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Aliases for C5AR1 Gene

Aliases for C5AR1 Gene

  • Complement C5a Receptor 1 2 3 5
  • Complement Component 5a Receptor 1 2 3
  • C5a-R 3 4
  • C5R1 3 4
  • C5AR 3 4
  • Complement Component 5 Receptor 1 (C5a Ligand) 2
  • C5a Anaphylatoxin Chemotactic Receptor 1 3
  • C5a Anaphylatoxin Chemotactic Receptor 4
  • Complement Component 5 Receptor 1 3
  • C5a Anaphylatoxin Receptor 3
  • CD88 Antigen 4
  • C5a Ligand 3
  • CD88 3
  • C5a 3

External Ids for C5AR1 Gene

Previous HGNC Symbols for C5AR1 Gene

  • C5R1

Previous GeneCards Identifiers for C5AR1 Gene

  • GC19P052505
  • GC19P047813
  • GC19P044237

Summaries for C5AR1 Gene

GeneCards Summary for C5AR1 Gene

C5AR1 (Complement C5a Receptor 1) is a Protein Coding gene. Diseases associated with C5AR1 include Mast-Cell Sarcoma and Listeria Meningitis. Among its related pathways are Signaling by GPCR and Peptide ligand-binding receptors. GO annotations related to this gene include G-protein coupled receptor activity and complement component C5a binding. An important paralog of this gene is C5AR2.

UniProtKB/Swiss-Prot for C5AR1 Gene

  • Receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a (PubMed:1847994, PubMed:8182049, PubMed:7622471, PubMed:9553099, PubMed:10636859, PubMed:15153520). The ligand interacts with at least two sites on the receptor: a high-affinity site on the extracellular N-terminus, and a second site in the transmembrane region which activates downstream signaling events (PubMed:8182049, PubMed:7622471, PubMed:9553099). Receptor activation stimulates chemotaxis, granule enzyme release, intracellular calcium release and superoxide anion production (PubMed:10636859, PubMed:15153520).

Tocris Summary for C5AR1 Gene

  • The complement system is a biochemical pathway involved in both innate and adaptive immune responses. There are four main functions of the complement system; lysis of microorganisms, promotion of phagocytosis, triggering inflammation and immune clearance.

Gene Wiki entry for C5AR1 Gene

No data available for Entrez Gene Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C5AR1 Gene

Genomics for C5AR1 Gene

Regulatory Elements for C5AR1 Gene

Enhancers for C5AR1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19F047369 1.4 FANTOM5 Ensembl ENCODE 45.2 +80.4 80354 2.0 CTCF KLF1 PKNOX1 MAX ZIC2 ZFHX2 NR2F6 FOS MAFK EGR2 DHX34 C5AR1 ZC3H4 C5AR2 CCDC9 NAPA PIR41927 GC19P047354 GC19P047388
GH19F047314 1.5 FANTOM5 ENCODE 35.5 +25.5 25543 1.8 PKNOX1 ARNT MLX ARID4B SIN3A DMAP1 YBX1 YY1 SLC30A9 FOS C5AR1 DHX34 ZC3H4 C5AR2 CCDC9 NAPA
GH19F047309 1.3 FANTOM5 ENCODE 40.1 +20.9 20860 2.2 ELF3 ZNF48 RAD21 ZNF121 RCOR1 THAP11 ZBTB11 CEBPB ZEB2 REST DHX34 C5AR1 C5AR2 ZC3H4 CCDC9 NAPA
GH19F047388 1.7 FANTOM5 Ensembl ENCODE 29.9 +100.8 100824 4.9 PKNOX1 MLX ARNT CREB3L1 ARID4B YY1 SLC30A9 ZNF766 CBX5 ZNF143 DHX34 ZC3H4 C5AR1 C5AR2 GLTSCR1 CABP5 CCDC9 NAPA BBC3 GC19P047388
GH19F047323 1.3 FANTOM5 Ensembl ENCODE 27.8 +34.3 34278 2.2 CTCF L3MBTL2 MAX USF2 RAD51 ZBTB48 IKZF1 FOXP2 MAFK EMSY C5AR1 DHX34 ZC3H4 CCDC9 C5AR2 NAPA ZNF541 GLTSCR1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around C5AR1 on UCSC Golden Path with GeneCards custom track

