Free for academic non-profit institutions. Other users need a Commercial license

C5orf58 Gene(Protein Coding)

Chromosome 5 Open Reading Frame 58

GCID:
GC05P170232
GIFtS:
36
Genes Participants
UDN Logo

Aliases for C5orf58 Gene

Aliases for C5orf58 Gene

  • Chromosome 5 Open Reading Frame 58 2 3 5

External Ids for C5orf58 Gene

Previous GeneCards Identifiers for C5orf58 Gene

  • GC05P169592
  • GC05P164758

Summaries for C5orf58 Gene

GeneCards Summary for C5orf58 Gene

C5orf58 (Chromosome 5 Open Reading Frame 58) is a Protein Coding gene.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C5orf58 Gene

Genomics for C5orf58 Gene

Products:

  1. Regulatory Element

Regulatory Elements for C5orf58 Gene

Enhancers for C5orf58 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05G170329 1.9 FANTOM5 Ensembl ENCODE dbSUPER 11.1 +101.3 101330 8.1 HDGF PKNOX1 ARNT SIN3A YBX1 FEZF1 FOS MCM3 JUNB ZNF662 LCP2 KCNMB1 CTD-2270F17.1 C5orf58 LINC01366 KCNIP1
GH05G170220 1 Ensembl ENCODE 12.1 -10.7 -10677 2.0 CTCF HDGF PKNOX1 MAX EED ZNF207 ETV6 NFE2 RELB CREM C5orf58 LCP2 LINC01187
GH05G170219 1 Ensembl ENCODE 11.8 -12.6 -12578 1.2 ZBTB21 JUN INSM2 FEZF1 ZIC2 ZEB1 ZNF101 GATA2 RBAK EED C5orf58 LCP2 LINC01187
GH05G170273 1.9 FANTOM5 Ensembl ENCODE dbSUPER 4.7 +49.6 49572 17.7 HDGF PKNOX1 SIN3A TCF12 GATA2 CBX5 ZNF143 ZNF207 FOS KDM4B KCNMB1 CTD-2270F17.1 LCP2 C5orf58 GC05M170247
GH05G170338 0.8 ENCODE 11.1 +106.4 106395 0.7 CTCF ESRRA PKNOX1 RB1 BACH1 EBF1 ZBTB40 RAD21 ZNF143 SMC3 CTD-2270F17.1 KCNMB1 C5orf58 LINC01366 KCNIP1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around C5orf58 on UCSC Golden Path with GeneCards custom track

Genomic Location for C5orf58 Gene

Chromosome:
5
Start:
170,232,447 bp from pter
End:
170,252,575 bp from pter
Size:
20,129 bases
Orientation:
Plus strand

Genomic View for C5orf58 Gene

Genes around C5orf58 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C5orf58 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C5orf58 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for C5orf58 Gene

Proteins for C5orf58 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for C5orf58 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    C9J3I9-CE058_HUMAN
    Recommended name:
    Putative uncharacterized protein C5orf58
    Protein Accession:
    C9J3I9

    Protein attributes for C5orf58 Gene

    Size:
    102 amino acids
    Molecular mass:
    11666 Da
    Quaternary structure:
    No Data Available

neXtProt entry for C5orf58 Gene

Protein Expression for C5orf58 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for C5orf58 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C5orf58 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for C5orf58 Gene

Domains & Families for C5orf58 Gene

Protein Domains for C5orf58 Gene

ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C5orf58: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for C5orf58 Gene

Function for C5orf58 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line
  7. Flow Cytometry

Phenotypes for C5orf58 Gene

GenomeRNAi human phenotypes for C5orf58:
genes like me logo Genes that share phenotypes with C5orf58: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for C5orf58 Gene

Localization for C5orf58 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C5orf58 gene
Compartment Confidence
nucleus 2
cytosol 2
plasma membrane 1
extracellular 1
mitochondrion 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for C5orf58 Gene

Pathways & Interactions for C5orf58 Gene

SuperPathways for C5orf58 Gene

PathCards logo More details on SuperPathways for C5orf58
No Data Available

Interacting Proteins for C5orf58 Gene

Gene Ontology (GO) - Biological Process for C5orf58 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for C5orf58 Gene

Drugs & Compounds for C5orf58 Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for C5orf58 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone
  5. Flow Cytometry

mRNA/cDNA for C5orf58 Gene

(12) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(26) Selected AceView cDNA sequences:
(6) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for C5orf58 Gene

Chromosome 5 open reading frame 58:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for C5orf58 Gene

No ASD Table

Relevant External Links for C5orf58 Gene

GeneLoc Exon Structure for
C5orf58
ECgene alternative splicing isoforms for
C5orf58

Expression for C5orf58 Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for C5orf58 Gene

mRNA expression in normal human tissues for C5orf58 Gene
mRNA expression by GTEx for C5orf58 Gene

mRNA differential expression in normal tissues according to GTEx for C5orf58 Gene

This gene is overexpressed in Testis (x43.4).

Protein differential expression in normal tissues from HIPED for C5orf58 Gene

This gene is overexpressed in Prostate (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for C5orf58 Gene



Protein tissue co-expression partners for C5orf58 Gene

NURSA nuclear receptor signaling pathways regulating expression of C5orf58 Gene:

C5orf58

SOURCE GeneReport for Unigene cluster for C5orf58 Gene:

Hs.519749

Evidence on tissue expression from TISSUES for C5orf58 Gene

  • Lung(2.9)
  • Kidney(2.7)
  • Intestine(2.4)
  • Bone(2.2)
genes like me logo Genes that share expression patterns with C5orf58: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for C5orf58 Gene

Orthologs for C5orf58 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for C5orf58 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia C5H5orf58 34
  • 99.67 (n)
C5orf58 35
  • 99 (a)
 OneToOne
Species where no ortholog for C5orf58 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for C5orf58 Gene

ENSEMBL:
Gene Tree for C5orf58 (if available)
TreeFam:
Gene Tree for C5orf58 (if available)

Paralogs for C5orf58 Gene

No data available for Paralogs for C5orf58 Gene

Variants for C5orf58 Gene

Sequence variations from dbSNP and Humsavar for C5orf58 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs1000016857 -- 170,239,732(+) CTTTT(A/G)GTAAG intron-variant
rs1000233765 -- 170,232,094(+) AGCTG(G/T)TTATC upstream-variant-2KB, utr-variant-5-prime
rs1000262893 -- 170,236,051(+) GATCC(A/C)TCCAG intron-variant
rs1000574461 -- 170,246,360(+) TTGGC(C/T)CAGGT intron-variant, downstream-variant-500B, utr-variant-3-prime
rs1000698290 -- 170,236,470(+) TTCAT(C/T)ATTTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for C5orf58 Gene

Variant ID Type Subtype PubMed ID
nsv1115705 CNV duplication 24896259
nsv1149960 CNV duplication 26484159
nsv830547 CNV gain+loss 17160897

Variation tolerance for C5orf58 Gene

Residual Variation Intolerance Score: 58.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.19; 4.17% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C5orf58 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
C5orf58

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C5orf58 Gene

Disorders for C5orf58 Gene

Relevant External Links for C5orf58

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
C5orf58

No disorders were found for C5orf58 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C5orf58 Gene

Publications for C5orf58 Gene

  1. Genome-wide association study identifies three novel susceptibility loci for severe Acne vulgaris. (PMID: 24927181) Navarini A.A. … Barker J.N. (Nat Commun 2014) 3 64
  2. The DNA sequence and comparative analysis of human chromosome 5. (PMID: 15372022) Schmutz J. … Rubin E.M. (Nature 2004) 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4 64
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 64

Products for C5orf58 Gene

Sources for C5orf58 Gene

Content
Loading form....