F032793 0.8 FANTOM5 Ensembl ENCODE 11.6 -422.4 -422387 1.4 HLA-DOB C4A TAP1 PSMB8 HCG23 C6orf10 SYNGAP1 PSMB9 HLA-DMA TAP2
GH06F032432 0.6 ENCODE 10.8 -60.1 -60055 0.1 ZNF664 CTCF ZNF654 JUNB SMC3 TRIM22 REST RAD21 RFX5 HCG23 C6orf10 HLA-DQB1-AS1 HLA-DQB1 PSMB9 TAP1 HLA-DRA BTNL2
GH06F032528 0.7 ENCODE 4.2 -157.9 -157895 2.4 TBP SMAD5 RFX5 RELA SP1 RFXANK POLR2A EGR1 IKZF1 MLLT1 HLA-DRB1 HLA-DRB6 HLA-DQA2 HLA-DRB5 HLA-DQA1 HLA-DQB2 HLA-DQB1-AS1 HCG23 C6orf10 GC06M032524
GH06F032369 0.7 ENCODE 0.8 +1.3 1325 2.6 JUN CEBPB RAD21 EP300 RFX5 JUND MAFF STAT3 RCOR1 FOS HLA-DRB1 HLA-DRB6 HLA-DQA2 RNF5 C4A HLA-DRB5 HLA-DQB2 LOC101929163 ATF6B TNXB
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around C6orf10 on UCSC Golden Path with GeneCards custom track

Genomic Location for C6orf10 Gene

Chromosome:
6
Start:
32,288,526 bp from pter
End:
32,372,114 bp from pter
Size:
83,589 bases
Orientation:
Minus strand

Genomic View for C6orf10 Gene

Genes around C6orf10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C6orf10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C6orf10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Proteins for C6orf10 Gene

  • Protein details for C6orf10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5SRN2-CF010_HUMAN
    Recommended name:
    Uncharacterized protein C6orf10
    Protein Accession:
    Q5SRN2
    Secondary Accessions:
    • A2BET1
    • A2BET2
    • A6NME2
    • B0S7R2
    • B0S7R3
    • E9PMB1
    • Q5SPI9
    • Q5SPJ0
    • Q5SPK9
    • Q5SPL0
    • Q5SRN3
    • Q5TG25
    • Q5TG26
    • Q8N4B6

    Protein attributes for C6orf10 Gene

    Size:
    563 amino acids
    Molecular mass:
    61626 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for C6orf10 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for C6orf10 Gene

Post-translational modifications for C6orf10 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for C6orf10 Gene

Domains & Families for C6orf10 Gene

Protein Domains for C6orf10 Gene

ProtoNet:

Suggested Antigen Peptide Sequences for C6orf10 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C6orf10: view

No data available for Gene Families and UniProtKB/Swiss-Prot for C6orf10 Gene

Function for C6orf10 Gene

Phenotypes for C6orf10 Gene

genes like me logo Genes that share phenotypes with C6orf10: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for C6orf10 Gene

Localization for C6orf10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for C6orf10 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C6orf10 gene
Compartment Confidence
nucleus 5
extracellular 2
endoplasmic reticulum 2
plasma membrane 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for C6orf10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 21630459
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with C6orf10: view

Pathways & Interactions for C6orf10 Gene

SuperPathways for C6orf10 Gene

No Data Available

Interacting Proteins for C6orf10 Gene

Selected Interacting proteins: Q5SRN2-CF010_HUMAN for C6orf10 Gene via IID

Symbol External ID(s) Details
SLA

Gene Ontology (GO) - Biological Process for C6orf10 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for C6orf10 Gene

Transcripts for C6orf10 Gene

mRNA/cDNA for C6orf10 Gene

Unigene Clusters for C6orf10 Gene

Chromosome 6 open reading frame 10:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for C6orf10 Gene

No ASD Table

Relevant External Links for C6orf10 Gene

GeneLoc Exon Structure for
C6orf10
ECgene alternative splicing isoforms for
C6orf10

Expression for C6orf10 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for C6orf10 Gene

mRNA differential expression in normal tissues according to GTEx for C6orf10 Gene

This gene is overexpressed in Testis (x51.8).

