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Aliases for C5orf24 Gene

Aliases for C5orf24 Gene

  • Chromosome 5 Open Reading Frame 24 2 3 5

External Ids for C5orf24 Gene

Previous GeneCards Identifiers for C5orf24 Gene

  • GC05P134210
  • GC05P129367
  • GC05P134181

Summaries for C5orf24 Gene

GeneCards Summary for C5orf24 Gene

C5orf24 (Chromosome 5 Open Reading Frame 24) is a Protein Coding gene.

Additional gene information for C5orf24 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C5orf24 Gene

Genomics for C5orf24 Gene

Regulatory Elements for C5orf24 Gene

Enhancers for C5orf24 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05H134508 1.9 FANTOM5 Ensembl ENCODE dbSUPER 29.3 -334.9 -334857 4 HDGF PKNOX1 FOXA2 ZFP64 ARID4B DMAP1 ZBTB7B YY1 ZNF766 ZNF416 DDX46 C5orf24 RPS10P11 CDKN2AIPNL ENSG00000248559 CATSPER3 SKP1 LINC01843 CAMLG RN7SL541P
GH05H134464 2 FANTOM5 Ensembl ENCODE dbSUPER 21.1 -379.4 -379422 2 PKNOX1 FOXA2 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 FOS ZNF548 DDX46 C5orf24 TXNDC15 C5orf66 PPP2CA SEC24A UBE2B LOC102546229 RNU6-456P
GH05H134369 1.4 ENCODE dbSUPER 19 -474.2 -474159 3 MLX DMAP1 YY1 ZNF143 ZNF548 SP3 NFYC MEF2D ZNF610 GLIS1 DDX46 SKP1 JADE2 C5orf24 SEC24A ENSG00000248559 C5orf66 CDKL3 ENSG00000279469
GH05H134630 1.4 ENCODE dbSUPER 11.7 -213.5 -213480 2 HDGF PKNOX1 ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 DDX46 JADE2 C5orf66 TXNDC15 SEC24A C5orf24 SKP1 C5orf66-AS1 CAMLG RNU6-1311P
GH05H134844 1.1 ENCODE 12.4 +0.9 943 3 ARNT ARID4B SIN3A DMAP1 YY1 ZNF766 ZNF143 ZNF207 ZHX2 MXD4 DDX46 TXNDC15 CAMLG C5orf66 C5orf24 JADE2 ENSG00000270021 GC05M134654
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around C5orf24 on UCSC Golden Path with GeneCards custom track

Promoters for C5orf24 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000187119 820 1801 ARNT ARID4B SIN3A DMAP1 YY1 ZNF766 ZNF143 ZNF207 ZHX2 MXD4

Genomic Location for C5orf24 Gene

Chromosome:
5
Start:
134,845,680 bp from pter
End:
134,859,737 bp from pter
Size:
14,058 bases
Orientation:
Plus strand

Genomic View for C5orf24 Gene

Genes around C5orf24 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C5orf24 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C5orf24 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C5orf24 Gene

Proteins for C5orf24 Gene

  • Protein details for C5orf24 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z6I8-CE024_HUMAN
    Recommended name:
    UPF0461 protein C5orf24
    Protein Accession:
    Q7Z6I8
    Secondary Accessions:
    • D3DQA7
    • Q86Y53
    • Q8N1T9

    Protein attributes for C5orf24 Gene

    Size:
    188 amino acids
    Molecular mass:
    20132 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for C5orf24 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for C5orf24 Gene

Post-translational modifications for C5orf24 Gene

  • Ubiquitination at Lys41 and posLast=146146
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for C5orf24 Gene

Domains & Families for C5orf24 Gene

Gene Families for C5orf24 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for C5orf24 Gene

ProtoNet:

Suggested Antigen Peptide Sequences for C5orf24 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q7Z6I8

UniProtKB/Swiss-Prot:

CE024_HUMAN :
  • Belongs to the UPF0461 family.
Family:
  • Belongs to the UPF0461 family.
genes like me logo Genes that share domains with C5orf24: view

Function for C5orf24 Gene

Gene Ontology (GO) - Molecular Function for C5orf24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with C5orf24: view
genes like me logo Genes that share phenotypes with C5orf24: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for C5orf24
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C5orf24 Gene

Localization for C5orf24 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C5orf24 gene
Compartment Confidence
nucleus 3
cytosol 2
extracellular 1

Subcellular locations from the

Human Protein Atlas (HPA)

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for C5orf24 Gene

Pathways & Interactions for C5orf24 Gene

SuperPathways for C5orf24 Gene

No Data Available

Gene Ontology (GO) - Biological Process for C5orf24 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for C5orf24 Gene

Drugs & Compounds for C5orf24 Gene

No Compound Related Data Available

Transcripts for C5orf24 Gene

Unigene Clusters for C5orf24 Gene

Chromosome 5 open reading frame 24:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for C5orf24
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for C5orf24 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b · 4c · 4d · 4e · 4f ^ 5a · 5b
SP1: - - - -
SP2:
SP3: - - - -
SP4: - - - -
SP5: -

Relevant External Links for C5orf24 Gene

GeneLoc Exon Structure for
C5orf24
ECgene alternative splicing isoforms for
C5orf24

Expression for C5orf24 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for C5orf24 Gene

Protein differential expression in normal tissues from HIPED for C5orf24 Gene

This gene is overexpressed in Serum (19.5), Fetal Brain (13.6), and Blymphocyte (10.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for C5orf24 Gene



Protein tissue co-expression partners for C5orf24 Gene

NURSA nuclear receptor signaling pathways regulating expression of C5orf24 Gene:

C5orf24

SOURCE GeneReport for Unigene cluster for C5orf24 Gene:

Hs.708536

Evidence on tissue expression from TISSUES for C5orf24 Gene

  • Lung(3.9)
  • Nervous system(3.8)
  • Kidney(2.7)
genes like me logo Genes that share expression patterns with C5orf24: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for C5orf24 Gene

Orthologs for C5orf24 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C5orf24 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C5orf24 34
  • 100 (a)
OneToOne
C5H5orf24 33
  • 99.65 (n)
dog
(Canis familiaris)
Mammalia C5orf24 34
  • 98 (a)
OneToOne
C11H5orf24 33
  • 95.04 (n)
cow
(Bos Taurus)
Mammalia C7H5orf24 33 34
  • 95.39 (n)
mouse
(Mus musculus)
Mammalia B230219D22Rik 33 16 34
  • 91.49 (n)
rat
(Rattus norvegicus)
Mammalia RGD1566359 33
  • 89.36 (n)
oppossum
(Monodelphis domestica)
Mammalia C5orf24 34
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia C5orf24 34
  • 76 (a)
OneToOne
chicken
(Gallus gallus)
Aves C13H5ORF24 33
  • 82.62 (n)
C5orf24 34
  • 81 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia C5orf24 34
  • 79 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia c5orf24 33
  • 74.91 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC797133 33
  • 59.88 (n)
C5orf24 (1 of 2) 34
  • 46 (a)
OneToMany
C21H5orf24 (2 of 2) 34
  • 35 (a)
OneToMany
Species where no ortholog for C5orf24 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C5orf24 Gene

ENSEMBL:
Gene Tree for C5orf24 (if available)
TreeFam:
Gene Tree for C5orf24 (if available)

Paralogs for C5orf24 Gene

No data available for Paralogs for C5orf24 Gene

Variants for C5orf24 Gene

Sequence variations from dbSNP and Humsavar for C5orf24 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs1000037532 -- 134,845,575(+) AATCT(C/G)CGTGG intron-variant, upstream-variant-2KB
rs1000252595 -- 134,842,720(+) TGCTG(A/G)TATTT intron-variant
rs1000462474 -- 134,836,793(+) CACCT(C/T)GGCCT intron-variant
rs1000653374 -- 134,853,504(+) AGAGA(-/CTT)CTTTG intron-variant
rs1000711425 -- 134,832,971(+) CTGTG(A/G)CCTCC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for C5orf24 Gene

Variant ID Type Subtype PubMed ID
dgv5810n100 CNV gain 25217958
nsv523937 CNV gain 19592680
nsv830493 CNV loss 17160897
nsv830494 CNV gain+loss 17160897

Variation tolerance for C5orf24 Gene

Residual Variation Intolerance Score: 31.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.66; 14.12% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C5orf24 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
C5orf24

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C5orf24 Gene

Disorders for C5orf24 Gene

Relevant External Links for C5orf24

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
C5orf24

No disorders were found for C5orf24 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C5orf24 Gene

Publications for C5orf24 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 60
  3. Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. (PMID: 28112733) Hendriks IA … Nielsen ML (Nature structural & molecular biology 2017) 4 60
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein MY … Mann M (Cell 2015) 3 60

Products for C5orf24 Gene

Sources for C5orf24 Gene

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