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Aliases for C5AR1 Gene

Aliases for C5AR1 Gene

  • Complement Component 5a Receptor 1 2 3
  • C5a-R 3 4
  • C5R1 3 4
  • C5AR 3 4
  • Complement Component 5 Receptor 1 (C5a Ligand) 2
  • C5a Anaphylatoxin Chemotactic Receptor 4
  • Complement Component 5 Receptor 1 3
  • C5a Anaphylatoxin Receptor 3
  • CD88 Antigen 4
  • C5a Ligand 3
  • CD88 3
  • C5A 3

External Ids for C5AR1 Gene

Previous HGNC Symbols for C5AR1 Gene

  • C5R1

Previous GeneCards Identifiers for C5AR1 Gene

  • GC19P052505
  • GC19P047813
  • GC19P044237

Summaries for C5AR1 Gene

GeneCards Summary for C5AR1 Gene

C5AR1 (Complement Component 5a Receptor 1) is a Protein Coding gene. Diseases associated with C5AR1 include listeria meningitis and mast-cell sarcoma. Among its related pathways are Signaling by GPCR and Complement and coagulation cascades. GO annotations related to this gene include G-protein coupled receptor activity and complement component C5a binding. An important paralog of this gene is FPR2.

UniProtKB/Swiss-Prot for C5AR1 Gene

  • Receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a (PubMed:1847994, PubMed:8182049, PubMed:7622471, PubMed:9553099, PubMed:10636859, PubMed:15153520). The ligand interacts with at least two sites on the receptor: a high-affinity site on the extracellular N-terminus, and a second site in the transmembrane region which activates downstream signaling events (PubMed:8182049, PubMed:7622471, PubMed:9553099). Receptor activation stimulates chemotaxis, granule enzyme release, intracellular calcium release and superoxide anion production (PubMed:10636859, PubMed:15153520).

Tocris Summary for C5AR1 Gene

  • The complement system is a biochemical pathway involved in both innate and adaptive immune responses. There are four main functions of the complement system; lysis of microorganisms, promotion of phagocytosis, triggering inflammation and immune clearance.

Gene Wiki entry for C5AR1 Gene

No data available for Entrez Gene Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C5AR1 Gene

Genomics for C5AR1 Gene

Regulatory Elements for C5AR1 Gene

Genomic Location for C5AR1 Gene

Chromosome:
19
Start:
47,290,023 bp from pter
End:
47,322,070 bp from pter
Size:
32,048 bases
Orientation:
Plus strand

Genomic View for C5AR1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for C5AR1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C5AR1 Gene

Proteins for C5AR1 Gene

  • Protein details for C5AR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P21730-C5AR1_HUMAN
    Recommended name:
    C5a anaphylatoxin chemotactic receptor 1
    Protein Accession:
    P21730

    Protein attributes for C5AR1 Gene

    Size:
    350 amino acids
    Molecular mass:
    39336 Da
    Quaternary structure:
    • Homodimer. May also form higher-order oligmers (PubMed:12835319). Interacts (when phosphorylated) with ARRB1 and ARRB2; the interaction is associated with internalization of C5aR (PubMed:12464600). Interacts (via N-terminal domain) with S.aureus chemotaxis inhibitory protein (CHIPS); the interaction blocks the receptor and may thus inhibit the immune response (PubMed:15153520, PubMed:15542591, PubMed:21706042).

neXtProt entry for C5AR1 Gene

Proteomics data for C5AR1 Gene at MOPED

Post-translational modifications for C5AR1 Gene

  • Phosphorylated on serine residues in response to C5a binding, resulting in internalization of the receptor and short-term desensitization to the ligand. The key residues involved in this process are Ser-334 and Ser-338.
  • Sulfation plays a critical role in the association of C5aR with C5a, but no significant role in the ability of the receptor to transduce a signal and mobilize calcium in response to a small a small peptide agonist (PubMed:11342590). Sulfation at Tyr-14 is important for CHIPS binding (PubMed:21706042).
  • Glycosylation at Asn 5
  • Modification sites at PhosphoSitePlus

Other Protein References for C5AR1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for C5AR1 (Complement Component C5a R1)

No data available for DME Specific Peptides for C5AR1 Gene

Domains & Families for C5AR1 Gene

Suggested Antigen Peptide Sequences for C5AR1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P21730