Protein differential expression in normal tissues from HIPED for C6orf10 Gene

This gene is overexpressed in Pancreas (68.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for C6orf10 Gene



Protein tissue co-expression partners for C6orf10 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of C6orf10 Gene:

C6orf10

SOURCE GeneReport for Unigene cluster for C6orf10 Gene:

Hs.567414
genes like me logo Genes that share expression patterns with C6orf10: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for C6orf10 Gene

Orthologs for C6orf10 Gene

This gene was present in the common ancestor of mammals.

Orthologs for C6orf10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C6orf10 35
  • 97 (a)
OneToOne
C6H6orf10 34
  • 89.46 (n)
cow
(Bos Taurus)
Mammalia C6orf10 35
  • 47 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C6orf10 35
  • 40 (a)
OneToOne
Species where no ortholog for C6orf10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for C6orf10 Gene

ENSEMBL:
Gene Tree for C6orf10 (if available)
TreeFam:
Gene Tree for C6orf10 (if available)

Paralogs for C6orf10 Gene

No data available for Paralogs for C6orf10 Gene

Variants for C6orf10 Gene

Sequence variations from dbSNP and Humsavar for C6orf10 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1003878 -- 32,332,045(-) AACTC(C/T)AGGAC intron-variant, reference, synonymous-codon, missense
rs1003879 -- 32,331,815(-) cttta(C/T)gtcca intron-variant
rs1003880 -- 32,330,707(-) ggcga(A/C)agagt intron-variant
rs1018430 -- 32,313,911(-) AACAC(A/G)CTGCC intron-variant
rs1018431 -- 32,313,899(-) CCCCA(C/T)GCGGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for C6orf10 Gene

Variant ID Type Subtype PubMed ID
nsv981130 CNV duplication 23825009
nsv956554 CNV deletion 24416366
nsv830630 CNV loss 17160897
nsv480054 CNV novel sequence insertion 20440878
nsv479933 CNV novel sequence insertion 20440878
nsv479791 CNV novel sequence insertion 20440878
nsv472192 CNV novel sequence insertion 20440878
nsv1126749 CNV deletion 24896259
nsv1112900 CNV deletion 24896259
nsv1073969 CNV deletion 25765185
esv9046 CNV loss 19470904
esv7532 CNV loss 19470904
esv3890829 CNV loss 25118596
esv3608581 CNV loss 21293372
esv3567544 CNV deletion 23714750
esv3397 CNV loss 18987735
esv3287273 CNV deletion 24192839
esv275065 CNV loss 21479260
esv2731828 CNV deletion 23290073
esv2731827 CNV deletion 23290073
esv2731826 CNV deletion 23290073
esv2569081 CNV deletion 19546169
esv2351738 CNV deletion 18987734
esv1081136 CNV deletion 17803354
dgv10472n54 CNV loss 21841781
dgv10463n54 CNV loss 21841781
dgv10404n54 CNV loss 21841781

Variation tolerance for C6orf10 Gene

Residual Variation Intolerance Score: 97.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 24.34; 99.63% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C6orf10 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
C6orf10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C6orf10 Gene

Disorders for C6orf10 Gene

Relevant External Links for C6orf10

Genetic Association Database (GAD)
C6orf10
Human Genome Epidemiology (HuGE) Navigator
C6orf10
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
C6orf10

No disorders were found for C6orf10 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C6orf10 Gene

Publications for C6orf10 Gene

  1. BTL-II: a polymorphic locus with homology to the butyrophilin gene family, located at the border of the major histocompatibility complex class II and class III regions in human and mouse. (PMID: 10803852) Stammers M. … Beck S. (Immunogenetics 2000) 2 3 22 64
  2. A genome-wide association study in progressive multiple sclerosis. (PMID: 22457343) Martinelli-Boneschi F. … Comi G. (Mult. Scler. 2012) 3 46 64
  3. Genome-wide association study identifies three new susceptibility loci for adult asthma in the Japanese population. (PMID: 21804548) Hirota T. … Tamari M. (Nat. Genet. 2011) 3 46 64
  4. Identification of independent risk loci for Graves' disease within the MHC in the Japanese population. (PMID: 21900946) Nakabayashi K. … Shirasawa S. (J. Hum. Genet. 2011) 3 46 64
  5. Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci. (PMID: 20453842) Stahl E.A. … Plenge R.M. (Nat. Genet. 2010) 3 46 64

Products for C6orf10 Gene

Sources for C6orf10 Gene

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