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Aliases for C5AR2 Gene

Aliases for C5AR2 Gene

  • Complement Component 5a Receptor 2 2 3 4 5
  • G Protein-Coupled Receptor 77 2 3
  • GPR77 3 4
  • C5L2 3 4
  • C5a Anaphylatoxin Chemotactic Receptor C5L2 3
  • G Protein-Coupled Receptor C5L2 3
  • G-Protein Coupled Receptor 77 4
  • GPF77 3

External Ids for C5AR2 Gene

Previous HGNC Symbols for C5AR2 Gene

  • GPR77

Previous GeneCards Identifiers for C5AR2 Gene

  • GC19P047841

Summaries for C5AR2 Gene

Entrez Gene Summary for C5AR2 Gene

  • This gene encodes a G-protein coupled receptor 1 family member involved in the complement system of the innate immune response. Unlike classical G-protein coupled receptors, the encoded protein does not associate with intracellular G-proteins. It may instead modulate signal transduction through the beta-arrestin pathway, and may alternatively act as a decoy receptor. This gene may be involved in coronary artery disease and in the pathogenesis of sepsis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012]

GeneCards Summary for C5AR2 Gene

C5AR2 (Complement Component 5a Receptor 2) is a Protein Coding gene. Diseases associated with C5AR2 include Complement Component 3 Deficiency and Artery Disease. Among its related pathways are Peptide ligand-binding receptors and Immune System. GO annotations related to this gene include G-protein coupled receptor activity and C5a anaphylatoxin receptor activity. An important paralog of this gene is FPR2.

UniProtKB/Swiss-Prot for C5AR2 Gene

  • Receptor for the chemotactic and inflammatory C3a, C4a and C5a anaphylatoxin peptides and also for their dearginated forms ASP/C3adesArg, C4adesArg and C5adesArg respectively. Couples weakly to G(i)-mediated signaling pathways.

Gene Wiki entry for C5AR2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C5AR2 Gene

Genomics for C5AR2 Gene

Regulatory Elements for C5AR2 Gene

Enhancers for C5AR2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around C5AR2 on UCSC Golden Path with GeneCards custom track

Promoters for C5AR2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around C5AR2 on UCSC Golden Path with GeneCards custom track

Genomic Location for C5AR2 Gene

Chromosome:
19
Start:
47,331,841 bp from pter
End:
47,347,327 bp from pter
Size:
15,487 bases
Orientation:
Plus strand

Genomic View for C5AR2 Gene

Genes around C5AR2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C5AR2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C5AR2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C5AR2 Gene

Proteins for C5AR2 Gene

  • Protein details for C5AR2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9P296-C5AR2_HUMAN
    Recommended name:
    C5a anaphylatoxin chemotactic receptor 2
    Protein Accession:
    Q9P296
    Secondary Accessions:
    • B2RA09

    Protein attributes for C5AR2 Gene

    Size:
    337 amino acids
    Molecular mass:
    36080 Da
    Quaternary structure:
    • Interacts with C3 (the anaphylatoxin peptide C3a and the adipogenic hormone ASP); the interaction occurs with higher affinity for ASP, enhancing the phosphorylation and activation of GPR77, recruitment of ARRB2 to the cell surface and endocytosis of GRP77.

neXtProt entry for C5AR2 Gene

Proteomics data for C5AR2 Gene at MOPED

Post-translational modifications for C5AR2 Gene

  • Glycosylation at Asn 3
  • Modification sites at PhosphoSitePlus

Other Protein References for C5AR2 Gene

No data available for DME Specific Peptides for C5AR2 Gene

Domains & Families for C5AR2 Gene

Gene Families for C5AR2 Gene

Protein Domains for C5AR2 Gene

Graphical View of Domain Structure for InterPro Entry

Q9P296

UniProtKB/Swiss-Prot:

C5AR2_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with C5AR2: view

Function for C5AR2 Gene

Molecular function for C5AR2 Gene

UniProtKB/Swiss-Prot Function:
Receptor for the chemotactic and inflammatory C3a, C4a and C5a anaphylatoxin peptides and also for their dearginated forms ASP/C3adesArg, C4adesArg and C5adesArg respectively. Couples weakly to G(i)-mediated signaling pathways.

Gene Ontology (GO) - Molecular Function for C5AR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004944 C5a anaphylatoxin receptor activity IEA --
genes like me logo Genes that share ontologies with C5AR2: view
genes like me logo Genes that share phenotypes with C5AR2: view

Animal Models for C5AR2 Gene

MGI Knock Outs for C5AR2:

Animal Model Products

  • Taconic Biosciences Mouse Models for C5AR2

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for C5AR2 Gene

Localization for C5AR2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for C5AR2 Gene

Cell membrane; Multi-pass membrane protein.

