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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

C5orf60 Gene

protein-coding   GIFtS: 36
GCID: GC05M179071

Chromosome 5 Open Reading Frame 60

  Search for C5orf60
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Chromosome 5 Open Reading Frame 601 2
Putative Uncharacterized Protein C5orf602
Putative Uncharacterized Protein FLJ357232

External Ids:    HGNC: 277531   Entrez Gene: 2856792   Ensembl: ENSG000002046617   UniProtKB: A6NFR63   

Export aliases for C5orf60 gene to outside databases

Previous GC identifers: GC05M179003 GC05P173801


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for C5orf60 Gene: 
C5orf60 (chromosome 5 open reading frame 60) is a protein-coding gene. An important paralog of this gene is LOC100502572.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000005.9  NT_023133.13  NC_018916.2  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for C5orf60
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for C5orf60

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C5orf60


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q35.3   Ensembl cytogenetic band:  5q35.3   HGNC cytogenetic band: 5q35.3

C5orf60 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
C5orf60 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M179071:  view genomic region     (about GC identifiers)

Start:
179,068,545 bp from pter      End:
179,072,047 bp from pter
Size:
3,503 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CE060_HUMAN, A6NFR6 (See protein sequence)
Recommended Name: Putative uncharacterized protein C5orf60  
Size: 353 amino acids; 39250 Da
Subcellular location: Membrane; Single-pass membrane protein (Potential)
Sequence caution: Sequence=AAI30443.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=AAI30445.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: A1L488 B7ZM52 B7ZM53
Alternative splicing: 4 isoforms:  A6NFR6-1   A6NFR6-2   A6NFR6-3   A6NFR6-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for C5orf60: NX_A6NFR6

Explore proteomics data for C5orf60 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_A6NFR6

  • C5orf60 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    C5orf60 Protein Expression
    REFSEQ proteins: NP_001135778.1  
    ENSEMBL proteins: 
     ENSP00000404583   ENSP00000421415   ENSP00000421635  

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    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral to membrane IEA--

    C5orf60 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ProtoNet protein and cluster: A6NFR6


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Animal Models:
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for C5orf60

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for C5orf60 (CE060)

    Search CenterWatch for drugs/clinical trials and news about C5orf60 / CE060

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    About This Section

    REFSEQ mRNAs for C5orf60 gene (2 alternative transcripts): 
    NM_001142306.1  NM_001013718.1  

    Unigene Cluster for C5orf60:

    Chromosome 5 open reading frame 60
    Hs.558748  [show with all ESTs]
    Unigene Representative Sequence: AK093042
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000514664 ENST00000448248(uc003mki.3 uc011dgo.2) ENST00000511063
    ENST00000512899 ENST00000506142 ENST00000513845 ENST00000513142 ENST00000503358

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    Additional mRNA sequence: 

    AK093042.1 BC130442.1 BC130444.1 BC144274.1 BC144275.1 

    5 DOTS entries:

    DT.120863443  DT.100713990  DT.100748503  DT.120863446  DT.95230313 

    5 AceView cDNA sequences:

    BX088746 AI024381 AA453979 BC040992 BI461388 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    C5orf60 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GACACCGAAT
    C5orf60 Expression
    About this image


    See C5orf60 Protein Expression from SPIRE MOPED and PaxDB
    SOURCE GeneReport for Unigene cluster: Hs.558748
        SABiosciences Custom PCR Arrays for C5orf60
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C5orf60

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of human and chimp.

    Orthologs for C5orf60 gene from 1 species (see representative species )    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chimpanzee
    (Pan troglodytes)
    Mammalia LOC4623261 putative uncharacterized protein C5orf60-like 97.51(n)
    95.18(a)
      462326  XM_518148.4  XP_518148.4 


    ENSEMBL Gene Tree for C5orf60 (if available)
    TreeFam Gene Tree for C5orf60 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for C5orf60 gene
    LOC1005025722  

    C5orf60 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for C5orf60
    PGOHUM00000235864


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/147 SNPs in C5orf60 are shown (see all 147)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs117473101,2
    C,F,H--179068067(-) cgcaaC/Gtcact 1 -- int12Minor allele frequency- G:0.08WA NA 238
    rs1145442251,2
    F--179068071(+) AGTTGC/TGATCT 1 -- int11Minor allele frequency- T:0.04WA 118
    rs1864106671,2
    --179068078(+) ATCTCA/GCCACT 1 -- int10--------
    rs1478629951,2
    --179068086(+) ACTGCA/GCTCCA 1 -- int10--------
    rs68938821,2
    C--179068116(-) tgagaC/Tggagt 1 -- int10--------
    rs1132112701,2
    C,F--179068164(+) AACAGC/ATTAAG 1 -- int11Minor allele frequency- A:0.50WA 2
    rs1906707841,2
    --179068166(+) CAGCTA/TAAGCC 1 -- int10--------
    rs131675381,2
    C,F--179068192(-) ACAAAG/ATCTTA 1 -- int17Minor allele frequency- A:0.12NA WA EA 366
    rs2003542381,2
    --179068193(+) AAGAC-/TTTGTCA 1 -- int10--------
    rs1828610771,2
    --179068199(+) TTGTCA/CAATCC 1 -- int10--------

    HapMap Linkage Disequilibrium report for C5orf60 (179068545 - 179072047 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for C5orf60:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv883270CNV Loss21882294
    nsv823358CNV Loss20364138
    nsv883273CNV Loss21882294
    nsv830560CNV Loss17160897
    esv1005618OTHER Inversion20482838
    nsv7375OTHER Inversion18451855
    esv1419350OTHER Inversion17803354
    nsv281OTHER Inversion15895083
    nsv499095OTHER Inversion21111241

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for C5orf60 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with C5orf60)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The DNA sequence and comparative analysis of human chromosome 5. (PubMed id 15372022)1, 2 Schmutz J.... Rubin E.M. (2004)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 285679 HGNC: 27753 AceView: LOC285679 Ensembl:ENSG00000204661 euGenes: HUgn285679
    ECgene: C5orf60 H-InvDB: C5orf60

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for C5orf60 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for C5orf60 gene:
    Search GeneIP for patents involving C5orf60

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    About This Section

     
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     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C5orf60
     Browse SwitchGear 3'UTR luciferase reporter plasmids for C5orf60
     Browse SwitchGear Promoter luciferase reporter plasmids for C5orf60
     ThermoFisher Antibodies for C5orf60
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C5orf60
     inGenious Targeting Laboratory - Custom generated mouse model solutions for C5orf60
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for C5orf60
    Customized:
     lentivirus for stable overexpression of C5orf60
     lentivirus expression plasmids for stable overexpression of C5orf60
     adenovirus for overexpression of C5orf60
     Search LSBio for Antibodies for C5orf60
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
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