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Aliases for C5orf24 Gene

Aliases for C5orf24 Gene

  • Chromosome 5 Open Reading Frame 24 2 3 5

External Ids for C5orf24 Gene

Previous GeneCards Identifiers for C5orf24 Gene

  • GC05P134210
  • GC05P129367
  • GC05P134181

Summaries for C5orf24 Gene

GeneCards Summary for C5orf24 Gene

C5orf24 (Chromosome 5 Open Reading Frame 24) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C5orf24 Gene

Genomics for C5orf24 Gene

Regulatory Elements for C5orf24 Gene

Enhancers for C5orf24 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05F134113 1 FANTOM5 Ensembl ENCODE 14.6 -715.2 -715155 34.1 HDGF PKNOX1 WRNIP1 ARID4B YBX1 ZNF2 YY1 ZNF143 ZNF207 FOS TCF7 ENSG00000271128 CTB-3M24.3 ENSG00000270892 ENSG00000248753 C5orf24 VDAC1 SKP1 CDKL3 MTND4LP30
GH05F134844 0.9 ENCODE 12.4 +0.9 943 3.5 CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 YY1 ZNF143 ZNF207 ZNF263 MXD4 CAMLG C5orf24 TXNDC15 DDX46 ENSG00000270021 GC05M134654
GH05F134757 0.8 ENCODE 11.8 -86.5 -86519 2.6 HDGF PKNOX1 CREB3L1 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 C5orf66 SEC24A C5orf24 C5orf15 DDX46 RPL34P13
GH05F134630 0.2 ENCODE 11.7 -213.5 -213480 2.5 CREB3L1 ZFP64 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC TBX21 ENSG00000271737 C5orf24 C5orf66 JADE2 C5orf66-AS1 CAMLG GC05M134635 RNU6-1311P GC05M134578
GH05F135423 0.7 Ensembl ENCODE 11.7 +577.9 577921 1.2 HDGF PKNOX1 ARNT CREB3L1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 ENSG00000270021 H2AFY C5orf24 DCANP1
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around C5orf24 on UCSC Golden Path with GeneCards custom track

Promoters for C5orf24 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001290637 920 2001 CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 YY1 ZNF143 ZNF207 ZNF263 MXD4

Genomic Location for C5orf24 Gene

Chromosome:
5
Start:
134,845,680 bp from pter
End:
134,859,737 bp from pter
Size:
14,058 bases
Orientation:
Plus strand

Genomic View for C5orf24 Gene

Genes around C5orf24 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C5orf24 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C5orf24 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C5orf24 Gene

Proteins for C5orf24 Gene

  • Protein details for C5orf24 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z6I8-CE024_HUMAN
    Recommended name:
    UPF0461 protein C5orf24
    Protein Accession:
    Q7Z6I8
    Secondary Accessions:
    • D3DQA7
    • Q86Y53
    • Q8N1T9

    Protein attributes for C5orf24 Gene

    Size:
    188 amino acids
    Molecular mass:
    20132 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for C5orf24 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for C5orf24 Gene

Post-translational modifications for C5orf24 Gene

  • Ubiquitination at Lys 41 and Lys 146
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for C5orf24 Gene

Domains & Families for C5orf24 Gene

Protein Domains for C5orf24 Gene

ProtoNet:

Suggested Antigen Peptide Sequences for C5orf24 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q7Z6I8

UniProtKB/Swiss-Prot:

CE024_HUMAN :
  • Belongs to the UPF0461 family.
Family:
  • Belongs to the UPF0461 family.
genes like me logo Genes that share domains with C5orf24: view

No data available for Gene Families for C5orf24 Gene

Function for C5orf24 Gene

Gene Ontology (GO) - Molecular Function for C5orf24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with C5orf24: view
genes like me logo Genes that share phenotypes with C5orf24: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C5orf24 Gene

Localization for C5orf24 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for C5orf24 Gene COMPARTMENTS Subcellular localization image for C5orf24 gene
Compartment Confidence
nucleus 3
cytosol 2
extracellular 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for C5orf24 Gene

Pathways & Interactions for C5orf24 Gene

SuperPathways for C5orf24 Gene

No Data Available

Interacting Proteins for C5orf24 Gene

Gene Ontology (GO) - Biological Process for C5orf24 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for C5orf24 Gene

Transcripts for C5orf24 Gene

Unigene Clusters for C5orf24 Gene

Chromosome 5 open reading frame 24:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for C5orf24 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b · 4c · 4d · 4e · 4f ^ 5a · 5b
SP1: - - - -
SP2:
SP3: - - - -
SP4: - - - -
SP5: -

Relevant External Links for C5orf24 Gene

GeneLoc Exon Structure for
C5orf24
ECgene alternative splicing isoforms for
C5orf24

Expression for C5orf24 Gene

mRNA expression in normal human tissues for C5orf24 Gene

Protein differential expression in normal tissues from HIPED for C5orf24 Gene

This gene is overexpressed in Serum (19.5), Fetal Brain (13.6), and Blymphocyte (10.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for C5orf24 Gene



Protein tissue co-expression partners for C5orf24 Gene

NURSA nuclear receptor signaling pathways regulating expression of C5orf24 Gene:

C5orf24

SOURCE GeneReport for Unigene cluster for C5orf24 Gene:

Hs.708536
genes like me logo Genes that share expression patterns with C5orf24: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for C5orf24 Gene

Orthologs for C5orf24 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C5orf24 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C5orf24 35
  • 100 (a)
OneToOne
C5H5orf24 34
  • 99.65 (n)
dog
(Canis familiaris)
Mammalia C5orf24 35
  • 98 (a)
OneToOne
C11H5orf24 34
  • 95.04 (n)
cow
(Bos Taurus)
Mammalia C7H5orf24 34 35
  • 95.39 (n)
mouse
(Mus musculus)
Mammalia B230219D22Rik 34 16 35
  • 91.49 (n)
rat
(Rattus norvegicus)
Mammalia RGD1566359 34
  • 89.36 (n)
oppossum
(Monodelphis domestica)
Mammalia C5orf24 35
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia C5orf24 35
  • 76 (a)
OneToOne
chicken
(Gallus gallus)
Aves C13H5ORF24 34
  • 82.62 (n)
C5orf24 35
  • 81 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia C5orf24 35
  • 79 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia c5orf24 34
  • 74.91 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC797133 34
  • 59.88 (n)
C5orf24 (1 of 2) 35
  • 46 (a)
OneToMany
C21H5orf24 (2 of 2) 35
  • 35 (a)
OneToMany
Species where no ortholog for C5orf24 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C5orf24 Gene

ENSEMBL:
Gene Tree for C5orf24 (if available)
TreeFam:
Gene Tree for C5orf24 (if available)

Paralogs for C5orf24 Gene

No data available for Paralogs for C5orf24 Gene

Variants for C5orf24 Gene

Sequence variations from dbSNP and Humsavar for C5orf24 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs10440784 -- 134,853,707(+) GGGAA(A/G)ATGAT intron-variant
rs10440785 -- 134,853,859(+) gggca(A/G)atcac intron-variant
rs111270440 -- 134,840,566(+) TCTCA(-/CT)CTGTC intron-variant
rs111387142 -- 134,850,170(+) TTGAG(A/G)TGGAG intron-variant
rs111589386 -- 134,841,562(+) AGCCT(C/G)GGTGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for C5orf24 Gene

Variant ID Type Subtype PubMed ID
dgv5810n100 CNV gain 25217958
nsv523937 CNV gain 19592680
nsv830493 CNV loss 17160897
nsv830494 CNV gain+loss 17160897

Variation tolerance for C5orf24 Gene

Residual Variation Intolerance Score: 31.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.66; 14.12% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C5orf24 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
C5orf24

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C5orf24 Gene

Disorders for C5orf24 Gene

Relevant External Links for C5orf24

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
C5orf24

No disorders were found for C5orf24 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C5orf24 Gene

Publications for C5orf24 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64
  3. Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes. (PMID: 25609649) Li X. … Chen J. (Mol. Syst. Biol. 2015) 3 64
  4. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3 64
  5. System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability. (PMID: 25755297) Xiao Z. … Vertegaal A.C. (Mol. Cell. Proteomics 2015) 4 64

Products for C5orf24 Gene

Sources for C5orf24 Gene

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