Free for academic non-profit institutions. Other users need a Commercial license

Aliases for C5orf66 Gene

Aliases for C5orf66 Gene

  • Chromosome 5 Open Reading Frame 66 2 3 5

External Ids for C5orf66 Gene

Previous GeneCards Identifiers for C5orf66 Gene

  • GC05P134373

Summaries for C5orf66 Gene

GeneCards Summary for C5orf66 Gene

C5orf66 (Chromosome 5 Open Reading Frame 66) is a Protein Coding gene.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C5orf66 Gene

Genomics for C5orf66 Gene

Regulatory Elements for C5orf66 Gene

Enhancers for C5orf66 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05G134757 1.2 ENCODE 20.8 -274.1 -274119 2.6 MLX CREB3L1 ZFP64 DMAP1 YY1 SLC30A9 ZNF143 ZNF548 ZNF263 SP3 C5orf66 C5orf24 SEC24A CDKL3 DDX46 RPL34P13
GH05G134464 2 FANTOM5 Ensembl ENCODE dbSUPER 10.7 -567.0 -567022 2.8 PKNOX1 FOXA2 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF548 FOS ZNF263 C5orf66 C5orf24 PPP2CA SEC24A UBE2B LOC102546229 RNU6-456P
GH05G134039 1.5 Ensembl ENCODE dbSUPER 12.5 -993.6 -993649 1.0 ATF1 MLX ARNT ARID4B SIN3A BRCA1 ZNF2 ZNF48 GTF3C2 SLC30A9 C5orf66 SEC24A GC05P134014 ENSG00000271128
GH05G134521 1.4 ENCODE dbSUPER 12.5 -507.8 -507757 7.3 HDGF HNRNPUL1 PKNOX1 FOXA2 MLX AGO1 ARID4B SIN3A FEZF1 DMAP1 C5orf66 RNU6-456P RPS10P11 CDKN2AIPNL SEC24A ENSG00000248559 LINC01843 JADE2 GC05M134520
GH05G135190 1.6 Ensembl ENCODE dbSUPER 10 +158.5 158469 2.0 HNRNPUL1 HDGF FOXA2 PKNOX1 ARNT MLX AGO1 ARID4B SIN3A DMAP1 C5orf66 C5orf66-AS2 LOC105379188
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around C5orf66 on UCSC Golden Path with GeneCards custom track

Promoters for C5orf66 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000187137 221 2200 HDGF PKNOX1 ZFP64 ARID4B SIN3A FEZF1 ZNF2 ZNF766 KLF13 ZNF263

Genomic Location for C5orf66 Gene

Chromosome:
5
Start:
135,033,280 bp from pter
End:
135,358,219 bp from pter
Size:
324,940 bases
Orientation:
Plus strand

Genomic View for C5orf66 Gene

Genes around C5orf66 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C5orf66 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C5orf66 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C5orf66 Gene

Proteins for C5orf66 Gene

  • Protein details for C5orf66 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H5L9-CE066_HUMAN
    Recommended name:
    Putative uncharacterized protein C5orf66
    Protein Accession:
    Q9H5L9

    Protein attributes for C5orf66 Gene

    Size:
    145 amino acids
    Molecular mass:
    15570 Da
    Quaternary structure:
    No Data Available

neXtProt entry for C5orf66 Gene

Post-translational modifications for C5orf66 Gene

No Post-translational modifications

Other Protein References for C5orf66 Gene

REFSEQ proteins:

No data available for DME Specific Peptides for C5orf66 Gene

Domains & Families for C5orf66 Gene

Protein Domains for C5orf66 Gene

ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C5orf66: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for C5orf66 Gene

Function for C5orf66 Gene

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for C5orf66 Gene

Localization for C5orf66 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for C5orf66 Gene

Pathways & Interactions for C5orf66 Gene

SuperPathways for C5orf66 Gene

No Data Available

Interacting Proteins for C5orf66 Gene

Gene Ontology (GO) - Biological Process for C5orf66 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for C5orf66 Gene

Drugs & Compounds for C5orf66 Gene

No Compound Related Data Available

Transcripts for C5orf66 Gene

mRNA/cDNA for C5orf66 Gene

(1) REFSEQ mRNAs :
(6) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for C5orf66 Gene

No ASD Table

Relevant External Links for C5orf66 Gene

GeneLoc Exon Structure for
C5orf66
ECgene alternative splicing isoforms for
C5orf66

Expression for C5orf66 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for C5orf66 Gene

mRNA differential expression in normal tissues according to GTEx for C5orf66 Gene

This gene is overexpressed in Esophagus - Mucosa (x17.8), Vagina (x7.8), Pituitary (x6.5), Cervix - Ectocervix (x5.1), and Minor Salivary Gland (x4.8).

