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C5AR1 Gene

protein-coding   GIFtS: 65
GCID: GC19P047813

Complement Component 5a Receptor 1

(Previous name: complement component 5 receptor 1 (C5a ligand))
(Previous symbol: C5R1)
  See C5AR1-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Complement Component 5a Receptor 11 2     C5a Anaphylatoxin Chemotactic Receptor 12
C5R11 2 3 5     C5a Anaphylatoxin Receptor2
C5AR2 3 5     C5a Ligand2
C5a-R2 3     Complement Component 5 Receptor 12
Complement Component 5 Receptor 1 (C5a Ligand)1     C5aR3
C5A2     C5a Anaphylatoxin Chemotactic Receptor3
CD882     CD88 Antigen3

External Ids:    HGNC: 13381   Entrez Gene: 7282   Ensembl: ENSG000001974057   OMIM: 1139955   UniProtKB: P217303   
ORGUL members:         

Export aliases for C5AR1 gene to outside databases

Previous GC identifers: GC19P052505 GC19P044237


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for C5AR1 Gene:
C5AR1 (complement component 5a receptor 1) is a protein-coding gene. Diseases associated with C5AR1 include hypersensitivity reaction type iii disease, and mannose-binding lectin deficiency. GO annotations related to this gene include complement component C5a binding and N-formyl peptide receptor activity. An important paralog of this gene is LTB4R.

UniProtKB/Swiss-Prot: C5AR1_HUMAN, P21730
Function: Receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a. This receptor stimulates
chemotaxis, granule enzyme release and superoxide anion production

summary for C5AR1 Gene:
The complement system is a biochemical pathway involved in both innate and adaptive immune responses. There
are four main functions of the complement system; lysis of microorganisms, promotion of phagocytosis,
triggering inflammation and immune clearance. There are three pathways that can activate the complement
system; the classical complement pathway (in response to IgG- or IgM-antigen complexes), the alternative
complement pathway (spontaneous activation) and the mannose-binding lectin pathway (in response to lectin
residues on pathogen cell surface membranes). All three pathway generate variants of C3 convertase, which
cleaves C3 into C3a and C3b. C3a and C3b activate a series of further cleavage events that activates the
complement cascade. This leads to immune defence responses such as degranulation of mast cells, increasing
vascular permeability and initiation of the membrane attack pathway. Deregulation of the complement system
would be extremely damaging to the host, so it is tightly regulated by complement control proteins. These
regulatory proteins are found in much higher concentrations that complement proteins themselves and prevent
complement system activation in 'self' tissues. The complement system has been implicated in many autoimmune
disorders, including systemic lupus erythematosus, multiple sclerosis and arthritis, and more recently has
been suggested to have a pathophysiological role in Alzheimer's and other neurodegenerative disorders.

Gene Wiki entry for C5AR1 (C5a receptor) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NT_011109.17  NC_018930.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the C5AR1 gene promoter:
         AhR   CREB   deltaCREB   NF-kappaB   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidC5AR1 promoter sequence
   Search Chromatin IP Primers for C5AR1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat C5AR1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.3-q13.4   Ensembl cytogenetic band:  19q13.32   HGNC cytogenetic band: 19q13.3-q13.4

C5AR1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
C5AR1 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P047813:  view genomic region     (about GC identifiers)

Start:
47,793,280 bp from pter      End:
47,825,327 bp from pter
Size:
32,048 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: C5AR1_HUMAN, P21730 (See protein sequence)
Recommended Name: C5a anaphylatoxin chemotactic receptor 1  
Size: 350 amino acids; 39336 Da
Subunit: Interacts with ARRB1 and ARRB2 (By similarity)

Explore the universe of human proteins at neXtProt for C5AR1: NX_P21730

Explore proteomics data for C5AR1 at MOPED

Post-translational modifications: 

  • Sulfation plays a critical role in the association of the receptor with C5a, but no significant role in the
    ability of the receptor to transduce a signal and mobilize calcium in response to a small peptide agonist1
  • Glycosylation2 at Asn5
  • Modification sites at PhosphoSitePlus

  • See C5AR1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001727.1  
    ENSEMBL proteins: 
     ENSP00000470613   ENSP00000347197  
    Reactome Protein details: P21730

    C5AR1 Human Recombinant Protein Products:

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    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for C5AR1 

     
    antibodies-online proteins for C5AR1 (7 products) 

     
    antibodies-online peptides for C5AR1

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    antibodies-online antibodies for C5AR1 (151 products) 

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    antibodies-online kits for C5AR1 (15 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CD: CD molecules
    CNAR: GPCR / Class A : Complement component receptors
    complement: Complement system

