C5orf54 Gene
protein-coding GIFtS: 38
GCID: GC05M159752
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chromosome 5 open reading frame 54
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Aliases
for C5orf54 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Chromosome 5 Open Reading Frame 541 2 | | Buster31 2 | | Transposon-Derived Buster3 Transposase-Like Protein2 |
Export aliases for C5orf54 gene to outside databasesPrevious GC identifer: GC05M154913 |
Summaries
for C5orf54 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for C5orf54 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000005.9 NC_018916.1 NT_023133.13
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the C5orf54 gene promoter:
Oct-B1 Elk-1 Lmo2 IRF-1 LCR-F1 POU2F2C PPAR-gamma1 POU2F1 POU2F1a PPAR-gamma2
Other transcription factors
Search SABiosciences Chromatin IP Primers for C5orf54
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C5orf54 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 5q33.3 Ensembl cytogenetic band: 5q33.3 HGNC cytogenetic band: 5q33.3C5orf54 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 5 GeneLoc Exon Structure GeneLoc location for GC05M159752: view genomic region
(about GC identifiers)
Start:
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159,820,155 bp from pter |
End:
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159,827,104 bp from pter |
Size:
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6,950 bases |
Orientation:
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minus strand |
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Proteins
for C5orf54 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CE054_HUMAN, Q8IZ13 (See
protein sequence)Recommended Name: Transposon-derived Buster3 transposase-like protein Size: 594 amino acids; 68327 Da
Miscellaneous: May be derived from an ancient transposon that has lost its ability to translocate
Secondary accessions: D3DQJ9 Q9H5S8 Q9UH87Explore the universe of human proteins at neXtProt for C5orf54: NX_Q8IZ13
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8IZ13
C5orf54 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_071373.2
ENSEMBL proteins: ENSP00000386184 ENSP00000428831
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005739 | mitochondrion |
IEA | -- |
C5orf54 for ontologies About GeneDecksing
C5orf54 Antibody Products:
Assay Products for C5orf54: |
Protein
Domains /
Families
for C5orf54 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
C5orf54 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q8IZ13ProtoNet protein and cluster: Q8IZ13 |
Function
for C5orf54 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for C5orf54
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for C5orf54
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C5orf54 |
|
Pathways & Interactions
for C5orf54 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for C5orf54
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
5/6 Interacting proteins for C5orf54 (Q8IZ132, 3 ENSP000003861844) via UniProtKB, MINT, STRING, and/or I2D (see all 6)About this table
|
Drugs & Compounds
for C5orf54 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for C5orf54
Search CenterWatch for drugs/clinical trials and news about C5orf54 / CE054
|
Transcripts
for C5orf54 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for C5orf54 gene: NM_022090.3 Unigene Cluster for C5orf54: Chromosome 5 open reading frame 54 Hs.529464 [show with all ESTs]Unigene Representative Sequence: NM_0220902 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000408953(uc003lye.1 uc003lyf.1) ENST00000523213
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for C5orf54
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for C5orf54
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: C5orf54 (NM_022090) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for C5orf54 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C5orf54 |
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for C5orf54
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat C5orf54 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat C5orf54 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat C5orf54 |
4 DOTS entries: DT.311239 DT.120860028 DT.87010368 DT.120860025 24/61 AceView cDNA sequences (see all 61): AA577540 CB052583 AA403133 CR612548 D62521 W94245 CK903902 AW236662 AI193935 AA954962 AA450377 BM052948 BX333279 BG104921 BM903536 BP375959 BX333442 AA331414 BX333441 CK903901 AK026754 AA728782 T11734 BG545470
GeneLoc Exon Structure
|
Expression
for C5orf54 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| C5orf54 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See C5orf54 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for C5orf54
SOURCE GeneReport for Unigene cluster: Hs.529464
SABiosciences Custom PCR Arrays for C5orf54
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for C5orf54
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat C5orf54 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat C5orf54 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat C5orf54 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C5orf54 |
Orthologs
for C5orf54 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for C5orf54 gene from 2/6 species (see all 6) About this table
Species with no ortholog for C5orf54
ENSEMBL Gene Tree for C5orf54 (if available)
TreeFam Gene Tree for C5orf54 (if available) |
Paralogs
for C5orf54 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for C5orf54 gene
- ZBED52 KRBA22 SCAND32 GTF2IRD22 FAM200A2 GTF2IRD2B2 FAM200B2 EPM2AIP12
5 SIMAP similar genes for C5orf54 using alignment to 1 protein entry: CE054_HUMAN:ZBED5 FAM200B SCAND3 ZMYM6 FAM200A
C5orf54 for paralogs About GeneDecksing
|
Genomic Variants
for C5orf54 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 5 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for C5orf54 (159820155 - 159827104 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for C5orf54: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing C5orf54 |
|
Disorders
/ Diseases
for C5orf54 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for C5orf54 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for C5orf54 gene integrated from 9 sources:
(articles sorted by number of sources associating them with C5orf54) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Interspersed repeats and other mementos of transposable elements in mammalian genomes. (PubMed id 10607616)1, 2, 3 Smit A.F.A. (1999)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- A directed protein interaction network for investigat ing intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (2011)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for C5orf54 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing C5orf54 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing C5orf54 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing C5orf54 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for C5orf54 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for C5orf54 gene:
Search GeneIP for patents involving C5orf54
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for C5orf54 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
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 | |
 |
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 | | | C5orf54 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C5orf54 |
|  |  |  | | | | Search ThermoFisher Antibodies for C5orf54 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C5orf54 |
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