Aliases for C5orf60 Gene
External Ids for C5orf60 Gene
- HGNC: 27753
- Entrez Gene: 285679
- Ensembl: ENSG00000204661
- UniProtKB: A6NFR6
Previous GeneCards Identifiers for C5orf60 Gene
- GC05M179003
- GC05M179071
- GC05P173801
Summaries for C5orf60 Gene
GeneCards Summary for C5orf60 Gene
C5orf60 (Chromosome 5 Open Reading Frame 60) is a Protein Coding gene.
No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C5orf60 Gene
Genomics for C5orf60 Gene
Regulatory Elements for C5orf60 Gene
Enhancers for C5orf60 Gene
| GeneHancer Identifier | Enhancer Score | Enhancer Sources | Gene-Enhancer Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Gene Targets for Enhancer |
|---|---|---|---|---|---|---|---|---|
| GH05G179373 | 0.5 | FANTOM5 | 28 | +271.8 | 271808 | 0.1 | PKNOX1 NFYB | C5orf60 CBY3 ADAMTS2 ENSG00000253979 LOC105377759 |
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around C5orf60 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Location for C5orf60 Gene
- Chromosome:
- 5
- Start:
- 179,641,542 bp from pter
- End:
- 179,645,167 bp from pter
- Size:
- 3,626 bases
- Orientation:
- Minus strand
Genomic View for C5orf60 Gene
Genes around C5orf60 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 5q35.3 by Ensembl
- 5q35.3 by Entrez Gene
- 5q35.3 by HGNC
C5orf60 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for C5orf60 Gene
Proteins for C5orf60 Gene
-
Protein details for C5orf60 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- A6NFR6-CE060_HUMAN
- Recommended name:
- Putative uncharacterized protein C5orf60
- Protein Accession:
- A6NFR6
- A1L488
- B7ZM52
- B7ZM53
Protein attributes for C5orf60 Gene
- Size:
- 353 amino acids
- Molecular mass:
- 39250 Da
- Quaternary structure:
- No Data Available
- SequenceCaution:
-
- Sequence=AAI30443.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAI30445.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};
Protein Expression for C5orf60 Gene
Post-translational modifications for C5orf60 Gene
Other Protein References for C5orf60 Gene
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for C5orf60
-
Abcam antibodies for C5orf60
- Invitrogen Antibodies for C5orf60
- Search GeneTex for Antibodies for C5orf60
-
Santa Cruz Biotechnology (SCBT) Antibodies for C5orf60
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for C5orf60
- Origene Custom Protein Services for C5orf60
- Novus Biologicals proteins for C5orf60
- Search GeneTex for Proteins for C5orf60
Assay Products
No data available for DME Specific Peptides for C5orf60 Gene
Domains & Families for C5orf60 Gene
Protein Domains for C5orf60 Gene
- ProtoNet:
Graphical View of Domain Structure for InterPro Entry
No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for C5orf60 Gene
Function for C5orf60 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for C5orf60
-
-
ViGene Biosciences lentiviral particle packaged cDNA for C5orf60 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for C5orf60 gene
- Search ViGene Biosciences for C5orf60
CRISPR Products
-
OriGene CRISPR knockouts for C5orf60
-
Santa Cruz Biotechnology (SCBT) CRISPR for C5orf60
- GenScript: Design CRISPR guide RNA sequences for C5orf60
miRNA Products
- Search ViGene Biosciences for C5orf60
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for C5orf60
- Browse OriGene Inhibitory RNA Products For C5orf60
-
ViGene Biosciences ready-to-package AAV shRNAs for C5orf60 gene
Clone Products
-
OriGene ORF clones in human for C5orf60
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for C5orf60
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for C5orf60
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for C5orf60
-
ViGene Biosciences adenoviral particle packaged cDNA for C5orf60 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for C5orf60 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for C5orf60 gene
Flow Cytometry Products
No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for C5orf60 Gene
Localization for C5orf60 Gene
Subcellular locations from UniProtKB/Swiss-Prot for C5orf60 Gene
- Membrane; Single-pass membrane protein.
| Compartment | Confidence |
|---|---|
| plasma membrane | 1 |
| golgi apparatus | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0016021 | integral component of membrane | IEA | -- |
Transcripts for C5orf60 Gene
mRNA/cDNA for C5orf60 Gene
- (5) REFSEQ mRNAs :
- (5) Additional mRNA sequences :
- (5) Selected AceView cDNA sequences:
- (8) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for C5orf60 Gene
CRISPR Products
-
OriGene CRISPR knockouts for C5orf60
-
Santa Cruz Biotechnology (SCBT) CRISPR for C5orf60
- GenScript: Design CRISPR guide RNA sequences for C5orf60
miRNA Products
- Search ViGene Biosciences for C5orf60
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for C5orf60
- Browse OriGene Inhibitory RNA Products For C5orf60
-
ViGene Biosciences ready-to-package AAV shRNAs for C5orf60 gene
Clone Products
-
OriGene ORF clones in human for C5orf60
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for C5orf60
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for C5orf60
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Flow Cytometry Products
Expression for C5orf60 Gene
mRNA differential expression in normal tissues according to GTEx for C5orf60 Gene
This gene is overexpressed in Testis (x50.2).
