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Aliases for C6orf1 Gene

Aliases for C6orf1 Gene

  • Chromosome 6 Open Reading Frame 1 2 3 5
  • LBH 3 4
  • Uncharacterized Protein C6orf1 3
  • Protein LBH 4

External Ids for C6orf1 Gene

Previous GeneCards Identifiers for C6orf1 Gene

  • GC06U990175
  • GC06M034323
  • GC06M034214
  • GC06M033936
  • GC06M034540
  • GC06M035560
  • GC06M036274
  • GC06M036647

Summaries for C6orf1 Gene

GeneCards Summary for C6orf1 Gene

C6orf1 (Chromosome 6 Open Reading Frame 1) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C6orf1 Gene

Genomics for C6orf1 Gene

Regulatory Elements for C6orf1 Gene

Enhancers for C6orf1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06F034670 1.4 Ensembl ENCODE 11.6 -423.8 -423771 6.5 HDGF PKNOX1 MLX WRNIP1 ZFP64 ARID4B FEZF1 DMAP1 YBX1 YY1 UHRF1BP1 C6orf1 ENSG00000219023 FANCE RPL10A GC06M037076 RN7SL200P GC06P040024
GH06F033428 1.3 FANTOM5 ENCODE 11.6 +820.4 820360 1.7 HDGF ATF1 PKNOX1 ZFP64 ARID4B SIN3A DMAP1 YBX1 GLIS2 SMARCA4 ZBTB9 C6orf1 KIFC1 RPL35AP4 CUTA BAK1 SYNGAP1 MIR5004
GH06F033270 1.2 ENCODE 11.6 +974.3 974342 8.4 CREB3L1 MLX ZFP64 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC TBX21 DAXX RPS18 BRD2 VPS52 MIR6873 RGL2 LEMD2 RXRB ITPR3 MIR5004
GH06F033430 1.2 FANTOM5 ENCODE 11.6 +817.1 817051 4.5 HDGF SIN3A ARID4B ZNF48 GLIS2 ELK1 FOS SP3 MEF2D RFX3 DAXX ZBTB9 C6orf1 PHF1 KIFC1 RPL35AP4 HLA-DMA CUTA BAK1 HLA-DPB1
GH06F034223 1.8 FANTOM5 Ensembl ENCODE 6.4 +22.8 22835 7.3 HDGF CREB3L1 ARID4B SIN3A DMAP1 ZNF2 ZNF143 ZNF207 FOS KLF13 ENSG00000272374 RPS10 ITPR3 LEMD2 DAXX RGL2 MIR6873 B3GALT4 VPS52 HCG25
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around C6orf1 on UCSC Golden Path with GeneCards custom track

Promoters for C6orf1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001214845 270 1601 HDGF PKNOX1 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 SLC30A9 ZNF143

Genomic Location for C6orf1 Gene

Chromosome:
6
Start:
34,246,380 bp from pter
End:
34,249,470 bp from pter
Size:
3,091 bases
Orientation:
Minus strand

Genomic View for C6orf1 Gene

Genes around C6orf1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C6orf1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C6orf1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C6orf1 Gene

Proteins for C6orf1 Gene

  • Protein details for C6orf1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86T20-CF001_HUMAN
    Recommended name:
    Uncharacterized protein C6orf1
    Protein Accession:
    Q86T20
    Secondary Accessions:
    • A8K299

    Protein attributes for C6orf1 Gene

    Size:
    159 amino acids
    Molecular mass:
    17113 Da
    Quaternary structure:
    No Data Available

neXtProt entry for C6orf1 Gene

Post-translational modifications for C6orf1 Gene

No Post-translational modifications

No data available for DME Specific Peptides for C6orf1 Gene

Domains & Families for C6orf1 Gene

Protein Domains for C6orf1 Gene

ProtoNet:

Suggested Antigen Peptide Sequences for C6orf1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C6orf1: view

No data available for Gene Families and UniProtKB/Swiss-Prot for C6orf1 Gene

Function for C6orf1 Gene

Molecular function for C6orf1 Gene

GENATLAS Biochemistry:
chromosome 6 open reading frame 1,located 3of HMGIY,in opposite orientation
genes like me logo Genes that share phenotypes with C6orf1: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for C6orf1 Gene