    IUPHAR Guide to PHARMACOLOGY protein family classification: C5a1 receptor
    Complement peptide receptors

    Selected InterPro protein domains (see all 6):
     IPR002234 Anphylx_rcpt
     IPR027809 Anaphtx_C5AR1
     IPR017452 GPCR_Rhodpsn_7TM
     IPR000826 Formyl_pep_rcpt
     IPR001274 Anaphtx_C5AR1/C5AR2

    Graphical View of Domain Structure for InterPro Entry P21730

    ProtoNet protein and cluster: P21730

    2 Blocks protein domains:
    IPB001274 C5A-anaphylatoxin receptor signature
    IPB002234 Anaphylatoxin chemotactic receptor signature


    UniProtKB/Swiss-Prot: C5AR1_HUMAN, P21730
    Similarity: Belongs to the G-protein coupled receptor 1 family


    Find genes that share domains with C5AR1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: C5AR1_HUMAN, P21730
    Function: Receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a. This receptor stimulates
    chemotaxis, granule enzyme release and superoxide anion production

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001856complement component C5a binding IEA--
    GO:0004878complement component C5a receptor activity IDA--
    GO:0004930G-protein coupled receptor activity ----
    GO:0004944C5a anaphylatoxin receptor activity IDA--
    GO:0004982N-formyl peptide receptor activity IEA--
         
    Find genes that share ontologies with C5AR1           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for C5AR1:
     Increased gamma-H2AX phosphory 

         6 MGI mutant phenotypes (inferred from 3 alleles(MGI details for C5ar1):
     hematopoietic system  homeostasis/metabolism  immune system  mortality/aging  reproductive system 
     skeleton 

    Find genes that share phenotypes with C5AR1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for C5AR1: C5ar1tm1Raw C5ar1tm1Cge

       genOway: Develop your customized and physiologically relevant rodent model for C5AR1

    miRNA
    Products:
        
    miRTarBase miRNAs that target C5AR1:
    hsa-mir-335-5p (MIRT019124), hsa-mir-26b-5p (MIRT030190)

    Block miRNA regulation of human, mouse, rat C5AR1 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate C5AR1
    SwitchGear 3'UTR luciferase reporter plasmidC5AR1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat C5AR1

    Gene Editing
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    Clone
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    OriGene clones in human, mouse for C5AR1 (see all 9)
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: C5AR1 (NM_001736)
    Sino Biological Human cDNA Clone for C5AR1
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C5AR1

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C5AR1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    C5AR1_HUMAN, P21730: Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    cytosol3
    cytoskeleton2
    extracellular2
    lysosome2
    vacuole2
    endoplasmic reticulum1
    golgi apparatus1
    nucleus1

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane TAS2007135
    GO:0009986cell surface IEA--
    GO:0016021integral component of membrane ----
    GO:0016323basolateral plasma membrane IDA--

    Find genes that share ontologies with C5AR1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for C5AR1 About   (see all 7)  
    See pathways by source

    SuperPathContained pathways About
    1Peptide ligand-binding receptors
    Class A/1 (Rhodopsin-like receptors)0.71
    G alpha (i) signalling events0.44
    GPCR ligand binding0.71
    Neuroactive ligand-receptor interaction0.36
    Peptide ligand-binding receptors0.60
    2Complement and coagulation cascades
    Complement and coagulation cascades0.71
    Complement and Coagulation Cascades0.71
    3Neuropeptides signaling through G protein alpha i and G protein alpha q
    Peptide GPCRs0.46
    Neuropeptides signaling through G protein alpha i and G protein alpha q0.46
    4Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90
    5Complement Pathway
    Immune response Lectin Induced complement pathway0.56
    Immune response Alternative complement pathway0.56
    Immune response Classic complement pathway0.56


    Find genes that share SuperPaths with C5AR1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    3 GeneGo (Thomson Reuters) Pathways for C5AR1
        Immune response Alternative complement pathway
    Immune response Classical complement pathway
    Immune response Lectin induced complement pathway

    2 BioSystems Pathways for C5AR1
        Complement and Coagulation Cascades
    Peptide GPCRs


    2 Reactome Pathways for C5AR1
        Peptide ligand-binding receptors
    G alpha (i) signalling events


    3 Kegg Pathways  (Kegg details for C5AR1):
        Neuroactive ligand-receptor interaction
    Complement and coagulation cascades
    Staphylococcus aureus infection

