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Aliases for C5orf22 Gene

Aliases for C5orf22 Gene

  • Chromosome 5 Open Reading Frame 22 2 3

External Ids for C5orf22 Gene

Previous GeneCards Identifiers for C5orf22 Gene

  • GC05P031569
  • GC05P031498
  • GC05P031570
  • GC05P031500

Summaries for C5orf22 Gene

GeneCards Summary for C5orf22 Gene

C5orf22 (Chromosome 5 Open Reading Frame 22) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C5orf22 Gene

Genomics for C5orf22 Gene

Regulatory Elements for C5orf22 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for C5orf22 Gene

Start:
31,532,266 bp from pter
End:
31,555,058 bp from pter
Size:
22,793 bases
Orientation:
Plus strand

Genomic View for C5orf22 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for C5orf22 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C5orf22 Gene

Proteins for C5orf22 Gene

  • Protein details for C5orf22 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q49AR2-CE022_HUMAN
    Recommended name:
    UPF0489 protein C5orf22
    Protein Accession:
    Q49AR2
    Secondary Accessions:
    • Q8ND28
    • Q8WU61
    • Q9NUR1

    Protein attributes for C5orf22 Gene

    Size:
    442 amino acids
    Molecular mass:
    49967 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for C5orf22 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for C5orf22 Gene

Proteomics data for C5orf22 Gene at MOPED

Post-translational modifications for C5orf22 Gene

  • Ubiquitination at Lys118
  • Modification sites at PhosphoSitePlus

Other Protein References for C5orf22 Gene

No data available for DME Specific Peptides for C5orf22 Gene

Domains for C5orf22 Gene

Protein Domains for C5orf22 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for C5orf22 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q49AR2

UniProtKB/Swiss-Prot:

CE022_HUMAN :
  • Q49AR2
Family:
  • Belongs to the UPF0489 family.
genes like me logo Genes that share domains with C5orf22: view

No data available for Gene Families for C5orf22 Gene

Function for C5orf22 Gene

Gene Ontology (GO) - Molecular Function for C5orf22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008013 beta-catenin binding --
genes like me logo Genes that share ontologies with C5orf22: view

Phenotypes for C5orf22 Gene

GenomeRNAi human phenotypes for C5orf22:
genes like me logo Genes that share phenotypes with C5orf22: view

Animal Model Products

CRISPR Products

miRNA for C5orf22 Gene

miRTarBase miRNAs that target C5orf22

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for C5orf22 Gene

Localization for C5orf22 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for C5orf22 Gene COMPARTMENTS Subcellular localization image for C5orf22 gene
Compartment Confidence
cytosol 2
nucleus 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for C5orf22 Gene

Pathways for C5orf22 Gene

SuperPathways for C5orf22 Gene

No Data Available

Gene Ontology (GO) - Biological Process for C5orf22 Gene

None

No data available for Pathways by source for C5orf22 Gene

Transcripts for C5orf22 Gene

Unigene Clusters for C5orf22 Gene

Chromosome 5 open reading frame 22:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for C5orf22

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for C5orf22 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11
SP1: - - - - -
SP2: - -
SP3: - - - - - - -
SP4: - - - - -
SP5: - - - -
SP6:
SP7: - - - - -
SP8:
SP9: - - -

Relevant External Links for C5orf22 Gene

GeneLoc Exon Structure for
C5orf22
ECgene alternative splicing isoforms for
C5orf22

Expression for C5orf22 Gene

mRNA expression in normal human tissues for C5orf22 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for C5orf22 Gene

SOURCE GeneReport for Unigene cluster for C5orf22 Gene Hs.519246

genes like me logo Genes that share expressions with C5orf22: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for C5orf22 Gene

Orthologs for C5orf22 Gene

This gene was present in the common ancestor of animals.

Orthologs for C5orf22 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C5H5orf22 35
  • 99.47 (n)
  • 99.77 (a)
C5orf22 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia C20H5ORF22 36
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C4H5orf22 35
  • 91.03 (n)
  • 90.72 (a)
C5orf22 36
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia 6030458C11Rik 35
  • 81.78 (n)
  • 78.68 (a)
6030458C11Rik 16
6030458C11Rik 36
  • 79 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia C5orf22 36
  • 77 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia C5orf22 36
  • 61 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia RGD1306502 35
  • 83.49 (n)
  • 81.48 (a)
chicken
(Gallus gallus)
Aves C5ORF22 35
  • 69.84 (n)
  • 69.37 (a)
C5orf22 36
  • 64 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia C5orf22 36
  • 64 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia MGC68801 35
tropical clawed frog
(Silurana tropicalis)
Amphibia c5orf22 35
  • 69.01 (n)
  • 70.46 (a)
Str.11883 35
zebrafish
(Danio rerio)
Actinopterygii C2H5orf22 36
  • 56 (a)
OneToOne
zgc56556 35
zgc:56556 35
  • 59.6 (n)
  • 58.31 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005414 35
  • 47.48 (n)
  • 42.45 (a)
fruit fly
(Drosophila melanogaster)
Insecta MESR6 35
  • 47.34 (n)
  • 37.25 (a)
MESR6 36
  • 29 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 43 (a)
OneToOne
Species with no ortholog for C5orf22:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C5orf22 Gene

ENSEMBL:
Gene Tree for C5orf22 (if available)
TreeFam:
Gene Tree for C5orf22 (if available)

Paralogs for C5orf22 Gene

No data available for Paralogs for C5orf22 Gene

Variants for C5orf22 Gene

Sequence variations from dbSNP and Humsavar for C5orf22 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs1056490 -- 31,554,358(+) GCCTC(A/T)CAGTG utr-variant-3-prime, nc-transcript-variant
rs1056491 -- 31,554,486(+) CCTGA(C/G)TCAGC utr-variant-3-prime, nc-transcript-variant
rs1056492 -- 31,554,550(+) ATCAG(A/G)ATTGT utr-variant-3-prime, nc-transcript-variant
rs1993949 -- 31,539,677(-) AAAGT(G/T)TAATA intron-variant
rs2127389 -- 31,535,007(-) acagc(A/C)tatgg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for C5orf22 Gene

Variant ID Type Subtype PubMed ID
nsv830249 CNV Gain 17160897
esv34132 CNV Loss 18971310

Relevant External Links for C5orf22 Gene

HapMap Linkage Disequilibrium report
C5orf22

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C5orf22 Gene

Disorders for C5orf22 Gene

Relevant External Links for C5orf22

Genetic Association Database (GAD)
C5orf22
genes like me logo Genes that share disorders with C5orf22: view

No data available for UniProtKB/Swiss-Prot for C5orf22 Gene

Publications for C5orf22 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. Towards a proteome-scale map of the human protein-protein interaction network. (PMID: 16189514) Rual J.F. … Vidal M. (Nature 2005) 3
  3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  4. Ubiquitin-mediated proteolysis of HuR by heat shock. (PMID: 19322201) Abdelmohsen K. … Gorospe M. (EMBO J. 2009) 3
  5. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PMID: 21139048) Danielsen J.M. … Nielsen M.L. (Mol. Cell Proteomics 2011) 3

Products for C5orf22 Gene

Sources for C5orf22 Gene

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