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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

C5orf45 Gene

protein-coding   GIFtS: 38
GCID: GC05M179261

Chromosome 5 Open Reading Frame 45

  Search for C5orf45
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Chromosome 5 Open Reading Frame 451 2
Truncated Calcium Binding Protein1
UPF0544 Protein C5orf452

External Ids:    HGNC: 308171   Entrez Gene: 511492   Ensembl: ENSG000001610107   UniProtKB: Q6NTE83   

Export aliases for C5orf45 gene to outside databases

Previous GC identifers: GC05M179197 GC05M179198 GC05M173989


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for C5orf45 Gene: 
C5orf45 (chromosome 5 open reading frame 45) is a protein-coding gene. GO annotations related to this gene include molecular_function.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000005.9  NT_023133.13  NC_018916.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the C5orf45 gene promoter:
         Sp1   Pax-5   AML1a   Pax-2   Lmo2   Pax-2a   LUN-1   GATA-1   HOXA5   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for C5orf45

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C5orf45


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q35.3   Ensembl cytogenetic band:  5q35.3   HGNC cytogenetic band: 5q35.3

C5orf45 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
C5orf45 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M179261:  view genomic region     (about GC identifiers)

Start:
179,261,436 bp from pter      End:
179,289,173 bp from pter
Size:
27,738 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CE045_HUMAN, Q6NTE8 (See protein sequence)
Recommended Name: UPF0544 protein C5orf45  
Size: 343 amino acids; 37743 Da
Sequence caution: Sequence=AAD51611.1; Type=Frameshift; Positions=191; Sequence=CAD97932.1; Type=Erroneous
initiation; Note=Translation N-terminally shortened;
Secondary accessions: B5MD09 E9PAK6 Q7Z3D8 Q9BUC1 Q9UN54
Alternative splicing: 3 isoforms:  Q6NTE8-1   Q6NTE8-2   Q6NTE8-3   (No experimental confirmation available. Ref.3 (BC050714) sequence is in conflict in position: 42:Q->R)

Explore the universe of human proteins at neXtProt for C5orf45: NX_Q6NTE8

Explore proteomics data for C5orf45 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q6NTE8

  • C5orf45 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    C5orf45 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001017987.1  NP_057259.2  

    ENSEMBL proteins: 
     ENSP00000429835   ENSP00000430298   ENSP00000427849   ENSP00000366130   ENSP00000428460  
     ENSP00000429107   ENSP00000292586   ENSP00000429563   ENSP00000429651   ENSP00000430814  
     ENSP00000431019   ENSP00000429047   ENSP00000430766   ENSP00000428081   ENSP00000429427  
     ENSP00000430187   ENSP00000384599  

    Human Recombinant Protein Products for C5orf45: 
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    Novus Biologicals C5orf45 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--

    C5orf45 for ontologies           About GeneDecksing



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    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ProtoNet protein and cluster: Q6NTE8

    UniProtKB/Swiss-Prot: CE045_HUMAN, Q6NTE8
    Similarity: Belongs to the UPF0544 family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
         
    C5orf45 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for C5orf45:
     Decreased influenza A virus in  Increased gamma-H2AX phosphory 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for 3010026O09Rik):
     reproductive system 

    C5orf45 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for C5orf45 
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for C5orf45 
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C5orf45


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for C5orf45

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008150biological_process ND--

    C5orf45 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for C5orf45 (CE045)

    Search CenterWatch for drugs/clinical trials and news about C5orf45 / CE045

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for C5orf45 gene (4 alternative transcripts): 
    NM_001018061.1  NM_001018062.1  NM_001017987.2  NM_016175.3  

    Unigene Cluster for C5orf45:

    Chromosome 5 open reading frame 45
    Hs.741169  [show with all ESTs]
    Unigene Representative Sequence: BX537968
    18/25 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 25):
    ENST00000522663(uc003mky.2 uc011dgt.1 uc011dgu.1) ENST00000518235
    ENST00000520698 ENST00000518950 ENST00000376931 ENST00000523267 ENST00000518219
    ENST00000523084 ENST00000292586(uc003mla.3 uc003mlc.3 uc003mlb.3)
    ENST00000521299 ENST00000521333 ENST00000520150 ENST00000520900 ENST00000519208
    ENST00000523737 ENST00000520995 ENST00000521675 ENST00000524068
    miRNA
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    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for C5orf45
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C5orf45
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                         Customized lentivirus expression plasmids for stable overexpression of C5orf45 
    Primer
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat C5orf45

    Additional mRNA sequence: 

    AF153685.1 AK293901.1 AK295104.1 AK298954.1 BC002739.2 BC050714.1 BC056889.1 BC069051.1 
    BX537968.1 CR936785.1 

    24/40 DOTS entries (see all 40):

    DT.91906887  DT.95174397  DT.100039805  DT.100714884  DT.120832821  DT.95174386  DT.86857002  DT.100871233 
    DT.100714845  DT.100714896  DT.120832834  DT.92475216  DT.92475175  DT.100060154  DT.100060429  DT.102839204 
    DT.120832884  DT.120833058  DT.120833150  DT.100050927  DT.120832890  DT.120832975  DT.120833057  DT.120833165 

