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Aliases for C5AR2 Gene

Aliases for C5AR2 Gene

  • Complement Component 5a Receptor 2 2 3 4
  • C5L2 3 4 6
  • G Protein-Coupled Receptor 77 2 3
  • GPR77 3 4
  • GPF77 3 6
  • C5a Anaphylatoxin Chemotactic Receptor C5L2 3
  • C5a Anaphylatoxin Chemotactic Receptor 2 3
  • G Protein-Coupled Receptor C5L2 3
  • G-Protein Coupled Receptor 77 4

External Ids for C5AR2 Gene

Previous HGNC Symbols for C5AR2 Gene

  • GPR77

Previous GeneCards Identifiers for C5AR2 Gene

  • GC19P047841

Summaries for C5AR2 Gene

Entrez Gene Summary for C5AR2 Gene

  • This gene encodes a G-protein coupled receptor 1 family member involved in the complement system of the innate immune response. Unlike classical G-protein coupled receptors, the encoded protein does not associate with intracellular G-proteins. It may instead modulate signal transduction through the beta-arrestin pathway, and may alternatively act as a decoy receptor. This gene may be involved in coronary artery disease and in the pathogenesis of sepsis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012]

GeneCards Summary for C5AR2 Gene

C5AR2 (Complement Component 5a Receptor 2) is a Protein Coding gene. Diseases associated with C5AR2 include coronary artery disease and artery disease. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include N-formyl peptide receptor activity and C5a anaphylatoxin receptor activity. An important paralog of this gene is FPR2.

UniProtKB/Swiss-Prot for C5AR2 Gene

  • Receptor for the chemotactic and inflammatory C3a, C4a and C5a anaphylatoxin peptides and also for their dearginated forms ASP/C3adesArg, C4adesArg and C5adesArg respectively. Couples weakly to G(i)-mediated signaling pathways.

Gene Wiki entry for C5AR2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C5AR2 Gene

Genomics for C5AR2 Gene

Genomic Location for C5AR2 Gene

47,332,147 bp from pter
47,347,327 bp from pter
15,181 bases
Plus strand

Genomic View for C5AR2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for C5AR2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C5AR2 Gene

No data available for Regulatory Elements for C5AR2 Gene

Proteins for C5AR2 Gene

  • Protein details for C5AR2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    C5a anaphylatoxin chemotactic receptor 2
    Protein Accession:
    Secondary Accessions:
    • B2RA09

    Protein attributes for C5AR2 Gene

    337 amino acids
    Molecular mass:
    36080 Da
    Quaternary structure:
    • Interacts with C3 (the anaphylatoxin peptide C3a and the adipogenic hormone ASP); the interaction occurs with higher affinity for ASP, enhancing the phosphorylation and activation of GPR77, recruitment of ARRB2 to the cell surface and endocytosis of GRP77.

neXtProt entry for C5AR2 Gene

Proteomics data for C5AR2 Gene at MOPED

Post-translational modifications for C5AR2 Gene

  • Glycosylation at Asn3
  • Modification sites at PhosphoSitePlus

Other Protein References for C5AR2 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for C5AR2 Gene

Domains for C5AR2 Gene

Gene Families for C5AR2 Gene

  • CNAR :GPCR / Class A : Complement component receptors

Protein Domains for C5AR2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Q9P296
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with C5AR2: view

No data available for Suggested Antigen Peptide Sequences for C5AR2 Gene

Function for C5AR2 Gene

Molecular function for C5AR2 Gene

UniProtKB/Swiss-Prot Function: Receptor for the chemotactic and inflammatory C3a, C4a and C5a anaphylatoxin peptides and also for their dearginated forms ASP/C3adesArg, C4adesArg and C5adesArg respectively. Couples weakly to G(i)-mediated signaling pathways.

Gene Ontology (GO) - Molecular Function for C5AR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity --
GO:0004944 C5a anaphylatoxin receptor activity IEA --
GO:0005515 protein binding IPI 12540846
genes like me logo Genes that share ontologies with C5AR2: view
genes like me logo Genes that share phenotypes with C5AR2: view

Animal Models for C5AR2 Gene

MGI Knock Outs for C5AR2:

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for C5AR2 Gene

Localization for C5AR2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for C5AR2 Gene

Cell membrane; Multi-pass membrane protein.

