Aliases for C5orf49 Gene
External Ids for C5orf49 Gene
- HGNC: 27028
- Entrez Gene: 134121
- Ensembl: ENSG00000215217
- UniProtKB: A4QMS7
Summaries for C5orf49 Gene
GeneCards Summary for C5orf49 Gene
C5orf49 (Chromosome 5 Open Reading Frame 49) is a Protein Coding gene.
No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C5orf49 Gene
Genomics for C5orf49 Gene
Regulatory Elements for C5orf49 Gene
Enhancers for C5orf49 Gene
| GeneHancer Identifier | Enhancer Score | Enhancer Sources | Gene-Enhancer Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Gene Targets for Enhancer |
|---|---|---|---|---|---|---|---|---|
| GH05G007802 | 1 | FANTOM5 ENCODE | 11.7 | +48.4 | 48408 | 0.4 | CEBPB MAX MAFG CEBPG EP300 ATF2 MAFF ZNF316 CREB1 MAFK | MTRR C5orf49 ENSG00000250761 ADCY2 |
| GH05G007393 | 1.3 | FANTOM5 ENCODE dbSUPER | 6.5 | +455.8 | 455778 | 3.5 | CTCF SUZ12 RBBP5 RAD21 ZNF335 GLIS2 ZFHX2 POLR2A SMC3 EGR2 | ADCY2 C5orf49 LOC105374645 |
| GH05G007850 | 0.9 | ENCODE | 8.3 | +0.4 | 358 | 1.4 | PKNOX1 FOXA2 KLF17 ARID4B SIN3A BMI1 RAD21 YY1 ZNF143 EGR2 | C5orf49 MTRR ENSG00000250761 |
| GH05G007871 | 0.6 | ENCODE | 11.4 | -20.4 | -20427 | 1.1 | SCRT1 CTCF NR2F1 GFI1B TBX21 SCRT2 KDM1A PRDM10 NR2F6 | C5orf49 MTRR FASTKD3 ENSG00000251168 |
| GH05G007815 | 1.1 | Ensembl ENCODE | 5.7 | +35.2 | 35202 | 1.1 | HDGF CBX3 RB1 KLF17 ZSCAN9 ZNF48 RAD21 ZNF138 ZNF366 ZNF143 | C5orf49 MTRR ENSG00000250761 |
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around C5orf49 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the C5orf49 gene promoter:
Regulatory Element Products
Genomic Location for C5orf49 Gene
- Chromosome:
- 5
- Start:
- 7,830,378 bp from pter
- End:
- 7,851,490 bp from pter
- Size:
- 21,113 bases
- Orientation:
- Minus strand
Genomic View for C5orf49 Gene
Genes around C5orf49 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 5p15.31 by Ensembl
- 5p15.31 by Entrez Gene
- 5p15.31 by HGNC
C5orf49 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for C5orf49 Gene
Proteins for C5orf49 Gene
-
Protein details for C5orf49 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- A4QMS7-CE049_HUMAN
- Recommended name:
- Uncharacterized protein C5orf49
- Protein Accession:
- A4QMS7
Protein attributes for C5orf49 Gene
- Size:
- 147 amino acids
- Molecular mass:
- 16991 Da
- Quaternary structure:
- No Data Available
Protein Expression for C5orf49 Gene
Post-translational modifications for C5orf49 Gene
Other Protein References for C5orf49 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for C5orf49
- Invitrogen Antibodies for C5orf49
- Search GeneTex for Antibodies for C5orf49
Protein Products
-
OriGene Purified Proteins for C5orf49
- Search Origene for MassSpec and Protein Over-expression Lysates for C5orf49
- Origene Custom Protein Services for C5orf49
- Novus Biologicals proteins for C5orf49
- Search GeneTex for Proteins for C5orf49
Assay Products
No data available for DME Specific Peptides for C5orf49 Gene
Domains & Families for C5orf49 Gene
Graphical View of Domain Structure for InterPro Entry
No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for C5orf49 Gene
Function for C5orf49 Gene
Phenotypes for C5orf49 Gene
- GenomeRNAi human phenotypes for C5orf49:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for C5orf49
-
-
ViGene Biosciences lentiviral particle packaged cDNA for C5orf49 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for C5orf49 gene
- Search ViGene Biosciences for C5orf49
CRISPR Products
-
OriGene CRISPR knockouts for C5orf49
-
Santa Cruz Biotechnology (SCBT) CRISPR for C5orf49
- GenScript: Design CRISPR guide RNA sequences for C5orf49
miRNA for C5orf49 Gene
- miRTarBase miRNAs that target C5orf49
miRNA Products
- Search ViGene Biosciences for C5orf49
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for C5orf49
- Browse OriGene Inhibitory RNA Products For C5orf49
-
ViGene Biosciences ready-to-package AAV shRNAs for C5orf49 gene
Clone Products
-
OriGene ORF clones in human for C5orf49
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for C5orf49
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for C5orf49
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for C5orf49
-
ViGene Biosciences adenoviral particle packaged cDNA for C5orf49 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for C5orf49 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for C5orf49 gene
Flow Cytometry Products
No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C5orf49 Gene
Localization for C5orf49 Gene
| Compartment | Confidence |
|---|---|
| nucleus | 3 |
| cytosol | 3 |
No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for C5orf49 Gene
Transcripts for C5orf49 Gene
mRNA/cDNA for C5orf49 Gene
- (2) REFSEQ mRNAs :
- (5) Additional mRNA sequences :
- (36) Selected AceView cDNA sequences:
- (2) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for C5orf49 Gene
CRISPR Products
-
OriGene CRISPR knockouts for C5orf49
-
Santa Cruz Biotechnology (SCBT) CRISPR for C5orf49
- GenScript: Design CRISPR guide RNA sequences for C5orf49
miRNA Products
- Search ViGene Biosciences for C5orf49
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for C5orf49
- Browse OriGene Inhibitory RNA Products For C5orf49
-
ViGene Biosciences ready-to-package AAV shRNAs for C5orf49 gene
Clone Products
-
OriGene ORF clones in human for C5orf49
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for C5orf49
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for C5orf49
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Flow Cytometry Products
Expression for C5orf49 Gene
mRNA differential expression in normal tissues according to GTEx for C5orf49 Gene
This gene is overexpressed in Testis (x8.2) and Brain - Hypothalamus (x4.6).
