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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

C5orf34 Gene

protein-coding   GIFtS: 40
GCID: GC05M043437

Chromosome 5 Open Reading Frame 34

  Search for C5orf34
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Chromosome 5 Open Reading Frame 341 2
Uncharacterized Protein C5orf342

External Ids:    HGNC: 247381   Entrez Gene: 3754442   Ensembl: ENSG000001722447   UniProtKB: Q96MH73   

Export aliases for C5orf34 gene to outside databases

Previous GC identifers: GC05M043524 GC05M043525 GC05M043487


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for C5orf34 Gene: 
C5orf34 (chromosome 5 open reading frame 34) is a protein-coding gene.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000005.9  NC_018916.2  NT_006576.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the C5orf34 gene promoter:
         Nkx3-1   Nkx3-1 v4   Pbx1a   CUTL1   Nkx3-1 v1   Nkx3-1 v2   Nkx3-1 v3   RSRFC4   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for C5orf34

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C5orf34


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5p12   Ensembl cytogenetic band:  5p12   HGNC cytogenetic band: 5p12

C5orf34 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
C5orf34 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M043437:  view genomic region     (about GC identifiers)

Start:
43,486,803 bp from pter      End:
43,515,273 bp from pter
Size:
28,471 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CE034_HUMAN, Q96MH7 (See protein sequence)
Recommended Name: Uncharacterized protein C5orf34  
Size: 638 amino acids; 72898 Da

Explore the universe of human proteins at neXtProt for C5orf34: NX_Q96MH7

Explore proteomics data for C5orf34 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q96MH7

  • C5orf34 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    C5orf34 Protein Expression
    REFSEQ proteins: NP_940968.1  
    ENSEMBL proteins: 
     ENSP00000303490   ENSP00000426724   ENSP00000424486  

    Human Recombinant Protein Products for C5orf34: 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ProtoNet protein and cluster: Q96MH7


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for C5orf34 
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C5orf34


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for C5orf34

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for C5orf34 (ENSP000003034904) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for C5orf34 (CE034)

    Search CenterWatch for drugs/clinical trials and news about C5orf34 / CE034

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for C5orf34 gene: 
    NM_198566.2  

    Unigene Cluster for C5orf34:

    Chromosome 5 open reading frame 34
    Hs.661641  [show with all ESTs]
    Unigene Representative Sequence: NM_198566
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000306862(uc003jnz.2) ENST00000506213 ENST00000503655 ENST00000509489
    ENST00000514462(uc011cpx.2)
    miRNA
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    hsa-miR-4277
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    Inhib. RNA
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    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat C5orf34
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat C5orf34

    Additional mRNA sequence: 

    AK056925.1 BC036867.1 

    3 DOTS entries:

    DT.209609  DT.95367416  DT.100675304 

    24/144 AceView cDNA sequences (see all 144):

    AL137306 BG109782 BM695285 CA449575 CK430241 BM354220 BU145855 CK820131 
    BC063832 CA443961 BE675061 CK819968 AA648824 BX956424 BE221445 AI472136 
    AA281123 AI742105 AW170799 AA909452 CR604540 BG028350 BM273256 AA864902 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    C5orf34 expression in normal human tissues (normalized intensities)      C5orf34 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTGCAGGAGA
    C5orf34 Expression
    About this image


    C5orf34 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/2 selected tissues (see all 2) fully expand
     
     Ovary (Reproductive System)
             Secondary Oocyte Antral Follicle
     
     Gonad
             Secondary Oocyte Antral Follicle

    See C5orf34 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for C5orf34

    SOURCE GeneReport for Unigene cluster: Hs.661641
        SABiosciences Custom PCR Arrays for C5orf34
    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C5orf34

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for C5orf34 gene from 4/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia 4833420G17Rik1 , 5 RIKEN cDNA 4833420G17 gene1, 5 80.26(n)1
    75.59(a)1
      13 (67.24 cM)5
    673921  NM_001113550.11  NP_001107022.11 
     1194627595 
    chicken
    (Gallus gallus)
    Aves CZH5orf341 chromosome Z open reading frame, human C5orf34 60.15(n)
    50.16(a)
      427194  XM_424782.2  XP_424782.2 
    lizard
    (Anolis carolinensis)
    Reptilia C5orf346
    chromosome 5 open reading frame 34
    46(a)
    1 ↔ 1
    2(6038279-6063564)
    zebrafish
    (Danio rerio)
    Actinopterygii zgc:1533521 zgc:153352 49.13(n)
    39.73(a)
      767733  NM_001076671.1  NP_001070139.1 


    ENSEMBL Gene Tree for C5orf34 (if available)
    TreeFam Gene Tree for C5orf34 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/655 SNPs in C5orf34 are shown (see all 655)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0356184
    A breast cancer sample4--see VAR_0356182 S R mis40--------
    VAR_0615894
    ----see VAR_0615892 T S mis40--------
    rs786545241,2
    C,F--43486307(+) CATAGC/TTCTAC 1 -- int11Minor allele frequency- T:0.03EA 120
    rs1399263971,2
    --43486324(+) ATACTG/TGGAGT 1 -- int10--------
    rs1498147271,2
    C--43486337(+) AGGGAC/TCAAAT 1 -- int10--------
    rs1137308091,2
    C--43486375(+) ATATT-/AAAAAA 1 -- int11Minor allele frequency- A:0.50CSA 2
    rs1458685251,2
    --43486541(+) GGTGGC/TACATG 1 -- int10--------
    rs48667461,2
    C,F,A--43486566(+) TACTCG/AGAAGG 1 -- int110Minor allele frequency- A:0.44NA WA CSA EA 370
    rs1401619571,2
    --43486625(+) CTATGA/GTTGCA 1 -- int10--------
    rs48668301,2
    C,F,H--43486647(+) CAGCCT/CGGGTG 1 -- int14Minor allele frequency- C:0.10NS NA EA 416

    HapMap Linkage Disequilibrium report for C5orf34 (43486803 - 43515273 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for C5orf34:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv830275CNV Gain17160897
    dgv6043n71CNV Gain21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    C5orf34 for disorders           About MalaCards

    C5orf34 for disorders           About GeneDecksing

    Genetic Association Database (GAD): C5orf34

    Export disorders for C5orf34 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for C5orf34 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with C5orf34)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
    3. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    4. Ubiquitin ligase substrate identification through qua ntitative proteomics at both the protein and peptide levels. (PubMed id 21987572)1 Lee K.A....Doedens J.R. (2011)
    5. Global identification of modular cullin-RING ligase su bstrates. (PubMed id 21963094)1 Emanuele M.J....Elledge S.J. (2011)
    6. The consensus coding sequences of human breast and colorectal cancers. (PubMed id 16959974)2 Sjoeblom T.... Velculescu V.E. (2006)
    7. The DNA sequence and comparative analysis of human chromosome 5. (PubMed id 15372022)2 Schmutz J.... Rubin E.M. (2004)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 375444 HGNC: 24738 AceView: FLJ21657andFLJ32363 Ensembl:ENSG00000172244 euGenes: HUgn375444
    ECgene: C5orf34 H-InvDB: C5orf34

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for C5orf34 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for C5orf34 gene:
    Search GeneIP for patents involving C5orf34

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    (GIFtS: 73)
    transforming growth factor, beta 1
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