Localization for C6orf1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for C6orf1 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C6orf1 gene
Compartment Confidence
extracellular 4
mitochondrion 2
plasma membrane 1
nucleus 1
cytosol 1

Gene Ontology (GO) - Cellular Components for C6orf1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with C6orf1: view

Pathways & Interactions for C6orf1 Gene

SuperPathways for C6orf1 Gene

No Data Available

Interacting Proteins for C6orf1 Gene

Selected Interacting proteins: Q86T20-CF001_HUMAN for C6orf1 Gene via IID

Symbol External ID(s) Details
HMGA1

Gene Ontology (GO) - Biological Process for C6orf1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for C6orf1 Gene

Transcripts for C6orf1 Gene

Unigene Clusters for C6orf1 Gene

Chromosome 6 open reading frame 1:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for C6orf1 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b · 6c · 6d
SP1: - -
SP2: - - -
SP3: - -
SP4: -
SP5: - - -
SP6: - -
SP7: -

Relevant External Links for C6orf1 Gene

GeneLoc Exon Structure for
C6orf1
ECgene alternative splicing isoforms for
C6orf1

Expression for C6orf1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for C6orf1 Gene

NURSA nuclear receptor signaling pathways regulating expression of C6orf1 Gene:

C6orf1

SOURCE GeneReport for Unigene cluster for C6orf1 Gene:

Hs.381300

mRNA Expression by UniProt/SwissProt for C6orf1 Gene:

Q86T20-CF001_HUMAN
Tissue specificity: Expressed in spleen, thymus, prostate, testis, uterus, small intestine, colon and peripheral blood leukocytes.
genes like me logo Genes that share expression patterns with C6orf1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for C6orf1 Gene

Orthologs for C6orf1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C6orf1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C6H6orf1 34
  • 99.78 (n)
C6orf1 35
  • 99 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii Dr.3972 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.7226 34
Species where no ortholog for C6orf1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C6orf1 Gene

ENSEMBL:
Gene Tree for C6orf1 (if available)
TreeFam:
Gene Tree for C6orf1 (if available)

Paralogs for C6orf1 Gene

(1) SIMAP similar genes for C6orf1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with C6orf1: view

No data available for Paralogs for C6orf1 Gene

Variants for C6orf1 Gene

Sequence variations from dbSNP and Humsavar for C6orf1 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs10080749 -- 34,250,388(+) CACTG(A/G)ACAAA upstream-variant-2KB
rs1048600 -- 34,246,618(-) GCCTT(C/T)TGCCC downstream-variant-500B, reference, synonymous-codon
rs1048605 -- 34,246,566(-) GGGAA(A/G)AGGCT downstream-variant-500B, reference, missense
rs1048606 -- 34,246,554(-) TCCTT(C/T)TGGGA downstream-variant-500B, reference, missense
rs112724424 -- 34,247,224(+) CTCCT(C/T)CCTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for C6orf1 Gene

Variant ID Type Subtype PubMed ID
nsv969388 CNV duplication 23825009
nsv602865 CNV loss 21841781
nsv602863 CNV loss 21841781

Variation tolerance for C6orf1 Gene

Residual Variation Intolerance Score: 71.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.18; 39.51% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C6orf1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
C6orf1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C6orf1 Gene

Disorders for C6orf1 Gene

Relevant External Links for C6orf1

Genetic Association Database (GAD)
C6orf1
Human Genome Epidemiology (HuGE) Navigator
C6orf1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
C6orf1

No disorders were found for C6orf1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C6orf1 Gene

Publications for C6orf1 Gene

  1. Assignment of a new gene (LBH). (PMID: 10036196) Kazmierczak B. … Bullerdiek J. (Genomics 1999) 2 3 4 64
  2. Identification, replication, and fine-mapping of Loci associated with adult height in individuals of african ancestry. (PMID: 21998595) N'Diaye A. … Haiman C.A. (PLoS Genet. 2011) 3 46 64
  3. Identification of 15 loci influencing height in a Korean population. (PMID: 19893584) Kim J.J. … Lee J.K. (J. Hum. Genet. 2010) 3 46 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. Genome wide association study (GWAS) of Chagas cardiomyopathy in Trypanosoma cruzi seropositive subjects. (PMID: 24324551) Deng X. … Seielstad M. (PLoS ONE 2013) 3 64

Products for C6orf1 Gene

Sources for C6orf1 Gene

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