Genomic Location for C5AR1 Gene

Chromosome:
19
Start:
47,290,023 bp from pter
End:
47,322,070 bp from pter
Size:
32,048 bases
Orientation:
Plus strand

Genomic View for C5AR1 Gene

Genes around C5AR1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C5AR1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C5AR1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C5AR1 Gene

Proteins for C5AR1 Gene

  • Protein details for C5AR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P21730-C5AR1_HUMAN
    Recommended name:
    C5a anaphylatoxin chemotactic receptor 1
    Protein Accession:
    P21730

    Protein attributes for C5AR1 Gene

    Size:
    350 amino acids
    Molecular mass:
    39336 Da
    Quaternary structure:
    • Homodimer. May also form higher-order oligomers (PubMed:12835319). Interacts (when phosphorylated) with ARRB1 and ARRB2; the interaction is associated with internalization of C5aR (PubMed:12464600). Interacts (via N-terminal domain) with S.aureus chemotaxis inhibitory protein (CHIPS); the interaction blocks the receptor and may thus inhibit the immune response (PubMed:15153520, PubMed:15542591, PubMed:21706042).

neXtProt entry for C5AR1 Gene

Post-translational modifications for C5AR1 Gene

  • Phosphorylated on serine residues in response to C5a binding, resulting in internalization of the receptor and short-term desensitization to the ligand. The key residues involved in this process are Ser-334 and Ser-338.
  • Sulfation plays a critical role in the association of C5aR with C5a, but no significant role in the ability of the receptor to transduce a signal and mobilize calcium in response to a small a small peptide agonist (PubMed:11342590). Sulfation at Tyr-14 is important for CHIPS binding (PubMed:21706042).
  • Glycosylation at Asn 5
  • Modification sites at PhosphoSitePlus

Other Protein References for C5AR1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for C5AR1 Gene

Domains & Families for C5AR1 Gene

Suggested Antigen Peptide Sequences for C5AR1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P21730

UniProtKB/Swiss-Prot:

C5AR1_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with C5AR1: view

Function for C5AR1 Gene

Molecular function for C5AR1 Gene

UniProtKB/Swiss-Prot Function:
Receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a (PubMed:1847994, PubMed:8182049, PubMed:7622471, PubMed:9553099, PubMed:10636859, PubMed:15153520). The ligand interacts with at least two sites on the receptor: a high-affinity site on the extracellular N-terminus, and a second site in the transmembrane region which activates downstream signaling events (PubMed:8182049, PubMed:7622471, PubMed:9553099). Receptor activation stimulates chemotaxis, granule enzyme release, intracellular calcium release and superoxide anion production (PubMed:10636859, PubMed:15153520).

Gene Ontology (GO) - Molecular Function for C5AR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001856 complement component C5a binding IEA --
GO:0004871 signal transducer activity IEA --
GO:0004875 complement receptor activity IEA --
GO:0004878 complement component C5a receptor activity IEA,IDA 22496247
GO:0004930 G-protein coupled receptor activity IBA --
genes like me logo Genes that share ontologies with C5AR1: view
genes like me logo Genes that share phenotypes with C5AR1: view

Animal Models for C5AR1 Gene

MGI Knock Outs for C5AR1:

Animal Model Products

miRNA for C5AR1 Gene

miRTarBase miRNAs that target C5AR1

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for C5AR1
  • R&D Systems cDNA Clones for C5AR1 (Complement Component C5a R1)

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for C5AR1 Gene

Localization for C5AR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for C5AR1 Gene

Cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle. Note=Phosphorylated C5aR colocalizes with ARRB1 and ARRB2 in cytoplasmic vesicles. {ECO:0000269 PubMed:12464600}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C5AR1 gene
Compartment Confidence
plasma membrane 5
cytosol 3
extracellular 2
cytoskeleton 1
nucleus 1
endoplasmic reticulum 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for C5AR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA,TAS --
GO:0005887 integral component of plasma membrane TAS 2007135
GO:0009986 cell surface IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with C5AR1: view

Pathways & Interactions for C5AR1 Gene

genes like me logo Genes that share pathways with C5AR1: view

SIGNOR curated interactions for C5AR1 Gene

Is inactivated by:

Gene Ontology (GO) - Biological Process for C5AR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000187 activation of MAPK activity TAS 7649993
GO:0002430 complement receptor mediated signaling pathway IEA --
GO:0006915 apoptotic process IEA --
GO:0006935 chemotaxis IEA,TAS 10352266
GO:0006954 inflammatory response IBA --
genes like me logo Genes that share ontologies with C5AR1: view

Drugs & Compounds for C5AR1 Gene

(45) Drugs for C5AR1 Gene - From: ApexBio, DGIdb, IUPHAR, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
PMX 205 Pharma C5a receptor peptide antagonist, Potent C5a receptor peptide antagonist 0
[<sup>125</sup>I]C5a (human) Pharma Full agonist, Agonist 0
<i>N</i>-methyl-Phe-Lys-Pro-<small>D</small>-Cha-Cha-<small>D</small>-Arg-CO<sub>2</sub>H Pharma Full agonist, Agonist 0
<i>N</i>-methyl-Phe-Lys-Pro-<small>D</small>-Cha-Trp-<small>D</small>-Arg-CO<sub>2</sub>H Pharma Antagonist 0
AcPhe-Orn-Pro-D-Cha-Trp-Arg Pharma Antagonist 0

(48) Additional Compounds for C5AR1 Gene - From: Novoseek and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Compstatin
206645-99-0
NDT 9513727
439571-48-9
PMX 53
219639-75-5
PMX 53c

(5) Tocris Compounds for C5AR1 Gene

Compound Action Cas Number
Compstatin C3-binding protein, inhibits complement activation 206645-99-0
NDT 9513727 Potent, selective human C5a receptor antagonist 439571-48-9
PMX 205 Potent C5a receptor peptide antagonist 514814-49-4
PMX 53 Potent C5a receptor antagonist 219639-75-5
PMX 53c Negative control for PMX 53 (Cat. No. 5473)

(1) ApexBio Compounds for C5AR1 Gene

Compound Action Cas Number
PMX 205 C5a receptor peptide antagonist 514814-49-4
genes like me logo Genes that share compounds with C5AR1: view

Drug Products

Transcripts for C5AR1 Gene

mRNA/cDNA for C5AR1 Gene

(2) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for C5AR1 Gene

Complement component 5a receptor 1:
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for C5AR1
  • R&D Systems cDNA Clones for C5AR1 (Complement Component C5a R1)

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for C5AR1 Gene

No ASD Table

Relevant External Links for C5AR1 Gene

GeneLoc Exon Structure for
C5AR1
ECgene alternative splicing isoforms for
C5AR1

Expression for C5AR1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for C5AR1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for C5AR1 Gene

This gene is overexpressed in Whole Blood (x31.7).

Protein differential expression in normal tissues from HIPED for C5AR1 Gene

This gene is overexpressed in Nasal epithelium (56.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for C5AR1 Gene



NURSA nuclear receptor signaling pathways regulating expression of C5AR1 Gene:

C5AR1

SOURCE GeneReport for Unigene cluster for C5AR1 Gene:

Hs.2161
genes like me logo Genes that share expression patterns with C5AR1: view

Primer Products

No data available for Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for C5AR1 Gene

