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Aliases for C5orf28 Gene

Aliases for C5orf28 Gene

  • Chromosome 5 Open Reading Frame 28 2 3

External Ids for C5orf28 Gene

Previous GeneCards Identifiers for C5orf28 Gene

  • GC05M043481
  • GC05M043395

Summaries for C5orf28 Gene

GeneCards Summary for C5orf28 Gene

C5orf28 (Chromosome 5 Open Reading Frame 28) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C5orf28 Gene

Genomics for C5orf28 Gene

Regulatory Elements for C5orf28 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for C5orf28 Gene

43,444,252 bp from pter
43,485,178 bp from pter
40,927 bases
Minus strand

Genomic View for C5orf28 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for C5orf28 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C5orf28 Gene

Proteins for C5orf28 Gene

  • Protein details for C5orf28 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Transmembrane protein C5orf28
    Protein Accession:
    Secondary Accessions:
    • B2RDA6
    • Q9H6Z2

    Protein attributes for C5orf28 Gene

    215 amino acids
    Molecular mass:
    24217 Da
    Quaternary structure:
    No Data Available

neXtProt entry for C5orf28 Gene

Proteomics data for C5orf28 Gene at MOPED

Post-translational modifications for C5orf28 Gene

No Post-translational modifications

Other Protein References for C5orf28 Gene

No data available for DME Specific Peptides for C5orf28 Gene

Domains & Families for C5orf28 Gene

Protein Domains for C5orf28 Gene


Suggested Antigen Peptide Sequences for C5orf28 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C5orf28: view

No data available for Gene Families and UniProtKB/Swiss-Prot for C5orf28 Gene

Function for C5orf28 Gene

Phenotypes for C5orf28 Gene

genes like me logo Genes that share phenotypes with C5orf28: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targets and HOMER Transcription for C5orf28 Gene

Localization for C5orf28 Gene

Subcellular locations from UniProtKB/Swiss-Prot for C5orf28 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for C5orf28 Gene COMPARTMENTS Subcellular localization image for C5orf28 gene
Compartment Confidence
nucleus 2

Gene Ontology (GO) - Cellular Components for C5orf28 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with C5orf28: view

Pathways & Interactions for C5orf28 Gene

SuperPathways for C5orf28 Gene

No Data Available

Interacting Proteins for C5orf28 Gene

Gene Ontology (GO) - Biological Process for C5orf28 Gene


No data available for Pathways by source and SIGNOR curated interactions for C5orf28 Gene

Drugs & Compounds for C5orf28 Gene

No Compound Related Data Available

Transcripts for C5orf28 Gene

Unigene Clusters for C5orf28 Gene

Chromosome 5 open reading frame 28:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for C5orf28 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b · 6c · 6d
SP1: - -
SP2: - - -
SP3: - - - - -
SP4: - - - - - -
SP5: - - - - - - -
SP7: - - - -
SP8: - - - -

Relevant External Links for C5orf28 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for C5orf28 Gene

mRNA expression in normal human tissues for C5orf28 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for C5orf28 Gene

SOURCE GeneReport for Unigene cluster for C5orf28 Gene Hs.732093

genes like me logo Genes that share expression patterns with C5orf28: view

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for C5orf28 Gene

Orthologs for C5orf28 Gene

This gene was present in the common ancestor of animals.

Orthologs for C5orf28 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia C20H5orf28 35
  • 90.08 (n)
  • 89.77 (a)
C5orf28 36
  • 90 (a)
(Canis familiaris)
Mammalia C4H5orf28 35
  • 91.63 (n)
  • 93.02 (a)
C5orf28 36
  • 79 (a)
(Mus musculus)
Mammalia Gm7120 35
  • 80.93 (n)
  • 78.6 (a)
Gm7120 16
Gm21967 36
  • 71 (a)
Gm7120 36
  • 71 (a)
(Pan troglodytes)
Mammalia C5H5orf28 35
  • 99.53 (n)
  • 99.53 (a)
C5orf28 36
  • 100 (a)
(Rattus norvegicus)
Mammalia RGD1562550 35
  • 80.78 (n)
  • 80 (a)
(Monodelphis domestica)
Mammalia C5orf28 36
  • 83 (a)
(Ornithorhynchus anatinus)
Mammalia C5orf28 36
  • 75 (a)
(Gallus gallus)
Aves CZH5ORF28 35
  • 78.91 (n)
  • 80 (a)
C5orf28 36
  • 78 (a)
(Anolis carolinensis)
Reptilia C5orf28 36
  • 81 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100490930 35
  • 68.06 (n)
  • 74.42 (a)
(Danio rerio)
Actinopterygii si:busm1-79m10.4 35
  • 64.81 (n)
  • 66.51 (a)
C10H5orf28 36
  • 61 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005379 35
  • 43.08 (n)
  • 33.33 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG10866 35
  • 48.68 (n)
  • 41.45 (a)
CG10866 36
  • 29 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 28 (a)
Species with no ortholog for C5orf28:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C5orf28 Gene

Gene Tree for C5orf28 (if available)
Gene Tree for C5orf28 (if available)

Paralogs for C5orf28 Gene

No data available for Paralogs for C5orf28 Gene

Variants for C5orf28 Gene

Structural Variations from Database of Genomic Variants (DGV) for C5orf28 Gene

Variant ID Type Subtype PubMed ID
dgv6043n71 CNV Gain 21882294
esv2597772 CNV Deletion 19546169
nsv830275 CNV Gain 17160897
esv2665243 CNV Deletion 23128226

Variation tolerance for C5orf28 Gene

Residual Variation Intolerance Score: 33.92% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.58; 12.51% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C5orf28 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for C5orf28 Gene

Disorders for C5orf28 Gene

Relevant External Links for C5orf28

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with C5orf28: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C5orf28 Gene

Publications for C5orf28 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 67
  2. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 67
  3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 67
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 67
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 67

Products for C5orf28 Gene

Sources for C5orf28 Gene

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