Free for academic non-profit institutions. Other users need a Commercial license

Aliases for C5orf15 Gene

Aliases for C5orf15 Gene

  • Chromosome 5 Open Reading Frame 15 2 3 5
  • Keratinocytes Associated Transmembrane Protein 2 2 3
  • KCT2 3 4
  • Keratinocyte-Associated Transmembrane Protein 2 3
  • HTGN29 3

External Ids for C5orf15 Gene

Previous GeneCards Identifiers for C5orf15 Gene

  • GC05M133368
  • GC05M133319
  • GC05M133291
  • GC05M128476

Summaries for C5orf15 Gene

GeneCards Summary for C5orf15 Gene

C5orf15 (Chromosome 5 Open Reading Frame 15) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C5orf15 Gene

Genomics for C5orf15 Gene

Regulatory Elements for C5orf15 Gene

Enhancers for C5orf15 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05F133904 0.5 ENCODE 10.6 +63.2 63230 1.7 HDGF PKNOX1 ARNT CREB3L1 SLC30A9 ZNF766 CBX5 FOS ZNF263 JUNB AFF4 SEC24A C5orf15 WSPAR FSTL4
GH05F134410 1.3 FANTOM5 Ensembl ENCODE 10.5 -446.0 -446004 8.5 PKNOX1 CREB3L1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF143 C5orf66 ENSG00000271737 SEC24A RNU6-456P JADE2 C5orf15 SKP1 CDKN2AIPNL RPS10P11
GH05F134521 1.1 ENCODE 10.5 -556.7 -556737 7.3 HDGF PKNOX1 MLX ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF143 C5orf66 SEC24A ENSG00000270892 ENSG00000271128 ENSG00000248753 LOC105379188 RNU6-456P ENSG00000243648 CDKN2AIPNL ENSG00000248559
GH05F134369 0.4 ENCODE 10.5 -402.7 -402735 3.5 CREB3L1 MLX DMAP1 YY1 ZNF143 ZNF548 ZNF263 SP3 NFYC TBX21 ENSG00000248559 SEC24A JADE2 CAMLG C5orf15 C5orf66 SKP1 CDKL3 ENSG00000279469
GH05F134757 0.8 ENCODE 10.5 -790.4 -790375 2.6 HDGF PKNOX1 CREB3L1 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 C5orf66 SEC24A C5orf24 C5orf15 DDX46 RPL34P13
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around C5orf15 on UCSC Golden Path with GeneCards custom track

Promoters for C5orf15 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001290428 187 2001 HDGF PKNOX1 CREB3L1 MLX ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9

Genomic Location for C5orf15 Gene

Chromosome:
5
Start:
133,955,502 bp from pter
End:
133,968,787 bp from pter
Size:
13,286 bases
Orientation:
Minus strand

Genomic View for C5orf15 Gene

Genes around C5orf15 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C5orf15 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C5orf15 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C5orf15 Gene

Proteins for C5orf15 Gene

  • Protein details for C5orf15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NC54-KCT2_HUMAN
    Recommended name:
    Keratinocyte-associated transmembrane protein 2
    Protein Accession:
    Q8NC54
    Secondary Accessions:
    • B2RD10
    • D3DQ92
    • Q9NRG2

    Protein attributes for C5orf15 Gene

    Size:
    265 amino acids
    Molecular mass:
    29235 Da
    Quaternary structure:
    No Data Available

neXtProt entry for C5orf15 Gene

Post-translational modifications for C5orf15 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C5orf15 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for C5orf15 Gene

Domains & Families for C5orf15 Gene

Protein Domains for C5orf15 Gene

ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C5orf15: view

No data available for Gene Families and UniProtKB/Swiss-Prot for C5orf15 Gene

Function for C5orf15 Gene

genes like me logo Genes that share phenotypes with C5orf15: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C5orf15 Gene

Localization for C5orf15 Gene

Subcellular locations from UniProtKB/Swiss-Prot for C5orf15 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for C5orf15 Gene COMPARTMENTS Subcellular localization image for C5orf15 gene
Compartment Confidence
golgi apparatus 2
nucleus 2
plasma membrane 2
endoplasmic reticulum 1
extracellular 1

Gene Ontology (GO) - Cellular Components for C5orf15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with C5orf15: view

Pathways & Interactions for C5orf15 Gene

SuperPathways for C5orf15 Gene

No Data Available

Interacting Proteins for C5orf15 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000231512%0d%0a9606.ENSP00000344818%0d%0a9606.ENSP00000385269%0d%0a
Selected Interacting proteins: Q8NC54-KCT2_HUMAN ENSP00000231512 for C5orf15 Gene via IID STRING

