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C5orf63 Gene

protein-coding   GIFtS: 28
GCID: GC05M126379

Chromosome 5 Open Reading Frame 63

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Chromosome 5 Open Reading Frame 631 2
YDR286C2
Glutaredoxin-Like Protein C5orf632
Glutaredoxin-Like Protein YDR286C Homolog2

External Ids:    HGNC: 400511   Entrez Gene: 4012072   Ensembl: ENSG000001642417   UniProtKB: A6NC053   

Export aliases for C5orf63 gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for C5orf63 Gene:
C5orf63 (chromosome 5 open reading frame 63) is a protein-coding gene.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000005.9  NC_018916.2  NT_034772.7  
Regulatory elements:
   Search for regulatory transcription factor binding sites for C5orf63
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for C5orf63

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat C5orf63


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q23.2   Ensembl cytogenetic band:  5q23.2   HGNC cytogenetic band: 5q23.2

C5orf63 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
C5orf63 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M126379:  view genomic region     (about GC identifiers)

Start:
126,378,250 bp from pter      End:
126,409,184 bp from pter
Size:
30,935 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: YD286_HUMAN, A6NC05 (See protein sequence)
Recommended Name: Glutaredoxin-like protein C5orf63  
Size: 138 amino acids; 15764 Da
Secondary accessions: G3V557
Alternative splicing: 2 isoforms:  A6NC05-1   A6NC05-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for C5orf63: NX_A6NC05

Explore proteomics data for C5orf63 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See C5orf63 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001157950.1  NP_001157951.1  

    ENSEMBL proteins: 
     ENSP00000475157   ENSP00000475810   ENSP00000476160   ENSP00000475733   ENSP00000475415  
     ENSP00000454153   ENSP00000453964  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR008554 Glutaredoxin-like
     IPR012336 Thioredoxin-like_fold

    Graphical View of Domain Structure for InterPro Entry A6NC05

    ProtoNet protein and cluster: A6NC05

    UniProtKB/Swiss-Prot: YD286_HUMAN, A6NC05
    Similarity: Belongs to the glutaredoxin family. YDR286C subfamily


    Find genes that share domains with C5orf63           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for C5orf63
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion IEA--

    Find genes that share ontologies with C5orf63           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for C5orf63
    Interactions:

        Search GeneGlobe Interaction Network for C5orf63

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0055114oxidation-reduction process IEA--

    Find genes that share ontologies with C5orf63           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for C5orf63 (YD286)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for C5orf63 gene (2 alternative transcripts): 
    NM_001164478.1  NM_001164479.1  

    Unigene Cluster for C5orf63:

    Chromosome 5 open reading frame 63
    Hs.49573  [show with all ESTs]
    Unigene Representative Sequence: NM_001164479
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000508527 ENST00000606937 ENST00000607731 ENST00000606042 ENST00000509733
    ENST00000515558 ENST00000535381(uc021ydb.1 uc003kug.2) ENST00000296662(uc021ydc.1)

    miRNA
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    hsa-miR-1321 hsa-miR-4307 hsa-miR-136 hsa-miR-19b-2* hsa-miR-15a hsa-miR-1245 hsa-miR-25 hsa-miR-374c
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    Additional mRNA sequence: AK126569.1 

    10 DOTS entries:

    DT.101975559  DT.451860  DT.105615  DT.40210968  DT.75101224  DT.91724340  DT.91973465  DT.97812545 
    DT.102822283  DT.120814728 

    Selected AceView cDNA sequences (see all 46):

    BE674694 AK126569 AI348634 AI418538 AW297702 AA583280 AW612164 AI828014 
    BX100703 AA768722 AA844061 BX094840 AI027976 AA593988 AW316929 W38954 
    BE551203 BQ269742 BM874676 AV718182 AI028435 AW070420 AI339557 AA353425 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for C5orf63    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5
    SP1:                          -     -               
    SP2:                                                
    SP3:              -           -     -     -         
    SP4:              -                                 


    ECgene alternative splicing isoforms for C5orf63

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    See probesets specificity/sensitivity at GeneAnnot
    CGAP TAG: --

    C5orf63 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    C5orf63 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.49573
        Custom PCR Arrays for C5orf63
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C5orf63

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for C5orf63 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia C330018D20Rik1 , 5 RIKEN cDNA C330018D20 gene1, 5 88.18(n)1
    86.36(a)1
      18 (31.22 cM)5
    774221  NM_029909.11  NP_084185.11 
     569558335 
    chicken
    (Gallus gallus)
    Aves CZH5ORF631 chromosome Z open reading frame, human C5orf63 66.67(n)
    64.29(a)
      427125  XM_424718.4  XP_424718.2 
    lizard
    (Anolis carolinensis)
    Reptilia C5orf636
    chromosome 5 open reading frame 63
    32(a)
    1 ↔ 1
    2(29527177-29561856)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia LOC1017339201 chromosome unknown open reading frame, human C5orf63 63.43(n)
    63.11(a)
      101733920  XM_004910475.1  XP_004910532.1 
    zebrafish
    (Danio rerio)
    Actinopterygii im:71545161 im:7154516 70.88(n)
    73.56(a)
      492754  XM_003199318.2  XP_003199366.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG91476
    --
    6(a)
    1 ↔ 1
    2L(6066186-6067635)


    ENSEMBL Gene Tree for C5orf63 (if available)
    TreeFam Gene Tree for C5orf63 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for C5orf63 gene

    Find genes that share paralogs with C5orf63           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for C5orf63
    PGOHUM00000242770


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for C5orf63 (see all 568)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs744517891,2
    F--126377829(+) CCCAAT/ATTGTT 1 -- ds50012Minor allele frequency- A:0.05CSA WA 120
    rs1911841631,2
    --126377879(+) AGGAGA/GAGAGG 1 -- ds50010--------
    rs1821106481,2
    --126377929(+) TTTTAA/GTCTCT 1 -- ds50010--------
    rs1487173171,2
    --126378116(+) ACAACA/GTGCCC 1 -- ds50010--------
    rs1131283651,2
    C--126378195(+) CCAAGC/AAAGGC 1 -- ds50011Minor allele frequency- A:0.50CSA 2
    rs2021739711,2
    --126378330(+) GAATA-/TTTAAA 1 -- ut310--------
    rs32167301,2
    C--126378333(+) ATATT-/AAAAAAA 1 -- ut310--------
    rs742906401,2
    C,F--126378361(+) GATCAT/AGTTTT 1 -- ut312Minor allele frequency- A:0.05NA EA 240
    rs1422504711,2
    C--126378415(+) ACTTAA/TAAGGA 1 -- ut310--------
    rs1478538991,2
    --126378435(+) CATGAC/TAAAAC 1 -- ut310--------

    HapMap Linkage Disequilibrium report for C5orf63 (126378250 - 126409184 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for C5orf63: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing C5orf63
    DNA2.0 Custom Variant and Variant Library Synthesis for C5orf63

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for C5orf63 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with C5orf63)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
    2. The DNA sequence and comparative analysis of human chromosome 5. (PubMed id 15372022)2 Schmutz J.... Rubin E.M. (Nature 2004)
    3. (PubMed id )2 

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 401207 HGNC: 40051 AceView: LOC401207 Ensembl:ENSG00000164241 euGenes: HUgn401207
    ECgene: C5orf63 H-InvDB: C5orf63

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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      --

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for C5orf63 gene:
    Search GeneIP for patents involving C5orf63

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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