C5orf34 Gene
protein-coding GIFtS : 38
GCID: GC05 M043437
chromosome 5 open reading frame 34
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Aliasesfor C5orf34 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Chromosome 5 Open Reading Frame 34 1 2 FLJ323631 Uncharacterized Protein C5orf342
Export aliases for C5orf34 gene to outside databases Previous GC identifers: GC05M043524 GC05M043525 GC05M043487
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Summariesfor C5orf34 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
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Genomic Viewsfor C5orf34 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000005.9 NC_018916.1 NT_006576.16 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the C5orf34 gene promoter: Nkx3-1 Nkx3-1 v4 Pbx1a CUTL1 Nkx3-1 v1 Nkx3-1 v2 Nkx3-1 v3 RSRFC4 Other transcription factors Search SABiosciences Chromatin IP Primers for C5orf34 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C5orf34
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 5p12 Ensembl cytogenetic band: 5p12 HGNC cytogenetic band: 5p12 C5orf34 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 5 GeneLoc Exon Structure
GeneLoc location for GC05M043437: view genomic region
(about GC identifiers )
Start:
43,486,803 bp from pter
End:
43,515,247 bp from pter
Size:
28,445 bases
Orientation:
minus strand
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Proteinsfor C5orf34 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: CE034_HUMAN, Q96MH7 (See
protein sequence )Recommended Name: Uncharacterized protein C5orf34 Size : 638 amino acids; 72898 DaExplore the universe of human proteins at neXtProt for C5orf34: NX_Q96MH7 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_Q96MH7 C5orf34 Protein expression data from MOPED and PaxDb : About this image
REFSEQ proteins: NP_940968.1 ENSEMBL proteins: ENSP00000303490 ENSP00000426724 ENSP00000424486 Human Recombinant Protein Products: C5orf34 Antibody Products: Assay Products for C5orf34:
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Protein
Domains / Familiesfor C5orf34 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section ProtoNet protein and cluster: Q96MH7
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Functionfor C5orf34 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for C5orf34 (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for C5orf34OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: C5orf34 (NM_198566 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for C5orf34 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat C5orf34
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C5orf34
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Pathways & Interactionsfor C5orf34 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for C5orf34 STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)1 Interacting protein for C5orf34 (ENSP00000303490 4 ) via UniProtKB, MINT, STRING , and/or I2D About this table
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Drugs & Compoundsfor C5orf34 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for C5orf34 Search CenterWatch for drugs/clinical trials and news about C5orf34 / CE034
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Transcriptsfor C5orf34 gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
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Primers from
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SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for C5orf34 gene: NM_198566.2 Unigene Cluster for C5orf34:
Chromosome 5 open reading frame 34 Hs.661641 [show with all ESTs ] Unigene Representative Sequence: NM_198566 5 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000306862 (uc003jnz.2 ) ENST00000506213 ENST00000503655 ENST00000509489 ENST00000514462 (uc011cpx.2 ) Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for C5orf34 (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for C5orf34OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: C5orf34 (NM_198566 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for C5orf34 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat C5orf34
Additional cDNA sequence: AK056925.1 BC036867.1
3 DOTS entries : DT.209609 DT.95367416
DT.100675304 24/144 AceView cDNA sequences (see all 144 ):
BX956424 BM683064 CK430241 BE221445 AI742105 AA648824 BC073852 AA857274 AL137306 BM354220 AI472136 BG778586 AA864902 BM695285 AA909452 CR604540 BG028350 BE675061 AA281123 BG109782 CK819968 CA443961 AA890140 BM273256 GeneLoc Exon Structure
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Expression for C5orf34 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section C5orf34 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: GTGCAGGAGA
About this image C5orf34 expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table 1 LifeMap In Vivo Development Anatomical Compartment/Cell Tissue Anatomical Compartment
Cell Category (developmental path) Ovary Antral Follicle Secondary Oocyte Female Gametocytes, Germ Cells Expression: Positive Negative
Selective markerExperimental details:
Curated
Microarrays
In-situ hybridization
See C5orf34 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for C5orf34 SOURCE GeneReport for Unigene cluster: Hs.661641 SABiosciences Custom PCR Arrays for C5orf34 Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for C5orf34Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat C5orf34 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat C5orf34 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat C5orf34 In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C5orf34
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Orthologsfor C5orf34 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of chordates.
Orthologs for C5orf34 gene from 4/14 species (see all 14 ) About this table
ENSEMBL Gene Tree for C5orf34 (if available)TreeFam Gene Tree for C5orf34 (if available)
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Paralogsfor C5orf34 gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section --
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Genomic Variantsfor C5orf34 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 5 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for C5orf34 (43486803 - 43515247 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 1 variation for C5orf34 1 CNV : 93009
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing C5orf34
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Disorders
/ Diseasesfor C5orf34 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
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Publicationsfor C5orf34 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for C5orf34 gene integrated from 9 sources : (articles sorted by number of sources associating them with C5orf34) Utopia : connect your pdf to the dynamic world of online information
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039) 1 , 2 Ota T.... Sugano S. (2004) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932) 1 , 3 Strausberg R.L....Marra M.A. (2002) Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983) 1 Kim W....Gygi S.P. (2011) Ubiquitin ligase substrate identification through qua ntitative proteomics at both the protein and peptide levels. (PubMed id 21987572) 1 Lee K.A....Doedens J.R. (2011) The consensus coding sequences of human breast and colorectal cancers. (PubMed id 16959974) 2 Sjoeblom T.... Velculescu V.E. (2006) The DNA sequence and comparative analysis of human chromosome 5. (PubMed id 15372022) 2 Schmutz J.... Rubin E.M. (2004) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 2 Gerhard D.S....Malek J. (2004)
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External Searches for C5orf34 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing C5orf34 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing C5orf34 gene
(According to HUGE )
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Specialized Databases showing C5orf34 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
PharmGKB entry for C5orf34 Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for C5orf34 gene: Search GeneIP for patents involving C5orf34 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor C5orf34 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
Browse OriGene Antibodies OriGene shRNA RFP for C5orf34 OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for C5orf34 OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for C5orf34 OriGene Protein Over-expression Lysate for C5orf34 Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for C5orf34 OriGene 3'-UTR Clone for C5orf34 OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for C5orf34 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for C5orf34 Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for C5orf34 OriGene Custom Protein Services for C5orf34 OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat C5orf34 QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing C5orf34 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C5orf34 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat C5orf34 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat C5orf34 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat C5orf34
Search Tocris compounds for C5orf34
C5orf34 Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C5orf34
Search ThermoFisher Antibodies for C5orf34
Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat C5orf34
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