    24/101 AceView cDNA sequences (see all 101):

    AA350091 BQ478342 AI569230 BQ478113 AI686025 CD251584 CA394510 AL043745 
    BC056889 AW613959 AI632394 BC069051 AW054784 BQ718580 AI341636 AW195554 
    BX641720 AL134216 BC050714 BQ082478 BU689378 AI200102 AW071915 BF527620 

    GeneLoc Exon Structure

    5/11 Alternative Splicing Database (ASD) splice patterns (SP) for C5orf45 (see all 11)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b · 9c · 9d ^ 10a · 10b · 10c · 10d · 10e ^ 11
    SP1:                          -     -           -                             -     -           -     -     -     -                                 
    SP2:                          -     -           -                             -     -                                                               
    SP3:                          -     -     -     -                             -     -           -     -     -     -                                 
    SP4:                                -           -                                                                                                   
    SP5:                          -     -           -     -     -                 -     -                                                               


    ECgene alternative splicing isoforms for C5orf45

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    C5orf45 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    C5orf45 Expression
    About this image


    See C5orf45 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for C5orf45

    SOURCE GeneReport for Unigene cluster: Hs.741169
        SABiosciences Custom PCR Arrays for C5orf45
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C5orf45

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for C5orf45 gene from 4/8 species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia 3010026O09Rik1 , 5 RIKEN cDNA 3010026O09 gene1, 5 67.57(n)1
    53.01(a)1
      11 (30.33 cM)5
    680671  NM_026543.31  NP_080819.21 
     501744445 
    lizard
    (Anolis carolinensis)
    Reptilia C5ORF456
    Uncharacterized protein
    42(a)
    1 ↔ 1
    2(140123013-140130094)
    zebrafish
    (Danio rerio)
    Actinopterygii C14H5orf456
    chromosome 5 open reading frame 45
    18(a)
    1 ↔ 1
    14(14452352-14457584)
    fruit fly
    (Drosophila melanogaster)
    Insecta CG432956
    --
    30(a)
    1 ↔ 1
    3L(16098952-16099528)


    ENSEMBL Gene Tree for C5orf45 (if available)
    TreeFam Gene Tree for C5orf45 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/527 SNPs in C5orf45 are shown (see all 527)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0399924
    ----see VAR_0399922 Q R mis40--------
    rs1429970001,2
    --179265651(+) AGCCTA/GGGCAA 2 -- int10--------
    rs1506924621,2
    --179265662(+) CAGAGC/TGAACT 2 -- int10--------
    rs1836747371,2
    --179265867(+) CTCGGA/GAGGAT 2 -- int10--------
    rs1161369101,2
    F--179265883(+) AAGCCC/TGGGAG 2 -- int11Minor allele frequency- T:0.02WA 118
    rs733340631,2
    C,F--179265884(+) AGCCCG/AGGAGA 2 -- int13Minor allele frequency- A:0.08WA 122
    rs1398861831,2
    --179265924(+) ATTGCA/GCTCCA 2 -- int10--------
    rs1447829151,2
    --179265935(+) GCCTAA/GGTGAC 2 -- int10--------
    rs4416591,2
    C,F--179266242(+) GTGAAA/GCTCCT 2 -- int13Minor allele frequency- G:0.20WA CSA 121
    rs2482461,2
    C--179266268(+) aaaaaC/AaaCAG 2 -- int11Minor allele frequency- A:0.50NA 2

    HapMap Linkage Disequilibrium report for C5orf45 (179261436 - 179289173 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for C5orf45:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2667626CNV Deletion23128226
    esv2731311CNV Deletion23290073
    esv2731309CNV Deletion23290073
    esv2731310CNV Deletion23290073
    nsv883270CNV Loss21882294
    nsv469579CNV Loss16826518
    nsv483062CNV Loss15286789
    nsv883275CNV Loss21882294
    dgv6400n71CNV Loss21882294

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing C5orf45
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for C5orf45 gene, integrated from 9 sources (see all 11):
    (articles sorted by number of sources associating them with C5orf45)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
    2. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
    3. The LIFEdb database in 2006. (PubMed id 16381901)1 Mehrle A....Wiemann S. (2006)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)
    6. The DNA sequence and comparative analysis of human chromosome 5. (PubMed id 15372022)2 Schmutz J.... Rubin E.M. (2004)
    7. From ORFeome to biology: a functional genomics pipeline. (PubMed id 15489336)1 Wiemann S....Poustka A. (2004)
    8. Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. (PubMed id 15146197)1 Brandenberger R.... Stanton L.W. (2004)
    9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    10. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1 Wiemann S.... Poustka A. (2001)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 51149 HGNC: 30817 AceView: LOC51149 Ensembl:ENSG00000161010 euGenes: HUgn51149
    ECgene: C5orf45 H-InvDB: C5orf45

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for C5orf45 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for C5orf45 gene:
    Search GeneIP for patents involving C5orf45

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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