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Aliases for C5orf15 Gene

Aliases for C5orf15 Gene

  • Chromosome 5 Open Reading Frame 15 2 3 5
  • KCT2 3 4
  • Keratinocytes Associated Transmembrane Protein 2 3
  • Keratinocyte Associated Transmembrane Protein 2 2
  • Keratinocyte-Associated Transmembrane Protein 2 3
  • HTGN29 3

External Ids for C5orf15 Gene

Previous GeneCards Identifiers for C5orf15 Gene

  • GC05M133368
  • GC05M133319
  • GC05M133291
  • GC05M128476

Summaries for C5orf15 Gene

GeneCards Summary for C5orf15 Gene

C5orf15 (Chromosome 5 Open Reading Frame 15) is a Protein Coding gene.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C5orf15 Gene

Genomics for C5orf15 Gene

Regulatory Elements for C5orf15 Gene

Enhancers for C5orf15 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05G133967 1.4 ENCODE dbSUPER 0.7 -0.3 -263 3.8 HDGF PKNOX1 FOXA2 MLX CREB3L1 AGO1 ZFP64 ARID4B SIN3A DMAP1 VDAC1 ENSG00000270177 C5orf15 GC05P134006
GH05G133976 1.5 FANTOM5 Ensembl ENCODE dbSUPER 0.4 -9.3 -9251 2.1 SOX13 SAP130 ZFP64 JUNB HMG20A GLIS1 EED IKZF1 SCRT2 FOS VDAC1 PPP2CA UBE2B C5orf15 GC05P134006
GH05G133994 1.6 FANTOM5 Ensembl ENCODE dbSUPER 0.3 -26.5 -26518 2.3 ARID4B KLF17 RAD21 GLIS2 FOS SP5 CEBPB REST SSRP1 SMARCA4 VDAC1 GC05P134006 C5orf15
GH05G134002 1.4 ENCODE dbSUPER 0.3 -35.7 -35702 4.9 CREB3L1 ZFP64 WRNIP1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 SLC30A9 VDAC1 GC05P134006 C5orf15
GH05G133996 1 ENCODE dbSUPER 0.3 -28.1 -28058 0.1 ELF3 CTCF SAP130 ETV1 TRIM22 ELF4 ELF1 ZBTB7A RAD21 ATF2 GC05P134006 C5orf15
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around C5orf15 on UCSC Golden Path with GeneCards custom track

Promoters for C5orf15 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for C5orf15 Gene

133,955,502 bp from pter
133,968,787 bp from pter
13,286 bases
Minus strand

Genomic View for C5orf15 Gene

Genes around C5orf15 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C5orf15 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C5orf15 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C5orf15 Gene

Proteins for C5orf15 Gene

  • Protein details for C5orf15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Keratinocyte-associated transmembrane protein 2
    Protein Accession:
    Secondary Accessions:
    • B2RD10
    • D3DQ92
    • Q9NRG2

    Protein attributes for C5orf15 Gene

    265 amino acids
    Molecular mass:
    29235 Da
    Quaternary structure:
    No Data Available

neXtProt entry for C5orf15 Gene

Post-translational modifications for C5orf15 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C5orf15 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for C5orf15 Gene

Domains & Families for C5orf15 Gene

Protein Domains for C5orf15 Gene


Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C5orf15: view

No data available for Gene Families and UniProtKB/Swiss-Prot for C5orf15 Gene

Function for C5orf15 Gene

genes like me logo Genes that share phenotypes with C5orf15: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C5orf15 Gene

Localization for C5orf15 Gene

Subcellular locations from UniProtKB/Swiss-Prot for C5orf15 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C5orf15 gene
Compartment Confidence
plasma membrane 2
nucleus 2
golgi apparatus 2
extracellular 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for C5orf15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with C5orf15: view

Pathways & Interactions for C5orf15 Gene

SuperPathways for C5orf15 Gene

No Data Available

Interacting Proteins for C5orf15 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
Selected Interacting proteins: Q8NC54-KCT2_HUMAN ENSP00000231512 for C5orf15 Gene via IID STRING

