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Aliases for C5orf46 Gene

Aliases for C5orf46 Gene

  • Chromosome 5 Open Reading Frame 46 2 3 5
  • Skin And Saliva Secreted Protein 1 2 3
  • Uncharacterized Protein C5orf46 3
  • CTC-327F10.5 3
  • SSSP1 3

External Ids for C5orf46 Gene

Previous GeneCards Identifiers for C5orf46 Gene

  • GC05M147253
  • GC05M142419

Summaries for C5orf46 Gene

GeneCards Summary for C5orf46 Gene

C5orf46 (Chromosome 5 Open Reading Frame 46) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C5orf46 Gene

Genomics for C5orf46 Gene

Regulatory Elements for C5orf46 Gene

Enhancers for C5orf46 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05F147882 0.2 ENCODE 11.9 +23.5 23542 0.7 C5orf46 ENSG00000251320 ENSG00000248362 SCGB3A2
GH05F147905 1.1 Ensembl ENCODE 0.8 +0.2 227 1.7 TBP SMARCC1 HLF JUN CEBPB EP300 ATF2 JUND CEBPA STAT3 ENSG00000251320 SCGB3A2 C5orf46
GH05F147898 0.2 ENCODE 0.4 +7.4 7362 1.5 JUND EP300 SCGB3A2 SPINK1 C5orf46 ENSG00000251320
GH05F147900 0.4 ENCODE 0.4 +5.0 5048 2.0 SCGB3A2 SPINK1 C5orf46 ENSG00000251320
GH05F147892 1.3 Ensembl ENCODE 0.4 +13.2 13241 2.6 ZNF217 CTBP1 KLF9 DPF2 KLF4 ENSG00000251320 C5orf46
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around C5orf46 on UCSC Golden Path with GeneCards custom track

Genomic Location for C5orf46 Gene

Chromosome:
5
Start:
147,880,726 bp from pter
End:
147,906,589 bp from pter
Size:
25,864 bases
Orientation:
Minus strand

Genomic View for C5orf46 Gene

Genes around C5orf46 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C5orf46 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C5orf46 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C5orf46 Gene

Proteins for C5orf46 Gene

  • Protein details for C5orf46 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6UWT4-CE046_HUMAN
    Recommended name:
    Uncharacterized protein C5orf46
    Protein Accession:
    Q6UWT4
    Secondary Accessions:
    • A8K038
    • Q8WU04

    Protein attributes for C5orf46 Gene

    Size:
    87 amino acids
    Molecular mass:
    9693 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for C5orf46 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for C5orf46 Gene

Post-translational modifications for C5orf46 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C5orf46 Gene

No data available for DME Specific Peptides for C5orf46 Gene

Domains & Families for C5orf46 Gene

Protein Domains for C5orf46 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C5orf46: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for C5orf46 Gene

Function for C5orf46 Gene

Gene Ontology (GO) - Molecular Function for C5orf46 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with C5orf46: view
genes like me logo Genes that share phenotypes with C5orf46: view

Animal Model Products

  • Taconic Biosciences Mouse Models for C5orf46

Inhibitory RNA Products

Clone Products

Cell Line Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for C5orf46 Gene

Localization for C5orf46 Gene

Subcellular locations from UniProtKB/Swiss-Prot for C5orf46 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for C5orf46 Gene COMPARTMENTS Subcellular localization image for C5orf46 gene
Compartment Confidence
extracellular 5
mitochondrion 2

Gene Ontology (GO) - Cellular Components for C5orf46 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0070062 extracellular exosome IDA 19199708
genes like me logo Genes that share ontologies with C5orf46: view

Pathways & Interactions for C5orf46 Gene

SuperPathways for C5orf46 Gene

No Data Available

Interacting Proteins for C5orf46 Gene

Gene Ontology (GO) - Biological Process for C5orf46 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with C5orf46: view

No data available for Pathways by source and SIGNOR curated interactions for C5orf46 Gene

Transcripts for C5orf46 Gene

mRNA/cDNA for C5orf46 Gene

Unigene Clusters for C5orf46 Gene

Chromosome 5 open reading frame 46:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for C5orf46 Gene

No ASD Table

Relevant External Links for C5orf46 Gene

GeneLoc Exon Structure for
C5orf46
ECgene alternative splicing isoforms for
C5orf46

Expression for C5orf46 Gene

mRNA expression in normal human tissues for C5orf46 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for C5orf46 Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (x14.3), Artery - Aorta (x11.8), and Skin - Not Sun Exposed (Suprapubic) (x11.5).

Protein differential expression in normal tissues from HIPED for C5orf46 Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for C5orf46 Gene



Protein tissue co-expression partners for C5orf46 Gene

NURSA nuclear receptor signaling pathways regulating expression of C5orf46 Gene:

C5orf46

SOURCE GeneReport for Unigene cluster for C5orf46 Gene:

Hs.660038
genes like me logo Genes that share expression patterns with C5orf46: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for C5orf46 Gene

Orthologs for C5orf46 Gene

This gene was present in the common ancestor of mammals.

Orthologs for C5orf46 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C5orf46 35
  • 99 (a)
OneToOne
C5H5orf46 34
  • 97.7 (n)
cow
(Bos Taurus)
Mammalia C7H5orf46 34 35
  • 83.52 (n)
dog
(Canis familiaris)
Mammalia C2H5orf46 34
  • 83.14 (n)
C5orf46 35
  • 77 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia RGD1563060 34
  • 78.23 (n)
mouse
(Mus musculus)
Mammalia Gm94 34 16 35
  • 76.47 (n)
Species where no ortholog for C5orf46 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for C5orf46 Gene

ENSEMBL:
Gene Tree for C5orf46 (if available)
TreeFam:
Gene Tree for C5orf46 (if available)

Paralogs for C5orf46 Gene

No data available for Paralogs for C5orf46 Gene

Variants for C5orf46 Gene

Sequence variations from dbSNP and Humsavar for C5orf46 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs1002182 -- 147,856,983(-) TGTAA(C/T)ACTAT intron-variant
rs10035311 -- 147,902,642(+) TCACA(C/T)AGTTA intron-variant
rs10035432 -- 147,855,193(+) AATCC(A/G)TATAT intron-variant
rs10036880 -- 147,889,514(+) ACATT(C/T)TGTCA intron-variant, utr-variant-3-prime
rs10038438 -- 147,876,639(+) GGATT(A/T)AAAAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for C5orf46 Gene

Variant ID Type Subtype PubMed ID
nsv1021356 CNV gain 25217958
nsv1028477 CNV loss 25217958
nsv329560 CNV deletion 16902084
nsv520730 CNV gain 19592680

Variation tolerance for C5orf46 Gene

Residual Variation Intolerance Score: 62.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 15.64; 97.27% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C5orf46 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
C5orf46

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C5orf46 Gene

Disorders for C5orf46 Gene

Relevant External Links for C5orf46

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
C5orf46

No disorders were found for C5orf46 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C5orf46 Gene

Publications for C5orf46 Gene

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4 64
  2. Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT). (PMID: 19199708) Gonzalez-Begne M. … Yates J.R. (J. Proteome Res. 2009) 3 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 4 64
  4. The DNA sequence and comparative analysis of human chromosome 5. (PMID: 15372022) Schmutz J. … Rubin E.M. (Nature 2004) 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4 64

Products for C5orf46 Gene

Sources for C5orf46 Gene

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