Aliases for C5AR2 Gene
External Ids for C5AR2 Gene
Previous HGNC Symbols for C5AR2 Gene
Previous GeneCards Identifiers for C5AR2 Gene
This gene encodes a G-protein coupled receptor 1 family member involved in the complement system of the innate immune response. Unlike classical G-protein coupled receptors, the encoded protein does not associate with intracellular G-proteins. It may instead modulate signal transduction through the beta-arrestin pathway, and may alternatively act as a decoy receptor. This gene may be involved in coronary artery disease and in the pathogenesis of sepsis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012]
GeneCards Summary for C5AR2 Gene
C5AR2 (Complement Component 5a Receptor 2) is a Protein Coding gene. Diseases associated with C5AR2 include complement component 3 deficiency and artery disease. Among its related pathways are Signaling by GPCR and Peptide ligand-binding receptors. GO annotations related to this gene include G-protein coupled receptor activity and C5a anaphylatoxin receptor activity. An important paralog of this gene is FPR2.
UniProtKB/Swiss-Prot for C5AR2 Gene
Receptor for the chemotactic and inflammatory C3a, C4a and C5a anaphylatoxin peptides and also for their dearginated forms ASP/C3adesArg, C4adesArg and C5adesArg respectively. Couples weakly to G(i)-mediated signaling pathways.