C5orf22 Gene
protein-coding GIFtS: 43
GCID: GC05P031532
|
|
chromosome 5 open reading frame 22
| |
Aliases
for C5orf22 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Chromosome 5 Open Reading Frame 221 2 | | FLJ111931 | | UPF0489 Protein C5orf222 |
Export aliases for C5orf22 gene to outside databasesPrevious GC identifers: GC05P031569 GC05P031498 GC05P031570 GC05P031500 |
Summaries
for C5orf22 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for C5orf22 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000005.9 NC_018916.1 NT_006576.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the C5orf22 gene promoter:
N-Myc PPAR-alpha Elk-1 AML1a Bach2 c-Myb MyoD STAT5A LCR-F1
Other transcription factors
Search SABiosciences Chromatin IP Primers for C5orf22
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C5orf22 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 5p13.3 Ensembl cytogenetic band: 5p13.3 HGNC cytogenetic band: 5p13.3C5orf22 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 5 GeneLoc Exon Structure GeneLoc location for GC05P031532: view genomic region
(about GC identifiers)
Start:
|
31,532,373 bp from pter |
End:
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31,555,165 bp from pter |
Size:
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22,793 bases |
Orientation:
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plus strand |
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Proteins
for C5orf22 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CE022_HUMAN, Q49AR2 (See
protein sequence)Recommended Name: UPF0489 protein C5orf22 Size: 442 amino acids; 49967 Da
Secondary accessions: Q8ND28 Q8WU61 Q9NUR1Alternative splicing: 3 isoforms: Q49AR2-1 Q49AR2-2 Q49AR2-3 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for C5orf22: NX_Q49AR2
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q49AR2
C5orf22 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_060826.2
ENSEMBL proteins: ENSP00000326879 ENSP00000423039 ENSP00000421667 ENSP00000430860 ENSP00000428898 ENSP00000430261 ENSP00000348171
Human Recombinant Protein Products:
C5orf22 Antibody Products:
Assay Products for C5orf22: |
Protein
Domains /
Families
for C5orf22 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
C5orf22 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q49AR2ProtoNet protein and cluster: Q49AR2 UniProtKB/Swiss-Prot: CE022_HUMAN, Q49AR2Similarity: Belongs to the UPF0489 family |
Function
for C5orf22 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for C5orf22 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for C5orf22 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: C5orf22 (NM_018356) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for C5orf22 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C5orf22 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C5orf22 |
1 GenomeRNAi human phenotype for C5orf22:
|
Pathways & Interactions
for C5orf22 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for C5orf22
STRING Interaction
Network Preview (showing 5 interactants - click image to see more details)
5/7 Interacting proteins for C5orf22 (Q49AR22, 3 ENSP000003268794) via UniProtKB, MINT, STRING, and/or I2D (see all 7)About this table
|
Drugs & Compounds
for C5orf22 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for C5orf22
Search CenterWatch for drugs/clinical trials and news about C5orf22 / CE022
|
Transcripts
for C5orf22 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for C5orf22 gene: NM_018356.2 Unigene Cluster for C5orf22: Chromosome 5 open reading frame 22 Hs.519246 [show with all ESTs]Unigene Representative Sequence: NM_01835611 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000325366(uc011cnw.1 uc003jhj.4 uc003jhk.4) ENST00000510659
ENST00000513967 ENST00000515409 ENST00000507818 ENST00000517780 ENST00000511208
ENST00000504464 ENST00000510530 ENST00000504866 ENST00000355907(uc010iuj.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for C5orf22 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for C5orf22 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: C5orf22 (NM_018356) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for C5orf22 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C5orf22 |
Additional cDNA sequence: AF038176.1 AF085882.1 AK002055.1 AK074385.1 AK299156.1 AL834427.1 BC021215.2 BC032845.1 7 DOTS entries: DT.75195436 DT.100773310 DT.413168 DT.97842866 DT.99939935 DT.102823396 DT.91742793 24/93 AceView cDNA sequences (see all 93): BC021215 BQ218992 AV716181 T10799 BM788231 AA315446 AV710784 NM_018356 AW272881 BE765180 AV760227 BX327062 AU119403 BP355873 AA371112 BG034669 AF085882 AK074385 CB158209 AK002055 W03527 BM553884 CB988978 C16445
GeneLoc Exon Structure
5/9 Alternative Splicing Database (ASD) splice patterns (SP) for C5orf22 (see all 9) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2a | · | 2b | · | 2c | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | · | 5c | · | 5d | ^ | 6a | · | 6b | · | 6c | ^ | 7 | ^ | 8a | · | 8b | ^ | 9 | ^ | 10 | ^ | 11 |
|---|
|