        Pathway & Disease-focused RT2 Profiler PCR Arrays including C5AR1: 
              Innate & Adaptive Immune Responses in human mouse rat
              G Protein Coupled Receptors 384HT in human mouse rat
              Cell Surface Markers in human mouse rat
              Antifungal Response in human mouse rat
              Chemokines & Receptors in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for C5AR1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for C5AR1 (P217303 ENSP000003471974) via UniProtKB, MINT, STRING, and/or I2D (see all 150)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    WASP427683, ENSP000003658914I2D: score=1 STRING: ENSP00000365891
    ARRB1P494073, ENSP000003771414I2D: score=1 STRING: ENSP00000377141
    ARRB2P321213, ENSP000002692604I2D: score=1 STRING: ENSP00000269260
    C5P010313, ENSP000002236424I2D: score=3 STRING: ENSP00000223642
    C5AR2Q9P2963, ENSP000002572674I2D: score=1 STRING: ENSP00000257267
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 23):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000187activation of MAPK activity TAS7649993
    GO:0002430complement receptor mediated signaling pathway ----
    GO:0006915apoptotic process IEA--
    GO:0006935chemotaxis TAS10352266
    GO:0006954inflammatory response IEA--

    Find genes that share ontologies with C5AR1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for C5AR1 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    Compstatin C3-binding protein, inhibits complement activation [206645-99-0]
    Compstatin control peptideControl peptide for Compstatin (Cat. No. 2585)[301544-78-5]
    NDT 9513727 Potent, selective human C5a receptor antagonist [439571-48-9]

    1 HMDB Compound for C5AR1    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    Selected IUPHAR Ligands for C5AR1 (C5a1 receptor) (see all 17)    About this table
    LigandTypeActionAffinityPubmed IDs
    CHIPS
    AntagonistAntagonist915153520
    C5a
    AgonistFull agonist8 - 910602324 9881961
    [125I]C5a (human)
    AgonistFull agonist8.74020139
    W54011
    AntagonistAntagonist8.712384495
    AcPhe-Orn-Pro-D-Cha-Trp-Arg
    AntagonistAntagonist7.99719594
    PMX53
    AntagonistAntagonist7.1 - 7.711403208 15044616
    N-methyl-Phe-Lys-Pro-D-Cha-Cha-D-Arg-CO2H
    AgonistFull agonist7.67930622 1732540
    PMX205
    AntagonistAntagonist7.5115044616
    NDT9520492
    AntagonistAntagonist7.516230349
    N-methyl-Phe-Lys-Pro-D-Cha-Trp-D-Arg-CO2H
    AntagonistAntagonist7.27930622

    Selected Novoseek inferred chemical compound relationships for C5AR1 gene (see all 70)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    anaphylatoxin 97.5 176 1732540 (4), 10508278 (3), 9218605 (3), 7556629 (3) (see all 96)
    fmlp 83.7 114 9036983 (5), 8699129 (5), 17724165 (5), 2159036 (4) (see all 58)
    fmlpl 82 5 1564402 (3), 2161893 (1), 2295813 (1)
    leukotriene b4 72.6 52 12141728 (4), 7722425 (3), 1966131 (3), 8683135 (2) (see all 30)
    n-formylmethionyl-leucylphenylalanine 70.4 15 7722425 (2), 1722562 (1), 8699129 (1), 9358848 (1) (see all 14)
    rantes 50.1 16 9426639 (4), 1281207 (3), 7542307 (3), 9036983 (2) (see all 7)
    calcium 49 62 2159036 (4), 8223566 (3), 1472004 (2), 11342590 (2) (see all 35)
    superoxide 44.1 12 1966131 (2), 2159036 (1), 7722425 (1), 1850304 (1) (see all 8)
    histamine 42.5 23 7513741 (6), 12527821 (3), 11799375 (2), 17389757 (1) (see all 12)
    pertussis 41.9 4 10233875 (1), 16879222 (1), 10706729 (1), 9838061 (1)



    Find genes that share compounds with C5AR1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for C5AR1 gene: 
    NM_001736.3  

    Unigene Cluster for C5AR1:

    Complement component 5a receptor 1
    Hs.2161  [show with all ESTs]
    Unigene Representative Sequence: NM_001736
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000595501 ENST00000594787 ENST00000355085(uc002pgj.1)
    miRNA
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    GenScript: all cDNA clones in your preferred vector: C5AR1 (NM_001736)
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    Primer
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    OriGene qPCR primer pairs and template standards for C5AR1
    OriGene qSTAR qPCR primer pairs in human, mouse for C5AR1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat C5AR1
      QuantiTect SYBR Green Assays in human, mouse, rat C5AR1
      QuantiFast Probe-based Assays in human, mouse, rat C5AR1