Gene Ontology (GO) - Cellular Components for C5AR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0009925 basal plasma membrane IDA 22960554
GO:0016021 integral component of membrane IEA --
GO:0045177 apical part of cell IDA 22496247
genes like me logo Genes that share ontologies with C5AR2: view

No data available for Subcellular locations from COMPARTMENTS for C5AR2 Gene

Pathways for C5AR2 Gene

genes like me logo Genes that share pathways with C5AR2: view

Pathways by source for C5AR2 Gene

Interacting Proteins for C5AR2 Gene

Selected Interacting proteins: Q9P296-C5AR2_HUMAN for C5AR2 Gene via I2D

Gene Ontology (GO) - Biological Process for C5AR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006935 chemotaxis IEA --
GO:0006954 inflammatory response IEA --
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0032720 negative regulation of tumor necrosis factor production IMP 16204243
GO:0050679 positive regulation of epithelial cell proliferation IEA --
genes like me logo Genes that share ontologies with C5AR2: view

Compounds for C5AR2 Gene

(4) IUPHAR Ligand for C5AR2 Gene

Ligand Type Action Affinity Pubmed IDs
C5a Agonist Full agonist 9
CHIPS-(28-149) Antagonist Antagonist 6.6
C5a des-Arg Agonist Partial agonist 6.4
C5a hexapeptide analogue Agonist Agonist 4.74

(1) Novoseek inferred chemical compound relationships for C5AR2 Gene

Compound -log(P) Hits PubMed IDs
anaphylatoxin 88 6
genes like me logo Genes that share compounds with C5AR2: view

Transcripts for C5AR2 Gene

mRNA/cDNA for C5AR2 Gene

(6) Additional mRNA sequences :
(5) REFSEQ mRNAs :
(10) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for C5AR2 Gene

Complement component 5a receptor 2:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for C5AR2

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for C5AR2 Gene

No ASD Table

Relevant External Links for C5AR2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for C5AR2 Gene

mRNA expression in normal human tissues for C5AR2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for C5AR2 Gene

This gene is overexpressed in Whole Blood (28.7) and Spleen (4.0).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for C5AR2 Gene

SOURCE GeneReport for Unigene cluster for C5AR2 Gene Hs.534412

mRNA Expression by UniProt/SwissProt for C5AR2 Gene

Tissue specificity: Frontal cortex, hippocampus, hypothalamus, pons and liver.
genes like me logo Genes that share expressions with C5AR2: view

In Situ Assay Products

Orthologs for C5AR2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C5AR2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia C5AR2 36
  • 98 (a)
GPR77 35
  • 98.52 (n)
  • 97.63 (a)
(Bos Taurus)
Mammalia GPR77 35
  • 82.29 (n)
  • 76.26 (a)
GPR77 36
  • 76 (a)
(Canis familiaris)
Mammalia C5AR2 35
  • 82 (n)
  • 74.18 (a)
C5AR2 36
  • 74 (a)
(Mus musculus)
Mammalia C5ar2 35
  • 68.48 (n)
  • 61.03 (a)
C5ar2 16
C5ar2 36
  • 58 (a)
(Monodelphis domestica)
Mammalia C5AR2 36
  • 54 (a)
(Rattus norvegicus)
Mammalia C5ar2 35
  • 68.94 (n)
  • 59.94 (a)
(Danio rerio)
Actinopterygii si:dkeyp-66d1.2 36
  • 21 (a)
Species with no ortholog for C5AR2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C5AR2 Gene

Gene Tree for C5AR2 (if available)
Gene Tree for C5AR2 (if available)

Paralogs for C5AR2 Gene

Selected SIMAP similar genes for C5AR2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with C5AR2: view

Variants for C5AR2 Gene

Sequence variations from dbSNP and Humsavar for C5AR2 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
VAR_068748 -
VAR_068749 -

Relevant External Links for C5AR2 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for C5AR2 Gene

Disorders for C5AR2 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (2) Diseases for C5AR2 Gene including...

Search for C5AR2 Gene in MalaCards »

(2) Novoseek inferred disease relationships for C5AR2 Gene

Disease -log(P) Hits PubMed IDs
necrosis 0 2
tumors 0 2
genes like me logo Genes that share disorders with C5AR2: view

No data available for UniProtKB/Swiss-Prot for C5AR2 Gene

Publications for C5AR2 Gene

  1. Identification of four novel human G protein-coupled receptors expressed in the brain. (PMID: 11165367) Lee D.K. … O'Dowd B.F. (Brain Res. Mol. Brain Res. 2001) 2 3 4 23
  2. The orphan receptor C5L2 has high affinity binding sites for complement fragments C5a and C5a des Arg(74). (PMID: 11773063) Cain S.A. … Monk P.N. (J. Biol. Chem. 2002) 3 4 23
  3. The chemoattractant receptor-like protein C5L2 binds the C3a des- Arg77/acylation-stimulating protein. (PMID: 12540846) Kalant D. … Monk P.N. (J. Biol. Chem. 2003) 3 4 23
  4. A putative chemoattractant receptor, C5L2, is expressed in granulocyte and immature dendritic cells, but not in mature dendritic cells. (PMID: 11090875) Ohno M. … Takahashi T.A. (Mol. Immunol. 2000) 3 4 23
  5. C5a- and ASP-mediated C5L2 activation, endocytosis and recycling are lost in S323I-C5L2 mutation. (PMID: 19615750) Cui W. … Cianflone K. (Mol. Immunol. 2009) 3 4

Products for C5AR2 Gene

Sources for C5AR2 Gene

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