C5orf45 Gene
protein-coding GIFtS: 36
GCID: GC05M179261
|
|
chromosome 5 open reading frame 45
| |
Aliases
for C5orf45 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Chromosome 5 Open Reading Frame 451 2 | | DKFZp686L24521 | | LOC511491 | | MGC650271 | | MGC785371 | | UPF0544 Protein C5orf452 |
Export aliases for C5orf45 gene to outside databasesPrevious GC identifers: GC05M179197 GC05M179198 GC05M173989 |
Summaries
for C5orf45 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for C5orf45 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000005.9 NC_018916.1 NT_023133.13
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the C5orf45 gene promoter:
Sp1 Pax-5 AML1a Pax-2 Lmo2 Pax-2a LUN-1 GATA-1 HOXA5
Other transcription factors
Search SABiosciences Chromatin IP Primers for C5orf45
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C5orf45 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 5q35.3 Ensembl cytogenetic band: 5q35.3 HGNC cytogenetic band: 5q35.3C5orf45 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 5 GeneLoc Exon Structure GeneLoc location for GC05M179261: view genomic region
(about GC identifiers)
Start:
|
179,261,436 bp from pter |
End:
|
179,289,173 bp from pter |
Size:
|
27,738 bases |
Orientation:
|
minus strand |
|
Proteins
for C5orf45 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CE045_HUMAN, Q6NTE8 (See
protein sequence)Recommended Name: UPF0544 protein C5orf45 Size: 343 amino acids; 37743 Da
Sequence caution: Sequence=AAD51611.1; Type=Frameshift; Positions=191; Sequence=CAD97932.1; Type=Erroneous initiation;
Secondary accessions: B5MD09 Q7Z3D8 Q9BUC1 Q9UN54Alternative splicing: 2 isoforms: Q6NTE8-1 Q6NTE8-2 Explore the universe of human proteins at neXtProt for C5orf45: NX_Q6NTE8
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q6NTE8
C5orf45 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001017987.1 NP_057259.2
ENSEMBL proteins: ENSP00000429835 ENSP00000430298 ENSP00000427849 ENSP00000366130 ENSP00000428460 ENSP00000429107 ENSP00000292586 ENSP00000429563 ENSP00000429651 ENSP00000430814 ENSP00000431019 ENSP00000429047 ENSP00000430766 ENSP00000428081 ENSP00000429427 ENSP00000430187 ENSP00000384599
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005575 | cellular_component |
ND | -- |
C5orf45 for ontologies About GeneDecksing
C5orf45 Antibody Products:
Assay Products for C5orf45: |
Protein
Domains /
Families
for C5orf45 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| ProtoNet protein and cluster: Q6NTE8 UniProtKB/Swiss-Prot: CE045_HUMAN, Q6NTE8Similarity: Belongs to the UPF0544 family |
Function
for C5orf45 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for C5orf45 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for C5orf45 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): C5orf45 (NM_016175) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for C5orf45 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C5orf45 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C5orf45 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003674 | molecular_function |
ND | -- |
C5orf45 for ontologies About GeneDecksing
2 GenomeRNAi human phenotypes for C5orf45:
Animal Models:
1 MGI mutant phenotype (inferred from 1 allele ) (MGI details for 3010026O09Rik):
C5orf45 for phenotypes About GeneDecksing
|
Pathways & Interactions
for C5orf45 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for C5orf45
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008150 | biological_process |
ND | -- |
C5orf45 for ontologies About GeneDecksing
|
Drugs & Compounds
for C5orf45 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for C5orf45
Search CenterWatch for drugs/clinical trials and news about C5orf45 / CE045
|
Transcripts
for C5orf45 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for C5orf45 gene (4 alternative transcripts): NM_001018061.1 NM_001018062.1 NM_001017987.2 NM_016175.3 Unigene Cluster for C5orf45: Chromosome 5 open reading frame 45 Hs.741169 [show with all ESTs]Unigene Representative Sequence: BX53796818/25 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 25): ENST00000522663(uc003mky.2 uc011dgt.1 uc011dgu.1) ENST00000518235
ENST00000520698 ENST00000518950 ENST00000376931 ENST00000523267 ENST00000518219
ENST00000523084 ENST00000292586(uc003mla.3 uc003mlc.3 uc003mlb.3)
ENST00000521299 ENST00000521333 ENST00000520150 ENST00000520900 ENST00000519208
ENST00000523737 ENST00000520995 ENST00000521675 ENST00000524068
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for C5orf45 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for C5orf45 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): C5orf45 (NM_016175) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for C5orf45 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C5orf45 |
