Aliases for C5AR2 Gene
External Ids for C5AR2 Gene
Previous HGNC Symbols for C5AR2 Gene
Previous GeneCards Identifiers for C5AR2 Gene
This gene encodes a G-protein coupled receptor 1 family member involved in the complement system of the innate immune response. Unlike classical G-protein coupled receptors, the encoded protein does not associate with intracellular G-proteins. It may instead modulate signal transduction through the beta-arrestin pathway, and may alternatively act as a decoy receptor. This gene may be involved in coronary artery disease and in the pathogenesis of sepsis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012]
GeneCards Summary for C5AR2 Gene
C5AR2 (Complement Component 5a Receptor 2) is a Protein Coding gene. Diseases associated with C5AR2 include C3 Deficiency and Andersen Syndrome. Among its related pathways are Immune response Lectin induced complement pathway and GPCRs, Other. GO annotations related to this gene include G-protein coupled receptor activity. An important paralog of this gene is C5AR1.
UniProtKB/Swiss-Prot for C5AR2 Gene
Receptor for the chemotactic and inflammatory C3a, C4a and C5a anaphylatoxin peptides and also for their dearginated forms ASP/C3adesArg, C4adesArg and C5adesArg respectively. Couples weakly to G(i)-mediated signaling pathways.