No data available for Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for C5AR2 Gene

Pathways & Interactions for C5AR2 Gene

genes like me logo Genes that share pathways with C5AR2: view

Pathways by source for C5AR2 Gene

Interacting Proteins for C5AR2 Gene

Selected Interacting proteins: Q9P296-C5AR2_HUMAN for C5AR2 Gene via I2D

SIGNOR curated interactions for C5AR2 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for C5AR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030449 regulation of complement activation TAS --
GO:0070374 positive regulation of ERK1 and ERK2 cascade IEA --
GO:0090024 negative regulation of neutrophil chemotaxis IMP 16204243
GO:2000482 regulation of interleukin-8 secretion IMP 22496247
genes like me logo Genes that share ontologies with C5AR2: view

Drugs & Compounds for C5AR2 Gene

(2) Drugs for C5AR2 Gene - From: IUPHAR

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
C5a Pharma Full agonist, Agonist 0
C5a des-Arg Pharma Partial agonist, Agonist 0

(3) Additional Compounds for C5AR2 Gene - From: IUPHAR and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
C5a hexapeptide analogue
Agonist
CHIPS-(28-149)
Antagonist
genes like me logo Genes that share compounds with C5AR2: view

Transcripts for C5AR2 Gene

mRNA/cDNA for C5AR2 Gene

(5) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(10) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for C5AR2 Gene

Complement component 5a receptor 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for C5AR2 Gene

No ASD Table

Relevant External Links for C5AR2 Gene

GeneLoc Exon Structure for
C5AR2
ECgene alternative splicing isoforms for
C5AR2

Expression for C5AR2 Gene

mRNA expression in normal human tissues for C5AR2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for C5AR2 Gene

This gene is overexpressed in Whole Blood (x28.7) and Spleen (x4.0).

Protein differential expression in normal tissues from HIPED for C5AR2 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for C5AR2 Gene



SOURCE GeneReport for Unigene cluster for C5AR2 Gene Hs.534412

mRNA Expression by UniProt/SwissProt for C5AR2 Gene

Q9P296-C5AR2_HUMAN
Tissue specificity: Frontal cortex, hippocampus, hypothalamus, pons and liver.
genes like me logo Genes that share expression patterns with C5AR2: view

Protein tissue co-expression partners for C5AR2 Gene

- Elite partner

Primer Products

Orthologs for C5AR2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C5AR2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia GPR77 35
  • 82.29 (n)
  • 76.26 (a)
GPR77 36
  • 76 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C5AR2 35
  • 82 (n)
  • 74.18 (a)
C5AR2 36
  • 74 (a)
OneToOne
mouse
(Mus musculus)
Mammalia C5ar2 35
  • 68.48 (n)
  • 61.03 (a)
C5ar2 16
C5ar2 36
  • 58 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia GPR77 35
  • 98.52 (n)
  • 97.63 (a)
C5AR2 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia C5ar2 35
  • 68.94 (n)
  • 59.94 (a)
oppossum
(Monodelphis domestica)
Mammalia C5AR2 36
  • 54 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii si:dkeyp-66d1.2 36
  • 21 (a)
ManyToMany
Species with no ortholog for C5AR2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C5AR2 Gene

ENSEMBL:
Gene Tree for C5AR2 (if available)
TreeFam:
Gene Tree for C5AR2 (if available)

Paralogs for C5AR2 Gene

Paralogs for C5AR2 Gene

(7) SIMAP similar genes for C5AR2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with C5AR2: view

Variants for C5AR2 Gene

Sequence variations from dbSNP and Humsavar for C5AR2 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs149572881 - 47,341,497(+) CCGGC(C/T)GCTGG reference, missense
rs150599989 - 47,341,767(+) GGACA(A/G/T)CAAGA reference, missense
rs7256119 -- 47,331,032(+) CGCCC(A/G)GCTAA upstream-variant-2KB
rs7256417 -- 47,338,248(+) ccagc(C/G)ttggc intron-variant
rs7256886 -- 47,338,086(+) aaaaa(A/T)aaata intron-variant

Variation tolerance for C5AR2 Gene

Residual Variation Intolerance Score: 74.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.01; 37.07% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C5AR2 Gene

Human Gene Mutation Database (HGMD)
C5AR2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for C5AR2 Gene

Disorders for C5AR2 Gene

MalaCards: The human disease database

(2) MalaCards diseases for C5AR2 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
complement component 3 deficiency
  • c3 deficiency
artery disease
  • arteriopathic disease
- elite association - COSMIC cancer census association via MalaCards
Search C5AR2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for C5AR2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
C5AR2
genes like me logo Genes that share disorders with C5AR2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for C5AR2 Gene

Publications for C5AR2 Gene

  1. Identification of four novel human G protein-coupled receptors expressed in the brain. (PMID: 11165367) Lee D.K. … O'Dowd B.F. (Brain Res. Mol. Brain Res. 2001) 2 3 4 23 67
  2. The C5a receptor (C5aR) C5L2 is a modulator of C5aR-mediated signal transduction. (PMID: 20044484) Bamberg C.E. … Gerard N.P. (J. Biol. Chem. 2010) 3 23
  3. The human complement fragment receptor, C5L2, is a recycling decoy receptor. (PMID: 19100624) Scola A.M. … Monk P.N. (Mol. Immunol. 2009) 3 23
  4. The role of the N-terminal domain of the complement fragment receptor C5L2 in ligand binding. (PMID: 17158873) Scola A.M. … Monk P.N. (J. Biol. Chem. 2007) 3 23
  5. Ligand specificity of the anaphylatoxin C5L2 receptor and its regulation on myeloid and epithelial cell lines. (PMID: 17068344) Johswich K. … Klos A. (J. Biol. Chem. 2006) 3 23

Products for C5AR2 Gene

Sources for C5AR2 Gene

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