    Additional mRNA sequence: 

    BC008982.1 BT007358.1 M62505.1 X57250.1 

    3 DOTS entries:

    DT.95263655  DT.100877901  DT.92062932 

    1 AceView cDNA sequence:

    BF901094 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    C5AR1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    C5AR1 Expression
    About this image


    C5AR1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Blood (Hematopoietic System)    fully expand to see all 2 entries
             Monocytes Peripheral Blood
     
     Endothelium (Cardiovascular System)
             Extraembryonic Angioblasts Extraembryonic Capillary Plexus
     
     Extraembryonic Mesoderm (Extraembryonic Tissues)
             Extraembryonic Angioblasts Extraembryonic Capillary Plexus
     
     Bone (Muscoskeletal System)
             Bone Marrow
    C5AR1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    C5AR1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.2161
        Pathway & Disease-focused RT2 Profiler PCR Arrays including C5AR1: 
              Innate & Adaptive Immune Responses in human mouse rat
              G Protein Coupled Receptors 384HT in human mouse rat
              Cell Surface Markers in human mouse rat
              Antifungal Response in human mouse rat
              Chemokines & Receptors in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for C5AR1
    OriGene qSTAR qPCR primer pairs in human, mouse for C5AR1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat C5AR1
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    QuantiFast Probe-based Assays in human, mouse, rat C5AR1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C5AR1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for C5AR1 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia C5ar11 , 5 complement component 5a receptor 11, 5 73.37(n)1
    68.05(a)1
      7 (8.77 cM)5
    122731  NM_001173550.11  NP_001167021.11 
     162467435 
    chicken
    (Gallus gallus)
    Aves C5AR11 complement component 5a receptor 1 53.95(n)
    39.64(a)
      430484  XM_004950900.1  XP_004950957.1 
    lizard
    (Anolis carolinensis)
    Reptilia C5AR16
    complement component 5a receptor 1
    41(a)
    1 ↔ 1
    LGf(1670852-1671922)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia c5ar11 complement component 5a receptor 1 51.35(n)
    45.65(a)
      100379958  XM_002941282.2  XP_002941328.1 
    zebrafish
    (Danio rerio)
    Actinopterygii C5AR16
    C5a anaphylatoxin chemotactic receptor 1
    37(a)
    1 ↔ 1
    18(45207298-45208338) ENSDARG00000040319


    ENSEMBL Gene Tree for C5AR1 (if available)
    TreeFam Gene Tree for C5AR1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for C5AR1 gene
    LTB4R2  GPR332  LTB4R22  FPR32  FPR12  GPR322  GPR1522  FPR22  
    C5AR22  C3AR12  PTGDR22  GPR12  ENSG000002726582  CMKLR12  
    Selected SIMAP similar genes for C5AR1 using alignment to 2 protein entries:     C5AR1_HUMAN (see all proteins) (see all similar genes):
    CCR5    C5AR2    GPR77    FPR2    GPR1    GPR18
    CMKLR1    FPR1    CCR3    FPR3    FPRL2    GPR33
    CCR1    CCR7    PTGDR2    gpcr    AGTR1    CXCR1

    Find genes that share paralogs with C5AR1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for C5AR1 (see all 472)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1995592901,2
    Cuntested147824014(+) AGAGTA/C/TCGTGG 2 S F mis10--------
    rs172186971,2
    F--44248611(+) CCCCCC/ACACAC 2 -- ut311Minor allele frequency- A:0.27EA 722
    rs1885610331,2
    --47811113(+) ATAGCC/TACGCC 1 -- us2k10--------
    rs1810569361,2
    --47811115(+) AGCCAC/TGCCCC 1 -- us2k10--------
    rs1442037471,2
    C--47811128(+) CGCTCA/CTATTA 1 -- us2k10--------
    rs1860363811,2
    --47811158(+) AGGGGC/TGGAAT 1 -- us2k10--------
    rs1487502331,2
    --47811195(+) GGCCGA/GGCGCA 1 -- us2k10--------
    rs1137505511,2
    C,F--47811198(+) CGGGCA/GCAGTG 1 -- us2k12Minor allele frequency- G:0.00CSA 2
    rs1915779021,2
    --47811244(+) AGGCGG/TGTGGA 1 -- us2k10--------
    rs1138016051,2
    C,F--47811262(+) GTCAGG/AAGTTC 1 -- us2k11Minor allele frequency- A:0.50WA 2