Additional cDNA sequence: AF153685.1 AK293901.1 AK295104.1 AK298954.1 BC002739.2 BC050714.1 BC056889.1 BC069051.1 BX537968.1 CR936785.1 24/40 DOTS entries (see all 40): DT.91906887 DT.95174397 DT.100039805 DT.100714884 DT.120832821 DT.95174386 DT.86857002 DT.100871233 DT.100714845 DT.100714896 DT.120832834 DT.92475216 DT.92475175 DT.100060154 DT.100060429 DT.102839204 DT.120832884 DT.120833058 DT.120833150 DT.100050927 DT.120832890 DT.120832975 DT.120833057 DT.120833165 24/101 AceView cDNA sequences (see all 101): AW054784 AL043745 AW613959 AA350091 AI569230 BQ478342 CD251584 BC069051 AI632394 AI686025 BQ478113 CA394510 BC056889 BQ718580 AI341636 CB851316 AL134216 BF527620 BU176862 BP378662 T35011 AF153685 BQ082478 BQ062642
GeneLoc Exon Structure
5/11 Alternative Splicing Database (ASD) splice patterns (SP) for C5orf45 (see all 11) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | · | 6c | ^ | 7a | · | 7b | · | 7c | ^ | 8 | ^ | 9a | · | 9b | · | 9c | · | 9d | ^ | 10a | · | 10b | · | 10c | · | 10d | · | 10e | ^ | 11 |
|---|
|
| SP1: | | | | | | | | | - | | - | | | | - | | | | | | | | | | - | | - | | | | - | | - | | - | | - | | | | | | | | | | | | |
| SP2: | | | | | | | | | - | | - | | | | - | | | | | | | | | | - | | - | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | - | | - | | - | | - | | | | | | | | | | - | | - | | | | - | | - | | - | | - | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | - | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | - | | - | | | | - | | - | | - | | | | | | - | | - | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for C5orf45
|
Expression
for C5orf45 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| C5orf45 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See C5orf45 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for C5orf45
SOURCE GeneReport for Unigene cluster: Hs.741169
SABiosciences Custom PCR Arrays for C5orf45
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for C5orf45
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat C5orf45 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat C5orf45 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat C5orf45 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C5orf45 |
Orthologs
for C5orf45 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for C5orf45 gene from 5/11 species (see all 11) About this table
ENSEMBL Gene Tree for C5orf45 (if available)
TreeFam Gene Tree for C5orf45 (if available) |
Paralogs
for C5orf45 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for C5orf45 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 5 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for C5orf45 (179261436 - 179289173 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for C5orf45
1 CNV: 0068 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing C5orf45 |
|
Disorders
/ Diseases
for C5orf45 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for C5orf45 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for C5orf45 gene, integrated from 9 sources (see all 11):
(articles sorted by number of sources associating them with C5orf45) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
- The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
- The LIFEdb database in 2006. (PubMed id 16381901)1 Mehrle A....Wiemann S. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)
- The DNA sequence and comparative analysis of human chromosome 5. (PubMed id 15372022)2 Schmutz J.... Rubin E.M. (2004)
- From ORFeome to biology: a functional genomics pipeline. (PubMed id 15489336)1 Wiemann S....Poustka A. (2004)
- Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. (PubMed id 15146197)1 Brandenberger R.... Stanton L.W. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1 Wiemann S.... Poustka A. (2001)
|
External Searches for C5orf45 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing C5orf45 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing C5orf45 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing C5orf45 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for C5orf45 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for C5orf45 gene:
Search GeneIP for patents involving C5orf45
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for C5orf45 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat C5orf45 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing C5orf45 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C5orf45 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat C5orf45 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat C5orf45 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat C5orf45 |
| |
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| |  |  |  |  | | | | |
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