NURSA nuclear receptor signaling pathways regulating expression of C5orf66 Gene:

C5orf66
genes like me logo Genes that share expression patterns with C5orf66: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for C5orf66 Gene

Orthologs for C5orf66 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for C5orf66 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC101057750 34
  • 99.77 (n)
C5orf66 35
  • 99 (a)
OneToOne
Species where no ortholog for C5orf66 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for C5orf66 Gene

ENSEMBL:
Gene Tree for C5orf66 (if available)
TreeFam:
Gene Tree for C5orf66 (if available)

Paralogs for C5orf66 Gene

No data available for Paralogs for C5orf66 Gene

Variants for C5orf66 Gene

Sequence variations from dbSNP and Humsavar for C5orf66 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs121909109 Pathogenic 135,031,290(-) TCACC(A/G)AGCCG upstream-variant-2KB, reference, missense
rs200888898 Uncertain significance 135,031,416(+) CTGCT(G/T)CTTCT upstream-variant-2KB, reference, missense
rs201133610 Uncertain significance 135,031,427(+) TCTTG(G/T)CTGGG upstream-variant-2KB, reference, missense
rs1000011325 -- 135,300,237(+) CCTAG(A/C/T)TACTC intron-variant
rs1000024213 -- 135,296,698(+) GTTTA(C/T)TCTCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for C5orf66 Gene

Variant ID Type Subtype PubMed ID
dgv969n67 CNV gain 20364138
esv1002716 CNV deletion 20482838
esv2658273 CNV deletion 23128226
esv2676443 CNV deletion 23128226
esv275412 CNV loss 21479260
esv3344771 CNV insertion 20981092
esv3353228 CNV duplication 20981092
esv3606855 CNV loss 21293372
esv3606858 CNV loss 21293372
nsv1026820 CNV gain 25217958
nsv1073498 CNV deletion 25765185
nsv1078825 CNV insertion 25765185
nsv1123985 CNV deletion 24896259
nsv1129749 CNV tandem duplication 24896259
nsv327970 CNV insertion 16902084
nsv329851 CNV insertion 16902084
nsv462458 CNV loss 19166990
nsv5014 CNV insertion 18451855
nsv5015 CNV insertion 18451855
nsv518218 CNV loss 19592680
nsv519790 CNV gain 19592680
nsv599744 CNV loss 21841781
nsv599745 CNV loss 21841781
nsv823239 CNV gain 20364138
nsv823240 CNV gain 20364138
nsv823243 CNV gain 20364138
nsv830495 CNV loss 17160897
nsv830496 CNV gain 17160897
nsv950398 CNV deletion 24416366
nsv950399 CNV deletion 24416366
nsv950400 CNV deletion 24416366

Variation tolerance for C5orf66 Gene

Gene Damage Index Score: 1.11; 22.57% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C5orf66 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
C5orf66

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C5orf66 Gene

Disorders for C5orf66 Gene

Relevant External Links for C5orf66

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
C5orf66

No disorders were found for C5orf66 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C5orf66 Gene

Publications for C5orf66 Gene

  1. Large-scale genetic study in East Asians identifies six new loci associated with colorectal cancer risk. (PMID: 24836286) Zhang B. … Zheng W. (Nat. Genet. 2014) 3 64
  2. Genome-wide association analyses in East Asians identify new susceptibility loci for colorectal cancer. (PMID: 23263487) Jia W.H. … Zheng W. (Nat. Genet. 2013) 3 64
  3. A genome-wide association study of host genetic determinants of the antibody response to Anthrax Vaccine Adsorbed. (PMID: 22658931) Pajewski N.M. … Kaslow R.A. (Vaccine 2012) 3 64
  4. Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease. (PMID: 23128233) Jostins L. … Cho J.H. (Nature 2012) 3 64
  5. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PMID: 23251661) Comuzzie A.G. … Butte N.F. (PLoS ONE 2012) 3 64

Products for C5orf66 Gene

Sources for C5orf66 Gene

Content
Loading form....