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Aliases for C5orf63 Gene

Aliases for C5orf63 Gene

  • Chromosome 5 Open Reading Frame 63 2 3 5
  • Glutaredoxin-Like Protein YDR286C Homolog 3
  • Glutaredoxin-Like Protein C5orf63 3
  • YDR286C 3

External Ids for C5orf63 Gene

Previous GeneCards Identifiers for C5orf63 Gene

  • GC05M126379

Summaries for C5orf63 Gene

GeneCards Summary for C5orf63 Gene

C5orf63 (Chromosome 5 Open Reading Frame 63) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C5orf63 Gene

Genomics for C5orf63 Gene

Regulatory Elements for C5orf63 Gene

Enhancers for C5orf63 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05F127072 0.5 ENCODE 8.7 +0.2 177 1.4 ARID4B SIN3A DMAP1 ZNF48 ZNF2 YY1 SLC30A9 GLIS2 ELK1 ZHX2 MARCH3 C5orf63
GH05F127076 0.8 Ensembl ENCODE 8.1 -3.4 -3403 1.9 JUN NR2F2 RARA ARID1B JUND SMARCA4 ATF3 CEBPA MARCH3 C5orf63 ENSG00000279446 MRPS5P3
GH05F127029 1 ENCODE 7.2 +43.2 43232 3.4 PKNOX1 MLX ARID4B SIN3A ZNF2 YY1 SLC30A9 ZNF207 FOS ZNF263 MARCH3 C5orf63 GC05M127022 GC05P127033 PIR49999
GH05F127081 1.3 Ensembl ENCODE 7 -6.9 -6862 0.4 HDAC1 PKNOX1 FEZF1 ZIC2 ZNF2 ZFHX2 GATA3 CTBP1 ZNF791 TCF7L2 MARCH3 C5orf63 ENSG00000279446 MRPS5P3
GH05F127040 1.2 Ensembl ENCODE 6.9 +32.1 32068 2.4 CTCF KLF1 TAL1 JUN KLF17 FEZF1 ZIC2 RAD21 ZNF2 ZNF101 C5orf63 MARCH3
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around C5orf63 on UCSC Golden Path with GeneCards custom track

Promoters for C5orf63 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001289420 239 1401 ARID4B SIN3A DMAP1 ZNF48 ZNF2 YY1 SLC30A9 GLIS2 ELK1 ZHX2

Genomic Location for C5orf63 Gene

Chromosome:
5
Start:
127,035,666 bp from pter
End:
127,073,539 bp from pter
Size:
37,874 bases
Orientation:
Minus strand

Genomic View for C5orf63 Gene

Genes around C5orf63 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C5orf63 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C5orf63 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C5orf63 Gene

Proteins for C5orf63 Gene

  • Protein details for C5orf63 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NC05-YD286_HUMAN
    Recommended name:
    Glutaredoxin-like protein C5orf63
    Protein Accession:
    A6NC05
    Secondary Accessions:
    • G3V557

    Protein attributes for C5orf63 Gene

    Size:
    138 amino acids
    Molecular mass:
    15764 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for C5orf63 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for C5orf63 Gene

Post-translational modifications for C5orf63 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for C5orf63 Gene

Domains & Families for C5orf63 Gene

Protein Domains for C5orf63 Gene

Suggested Antigen Peptide Sequences for C5orf63 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A6NC05

UniProtKB/Swiss-Prot:

YD286_HUMAN :
  • Belongs to the glutaredoxin family. YDR286C subfamily.
Family:
  • Belongs to the glutaredoxin family. YDR286C subfamily.
genes like me logo Genes that share domains with C5orf63: view

No data available for Gene Families for C5orf63 Gene

Function for C5orf63 Gene

Phenotypes for C5orf63 Gene

genes like me logo Genes that share phenotypes with C5orf63: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for C5orf63 Gene

Localization for C5orf63 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for C5orf63 Gene COMPARTMENTS Subcellular localization image for C5orf63 gene
Compartment Confidence
mitochondrion 5
extracellular 2
cytosol 1
nucleus 1

