Free for academic non-profit institutions. Other users need a Commercial license

Aliases for C5orf45 Gene

Aliases for C5orf45 Gene

  • Chromosome 5 Open Reading Frame 45 2 3 5
  • Truncated Calcium Binding Protein 2

External Ids for C5orf45 Gene

Previous GeneCards Identifiers for C5orf45 Gene

  • GC05M179197
  • GC05M179198
  • GC05M179261
  • GC05M173989

Summaries for C5orf45 Gene

GeneCards Summary for C5orf45 Gene

C5orf45 (Chromosome 5 Open Reading Frame 45) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C5orf45 Gene

Genomics for C5orf45 Gene

Regulatory Elements for C5orf45 Gene

Enhancers for C5orf45 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around C5orf45 on UCSC Golden Path with GeneCards custom track

Genomic Location for C5orf45 Gene

179,835,133 bp from pter
179,862,173 bp from pter
27,041 bases
Minus strand

Genomic View for C5orf45 Gene

Genes around C5orf45 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C5orf45 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C5orf45 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C5orf45 Gene

Proteins for C5orf45 Gene

  • Protein details for C5orf45 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    UPF0544 protein C5orf45
    Protein Accession:
    Secondary Accessions:
    • B5MD09
    • E9PAK6
    • Q7Z3D8
    • Q9BUC1
    • Q9UN54

    Protein attributes for C5orf45 Gene

    343 amino acids
    Molecular mass:
    37743 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAD51611.1; Type=Frameshift; Positions=191; Evidence={ECO:0000305}; Sequence=CAD97932.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for C5orf45 Gene


neXtProt entry for C5orf45 Gene

Proteomics data for C5orf45 Gene at MOPED

Post-translational modifications for C5orf45 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for C5orf45 Gene

Domains & Families for C5orf45 Gene

Protein Domains for C5orf45 Gene


Suggested Antigen Peptide Sequences for C5orf45 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the UPF0544 family.
  • Belongs to the UPF0544 family.
genes like me logo Genes that share domains with C5orf45: view

No data available for Gene Families for C5orf45 Gene

Function for C5orf45 Gene

genes like me logo Genes that share phenotypes with C5orf45: view

Animal Models for C5orf45 Gene

MGI Knock Outs for C5orf45:

Animal Model Products

CRISPR Products

miRNA for C5orf45 Gene

miRTarBase miRNAs that target C5orf45

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for C5orf45 Gene

Localization for C5orf45 Gene

Subcellular locations from

Jensen Localization Image for C5orf45 Gene COMPARTMENTS Subcellular localization image for C5orf45 gene
Compartment Confidence
cytosol 3
mitochondrion 2
nucleus 2
plasma membrane 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for C5orf45 Gene

Pathways & Interactions for C5orf45 Gene

SuperPathways for C5orf45 Gene

No Data Available

Interacting Proteins for C5orf45 Gene

Gene Ontology (GO) - Biological Process for C5orf45 Gene


No data available for Pathways by source and SIGNOR curated interactions for C5orf45 Gene

Drugs & Compounds for C5orf45 Gene

No Compound Related Data Available

Transcripts for C5orf45 Gene

Unigene Clusters for C5orf45 Gene

Chromosome 5 open reading frame 45:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for C5orf45 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b · 9c · 9d ^ 10a · 10b · 10c · 10d · 10e ^ 11
SP1: - - - - - - - - -
SP2: - - - - -
SP3: - - - - - - - - - -
SP4: - -
SP5: - - - - - - -
SP6: - - - - - - - - - - - -
SP7: - - - - - - - -
SP9: - -
SP11: - - -

Relevant External Links for C5orf45 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for C5orf45 Gene

mRNA expression in normal human tissues for C5orf45 Gene

Protein differential expression in normal tissues from HIPED for C5orf45 Gene

This gene is overexpressed in Adipocyte (15.6), Blymphocyte (15.3), Testis (13.7), CD4 Tcells (7.0), and Retina (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for C5orf45 Gene

SOURCE GeneReport for Unigene cluster for C5orf45 Gene Hs.741169

genes like me logo Genes that share expression patterns with C5orf45: view

Protein tissue co-expression partners for C5orf45 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for C5orf45 Gene

Orthologs for C5orf45 Gene

This gene was present in the common ancestor of animals.

Orthologs for C5orf45 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia C7H5orf45 35
  • 72.07 (n)
  • 60.06 (a)
C7H5orf45 36
  • 53 (a)
(Canis familiaris)
Mammalia C11H5orf45 35
  • 71.26 (n)
  • 57.49 (a)
C5orf45 36
  • 83 (a)
(Mus musculus)
Mammalia 3010026O09Rik 35
  • 67.57 (n)
  • 53.01 (a)
3010026O09Rik 16
3010026O09Rik 36
  • 53 (a)
(Pan troglodytes)
Mammalia C5H5orf45 35
  • 99.13 (n)
  • 98.83 (a)
C5orf45 36
  • 99 (a)
(Rattus norvegicus)
Mammalia RGD1564036 35
  • 67.94 (n)
  • 51.62 (a)
(Anolis carolinensis)
Reptilia C5orf45 36
  • 46 (a)
(Danio rerio)
Actinopterygii C14H5orf45 36
  • 21 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG43295 36
  • 27 (a)
Species with no ortholog for C5orf45:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C5orf45 Gene

Gene Tree for C5orf45 (if available)
Gene Tree for C5orf45 (if available)

Paralogs for C5orf45 Gene

No data available for Paralogs for C5orf45 Gene

Variants for C5orf45 Gene

Sequence variations from dbSNP and Humsavar for C5orf45 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs1650893 -, - 179,853,379(-) TTTGC(A/G)GGTGA reference, missense
rs248248 - 179,840,949(+) GCTCC(C/T)GCTCC reference, missense
VAR_039992 -
rs748197 -- 179,846,820(+) GAGTG(A/G)ATCTA intron-variant
rs836348 -- 179,842,524(-) ttgtt(G/T)ttttt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for C5orf45 Gene

Variant ID Type Subtype PubMed ID
nsv883270 CNV Loss 21882294
nsv483062 CNV Loss 15286789
nsv469579 CNV Loss 16826518
dgv6400n71 CNV Loss 21882294
nsv883275 CNV Loss 21882294
esv2667626 CNV Deletion 23128226
esv2731309 CNV Deletion 23290073
esv2731310 CNV Deletion 23290073
esv2731311 CNV Deletion 23290073

Variation tolerance for C5orf45 Gene

Residual Variation Intolerance Score: 87.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.10; 38.31% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for C5orf45 Gene

Disorders for C5orf45 Gene

Relevant External Links for C5orf45

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for C5orf45 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C5orf45 Gene

Publications for C5orf45 Gene

  1. Genome-scale RNAi screen for host factors required for HIV replication. (PMID: 18976975) Zhou H. … Espeseth A.S. (Cell Host Microbe 2008) 3 67
  2. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 3
  3. The LIFEdb database in 2006. (PMID: 16381901) Mehrle A. … Wiemann S. (Nucleic Acids Res. 2006) 3
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3
  5. Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. (PMID: 15146197) Brandenberger R. … Stanton L.W. (Nat. Biotechnol. 2004) 3

Products for C5orf45 Gene

Sources for C5orf45 Gene