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Aliases for C5orf22 Gene

Aliases for C5orf22 Gene

  • Chromosome 5 Open Reading Frame 22 2 3 5

External Ids for C5orf22 Gene

Previous GeneCards Identifiers for C5orf22 Gene

  • GC05P031569
  • GC05P031498
  • GC05P031570
  • GC05P031500

Summaries for C5orf22 Gene

GeneCards Summary for C5orf22 Gene

C5orf22 (Chromosome 5 Open Reading Frame 22) is a Protein Coding gene. GO annotations related to this gene include beta-catenin binding.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C5orf22 Gene

Genomics for C5orf22 Gene

Regulatory Elements for C5orf22 Gene

Enhancers for C5orf22 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05F031530 0.2 ENCODE 12.7 -0.1 -82 3.8 PKNOX1 ARNT CREB3L1 ARID4B SIN3A ZNF2 YY1 SLC30A9 FOS DEK MTMR12 DROSHA C5orf22 ENSG00000206682
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around C5orf22 on UCSC Golden Path with GeneCards custom track

Promoters for C5orf22 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for C5orf22 Gene

31,532,266 bp from pter
31,555,058 bp from pter
22,793 bases
Plus strand

Genomic View for C5orf22 Gene

Genes around C5orf22 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C5orf22 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C5orf22 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C5orf22 Gene

Proteins for C5orf22 Gene

  • Protein details for C5orf22 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    UPF0489 protein C5orf22
    Protein Accession:
    Secondary Accessions:
    • Q8ND28
    • Q8WU61
    • Q9NUR1

    Protein attributes for C5orf22 Gene

    442 amino acids
    Molecular mass:
    49967 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for C5orf22 Gene


neXtProt entry for C5orf22 Gene

Post-translational modifications for C5orf22 Gene

  • Ubiquitination at Lys 118
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for C5orf22 Gene

Domains & Families for C5orf22 Gene

Protein Domains for C5orf22 Gene


Suggested Antigen Peptide Sequences for C5orf22 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the UPF0489 family.
  • Belongs to the UPF0489 family.
genes like me logo Genes that share domains with C5orf22: view

No data available for Gene Families for C5orf22 Gene

Function for C5orf22 Gene

genes like me logo Genes that share phenotypes with C5orf22: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C5orf22 Gene

Localization for C5orf22 Gene

Subcellular locations from

Jensen Localization Image for C5orf22 Gene COMPARTMENTS Subcellular localization image for C5orf22 gene
Compartment Confidence
nucleus 3
cytosol 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for C5orf22 Gene

Pathways & Interactions for C5orf22 Gene

SuperPathways for C5orf22 Gene

No Data Available

Gene Ontology (GO) - Biological Process for C5orf22 Gene


No data available for Pathways by source and SIGNOR curated interactions for C5orf22 Gene

Transcripts for C5orf22 Gene

Unigene Clusters for C5orf22 Gene

Chromosome 5 open reading frame 22:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for C5orf22 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11
SP1: - - - - -
SP2: - -
SP3: - - - - - - -
SP4: - - - - -
SP5: - - - -
SP7: - - - - -
SP9: - - -

Relevant External Links for C5orf22 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for C5orf22 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for C5orf22 Gene

Protein differential expression in normal tissues from HIPED for C5orf22 Gene

This gene is overexpressed in Lymph node (17.5), Blymphocyte (11.0), Peripheral blood mononuclear cells (8.1), and Pancreas (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for C5orf22 Gene

NURSA nuclear receptor signaling pathways regulating expression of C5orf22 Gene:


SOURCE GeneReport for Unigene cluster for C5orf22 Gene:

genes like me logo Genes that share expression patterns with C5orf22: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for C5orf22 Gene

Orthologs for C5orf22 Gene

This gene was present in the common ancestor of animals.

Orthologs for C5orf22 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia C5orf22 35
  • 100 (a)
C5H5orf22 34
  • 99.47 (n)
(Canis familiaris)
Mammalia C4H5orf22 34
  • 91.03 (n)
C5orf22 35
  • 88 (a)
(Bos Taurus)
Mammalia C20H5ORF22 35
  • 86 (a)
(Rattus norvegicus)
Mammalia RGD1306502 34
  • 83.49 (n)
(Mus musculus)
Mammalia 6030458C11Rik 34 16 35
  • 81.78 (n)
(Monodelphis domestica)
Mammalia C5orf22 35
  • 77 (a)
(Ornithorhynchus anatinus)
Mammalia C5orf22 35
  • 61 (a)
(Gallus gallus)
Aves C5ORF22 34
  • 69.84 (n)
C5orf22 35
  • 64 (a)
(Anolis carolinensis)
Reptilia C5orf22 35
  • 64 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia c5orf22 34
  • 69.01 (n)
Str.11883 34
African clawed frog
(Xenopus laevis)
Amphibia MGC68801 34
(Danio rerio)
Actinopterygii zgc:56556 34
  • 59.6 (n)
C2H5orf22 35
  • 56 (a)
zgc56556 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005414 34
  • 47.48 (n)
fruit fly
(Drosophila melanogaster)
Insecta MESR6 34 35
  • 47.34 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 43 (a)
Species where no ortholog for C5orf22 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C5orf22 Gene

Gene Tree for C5orf22 (if available)
Gene Tree for C5orf22 (if available)

Paralogs for C5orf22 Gene

No data available for Paralogs for C5orf22 Gene

Variants for C5orf22 Gene

Sequence variations from dbSNP and Humsavar for C5orf22 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs10035363 -- 31,539,028(+) CCCTC(C/T)GTATC intron-variant
rs10035435 -- 31,539,313(+) GGAGG(A/T)CCCAG intron-variant
rs10035440 -- 31,539,356(+) GTACA(C/T)TGAAA intron-variant
rs10040440 -- 31,548,825(+) catga(C/T)tggag intron-variant
rs10042915 -- 31,552,194(+) AGATA(C/T)CTGCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for C5orf22 Gene

Variant ID Type Subtype PubMed ID
esv34132 CNV loss 18971310
esv3604580 CNV gain 21293372
nsv830249 CNV gain 17160897

Variation tolerance for C5orf22 Gene

Residual Variation Intolerance Score: 40.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.33; 63.07% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C5orf22 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C5orf22 Gene

Disorders for C5orf22 Gene

Relevant External Links for C5orf22

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for C5orf22 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C5orf22 Gene

Publications for C5orf22 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  3. Ubiquitin-mediated proteolysis of HuR by heat shock. (PMID: 19322201) Abdelmohsen K. … Gorospe M. (EMBO J. 2009) 3 64
  4. Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. (PMID: 19413330) Gauci S. … Mohammed S. (Anal. Chem. 2009) 4 64
  5. A quantitative atlas of mitotic phosphorylation. (PMID: 18669648) Dephoure N. … Gygi S.P. (Proc. Natl. Acad. Sci. U.S.A. 2008) 4 64

Products for C5orf22 Gene

Sources for C5orf22 Gene

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