This gene is overexpressed in Plasma (69.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for C5orf60 Gene
NURSA nuclear receptor signaling pathways regulating expression of C5orf60 Gene:
C5orf60SOURCE GeneReport for Unigene cluster for C5orf60 Gene:
Hs.558748Primer Products
-
OriGene qPCR primer pairs for C5orf60
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for C5orf60 Gene
Orthologs for C5orf60 Gene
This gene was present in the common ancestor of human and chimp.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | LOC462326 34 |
|
||
| -- 35 |
|
OneToMany |
- Species where no ortholog for C5orf60 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- cow (Bos Taurus)
- dog (Canis familiaris)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- mouse (Mus musculus)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rat (Rattus norvegicus)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Paralogs for C5orf60 Gene
No data available for Paralogs for C5orf60 Gene
Variants for C5orf60 Gene
| SNP ID | Clin | Chr 05 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000182482 | -- | 179,642,716(+) | TGGTG(C/T)CAGTT | intron-variant, reference, missense | |
| rs1001088889 | -- | 179,643,830(+) | GGTCC(C/G)CTCCT | intron-variant | |
| rs1002231114 | -- | 179,645,489(+) | GCTTA(-/T)TTTTT | upstream-variant-2KB | |
| rs1003361723 | -- | 179,642,368(+) | GATGT(C/T)GGATA | nc-transcript-variant, reference, missense, utr-variant-3-prime | |
| rs1003906513 | -- | 179,641,973(+) | GCAGT(-/TC)TGTTA | intron-variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv214n111 | CNV | duplication | 26073780 |
| dgv5848n100 | CNV | gain | 25217958 |
| esv1005618 | OTHER | inversion | 20482838 |
| esv1419350 | OTHER | inversion | 17803354 |
| nsv1021275 | CNV | gain | 25217958 |
| nsv281 | OTHER | inversion | 15895083 |
| nsv499095 | OTHER | inversion | 21111241 |
| nsv7375 | OTHER | inversion | 18451855 |
| nsv823358 | CNV | loss | 20364138 |
| nsv830560 | CNV | loss | 17160897 |
| nsv969027 | CNV | duplication | 23825009 |
Gene Damage Index Score:
6.06;
75.24% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for C5orf60 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- C5orf60
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C5orf60 Gene
Disorders for C5orf60 Gene
Relevant External Links for C5orf60
- Atlas of Genetics and Cytogenetics in Oncology and Haematology:
- C5orf60
No disorders were found for C5orf60 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C5orf60 Gene
Publications for C5orf60 Gene
- The DNA sequence and comparative analysis of human chromosome 5. (PMID: 15372022) Schmutz J. … Rubin E.M. (Nature 2004) 3 4 64
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64
- A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3 64
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 64
Products for C5orf60 Gene
- Browse R&D Systems for Antibodies
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
- Browse DNA Damage and Repair Kits
- Browse ELISpot/FluoroSpot Kits and Development Modules
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- Browse Immunoprecipitation Assays
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- Browse OriGene Antibodies
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for C5orf60
- Origene Custom Protein Services for C5orf60
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for C5orf60
- Browse OriGene Inhibitory RNA Products For C5orf60
- OriGene qPCR primer pairs for C5orf60
- OriGene CRISPR knockouts for C5orf60
- OriGene ORF clones in human for C5orf60
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For C5orf60
- GenScript: Next-day shipping cDNA ORF clone for C5orf60 in any vector
- GenScript Custom Purified and Recombinant Proteins Services for C5orf60
- GenScript Custom Assay Services for C5orf60
- GenScript Custom overexpressing Cell Line Services for C5orf60
- GenScript: Design CRISPR guide RNA sequences for C5orf60
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- CloneReady with Over 120,000 Genes
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- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for C5orf60
- Browse Sino Biological cDNA Clones
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- Sino Biological Antibodies
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- Sino Biological Transfection Reagents
- Novus Biologicals Antibodies for C5orf60
- Novus Biologicals proteins for C5orf60
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- ViGene Biosciences adenoviral particle packaged cDNA for C5orf60 gene
- ViGene Biosciences lentiviral particle packaged cDNA for C5orf60 gene
- ViGene Biosciences ready-to-package AAV shRNAs for C5orf60 gene
- Search ViGene Biosciences for C5orf60
- Santa Cruz Biotechnology (SCBT) Antibodies for C5orf60
- Search Santa Cruz Biotechnology (SCBT) for C5orf60 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for C5orf60
- Horizon Cell Lines for C5orf60
- Cyagen custom Knockout/knockin (KOKI) mouse models for C5orf60
- VectorBuilder custom plasmid, inducible vectors for C5orf60
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for C5orf60
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for C5orf60 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
- (121) SIGNOR
- (122) diseasecard
- (123) NIH Rare Diseases
- (124) Orphanet
- (125) UMLS
- (126) GTR
- (127) Disease Ontology
- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
- (131) CDC
- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer