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C5orf34 Gene

protein-coding   GIFtS: 43
GCID: GC05M043488

Chromosome 5 Open Reading Frame 34

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Chromosome 5 Open Reading Frame 341 2
Uncharacterized Protein C5orf342

External Ids:    HGNC: 247381   Entrez Gene: 3754442   Ensembl: ENSG000001722447   UniProtKB: Q96MH73   

Export aliases for C5orf34 gene to outside databases

Previous GC identifers: GC05M043524 GC05M043525 GC05M043487 GC05M043437


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for C5orf34 Gene:
C5orf34 (chromosome 5 open reading frame 34) is a protein-coding gene. Diseases associated with C5orf34 include breast and colorectal cancer, and colorectal cancer.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000005.10  NT_006576.17  NC_018916.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the C5orf34 gene promoter:
         Nkx3-1   Nkx3-1 v4   Pbx1a   CUTL1   Nkx3-1 v1   Nkx3-1 v2   Nkx3-1 v3   RSRFC4   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for C5orf34

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat C5orf34


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5p12   Ensembl cytogenetic band:  5p12   HGNC cytogenetic band: 5p12

C5orf34 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
C5orf34 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M043488:  view genomic region     (about GC identifiers)

Start:
43,486,803 bp from pter      End:
43,515,273 bp from pter
Size:
28,471 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: CE034_HUMAN, Q96MH7 (See protein sequence)
Recommended Name: Uncharacterized protein C5orf34  
Size: 638 amino acids; 72898 Da

Explore the universe of human proteins at neXtProt for C5orf34: NX_Q96MH7

Explore proteomics data for C5orf34 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See C5orf34 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_940968.1  
    ENSEMBL proteins: 
     ENSP00000303490   ENSP00000426724   ENSP00000424486  

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    Cloud-Clone Corp. ELISAs for C5orf34
    Cloud-Clone Corp. CLIAs for C5orf34


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR027865 DUF4520
     IPR027830 DUF4524

    Graphical View of Domain Structure for InterPro Entry Q96MH7

    ProtoNet protein and cluster: Q96MH7


    C5orf34 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for C5orf34
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for C5orf34
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    miRNA
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    miRTarBase miRNAs that target C5orf34:
    hsa-mir-192-5p (MIRT026784), hsa-mir-181b-5p (MIRT047256)

    Block miRNA regulation of human, mouse, rat C5orf34 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate C5orf34:
    hsa-miR-4277
    SwitchGear 3'UTR luciferase reporter plasmidC5orf34 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat C5orf34

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    GenScript: all cDNA clones in your preferred vector: C5orf34 (NM_198566)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for C5orf34
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C5orf34

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C5orf34


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol2
    nucleus2

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for C5orf34
    Interactions:

        Search GeneGlobe Interaction Network for C5orf34

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for C5orf34 (ENSP000003034904) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for C5orf34 (CE034)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for C5orf34 gene: 
    NM_198566.2  

    Unigene Cluster for C5orf34:

    Chromosome 5 open reading frame 34
    Hs.661641  [show with all ESTs]
    Unigene Representative Sequence: NM_198566
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000306862(uc003jnz.2) ENST00000506213 ENST00000503655 ENST00000509489
    ENST00000514462(uc011cpx.2)
    miRNA
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    1 qRT-PCR Assays for microRNA that regulate C5orf34:
    hsa-miR-4277
    SwitchGear 3'UTR luciferase reporter plasmidC5orf34 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for C5orf34
    Predesigned siRNA for gene silencing in human, mouse, rat C5orf34
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C5orf34
    Primer
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    OriGene qPCR primer pairs and template standards for C5orf34
    OriGene qSTAR qPCR primer pairs in human, mouse for C5orf34
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat C5orf34
      QuantiTect SYBR Green Assays in human, mouse, rat C5orf34
      QuantiFast Probe-based Assays in human, mouse, rat C5orf34

    Additional mRNA sequence: 

    AK056925.1 BC036867.1 

    3 DOTS entries:

    DT.209609  DT.95367416  DT.100675304 

    Selected AceView cDNA sequences (see all 144):

    BE221445 CR604540 CA443961 AA281123 CA449575 CK819968 AA909452 BG028350 
    BG109782 AI472136 BM695285 BG778586 BE675061 BM273256 BX956424 AA890140 
    AL137306 CK430241 AW170799 AA648824 AI742105 AA864902 BM354220 BU145855 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    C5orf34 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTGCAGGAGA
    C5orf34 Expression
    About this image


    C5orf34 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Ovary (Reproductive System)
             Secondary Oocyte Antral Follicle
     
     Gonad
             Secondary Oocyte Antral Follicle
    C5orf34 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    C5orf34 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.661641
        Custom PCR Arrays for C5orf34
    Primer
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    OriGene qPCR primer pairs and template standards for C5orf34
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    QuantiFast Probe-based Assays in human, mouse, rat C5orf34
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C5orf34

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for C5orf34 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia 4833420G17Rik1 , 5 RIKEN cDNA 4833420G17 gene1, 5 80.26(n)1
    75.59(a)1
      13 (67.24 cM)5
    673921  NM_001113550.11  NP_001107022.11 
     1194627595 
    chicken
    (Gallus gallus)
    Aves CZH5ORF341 chromosome Z open reading frame, human C5orf34 59.93(n)
    50.24(a)
      427194  XM_424782.3  XP_424782.3 
    lizard
    (Anolis carolinensis)
    Reptilia C5orf346
    chromosome 5 open reading frame 34
    46(a)
    1 ↔ 1
    2(6038279-6063564)
    zebrafish
    (Danio rerio)
    Actinopterygii zgc:1533521 zgc:153352 48.82(n)
    39.62(a)
      767733  NM_001076671.1  NP_001070139.1 


    ENSEMBL Gene Tree for C5orf34 (if available)
    TreeFam Gene Tree for C5orf34 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for C5orf34 (see all 655)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0356184
    A breast cancer sample4--see VAR_0356182 S R mis40--------
    rs786545241,2
    C,F--43486307(+) CATAGC/TTCTAC 1 -- int11Minor allele frequency- T:0.03EA 120
    rs1399263971,2
    --43486324(+) ATACTG/TGGAGT 1 -- int10--------
    rs1498147271,2
    C--43486337(+) AGGGAC/TCAAAT 1 -- int10--------
    rs1137308091,2
    C--43486375(+) ATATT-/AAAAAA 1 -- int11Minor allele frequency- A:0.50CSA 2
    rs1458685251,2
    --43486541(+) GGTGGC/TACATG 1 -- int10--------
    rs48667461,2
    C,F,A--43486566(+) TACTCG/AGAAGG 1 -- int110Minor allele frequency- A:0.44NA WA CSA EA 370
    rs1401619571,2
    --43486625(+) CTATGA/GTTGCA 1 -- int10--------
    rs48668301,2
    C,F,H--43486647(+) CAGCCT/CGGGTG 1 -- int14Minor allele frequency- C:0.10NS NA EA 416
    rs803130471,2
    C,F--43486806(+) TGAAAC/GGTTCA 1 -- ut312Minor allele frequency- G:0.05WA NA 238

    HapMap Linkage Disequilibrium report for C5orf34 (43486803 - 43515273 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for C5orf34:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv830275CNV Gain17160897
    dgv6043n71CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing C5orf34
    DNA2.0 Custom Variant and Variant Library Synthesis for C5orf34

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    2 diseases for C5orf34:    
    About MalaCards
    breast and colorectal cancer    colorectal cancer


    C5orf34 for disorders           About GeneDecksing

    Genetic Association Database (GAD): C5orf34

    Export disorders for C5orf34 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for C5orf34 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with C5orf34)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    3. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    4. Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels. (PubMed id 21987572)1 Lee K.A....Doedens J.R. (J. Biol. Chem. 2011)
    5. Global identification of modular cullin-RING ligase substrates. (PubMed id 21963094)1 Emanuele M.J....Elledge S.J. (Cell 2011)
    6. The consensus coding sequences of human breast and colorectal cancers. (PubMed id 16959974)2 Sjoeblom T.... Velculescu V.E. (Science 2006)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. The DNA sequence and comparative analysis of human chromosome 5. (PubMed id 15372022)2 Schmutz J.... Rubin E.M. (Nature 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 375444 HGNC: 24738 AceView: FLJ21657andFLJ32363 Ensembl:ENSG00000172244 euGenes: HUgn375444
    ECgene: C5orf34 H-InvDB: C5orf34

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for C5orf34 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for C5orf34 gene:
    Search GeneIP for patents involving C5orf34

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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     Custom PCR Arrays for C5orf34 Search Chromatin IP Primers for C5orf34
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