    HapMap Linkage Disequilibrium report for C5AR1 (47793280 - 47825327 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for C5AR1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv912200CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing C5AR1
    DNA2.0 Custom Variant and Variant Library Synthesis for C5AR1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 113995    OMIM disorders: --

    9 diseases for C5AR1:    
    About MalaCards
    hypersensitivity reaction type iii disease    mannose-binding lectin deficiency    leukostasis    complement deficiency
    pulmonary disease, chronic obstructive    multiple sclerosis    lupus erythematosus    sepsis
    systemic lupus erythematosus

    10 diseases from the University of Copenhagen DISEASES database for C5AR1:
    Adult respiratory distress syndrome     Leukopenia     Urticaria     Hypersensitivity reaction type III disease
    Asthma     Complement deficiency     Hypersensitivity reaction type II disease     Peritonitis
    Arthritis     Leukostasis

    Find genes that share disorders with C5AR1           About GenesLikeMe

    Selected Novoseek inferred disease relationships for C5AR1 gene (see all 52)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    leukemia basophilic 56.6 4 7957584 (2), 7622471 (1), 10195437 (1)
    inflammation 54.6 37 17965442 (2), 1489124 (1), 7541417 (1), 10706689 (1) (see all 26)
    immune complex diseases 35.8 2 12869020 (1), 10395696 (1)
    necrosis 31.5 22 16499574 (2), 7978476 (2), 1489124 (1), 8391001 (1) (see all 19)
    shock septic 28 4 12225614 (2), 1847994 (1), 10927032 (1)
    sepsis 22.6 44 14676676 (5), 12225614 (4), 12960283 (3), 18848819 (3) (see all 9)
    neutropenia 20.5 6 19285573 (2), 10188960 (1), 1751793 (1), 10927032 (1) (see all 5)
    hypereosinophilic syndrome 18 2 2040692 (1), 7705383 (1)
    intestinal ischemia 17.8 2 10395696 (1), 15159277 (1)
    drusen 13.7 3 16452172 (2)

    Genetic Association Database (GAD): C5AR1
    Human Genome Epidemiology (HuGE) Navigator: C5AR1 (12 documents)

    Export disorders for C5AR1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for C5AR1 gene, integrated from 10 sources (see all 502):
    (articles sorted by number of sources associating them with C5AR1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Sulfated tyrosines contribute to the formation of the c5a docking site of the human c5a anaphylatoxin receptor. (PubMed id 11342590)1, 2, 9 Farzan M.... Choe H. (J. Exp. Med. 2001)
    2. Identification of the major phosphorylation sites in human C5a anaphylatoxin receptor in vivo. (PubMed id 7642584)1, 2, 9 Giannini E.... Boulay F. (J. Biol. Chem. 1995)
    3. Mapping of genes for the human C5a receptor (C5AR), human FMLP receptor (FPR), and two FMLP receptor homologue orphan receptors (FPRH1, FPRH2) to chromosome 19. (PubMed id 1612600)1, 3, 9 Bao L.... Gerard C. (Genomics 1992)
    4. Human chemotaxis receptor genes cluster at 19q13.3-13.4. Characterization of the human C5a receptor gene. (PubMed id 8383526)1, 2, 9 Gerard N.P....Gerard C. (Biochemistry 1993)
    5. The chemotactic receptor for human C5a anaphylatoxin. (PubMed id 1847994)1, 2, 9 Gerard N.P. and Gerard C. (Nature 1991)
    6. Expression cloning of a receptor for C5a anaphylatoxin on differentiated HL-60 cells. (PubMed id 2007135)1, 2, 9 Boulay F.... Vignais P. (Biochemistry 1991)
    7. Risk of meningioma and common variation in genes related to innate immunity. (PubMed id 20406964)1, 4 Rajaraman P....Inskip P.D. (amp 2010)
    8. Polymorphisms in innate immunity genes and risk of childhood leukemia. (PubMed id 20438785)1, 4 Han S....Kang D. (Hum. Immunol. 2010)
    9. Investigation of C5a receptor gene 450 C/T polymorphism in Turkish patients with familial Mediterranean fever. (PubMed id 19657723)1, 4 Erken E....Ozer H.T. (Mol. Biol. Rep. 2010)
    10. Complement component C5a activates ICAM-1 expression on human choroidal endothelial cells. (PubMed id 20484595)1, 4 Skeie J.M....Mullins R.F. (amp 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 728 HGNC: 1338 AceView: C5R1 Ensembl:ENSG00000197405 euGenes: HUgn728
    ECgene: C5AR1 Kegg: 728 H-InvDB: C5AR1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for C5AR1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for C5AR1 gene:
    Search GeneIP for patents involving C5AR1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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