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Aliases for C5orf58 Gene

Aliases for C5orf58 Gene

  • Chromosome 5 Open Reading Frame 58 2 3 5

External Ids for C5orf58 Gene

Previous GeneCards Identifiers for C5orf58 Gene

  • GC05P169592
  • GC05P164758

Summaries for C5orf58 Gene

GeneCards Summary for C5orf58 Gene

C5orf58 (Chromosome 5 Open Reading Frame 58) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C5orf58 Gene

Genomics for C5orf58 Gene

Regulatory Elements for C5orf58 Gene

Enhancers for C5orf58 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around C5orf58 on UCSC Golden Path with GeneCards custom track

Genomic Location for C5orf58 Gene

170,232,447 bp from pter
170,252,575 bp from pter
20,129 bases
Plus strand

Genomic View for C5orf58 Gene

Genes around C5orf58 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C5orf58 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C5orf58 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C5orf58 Gene

Proteins for C5orf58 Gene

  • Protein details for C5orf58 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Putative uncharacterized protein C5orf58
    Protein Accession:

    Protein attributes for C5orf58 Gene

    102 amino acids
    Molecular mass:
    11666 Da
    Quaternary structure:
    No Data Available

neXtProt entry for C5orf58 Gene

Post-translational modifications for C5orf58 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for C5orf58 Gene

Domains & Families for C5orf58 Gene

Protein Domains for C5orf58 Gene


Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C5orf58: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for C5orf58 Gene

Function for C5orf58 Gene

Phenotypes for C5orf58 Gene

genes like me logo Genes that share phenotypes with C5orf58: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for C5orf58 Gene

Localization for C5orf58 Gene

Subcellular locations from

Jensen Localization Image for C5orf58 Gene COMPARTMENTS Subcellular localization image for C5orf58 gene
Compartment Confidence
cytosol 2
nucleus 2
extracellular 1
mitochondrion 1
plasma membrane 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for C5orf58 Gene

Pathways & Interactions for C5orf58 Gene

SuperPathways for C5orf58 Gene

No Data Available

Interacting Proteins for C5orf58 Gene

Gene Ontology (GO) - Biological Process for C5orf58 Gene


No data available for Pathways by source and SIGNOR curated interactions for C5orf58 Gene

Drugs & Compounds for C5orf58 Gene

No Compound Related Data Available

Transcripts for C5orf58 Gene

Unigene Clusters for C5orf58 Gene

Chromosome 5 open reading frame 58:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for C5orf58 Gene

No ASD Table

Relevant External Links for C5orf58 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for C5orf58 Gene

mRNA expression in normal human tissues for C5orf58 Gene

mRNA differential expression in normal tissues according to GTEx for C5orf58 Gene

This gene is overexpressed in Testis (x43.4).

Protein differential expression in normal tissues from HIPED for C5orf58 Gene

This gene is overexpressed in Prostate (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for C5orf58 Gene

Protein tissue co-expression partners for C5orf58 Gene

NURSA nuclear receptor signaling pathways regulating expression of C5orf58 Gene:


SOURCE GeneReport for Unigene cluster for C5orf58 Gene:

genes like me logo Genes that share expression patterns with C5orf58: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for C5orf58 Gene

Orthologs for C5orf58 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for C5orf58 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia C5H5orf58 34
  • 99.67 (n)
  • 99.02 (a)
C5orf58 35
  • 99 (a)
Species where no ortholog for C5orf58 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for C5orf58 Gene

Gene Tree for C5orf58 (if available)
Gene Tree for C5orf58 (if available)

Paralogs for C5orf58 Gene

No data available for Paralogs for C5orf58 Gene

Variants for C5orf58 Gene

Sequence variations from dbSNP and Humsavar for C5orf58 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs1508759 -- 170,236,254(-) ACTCA(C/T)TATTT intron-variant, splice-donor-variant
rs4266418 -- 170,244,418(+) cacca(A/G)tcaga intron-variant
rs1810080 -- 170,245,506(+) AAAGC(A/G)CAATA intron-variant
rs10053116 -- 170,238,171(+) gcaga(A/G)aaaaa intron-variant
rs4605806 -- 170,245,639(+) CACAC(C/T)GTGCG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for C5orf58 Gene

Variant ID Type Subtype PubMed ID
nsv1115705 CNV duplication 24896259
nsv1149960 CNV duplication 26484159
nsv830547 CNV gain+loss 17160897

Variation tolerance for C5orf58 Gene

Residual Variation Intolerance Score: 58.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.19; 4.17% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C5orf58 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C5orf58 Gene

Disorders for C5orf58 Gene

Relevant External Links for C5orf58

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for C5orf58 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C5orf58 Gene

Publications for C5orf58 Gene

  1. Genome-wide association study identifies three novel susceptibility loci for severe Acne vulgaris. (PMID: 24927181) Navarini A.A. … Barker J.N. (Nat Commun 2014) 3 65
  2. The DNA sequence and comparative analysis of human chromosome 5. (PMID: 15372022) Schmutz J. … Rubin E.M. (Nature 2004) 4 65
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4 65
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 65

Products for C5orf58 Gene

Sources for C5orf58 Gene

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