Gene Ontology (GO) - Cellular Components for C5orf63 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA --
genes like me logo Genes that share ontologies with C5orf63: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for C5orf63 Gene

Pathways & Interactions for C5orf63 Gene

SuperPathways for C5orf63 Gene

No Data Available

Interacting Proteins for C5orf63 Gene

Gene Ontology (GO) - Biological Process for C5orf63 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with C5orf63: view

No data available for Pathways by source and SIGNOR curated interactions for C5orf63 Gene

Transcripts for C5orf63 Gene

Unigene Clusters for C5orf63 Gene

Chromosome 5 open reading frame 63:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for C5orf63 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5
SP1: - -
SP2:
SP3: - - - -
SP4: -

Relevant External Links for C5orf63 Gene

GeneLoc Exon Structure for
C5orf63
ECgene alternative splicing isoforms for
C5orf63

Expression for C5orf63 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for C5orf63 Gene

Protein differential expression in normal tissues from HIPED for C5orf63 Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for C5orf63 Gene



Protein tissue co-expression partners for C5orf63 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of C5orf63 Gene:

C5orf63

SOURCE GeneReport for Unigene cluster for C5orf63 Gene:

Hs.49573
genes like me logo Genes that share expression patterns with C5orf63: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for C5orf63 Gene

Orthologs for C5orf63 Gene

This gene was present in the common ancestor of animals.

Orthologs for C5orf63 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C5H5orf63 34
  • 100 (n)
dog
(Canis familiaris)
Mammalia C11H5orf63 34
  • 89.77 (n)
C5orf63 35
  • 46 (a)
OneToOne
cow
(Bos Taurus)
Mammalia C7H5orf63 34
  • 89.57 (n)
C5orf63 35
  • 48 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC100174910 34
  • 89.39 (n)
mouse
(Mus musculus)
Mammalia C330018D20Rik 34 16 35
  • 88.18 (n)
oppossum
(Monodelphis domestica)
Mammalia C5orf63 35
  • 35 (a)
OneToOne
chicken
(Gallus gallus)
Aves CZH5ORF63 34
  • 66.67 (n)
C5orf63 35
  • 30 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia C5orf63 35
  • 32 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101733920 34
  • 63.43 (n)
zebrafish
(Danio rerio)
Actinopterygii im:7154516 34
  • 70.88 (n)
C10H5orf63 35
  • 34 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG9147 35
  • 6 (a)
OneToOne
Species where no ortholog for C5orf63 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C5orf63 Gene

ENSEMBL:
Gene Tree for C5orf63 (if available)
TreeFam:
Gene Tree for C5orf63 (if available)

Paralogs for C5orf63 Gene

Pseudogenes.org Pseudogenes for C5orf63 Gene

genes like me logo Genes that share paralogs with C5orf63: view

No data available for Paralogs for C5orf63 Gene

Variants for C5orf63 Gene

Sequence variations from dbSNP and Humsavar for C5orf63 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs1004392 -- 127,052,302(+) AACAC(A/G)TCAGT intron-variant
rs10075097 -- 127,065,522(+) GAATG(A/C)CATGG intron-variant
rs10519919 -- 127,065,120(+) ACAGA(C/T)TCAGG intron-variant
rs10519920 -- 127,067,187(+) GTTGA(C/T)TGGGT intron-variant
rs10588323 -- 127,072,323(+) TCCCC(-/GT)GTTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for C5orf63 Gene

Variant ID Type Subtype PubMed ID
nsv1033607 CNV gain 25217958

Variation tolerance for C5orf63 Gene

Gene Damage Index Score: 1.25; 25.07% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C5orf63 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
C5orf63

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C5orf63 Gene

Disorders for C5orf63 Gene

Relevant External Links for C5orf63

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
C5orf63

No disorders were found for C5orf63 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C5orf63 Gene

Publications for C5orf63 Gene

  1. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3 64
  2. The DNA sequence and comparative analysis of human chromosome 5. (PMID: 15372022) Schmutz J. … Rubin E.M. (Nature 2004) 4 64

Products for C5orf63 Gene

Sources for C5orf63 Gene

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