Orthologs for C5AR1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C5AR1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C5AR1 34 35
  • 98.86 (n)
cow
(Bos Taurus)
Mammalia C5AR1 34 35
  • 77.08 (n)
dog
(Canis familiaris)
Mammalia C5AR1 34 35
  • 75.74 (n)
mouse
(Mus musculus)
Mammalia C5ar1 34 16 35
  • 73.37 (n)
rat
(Rattus norvegicus)
Mammalia C5ar1 34
  • 72.01 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia C5AR1 35
  • 54 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia C5AR1 35
  • 49 (a)
OneToOne
chicken
(Gallus gallus)
Aves C5AR1 34 35
  • 53.95 (n)
lizard
(Anolis carolinensis)
Reptilia C5AR1 35
  • 41 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia c5ar1 34
  • 51.35 (n)
zebrafish
(Danio rerio)
Actinopterygii C5AR1 35
  • 37 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5490 34
Species where no ortholog for C5AR1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C5AR1 Gene

ENSEMBL:
Gene Tree for C5AR1 (if available)
TreeFam:
Gene Tree for C5AR1 (if available)

Paralogs for C5AR1 Gene

Paralogs for C5AR1 Gene

(23) SIMAP similar genes for C5AR1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with C5AR1: view

Variants for C5AR1 Gene

Sequence variations from dbSNP and Humsavar for C5AR1 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs10404456 -- 47,309,643(+) GGGGC(C/T)GAGCC upstream-variant-2KB
rs10404886 -- 47,317,211(+) aaaaa(A/G)aaata intron-variant
rs10687182 -- 47,317,520(+) AAAAA(-/AA/AAAA/ATA)TATAT intron-variant
rs11083872 -- 47,317,278(+) aaggc(C/G)ggagg intron-variant
rs111339125 -- 47,322,108(+) TAGGT(A/T)TTAGT downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for C5AR1 Gene

Variant ID Type Subtype PubMed ID
nsv1067417 CNV gain 25217958

Variation tolerance for C5AR1 Gene

Residual Variation Intolerance Score: 46.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.85; 17.68% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C5AR1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
C5AR1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C5AR1 Gene

Disorders for C5AR1 Gene

MalaCards: The human disease database

(3) MalaCards diseases for C5AR1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
mast-cell sarcoma
  • mast cell sarcoma
listeria meningitis
  • meningitis, listeria
malaria
  • malaria, severe
- elite association - COSMIC cancer census association via MalaCards
Search C5AR1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for C5AR1

Genetic Association Database (GAD)
C5AR1
Human Genome Epidemiology (HuGE) Navigator
C5AR1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
C5AR1
genes like me logo Genes that share disorders with C5AR1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for C5AR1 Gene

Publications for C5AR1 Gene

  1. Phosphorylation of key serine residues is required for internalization of the complement 5a (C5a) anaphylatoxin receptor via a beta-arrestin, dynamin, and clathrin-dependent pathway. (PMID: 12464600) Braun L. … Boulay F. (J. Biol. Chem. 2003) 3 4 22 64
  2. Sulfated tyrosines contribute to the formation of the c5a docking site of the human c5a anaphylatoxin receptor. (PMID: 11342590) Farzan M. … Choe H. (J. Exp. Med. 2001) 3 4 22 64
  3. Residues 21-30 within the extracellular N-terminal region of the C5a receptor represent a binding domain for the C5a anaphylatoxin. (PMID: 9553099) Chen Z. … Ni F. (J. Biol. Chem. 1998) 3 4 22 64
  4. Identification of the major phosphorylation sites in human C5a anaphylatoxin receptor in vivo. (PMID: 7642584) Giannini E. … Boulay F. (J. Biol. Chem. 1995) 3 4 22 64
  5. Human chemotaxis receptor genes cluster at 19q13.3-13.4. Characterization of the human C5a receptor gene. (PMID: 8383526) Gerard N.P. … Gerard C. (Biochemistry 1993) 3 4 22 64

Products for C5AR1 Gene

  • Addgene plasmids for C5AR1

Sources for C5AR1 Gene

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