C5orf20 Gene
protein-coding GIFtS: 36
GCID: GC05M134808
|
|
chromosome 5 open reading frame 20
| |
Aliases
for C5orf20 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Chromosome 5 Open Reading Frame 201 2 | | DCNP11 2 5 | | Dendritic Cell Nuclear Protein 12 |
Export aliases for C5orf20 gene to outside databasesPrevious GC identifer: GC05M129967 |
Summaries
for C5orf20 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for C5orf20:
This intronless gene is specifically expressed in dendritic cells (DCs), which are potent antigen-presenting cellsinvolved in activating naive T cells to initiate antigen-specific immune response. The encoded protein is localizedmainly in the perinucleus. One of the alleles (A/T) of this gene, that causes premature translation termination at aa117, has been associated with an increased prevalence of major depression in humans. (provided by RefSeq, Jul 2008)
|
Genomic Views
for C5orf20 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000005.9 NC_018916.1 NT_034772.6
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the C5orf20 gene promoter:
AML1a SRF (504 AA) Brachyury POU3F1 RelA NF-kappaB POU2F1 POU2F1a NF-kappaB1
Other transcription factors
Search SABiosciences Chromatin IP Primers for C5orf20
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C5orf20 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 5q31.1 Ensembl cytogenetic band: 5q31.1 HGNC cytogenetic band: 5q31.1C5orf20 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 5 GeneLoc Exon Structure GeneLoc location for GC05M134808: view genomic region
(about GC identifiers)
Start:
|
134,779,904 bp from pter |
End:
|
134,783,038 bp from pter |
Size:
|
3,135 bases |
Orientation:
|
minus strand |
|
Proteins
for C5orf20 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: DCNP1_HUMAN, Q8TF63 (See
protein sequence)Recommended Name: Dendritic cell nuclear protein 1 Size: 244 amino acids; 26704 Da
Subcellular location: Nucleus. Note=Particularly on the peripheryExplore the universe of human proteins at neXtProt for C5orf20: NX_Q8TF63
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8TF63
C5orf20 Protein expression data from MOPED and PaxDb: --
REFSEQ proteins: NP_570900.1
ENSEMBL proteins: ENSP00000421871
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005634 | nucleus |
IEA | -- |
C5orf20 for ontologies About GeneDecksing
C5orf20 Antibody Products:
Assay Products for C5orf20: |
Protein
Domains /
Families
for C5orf20 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| ProtoNet protein and cluster: Q8TF63 |
Function
for C5orf20 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for C5orf20
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for C5orf20
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: C5orf20 (NM_130848) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for C5orf20 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C5orf20 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C5orf20 |
|
Pathways & Interactions
for C5orf20 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for C5orf20
|
Drugs & Compounds
for C5orf20 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for C5orf20
Search CenterWatch for drugs/clinical trials and news about C5orf20 / DCNP1
|
Transcripts
for C5orf20 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for C5orf20 gene: NM_130848.2 Unigene Cluster for C5orf20: Chromosome 5 open reading frame 20 Hs.152477 [show with all ESTs]Unigene Representative Sequence: NM_1308481 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000503143(uc003lav.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for C5orf20
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for C5orf20
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: C5orf20 (NM_130848) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for C5orf20 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C5orf20 |
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for C5orf20
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat C5orf20 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat C5orf20 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat C5orf20 |
Additional cDNA sequence: AB074498.1 BC069608.1 BC069610.1 BC074831.2 BC074832.2 BC117156.1 BC117158.1 1 DOTS entry: DT.40118818 19 AceView cDNA sequences: NM_130848 BC074831 AA342611 AK131088 AI192229 AB074498 AI554057 AI439681 BC069608 BC069610 BC074832 AI372915 AA565873 BX114721 AW136257 AI141949 AI673027 AJ715236 BF352034
GeneLoc Exon Structure
|
Expression
for C5orf20 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| C5orf20 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GTGGCAGCCT
About this image
Genevestigator expression for C5orf20
SOURCE GeneReport for Unigene cluster: Hs.152477
UniProtKB/Swiss-Prot: DCNP1_HUMAN, Q8TF63Tissue specificity: Predominantly expressed in dendritic cells. Detected in brain and skeletal muscle. Highly expressedin mature dendritic cells and at a lower level in immature dendritic cells. Not expressed in monocytes and B-cells
SABiosciences Custom PCR Arrays for C5orf20
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for C5orf20
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat C5orf20 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat C5orf20 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat C5orf20 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C5orf20 |
Orthologs
for C5orf20 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
--
ENSEMBL Gene Tree for C5orf20 (if available)
TreeFam Gene Tree for C5orf20 (if available) |
Paralogs
for C5orf20 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for C5orf20 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 5 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for C5orf20 (134779904 - 134783038 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for C5orf20: -- | SABiosciences Cancer Mutation PCR Assays |
|
Disorders
/ Diseases
for C5orf20 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 C5orf20 for disorders About MalaCards
C5orf20 for disorders About GeneDecksing
OMIM gene information: 609710
OMIM disorders: --
Human Genome Epidemiology (HuGE) Navigator: C5orf20 (2 documents)
Export disorders for C5orf20 gene to outside databases
|
Publications
for C5orf20 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for C5orf20 gene integrated from 9 sources:
(articles sorted by number of sources associating them with C5orf20) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Identification and immunocytochemical analysis of DCNP1, a dendritic cell-associated nuclear protein. (PubMed id 11798177)1, 2, 3, 9 Masuda M.... Nishimura Y. (2002)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Shotgun sequencing of the human transcriptome with ORF expressed sequence tags. (PubMed id 10737800)1, 3 Dias Neto E....Simpson A.J.G. (2000)
- Dendritic cell nuclear protein-1, a novel depression- related protein, upregulates corticotropin-releasing hormone expression. (PubMed id 20693543)1 Zhou T....Swaab D.F. (2010)
- Poor replication of candidate genes for major depress ive disorder using genome-wide association data. (PubMed id 20351714)1 Bosker F.J....Nolen W.A. (2010)
- A promoter nucleotide variant of the dendritic cell-specific DCNP1 associates with serum IgE levels specific for dust mite allergens among the Korean asthmatics. (PubMed id 17460725)1 Kim Y....Kimm K. (2007)
- hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
- DCNP1: a novel candidate gene for major depression. (PubMed id 16189510)1 Willis-Owen S.A.G.... Flint J. (2006)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- The sequence of the human genome. (PubMed id 11181995)1 Venter J.C.... Zhu X. (2001)
|
External Searches for C5orf20 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing C5orf20 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing C5orf20 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing C5orf20 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for C5orf20 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for C5orf20 gene:
Search GeneIP for patents involving C5orf20
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for C5orf20 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for C5orf20 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for C5orf20 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for C5orf20 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for C5orf20 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for C5orf20 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for C5orf20 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for C5orf20 | | OriGene Custom Protein Services for C5orf20 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat C5orf20 | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing C5orf20 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C5orf20 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat C5orf20 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat C5orf20 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat C5orf20 |
| |
 |  |  |  | |
| | | | Search Tocris compounds for C5orf20 |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | C5orf20 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C5orf20 |
|  |  |  | | | | Search ThermoFisher Antibodies for C5orf20 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C5orf20 |
|
|
|
|