Gene Ontology (GO) - Biological Process for C5orf15 Gene


No data available for Pathways by source and SIGNOR curated interactions for C5orf15 Gene

Drugs & Compounds for C5orf15 Gene

No Compound Related Data Available

Transcripts for C5orf15 Gene

mRNA/cDNA for C5orf15 Gene

Unigene Clusters for C5orf15 Gene

Chromosome 5 open reading frame 15:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for C5orf15 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5
SP3: -
SP4: - -

Relevant External Links for C5orf15 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for C5orf15 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for C5orf15 Gene

Protein differential expression in normal tissues from HIPED for C5orf15 Gene

This gene is overexpressed in Adrenal (22.3), Islet of Langerhans (19.4), Vitreous humor (11.1), and Fetal heart (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for C5orf15 Gene

NURSA nuclear receptor signaling pathways regulating expression of C5orf15 Gene:


SOURCE GeneReport for Unigene cluster for C5orf15 Gene:


mRNA Expression by UniProt/SwissProt for C5orf15 Gene:

Tissue specificity: Widely expressed.

Evidence on tissue expression from TISSUES for C5orf15 Gene

  • Kidney(4.4)
  • Liver(4.3)
  • Nervous system(4)
genes like me logo Genes that share expression patterns with C5orf15: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for C5orf15 Gene

Orthologs for C5orf15 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C5orf15 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia C5H5orf15 34
  • 99.37 (n)
C5orf15 35
  • 99 (a)
(Canis familiaris)
Mammalia C11H5orf15 34
  • 85.35 (n)
C5orf15 35
  • 79 (a)
(Bos Taurus)
Mammalia C7H5orf15 34
  • 83.59 (n)
C7H5ORF15 35
  • 79 (a)
(Rattus norvegicus)
Mammalia RGD1310352 34
  • 70.24 (n)
(Mus musculus)
Mammalia 9530068E07Rik 34 16 35
  • 67.06 (n)
(Ornithorhynchus anatinus)
Mammalia C5orf15 35
  • 51 (a)
(Monodelphis domestica)
Mammalia C5orf15 35
  • 50 (a)
(Gallus gallus)
Aves C13H5ORF15 34 35
  • 59.46 (n)
(Anolis carolinensis)
Reptilia C5orf15 35
  • 26 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.14510 34
(Danio rerio)
Actinopterygii C21H5orf15 35
  • 15 (a)
Species where no ortholog for C5orf15 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C5orf15 Gene

Gene Tree for C5orf15 (if available)
Gene Tree for C5orf15 (if available)

Paralogs for C5orf15 Gene Pseudogenes for C5orf15 Gene

genes like me logo Genes that share paralogs with C5orf15: view

No data available for Paralogs for C5orf15 Gene

Variants for C5orf15 Gene

Sequence variations from dbSNP and Humsavar for C5orf15 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs1000234126 -- 133,964,819(+) TTTTC(A/C)CCCTC intron-variant
rs1000753757 -- 133,961,231(+) AGTTA(G/T)TAAAA intron-variant
rs1001084276 -- 133,966,502(+) TTATG(A/T)TAATT intron-variant
rs1001205621 -- 133,966,119(+) GGGAG(A/G)CTGAG intron-variant
rs1001421390 -- 133,967,814(+) CTTCA(A/G)ATATG intron-variant, upstream-variant-2KB

Variation tolerance for C5orf15 Gene

Residual Variation Intolerance Score: 93% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.69; 46.17% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C5orf15 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for C5orf15 Gene

Disorders for C5orf15 Gene

Relevant External Links for C5orf15

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for C5orf15 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C5orf15 Gene

Publications for C5orf15 Gene

  1. Conduct disorder and ADHD: evaluation of conduct problems as a categorical and quantitative trait in the international multicentre ADHD genetics study. (PMID: 18951430) Anney R.J. … Gill M. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2008) 3 46 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. Identification of novel genes for secreted and membrane-anchored proteins in human keratinocytes. (PMID: 12752121) Bonkobara M. … Ariizumi K. (Br. J. Dermatol. 2003) 3 4 64
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64

Products for C5orf15 Gene

Sources for C5orf15 Gene

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