C5orf28 Gene
protein-coding GIFtS : 37
GCID: GC05 M043395
chromosome 5 open reading frame 28
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Aliasesfor C5orf28 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Chromosome 5 Open Reading Frame 28 1 2 FLJ216571 Transmembrane Protein C5orf282
Export aliases for C5orf28 gene to outside databases Previous GC identifer: GC05M043481
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Summariesfor C5orf28 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section --
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Genomic Viewsfor C5orf28 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000005.9 NC_018916.1 NT_006576.16 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the C5orf28 gene promoter: SRF STAT1 Sox5 Pax-6 POU3F1 HTF SRF (504 AA) FOXC1 HFH-1 MRF-2 Other transcription factors Search SABiosciences Chromatin IP Primers for C5orf28 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat C5orf28
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 5p12 Ensembl cytogenetic band: 5p12 HGNC cytogenetic band: 5p12 C5orf28 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 5 GeneLoc Exon Structure
GeneLoc location for GC05M043395: view genomic region
(about GC identifiers )
Start:
43,444,354 bp from pter
End:
43,483,995 bp from pter
Size:
39,642 bases
Orientation:
minus strand
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Proteinsfor C5orf28 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: CE028_HUMAN, Q0VDI3 (See
protein sequence )Recommended Name: Transmembrane protein C5orf28 Size : 215 amino acids; 24217 Da
Subcellular location : Membrane; Multi-pass membrane protein (Potential)
Secondary accessions : B2RDA6 Q9H6Z2Explore the universe of human proteins at neXtProt for C5orf28: NX_Q0VDI3 C5orf28 Protein expression data from MOPED and PaxDb : About this image
REFSEQ proteins: NP_071928.2 ENSEMBL proteins: ENSP00000426067 ENSP00000380270 ENSP00000422881 ENSP00000427099 ENSP00000424720 ENSP00000443629 Human Recombinant Protein Products: Gene Ontology (GO): 1 cellular component term (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0016021 integral to membrane
IEA --
C5orf28 for ontologies About GeneDecksing C5orf28 Antibody Products: Assay Products for C5orf28:
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Protein
Domains / Familiesfor C5orf28 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
C5orf28 for domains About GeneDecksing 1 InterPro domain/family :
Graphical View of Domain Structure for InterPro Entry Q0VDI3 ProtoNet protein and cluster: Q0VDI3
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Functionfor C5orf28 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for C5orf28 (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for C5orf28OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: C5orf28 (NM_022483 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for C5orf28 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat C5orf28
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C5orf28
1 GenomeRNAi human phenotype for C5orf28 :
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Pathways & Interactionsfor C5orf28 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for C5orf28
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Drugs & Compoundsfor C5orf28 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for C5orf28 Search CenterWatch for drugs/clinical trials and news about C5orf28 / CE028
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Transcriptsfor C5orf28 gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
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siRNAs from
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QIAGEN ,
shRNA from
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Tagged/untagged cDNA clones from
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Primers from
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QIAGEN
)About This Section REFSEQ mRNAs for C5orf28 gene: NM_022483.4 Unigene Cluster for C5orf28:
Chromosome 5 open reading frame 28 Hs.732093 [show with all ESTs ] Unigene Representative Sequence: BC013351 7 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000500337 (uc003jny.3 uc003jnv.4 uc003jnx.3 ) ENST00000397080 ENST00000512085 ENST00000511525 ENST00000510130 ENST00000506860 ENST00000537319 Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for C5orf28 (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for C5orf28OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: C5orf28 (NM_022483 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for C5orf28 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat C5orf28
Additional cDNA sequence: AK025310.1 AK094078.1 AK225220.1 AK315466.1 AL137306.1 BC013351.2 BC063832.1 BC073852.1 BC119658.1 BC119659.1
9 DOTS entries : DT.448282 DT.100770508
DT.97840416 DT.95163322 DT.97791888 DT.92428579 DT.92023232 DT.92428583 DT.40110474 24/144 AceView cDNA sequences (see all 144 ):
CK430241 CA449575 AL137306 AI472136 CR604540 AA281123 CA443961 BM695285 BG109782 CK819968 BE675061 BG778586 BG028350 BM354220 AA864902 BU145855 BC063832 BM683064 AA857274 BC073852 AL523444 CK820131 BM273256 AA909452 GeneLoc Exon Structure 5/8 Alternative Splicing Database (ASD) splice patterns (SP) for C5orf28 (see all 8 ) About this scheme ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b · 6c · 6d SP1 :           -       -                 SP2 :           -   -     -                 SP3 :       -   -   -   -   -                   SP4 :       -   -   -   -   -   -                 SP5 :           -   -   -   -   -   -   -          
ECgene alternative splicing isoforms for C5orf28
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Expression for C5orf28 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section C5orf28 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: --
About this image C5orf28 expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table Stem Cell Differentiation: 1 LifeMap Cell Name Category Definitive endoderm-like cells (A scalable, suspensi... )Expression: Positive Negative
Selective markerExperimental details:
Curated
Microarrays
In-situ hybridization
See C5orf28 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for C5orf28 SOURCE GeneReport for Unigene cluster: Hs.732093 SABiosciences Custom PCR Arrays for C5orf28 Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for C5orf28Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat C5orf28 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat C5orf28 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat C5orf28 In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C5orf28
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Orthologsfor C5orf28 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of animals.
Orthologs for C5orf28 gene from 6/18 species (see all 18 ) About this table
ENSEMBL Gene Tree for C5orf28 (if available)TreeFam Gene Tree for C5orf28 (if available)
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Paralogsfor C5orf28 gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section --
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Genomic Variantsfor C5orf28 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 5 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for C5orf28 (43444354 - 43483995 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for C5orf28: --
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing C5orf28
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Disorders
/ Diseasesfor C5orf28 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
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Publicationsfor C5orf28 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for C5orf28 gene integrated from 9 sources : (articles sorted by number of sources associating them with C5orf28) Utopia : connect your pdf to the dynamic world of online information
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 1 , 2 Gerhard D.S....Malek J. (2004) Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039) 1 , 2 Ota T.... Sugano S. (2004) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932) 1 , 3 Strausberg R.L....Marra M.A. (2002) Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049) 1 OlA!h J....OvA!di J. (2011) Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560) 1 Kimura K.... Sugano S. (2006)
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External Searches for C5orf28 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing C5orf28 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing C5orf28 gene
(According to HUGE )
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Specialized Databases showing C5orf28 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
PharmGKB entry for C5orf28 Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for C5orf28 gene: Search GeneIP for patents involving C5orf28 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor C5orf28 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
Browse OriGene Antibodies OriGene shRNA RFP for C5orf28 OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for C5orf28 OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for C5orf28 Browse OriGene Protein Over-expression Lysates Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for C5orf28 OriGene 3'-UTR Clone for C5orf28 OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for C5orf28 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for C5orf28 Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for C5orf28 OriGene Custom Protein Services for C5orf28 OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat C5orf28 QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing C5orf28 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat C5orf28 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat C5orf28 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat C5orf28 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat C5orf28
Search Tocris compounds for C5orf28
C5orf28 Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C5orf28
Search ThermoFisher Antibodies for C5orf28
Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat C5orf28
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Genomic Views for C5orf28
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