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Aliases for C5orf64 Gene

Aliases for C5orf64 Gene

  • Chromosome 5 Open Reading Frame 64 2 3 5

External Ids for C5orf64 Gene

Previous GeneCards Identifiers for C5orf64 Gene

  • GC05P060933

Summaries for C5orf64 Gene

GeneCards Summary for C5orf64 Gene

C5orf64 (Chromosome 5 Open Reading Frame 64) is a Protein Coding gene.

Additional gene information for C5orf64 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C5orf64 Gene

Genomics for C5orf64 Gene

Regulatory Elements for C5orf64 Gene

Enhancers for C5orf64 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05H061658 1.3 Ensembl ENCODE dbSUPER 4.4 +21.6 21606 1 CTCF MAX EBF1 BRCA1 RAD21 ZFHX2 ZNF316 SMC3 ZNF143 RCOR1 C5orf64 HSPD1P22
GH05H061672 0.9 Ensembl ENCODE dbSUPER 6.3 +35.5 35456 1 NR2F2 C5orf64 RNU6-913P GC05M061665 LOC101928651
GH05H061665 0.8 Ensembl dbSUPER 6.7 +28.5 28493 0 ZFHX2 RAD21 NR2F2 EGR2 C5orf64 RNU6-913P GC05M061665 LOC101928651
GH05H061625 1.5 FANTOM5 Ensembl ENCODE dbSUPER 3.2 -11.6 -11608 2 NR2F1 SIN3A EBF1 RAD21 NR2F2 YY1 ETS1 POLR2A EGR1 RUNX3 C5orf64 LOC105378997 GC05P061534
GH05H061674 0.7 ENCODE dbSUPER 5.7 +37.3 37328 1 CTCF RAD21 C5orf64 RNU6-913P GC05M061665 LOC101928651
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around C5orf64 on UCSC Golden Path with GeneCards custom track

Genomic Location for C5orf64 Gene

Chromosome:
5
Start:
61,637,708 bp from pter
End:
61,751,763 bp from pter
Size:
114,056 bases
Orientation:
Plus strand

Genomic View for C5orf64 Gene

Genes around C5orf64 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C5orf64 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C5orf64 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C5orf64 Gene

Proteins for C5orf64 Gene

  • Protein details for C5orf64 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q2M2E5-CE064_HUMAN
    Recommended name:
    Uncharacterized protein C5orf64
    Protein Accession:
    Q2M2E5
    Secondary Accessions:
    • Q2M2H1
    • Q8N1U8

    Protein attributes for C5orf64 Gene

    Size:
    130 amino acids
    Molecular mass:
    14817 Da
    Quaternary structure:
    No Data Available

neXtProt entry for C5orf64 Gene

Post-translational modifications for C5orf64 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C5orf64 Gene

No data available for DME Specific Peptides for C5orf64 Gene

Domains & Families for C5orf64 Gene

Protein Domains for C5orf64 Gene

ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C5orf64: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for C5orf64 Gene

Function for C5orf64 Gene

Phenotypes From GWAS Catalog for C5orf64 Gene

genes like me logo Genes that share phenotypes with C5orf64: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for C5orf64
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C5orf64 Gene

Localization for C5orf64 Gene

Subcellular locations from UniProtKB/Swiss-Prot for C5orf64 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C5orf64 gene
Compartment Confidence
extracellular 4
mitochondrion 3

Gene Ontology (GO) - Cellular Components for C5orf64 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with C5orf64: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for C5orf64 Gene

Pathways & Interactions for C5orf64 Gene

SuperPathways for C5orf64 Gene

No Data Available

Interacting Proteins for C5orf64 Gene

Selected Interacting proteins: Q2M2E5-CE064_HUMAN for C5orf64 Gene via IID

Symbol External ID(s) Details
H2AFX

Gene Ontology (GO) - Biological Process for C5orf64 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for C5orf64 Gene

Drugs & Compounds for C5orf64 Gene

No Compound Related Data Available

Transcripts for C5orf64 Gene

mRNA/cDNA for C5orf64 Gene

(6) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(2) Selected AceView cDNA sequences:
(6) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for C5orf64 Gene

Chromosome 5 open reading frame 64:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for C5orf64
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for C5orf64 Gene

No ASD Table

Relevant External Links for C5orf64 Gene

GeneLoc Exon Structure for
C5orf64
ECgene alternative splicing isoforms for
C5orf64

Expression for C5orf64 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for C5orf64 Gene

mRNA differential expression in normal tissues according to GTEx for C5orf64 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x9.7), Brain - Substantia nigra (x7.5), Brain - Hippocampus (x4.6), Brain - Putamen (basal ganglia) (x4.5), Brain - Hypothalamus (x4.5), and Brain - Amygdala (x4.3).

NURSA nuclear receptor signaling pathways regulating expression of C5orf64 Gene:

C5orf64

SOURCE GeneReport for Unigene cluster for C5orf64 Gene:

Hs.683866

Evidence on tissue expression from TISSUES for C5orf64 Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with C5orf64: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for C5orf64 Gene

Orthologs for C5orf64 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for C5orf64 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C5H5orf64 33
  • 97.74 (n)
C5orf64 34
  • 95 (a)
OneToOne
Species where no ortholog for C5orf64 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for C5orf64 Gene

ENSEMBL:
Gene Tree for C5orf64 (if available)
TreeFam:
Gene Tree for C5orf64 (if available)

Paralogs for C5orf64 Gene

No data available for Paralogs for C5orf64 Gene

Variants for C5orf64 Gene

Sequence variations from dbSNP and Humsavar for C5orf64 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs1000037993 -- 61,645,080(+) AGGAG(A/C)CTTAC intron-variant
rs1000061363 -- 61,669,793(+) AAGTT(C/T)CATTC intron-variant
rs1000067314 -- 61,708,540(+) CAAGG(C/T)AACTG intron-variant
rs1000068335 -- 61,665,316(+) CACAC(A/G)AGAGC intron-variant
rs1000106470 -- 61,690,107(+) CTTTA(C/T)GAGGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for C5orf64 Gene

Variant ID Type Subtype PubMed ID
esv2671982 CNV deletion 23128226
esv2730246 CNV deletion 23290073
esv2730247 CNV deletion 23290073
esv3605219 CNV loss 21293372
esv3605221 CNV gain 21293372
esv3894197 CNV loss 25118596

Variation tolerance for C5orf64 Gene

Residual Variation Intolerance Score: 87.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 13.68; 95.71% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C5orf64 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
C5orf64

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C5orf64 Gene

Disorders for C5orf64 Gene

Relevant External Links for C5orf64

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
C5orf64

No disorders were found for C5orf64 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C5orf64 Gene

Publications for C5orf64 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  2. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 60
  4. Dependence of Human Colorectal Cells Lacking the FBW7 Tumor Suppressor on the Spindle Assembly Checkpoint. (PMID: 26354767) Bailey ML … Hieter P (Genetics 2015) 3 60
  5. Genome-wide association study of Alzheimer's disease. (PMID: 22832961) Kamboh MI … Barmada MM (Translational psychiatry 2012) 3 60

Products for C5orf64 Gene

Sources for C5orf64 Gene

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