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Aliases for C5orf60 Gene

Aliases for C5orf60 Gene

  • Chromosome 5 Open Reading Frame 60 2 3 5

External Ids for C5orf60 Gene

Previous GeneCards Identifiers for C5orf60 Gene

  • GC05M179003
  • GC05M179071
  • GC05P173801

Summaries for C5orf60 Gene

GeneCards Summary for C5orf60 Gene

C5orf60 (Chromosome 5 Open Reading Frame 60) is a Protein Coding gene.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C5orf60 Gene

Genomics for C5orf60 Gene

Regulatory Elements for C5orf60 Gene

Enhancers for C5orf60 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05G179373 0.5 FANTOM5 28 +271.8 271808 0.1 PKNOX1 NFYB C5orf60 CBY3 ADAMTS2 ENSG00000253979 LOC105377759
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around C5orf60 on UCSC Golden Path with GeneCards custom track

Genomic Location for C5orf60 Gene

179,641,542 bp from pter
179,645,167 bp from pter
3,626 bases
Minus strand

Genomic View for C5orf60 Gene

Genes around C5orf60 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C5orf60 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C5orf60 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C5orf60 Gene

Proteins for C5orf60 Gene

  • Protein details for C5orf60 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Putative uncharacterized protein C5orf60
    Protein Accession:
    Secondary Accessions:
    • A1L488
    • B7ZM52
    • B7ZM53

    Protein attributes for C5orf60 Gene

    353 amino acids
    Molecular mass:
    39250 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAI30443.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAI30445.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for C5orf60 Gene


neXtProt entry for C5orf60 Gene

Post-translational modifications for C5orf60 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C5orf60 Gene

No data available for DME Specific Peptides for C5orf60 Gene

Domains & Families for C5orf60 Gene

Protein Domains for C5orf60 Gene


Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C5orf60: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for C5orf60 Gene

Function for C5orf60 Gene

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for C5orf60 Gene

Localization for C5orf60 Gene

Subcellular locations from UniProtKB/Swiss-Prot for C5orf60 Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C5orf60 gene
Compartment Confidence
plasma membrane 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for C5orf60 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with C5orf60: view

Pathways & Interactions for C5orf60 Gene

SuperPathways for C5orf60 Gene

No Data Available

Gene Ontology (GO) - Biological Process for C5orf60 Gene


No data available for Pathways by source and SIGNOR curated interactions for C5orf60 Gene

Transcripts for C5orf60 Gene

mRNA/cDNA for C5orf60 Gene

(5) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(5) Selected AceView cDNA sequences:
(8) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for C5orf60 Gene

Chromosome 5 open reading frame 60:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for C5orf60 Gene

No ASD Table

Relevant External Links for C5orf60 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for C5orf60 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for C5orf60 Gene

mRNA differential expression in normal tissues according to GTEx for C5orf60 Gene

This gene is overexpressed in Testis (x50.2).

Protein differential expression in normal tissues from HIPED for C5orf60 Gene

This gene is overexpressed in Plasma (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for C5orf60 Gene

Protein tissue co-expression partners for C5orf60 Gene

NURSA nuclear receptor signaling pathways regulating expression of C5orf60 Gene:


SOURCE GeneReport for Unigene cluster for C5orf60 Gene:

genes like me logo Genes that share expression patterns with C5orf60: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for C5orf60 Gene

Orthologs for C5orf60 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for C5orf60 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LOC462326 34
  • 97.51 (n)
-- 35
  • 55 (a)
Species where no ortholog for C5orf60 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for C5orf60 Gene

Gene Tree for C5orf60 (if available)
Gene Tree for C5orf60 (if available)

Paralogs for C5orf60 Gene

No data available for Paralogs for C5orf60 Gene

Variants for C5orf60 Gene

Sequence variations from dbSNP and Humsavar for C5orf60 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs1000182482 -- 179,642,716(+) TGGTG(C/T)CAGTT intron-variant, reference, missense
rs1001088889 -- 179,643,830(+) GGTCC(C/G)CTCCT intron-variant
rs1002231114 -- 179,645,489(+) GCTTA(-/T)TTTTT upstream-variant-2KB
rs1003361723 -- 179,642,368(+) GATGT(C/T)GGATA nc-transcript-variant, reference, missense, utr-variant-3-prime
rs1003906513 -- 179,641,973(+) GCAGT(-/TC)TGTTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for C5orf60 Gene

Variant ID Type Subtype PubMed ID
dgv214n111 CNV duplication 26073780
dgv5848n100 CNV gain 25217958
esv1005618 OTHER inversion 20482838
esv1419350 OTHER inversion 17803354
nsv1021275 CNV gain 25217958
nsv281 OTHER inversion 15895083
nsv499095 OTHER inversion 21111241
nsv7375 OTHER inversion 18451855
nsv823358 CNV loss 20364138
nsv830560 CNV loss 17160897
nsv969027 CNV duplication 23825009

Variation tolerance for C5orf60 Gene

Gene Damage Index Score: 6.06; 75.24% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C5orf60 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C5orf60 Gene

Disorders for C5orf60 Gene

Relevant External Links for C5orf60

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for C5orf60 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C5orf60 Gene

Publications for C5orf60 Gene

  1. The DNA sequence and comparative analysis of human chromosome 5. (PMID: 15372022) Schmutz J. … Rubin E.M. (Nature 2004) 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3 64
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 64

Products for C5orf60 Gene

Sources for C5orf60 Gene

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