C5orf56 Gene
protein-coding GIFtS: 34
GCID: GC05P131775
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chromosome 5 open reading frame 56
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Aliases
for C5orf56 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Chromosome 5 Open Reading Frame 561 2 |
Export aliases for C5orf56 gene to outside databasesPrevious GC identifer: GC05P126938 |
Summaries
for C5orf56 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for C5orf56 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000005.9 NC_018916.1 NT_034772.6
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the C5orf56 gene promoter:
c-Fos C/EBPbeta AP-1 E47 GATA-2 c-Ets-1 MEF-2A aMEF-2 c-Jun Pax-4a
Other transcription factors
Search SABiosciences Chromatin IP Primers for C5orf56
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C5orf56 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 5q31.1 Ensembl cytogenetic band: 5q31.1 HGNC cytogenetic band: 5q31.1C5orf56 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 5 GeneLoc Exon Structure GeneLoc location for GC05P131775: view genomic region
(about GC identifiers)
Start:
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131,746,328 bp from pter |
End:
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131,811,736 bp from pter |
Size:
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65,409 bases |
Orientation:
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plus strand |
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Proteins
for C5orf56 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CE056_HUMAN, Q8N8D9 (See
protein sequence)Recommended Name: Uncharacterized protein C5orf56 Size: 126 amino acids; 14652 Da
Secondary accessions: A1L3V9 A6NKA0Alternative splicing: 2 isoforms: Q8N8D9-1 Q8N8D9-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for C5orf56: NX_Q8N8D9
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8N8D9
C5orf56 Protein expression data from MOPED and PaxDb: About this image 
ENSEMBL proteins: ENSP00000368236 ENSP00000338228 ENSP00000368230 ENSP00000385513
Human Recombinant Protein Products:
C5orf56 Antibody Products:
Assay Products for C5orf56: |
Protein
Domains /
Families
for C5orf56 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| ProtoNet protein and cluster: Q8N8D9 |
Function
for C5orf56 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for C5orf56
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for C5orf56
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: C5orf56 (NM_001013717) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for C5orf56 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C5orf56 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C5orf56 |
|
Pathways & Interactions
for C5orf56 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for C5orf56
|
Drugs & Compounds
for C5orf56 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for C5orf56
Search CenterWatch for drugs/clinical trials and news about C5orf56 / CE056
|
Transcripts
for C5orf56 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for C5orf56 gene (4 alternative transcripts): NM_001013717.2 NM_001207001.1 NM_001207002.1 NM_001207003.1 Unigene Cluster for C5orf56: Chromosome 5 open reading frame 56 Hs.658288 [show with all ESTs]Unigene Representative Sequence: AL7137216 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000378953(uc003kwz.2 uc010jds.2) ENST00000461203 ENST00000337752(uc003kwy.2 uc021ydl.1)
ENST00000378947 ENST00000407797 ENST00000464024
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for C5orf56
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for C5orf56
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: C5orf56 (NM_001013717) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for C5orf56 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C5orf56 |
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for C5orf56
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat C5orf56 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat C5orf56 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat C5orf56 |
Additional cDNA sequence: AK096941.1 AK128882.1 AK309191.1 AL713721.1 BC130299.1 BC130656.1 NR_045116.1 14 DOTS entries: DT.211638 DT.120846158 DT.97832204 DT.99930770 DT.120846277 DT.211640 DT.95136413 DT.86852360 DT.100652196 DT.211639 DT.40245309 DT.91666246 DT.92436975 DT.95220220 24/49 AceView cDNA sequences (see all 49): BM985103 CN480423 AA295106 AW014287 BX456850 AW002034 AA358892 AA324298 AK128882 CR615570 AL713721 BI822217 AL564637 AI018587 CK429631 BF476224 BE466979 BQ187613 AI033261 AK096941 AW072550 AA357749 BF931426 BE221920
GeneLoc Exon Structure
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Expression
for C5orf56 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| C5orf56 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTCCTTTTAC
About this image
See C5orf56 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for C5orf56
SOURCE GeneReport for Unigene cluster: Hs.658288
SABiosciences Custom PCR Arrays for C5orf56
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for C5orf56
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat C5orf56 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat C5orf56 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat C5orf56 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C5orf56 |
Orthologs
for C5orf56 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
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ENSEMBL Gene Tree for C5orf56 (if available)
TreeFam Gene Tree for C5orf56 (if available) |
Paralogs
for C5orf56 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for C5orf56 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 5 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
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HapMap Linkage Disequilibrium report for C5orf56 (131746328 - 131811736 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for C5orf56: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing C5orf56 |
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Disorders
/ Diseases
for C5orf56 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
C5orf56 for disorders About GeneDecksing
2  diseases for C5orf56: About MalaCardscrohn's disease psoriasis
Human Genome Epidemiology (HuGE) Navigator: C5orf56 (4 documents)
Export disorders for C5orf56 gene to outside databases
|
Publications
for C5orf56 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for C5orf56 gene, integrated from 9 sources (see all 12):
(articles sorted by number of sources associating them with C5orf56) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Genome-wide association study to identify genetic dete rminants of severe asthma. (PubMed id 22561531)1 Wan Y.I....Hall I.P. (2012)
- New gene functions in megakaryopoiesis and platelet fo rmation. (PubMed id 22139419)1 Gieger C....Soranzo N. (2011)
- Fucosyltransferase 2 (FUT2) non-secretor status is as sociated with Crohn's disease. (PubMed id 20570966)1 McGovern D.P....Rotter J.I. (2010)
- Analysis of 39 Crohn's disease risk loci in Swedish i nflammatory bowel disease patients. (PubMed id 19760754)1 TAPrkvist L....Pettersson S. (2010)
- Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci. (PubMed id 21102463)1 Franke A....Parkes M. (2010)
- Molecular reclassification of Crohn's disease by clus ter analysis of genetic variants. (PubMed id 20886065)1 Cleynen I....Vermeire S. (2010)
- Novel loci, including those related to Crohn disease, psoriasis, and inflammation, identified in a genome-wide association study of fibrinogen in 17 686 women: the Women's Genome Health Study. (PubMed id 20031577)1 Danik J.S....Ridker P.M. (2009)
- Association of novel genetic Loci with circulating fi brinogen levels: a genome-wide association study in 6 population-based cohorts. (PubMed id 20031576)1 Dehghan A....Gieger C. (2009)
- Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease. (PubMed id 18587394)1 Barrett J.C....Daly M.J. (2008)
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External Searches for C5orf56 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing C5orf56 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing C5orf56 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing C5orf56 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for C5orf56 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for C5orf56 gene:
Search GeneIP for patents involving C5orf56
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for C5orf56 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
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 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for C5orf56 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for C5orf56 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for C5orf56 | | | OriGene Protein Over-expression Lysate for C5orf56 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for C5orf56 | | OriGene 3'-UTR Clone for C5orf56 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for C5orf56 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for C5orf56 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | | Search Tocris compounds for C5orf56 |
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 | | | C5orf56 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C5orf56 |
|  |  |  | | | | Search ThermoFisher Antibodies for C5orf56 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C5orf56 |
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