This gene is overexpressed in Platelet (69.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for C5orf49 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of C5orf49 Gene:
C5orf49SOURCE GeneReport for Unigene cluster for C5orf49 Gene:
Hs.709979Evidence on tissue expression from TISSUES for C5orf49 Gene
- Nervous system(2.2)
Primer Products
-
OriGene qPCR primer pairs for C5orf49
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for C5orf49 Gene
Orthologs for C5orf49 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | C5H5orf49 34 |
|
||
| C5orf49 35 |
|
OneToOne | |||
| rat (Rattus norvegicus) |
Mammalia | RGD1308544 34 |
|
||
| mouse (Mus musculus) |
Mammalia | 1700001L19Rik 34 16 35 |
|
||
| dog (Canis familiaris) |
Mammalia | C5orf49 35 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | C5orf49 35 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | C5orf49 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | LOC100857376 34 |
|
||
| C5orf49 35 |
|
OneToOne | |||
| lizard (Anolis carolinensis) |
Reptilia | C5orf49 35 |
|
OneToOne | |
| zebrafish (Danio rerio) |
Actinopterygii | si:dkeyp-46h3.1 34 |
|
||
| C19H5orf49 35 |
|
OneToOne |
- Species where no ortholog for C5orf49 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- cow (Bos Taurus)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for C5orf49 Gene
No data available for Paralogs for C5orf49 Gene
Variants for C5orf49 Gene
| SNP ID | Clin | Chr 05 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000327017 | -- | 7,842,235(+) | TTTAT(A/T)TTCTC | intron-variant | |
| rs1000476851 | -- | 7,843,926(+) | ATCTC(A/G)ACAAA | intron-variant | |
| rs1000480952 | -- | 7,832,100(+) | TCCAT(C/G)AGCCT | intron-variant | |
| rs1000533331 | -- | 7,832,360(+) | GATCC(A/T)GGCTC | intron-variant | |
| rs1000567447 | -- | 7,831,467(+) | TCCCC(A/G)AAGAA | utr-variant-3-prime |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2659269 | CNV | deletion | 23128226 |
| esv26647 | CNV | loss | 19812545 |
| esv3307786 | CNV | mobile element insertion | 20981092 |
| esv3308933 | CNV | mobile element insertion | 20981092 |
| esv3368102 | CNV | insertion | 20981092 |
| esv3420607 | CNV | insertion | 20981092 |
| esv3603937 | CNV | loss | 21293372 |
| nsv1073855 | CNV | deletion | 25765185 |
| nsv597003 | CNV | gain | 21841781 |
| nsv597004 | CNV | gain | 21841781 |
Residual Variation Intolerance Score:
89.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
8.94;
87.24% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for C5orf49 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- C5orf49
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C5orf49 Gene
Disorders for C5orf49 Gene
Relevant External Links for C5orf49
No disorders were found for C5orf49 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C5orf49 Gene
Publications for C5orf49 Gene
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4 64
Products for C5orf49 Gene
- Browse R&D Systems for Antibodies
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
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- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Browse OriGene Antibodies
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for C5orf49
- Search Origene for MassSpec and Protein Over-expression Lysates for C5orf49
- Origene Custom Protein Services for C5orf49
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for C5orf49
- Browse OriGene Inhibitory RNA Products For C5orf49
- OriGene qPCR primer pairs for C5orf49
- OriGene CRISPR knockouts for C5orf49
- OriGene ORF clones in human for C5orf49
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For C5orf49
- GenScript: Next-day shipping cDNA ORF clone for C5orf49 in any vector
- GenScript Custom Purified and Recombinant Proteins Services for C5orf49
- GenScript Custom Assay Services for C5orf49
- GenScript Custom overexpressing Cell Line Services for C5orf49
- GenScript: Design CRISPR guide RNA sequences for C5orf49
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- CloneReady with Over 120,000 Genes
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- Browse Sino Biological cDNA Clones
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- Sino Biological Transfection Reagents
- Novus Biologicals Antibodies for C5orf49
- Novus Biologicals proteins for C5orf49
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- ViGene Biosciences adenoviral particle packaged cDNA for C5orf49 gene
- ViGene Biosciences lentiviral particle packaged cDNA for C5orf49 gene
- ViGene Biosciences ready-to-package AAV shRNAs for C5orf49 gene
- Search ViGene Biosciences for C5orf49
- Horizon Cell Lines for C5orf49
- Cyagen custom Knockout/knockin (KOKI) mouse models for C5orf49
- VectorBuilder custom plasmid, inducible vectors for C5orf49
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for C5orf49
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for C5orf49 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
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- (122) diseasecard
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- (124) Orphanet
- (125) UMLS
- (126) GTR
- (127) Disease Ontology
- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
- (131) CDC
- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer