C6orf1 Gene
protein-coding GIFtS: 43
GCID: GC06M034214
|
|
chromosome 6 open reading frame 1
| |
Aliases
for C6orf1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Chromosome 6 Open Reading Frame 11 2 | | LBH1 2 3 5 | | MGC578581 | | Uncharacterized Protein C6orf12 | | Protein LBH3 |
Export aliases for C6orf1 gene to outside databasesPrevious GC identifers: GC06U990175 GC06M034323 GC06M033936 |
Summaries
for C6orf1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for C6orf1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000006.11 NC_018917.1 NT_007592.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the C6orf1 gene promoter:
C/EBPbeta p300
Other transcription factors
Search SABiosciences Chromatin IP Primers for C6orf1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C6orf1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 6p21.31 Ensembl cytogenetic band: 6p21.31 HGNC cytogenetic band: 6p21.3C6orf1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 6 GeneLoc Exon Structure GeneLoc location for GC06M034214: view genomic region
(about GC identifiers)
Start:
|
34,214,157 bp from pter |
End:
|
34,217,247 bp from pter |
Size:
|
3,091 bases |
Orientation:
|
minus strand |
|
Proteins
for C6orf1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CF001_HUMAN, Q86T20 (See
protein sequence)Recommended Name: Uncharacterized protein C6orf1 precursor Size: 159 amino acids; 17113 Da
Subcellular location: Secreted (Potential)
Secondary accessions: A8K299Explore the universe of human proteins at neXtProt for C6orf1: NX_Q86T20
C6orf1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (3 alternative transcripts):
NP_001008703.1 NP_001008704.1 NP_848603.2
ENSEMBL proteins: ENSP00000417604 ENSP00000418062 ENSP00000387460 ENSP00000378441 ENSP00000334260 ENSP00000418884
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005576 | extracellular region |
IEA | -- |
C6orf1 for ontologies About GeneDecksing
C6orf1 Antibody Products:
Assay Products for C6orf1: |
Protein
Domains /
Families
for C6orf1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| ProtoNet protein and cluster: Q86T20 |
Function
for C6orf1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
Genatlas biochemistry entry for C6orf1:chromosome 6 open reading frame 1,located 3'of HMGIY,in opposite orientation
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for C6orf1 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for C6orf1 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): C6orf1 (NM_006443) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for C6orf1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C6orf1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C6orf1 |
2 GenomeRNAi human phenotypes for C6orf1:
|
Pathways & Interactions
for C6orf1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for C6orf1
|
Drugs & Compounds
for C6orf1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for C6orf1
Search CenterWatch for drugs/clinical trials and news about C6orf1 / CF001
|
Transcripts
for C6orf1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for C6orf1 gene (3 alternative transcripts): NM_001008703.1 NM_001008704.1 NM_178508.3 Unigene Cluster for C6orf1: Chromosome 6 open reading frame 1 Hs.381300 [show with all ESTs]Unigene Representative Sequence: NM_1785088 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000476320(uc003ojg.3 uc003ojh.3) ENST00000481533 ENST00000413013
ENST00000394990 ENST00000335352(uc003ojf.3 uc003oji.3) ENST00000463083
ENST00000468145 ENST00000495581
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for C6orf1 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for C6orf1 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): C6orf1 (NM_006443) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for C6orf1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C6orf1 |
Additional cDNA sequence: AK290164.1 BC009526.1 BC023627.2 BC047919.1 11 DOTS entries: DT.100036494 DT.92422661 DT.92422662 DT.211470 DT.121373596 DT.100776593 DT.95153763 DT.121373564 DT.100036493 DT.97795136 DT.121373517 24/134 AceView cDNA sequences (see all 134): BM761380 BU194178 BQ059575 BM808233 NM_178508 BC009526 BM843203 BI835676 BI524010 BM423397 CR619587 CF994102 BU956518 AA767552 BM840355 BU184027 AW631387 BQ058686 BM700276 BQ066439 BC047919 BM704613 BQ671349 CR592917
GeneLoc Exon Structure
5/7 Alternative Splicing Database (ASD) splice patterns (SP) for C6orf1 (see all 7) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | ^ | 2 | ^ | 3a | · | 3b | ^ | 4a | · | 4b | ^ | 5a | · | 5b | ^ | 6a | · | 6b | · | 6c | · | 6d |
|---|
|
| SP1: | | | | | | | | | | | - | | | | | | | | - | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | - | | | | - | | | | - | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | - | | | | - | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | - | | | | | | - | | - | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for C6orf1
|
Expression
for C6orf1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| C6orf1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GTGATGGGGC
About this image
See C6orf1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for C6orf1
SOURCE GeneReport for Unigene cluster: Hs.381300
UniProtKB/Swiss-Prot: CF001_HUMAN, Q86T20Tissue specificity: Expressed in spleen, thymus, prostate, testis, uterus, small intestine, colon and peripheral bloodleukocytes
SABiosciences Custom PCR Arrays for C6orf1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for C6orf1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat C6orf1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat C6orf1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat C6orf1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C6orf1 |
Orthologs
for C6orf1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for C6orf1 gene from 2/3 species (see all 3) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
AI4135825 |
expressed sequence AI413582 |
-- |
|
17 (14.53 cM) 27563575 |
zebrafish
(Danio rerio) |
Actinopterygii |
Dr.39722 |
Transcribed sequence with weak similarity to protein more |
71.65(n) |
|
BI844908.1 |
ENSEMBL Gene Tree for C6orf1 (if available)
TreeFam Gene Tree for C6orf1 (if available) |
Paralogs
for C6orf1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for C6orf1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 6 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for C6orf1 (34214157 - 34217247 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for C6orf1: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing C6orf1 |
|
Disorders
/ Diseases
for C6orf1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
C6orf1 for disorders About GeneDecksing
OMIM gene information: 611419
OMIM disorders: --
1  disease for C6orf1: About MalaCardsprostatitis
Human Genome Epidemiology (HuGE) Navigator: C6orf1 (5 documents)
Export disorders for C6orf1 gene to outside databases
|
Publications
for C6orf1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for C6orf1 gene, integrated from 9 sources (see all 11):
(articles sorted by number of sources associating them with C6orf1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Assignment of a new gene (LBH). (PubMed id 10036196)1, 2, 3 Kazmierczak B.... Bullerdiek J. (1999)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Identification, replication, and fine-mapping of Loci associated with adult height in individuals of african ancestry. (PubMed id 21998595)1 N'Diaye A....Haiman C.A. (2011)
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
- Identification of 15 loci influencing height in a Kor ean population. (PubMed id 19893584)1 Kim J.J....Lee J.K. (2010)
- Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1 Bailey S.D....Anand S. (2010)
- Gene-centric association signals for lipids and apoli poproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (2009)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
- The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)2 Mungall A.J.... Beck S. (2003)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for C6orf1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing C6orf1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing C6orf1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing C6orf1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for C6orf1 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for C6orf1 gene:
Search GeneIP for patents involving C6orf1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for C6orf1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for C6orf1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for C6orf1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for C6orf1 | | | OriGene Protein Over-expression Lysate for C6orf1 | | Browse OriGene Fluorogenic Cell Assay Kits | | | Browse OriGene siRNAs | | OriGene 3'-UTR Clone for C6orf1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for C6orf1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for C6orf1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for C6orf1 | | OriGene Custom Protein Services for C6orf1 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat C6orf1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing C6orf1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C6orf1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat C6orf1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat C6orf1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat C6orf1 |
| |
 |  |  |  | |
| | | | Search Tocris compounds for C6orf1 |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | C6orf1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C6orf1 |
|  |  |  | | | | ThermoFisher Antibodies for C6orf1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C6orf1 |
|
|
|
|
