Aliases for C5AR1 Gene
External Ids for C5AR1 Gene
Previous Symbols for C5AR1 Gene
GeneCards Summary for C5AR1 Gene
C5AR1 (Complement Component 5a Receptor 1) is a Protein Coding gene. Diseases associated with C5AR1 include hypersensitivity reaction type iii disease and systemic lupus erythematosus. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include N-formyl peptide receptor activity and complement component C5a binding. An important paralog of this gene is FPR2.
UniProtKB/Swiss-Prot for C5AR1 Gene
Receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a (PubMed:1847994, PubMed:8182049, PubMed:7622471, PubMed:9553099, PubMed:10636859, PubMed:15153520). The ligand interacts with at least two sites on the receptor: a high-affinity site on the extracellular N-terminus, and a second site in the transmembrane region which activates downstream signaling events (PubMed:8182049, PubMed:7622471, PubMed:9553099). Receptor activation stimulates chemotaxis, granule enzyme release, intracellular calcium release and superoxide anion production (PubMed:10636859, PubMed:15153520).
The complement system is a biochemical pathway involved in both innate and adaptive immune responses. There are four main functions of the complement system; lysis of microorganisms, promotion of phagocytosis, triggering inflammation and immune clearance. There are three pathways that can activate the complement system; the classical complement pathway (in response to IgG- or IgM-antigen complexes), the alternative complement pathway (spontaneous activation) and the mannose-binding lectin pathway (in response to lectin residues on pathogen cell surface membranes). All three pathway generate variants of C3 convertase, which cleaves C3 into C3a and C3b. C3a and C3b activate a series of further cleavage events that activates the complement cascade. This leads to immune defence responses such as degranulation of mast cells, increasing vascular permeability and initiation of the membrane attack pathway. Deregulation of the complement system would be extremely damaging to the host, so it is tightly regulated by complement control proteins. These regulatory proteins are found in much higher concentrations that complement proteins themselves and prevent complement system activation in self tissues. The complement system has been implicated in many autoimmune disorders, including systemic lupus erythematosus, multiple sclerosis and arthritis, and more recently has been suggested to have a pathophysiological role in Alzheimers and other neurodegenerative disorders.