Gene Ontology (GO) - Biological Process for C5orf15 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for C5orf15 Gene

Transcripts for C5orf15 Gene

mRNA/cDNA for C5orf15 Gene

Unigene Clusters for C5orf15 Gene

Chromosome 5 open reading frame 15:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for C5orf15 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5
SP1:
SP2:
SP3: -
SP4: - -

Relevant External Links for C5orf15 Gene

GeneLoc Exon Structure for
C5orf15
ECgene alternative splicing isoforms for
C5orf15

Expression for C5orf15 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for C5orf15 Gene

Protein differential expression in normal tissues from HIPED for C5orf15 Gene

This gene is overexpressed in Adrenal (22.3), Islet of Langerhans (19.4), Vitreous humor (11.1), and Fetal heart (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for C5orf15 Gene



NURSA nuclear receptor signaling pathways regulating expression of C5orf15 Gene:

C5orf15

SOURCE GeneReport for Unigene cluster for C5orf15 Gene:

Hs.744034

mRNA Expression by UniProt/SwissProt for C5orf15 Gene:

Q8NC54-KCT2_HUMAN
Tissue specificity: Widely expressed.
genes like me logo Genes that share expression patterns with C5orf15: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Protein tissue co-expression partners for C5orf15 Gene

Orthologs for C5orf15 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C5orf15 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C5H5orf15 34
  • 99.37 (n)
C5orf15 35
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C11H5orf15 34
  • 85.35 (n)
C5orf15 35
  • 79 (a)
OneToOne
cow
(Bos Taurus)
Mammalia C7H5orf15 34
  • 83.59 (n)
C7H5ORF15 35
  • 79 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia RGD1310352 34
  • 70.24 (n)
mouse
(Mus musculus)
Mammalia 9530068E07Rik 34 16 35
  • 67.06 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia C5orf15 35
  • 51 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia C5orf15 35
  • 50 (a)
OneToOne
chicken
(Gallus gallus)
Aves C13H5ORF15 34 35
  • 59.46 (n)
lizard
(Anolis carolinensis)
Reptilia C5orf15 35
  • 26 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.14510 34
zebrafish
(Danio rerio)
Actinopterygii C21H5orf15 35
  • 15 (a)
OneToOne
Species where no ortholog for C5orf15 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C5orf15 Gene

ENSEMBL:
Gene Tree for C5orf15 (if available)
TreeFam:
Gene Tree for C5orf15 (if available)

Paralogs for C5orf15 Gene

Pseudogenes.org Pseudogenes for C5orf15 Gene

genes like me logo Genes that share paralogs with C5orf15: view

No data available for Paralogs for C5orf15 Gene

Variants for C5orf15 Gene

Sequence variations from dbSNP and Humsavar for C5orf15 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs10045538 -- 133,958,330(+) ccagc(A/G)ttttg intron-variant
rs10078428 -- 133,964,172(+) agatc(A/C/G)tgcca intron-variant
rs10123 -- 133,955,631(-) TAGGG(A/G/T)AGGGA upstream-variant-2KB, utr-variant-3-prime
rs10422 -- 133,955,951(-) TTTGT(A/G)TACAT upstream-variant-2KB, utr-variant-3-prime
rs10644381 -- 133,969,466(+) GTCTC(-/AA/AAA)AAAAA intron-variant, upstream-variant-2KB

Variation tolerance for C5orf15 Gene

Residual Variation Intolerance Score: 93% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.69; 46.17% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C5orf15 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
C5orf15

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for C5orf15 Gene

Disorders for C5orf15 Gene

Relevant External Links for C5orf15

Genetic Association Database (GAD)
C5orf15
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
C5orf15

No disorders were found for C5orf15 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C5orf15 Gene

Publications for C5orf15 Gene

  1. Conduct disorder and ADHD: evaluation of conduct problems as a categorical and quantitative trait in the international multicentre ADHD genetics study. (PMID: 18951430) Anney R.J. … Gill M. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2008) 3 46 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. Identification of novel genes for secreted and membrane-anchored proteins in human keratinocytes. (PMID: 12752121) Bonkobara M. … Ariizumi K. (Br. J. Dermatol. 2003) 3 4 64
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64

Products for C5orf15 Gene

Sources for C5orf15 Gene

Content
Loading form....