| SP1: | | | | | | | | | | | | | - | | | | - | | - | | - | | - | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | - | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | - | | - | | - | | | | - | | - | | - | | - | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | - | | - | | - | | | | - | | | | | | - | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | - | | - | | - | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for C5orf22
|
Expression
for C5orf22 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| C5orf22 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AACTCTGATA
About this image
See C5orf22 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for C5orf22
SOURCE GeneReport for Unigene cluster: Hs.519246
SABiosciences Custom PCR Arrays for C5orf22
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for C5orf22
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat C5orf22 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat C5orf22 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat C5orf22 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C5orf22 |
Orthologs
for C5orf22 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for C5orf22 gene from 6/20 species (see all 20) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
6030458C11Rik1 , 5 |
RIKEN cDNA 6030458C11 gene1, 5 |
81.78(n)1
78.68(a)1 |
|
15 (5.98 cM)5
778771 NM_029998.31 NP_084274.11
128081775 |
chicken
(Gallus gallus) |
Aves |
C2H5orf221 |
chromosome 2 open reading frame, human C5orf22 |
69.46(n)
69(a) |
|
420910 XM_418996.3 XP_418996.3 |
lizard
(Anolis carolinensis) |
Reptilia |
C5orf226 |
-- |
67(a) |
1 ↔ 1 |
GL343408.1(212436-229989) |
African clawed frog
(Xenopus laevis) |
Amphibia |
MGC688012 |
hypothetical protein MGC68801 |
76.66(n) |
|
BC060349.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
zgc565562 |
hypothetical protein MGC56556 |
73.39(n) |
|
393302 BC052751.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
MESR61 |
Misexpression suppressor of ras 6 |
47.15(n)
36.97(a) |
|
40083 NM_079430.2 NP_524154.2 |
ENSEMBL Gene Tree for C5orf22 (if available)
TreeFam Gene Tree for C5orf22 (if available) |
Paralogs
for C5orf22 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for C5orf22 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 5 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for C5orf22 (31532373 - 31555165 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for C5orf22
1 CNV: 47879 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing C5orf22 |
|
Disorders
/ Diseases
for C5orf22 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for C5orf22 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for C5orf22 gene, integrated from 9 sources (see all 15):
(articles sorted by number of sources associating them with C5orf22) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Proteome-wide identification of ubiquitylation sites b y conjugation of engineered lysine-less ubiquitin. (PubMed id 22053931)1 Oshikawa K....Nakayama K.I. (2012)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)
- A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (2008)
- The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)1 Rual J.F....Vidal M. (2005)
|
External Searches for C5orf22 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing C5orf22 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing C5orf22 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing C5orf22 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for C5orf22 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for C5orf22 gene:
Search GeneIP for patents involving C5orf22
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for C5orf22 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for C5orf22 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for C5orf22 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for C5orf22 | | | OriGene Protein Over-expression Lysate for C5orf22 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for C5orf22 | | OriGene 3'-UTR Clone for C5orf22 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for C5orf22 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for C5orf22 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for C5orf22 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| |
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 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat C5orf22 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing C5orf22 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C5orf22 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat C5orf22 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat C5orf22 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat C5orf22 |
| |
 |  |  |  | |
| | | | Search Tocris compounds for C5orf22 |
| |  |  |  |  | | | | |
 |
 |
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 | | | C5orf22 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C5orf22 |
|  |  |  | | | | Search ThermoFisher Antibodies for C5orf22 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C5orf22 |
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