UniProtKB/Swiss-Prot:

C5AR1_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with C5AR1: view

Function for C5AR1 Gene

Molecular function for C5AR1 Gene

UniProtKB/Swiss-Prot Function:
Receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a (PubMed:1847994, PubMed:8182049, PubMed:7622471, PubMed:9553099, PubMed:10636859, PubMed:15153520). The ligand interacts with at least two sites on the receptor: a high-affinity site on the extracellular N-terminus, and a second site in the transmembrane region which activates downstream signaling events (PubMed:8182049, PubMed:7622471, PubMed:9553099). Receptor activation stimulates chemotaxis, granule enzyme release, intracellular calcium release and superoxide anion production (PubMed:10636859, PubMed:15153520).

Gene Ontology (GO) - Molecular Function for C5AR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001856 complement component C5a binding IEA --
GO:0004878 complement component C5a receptor activity IDA 22496247
GO:0004930 G-protein coupled receptor activity --
GO:0004944 C5a anaphylatoxin receptor activity IDA 22496247
genes like me logo Genes that share ontologies with C5AR1: view
genes like me logo Genes that share phenotypes with C5AR1: view

Animal Models for C5AR1 Gene

MGI Knock Outs for C5AR1:

Animal Model Products

CRISPR Products

miRNA for C5AR1 Gene

miRTarBase miRNAs that target C5AR1

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for C5AR1

Clone Products

  • Addgene plasmids for C5AR1
  • R&D Systems cDNA Clones for C5AR1 (Complement Component C5a R1)

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for C5AR1 Gene

Localization for C5AR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for C5AR1 Gene

Cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle. Note=Phosphorylated C5aR colocalizes with ARRB1 and ARRB2 in cytoplasmic vesicles. {ECO:0000269 PubMed:12464600}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for C5AR1 Gene COMPARTMENTS Subcellular localization image for C5AR1 gene
Compartment Confidence
plasma membrane 5
cytosol 4
cytoskeleton 1
extracellular 1
nucleus 1

Gene Ontology (GO) - Cellular Components for C5AR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS 8702752
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 2007135
GO:0009986 cell surface IEA --
GO:0016021 integral component of membrane --
genes like me logo Genes that share ontologies with C5AR1: view

Pathways & Interactions for C5AR1 Gene

genes like me logo Genes that share pathways with C5AR1: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Innate & Adaptive Immune Responses in human,mouse,rat
    • G Protein Coupled Receptors 384HT in human,mouse,rat

SIGNOR curated interactions for C5AR1 Gene

Is inactivated by:

Gene Ontology (GO) - Biological Process for C5AR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000187 activation of MAPK activity TAS 7649993
GO:0002430 complement receptor mediated signaling pathway --
GO:0006915 apoptotic process IEA --
GO:0006935 chemotaxis TAS 10352266
GO:0006954 inflammatory response IEA --
genes like me logo Genes that share ontologies with C5AR1: view

Drugs & Compounds for C5AR1 Gene

(43) Drugs for C5AR1 Gene - From: NovoSeek, IUPHAR, DGIdb, and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Ethanol Approved Pharma 1708
Fluorescein Approved Pharma 104
Heparin Approved, Investigational Pharma Antagonist 672,226
Nitric Oxide Approved Pharma 540
Prednisolone Approved Pharma Agonist 1033

(50) Additional Compounds for C5AR1 Gene - From: NovoSeek and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Compstatin
206645-99-0
Compstatin control peptide
301544-78-5
NDT 9513727
439571-48-9
PMX 205
514814-49-4
PMX 53
219639-75-5
genes like me logo Genes that share compounds with C5AR1: view

Transcripts for C5AR1 Gene

mRNA/cDNA for C5AR1 Gene

(3) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for C5AR1 Gene

Complement component 5a receptor 1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for C5AR1

Clone Products

  • Addgene plasmids for C5AR1
  • R&D Systems cDNA Clones for C5AR1 (Complement Component C5a R1)

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for C5AR1 Gene

No ASD Table

Relevant External Links for C5AR1 Gene

GeneLoc Exon Structure for
C5AR1
ECgene alternative splicing isoforms for
C5AR1

Expression for C5AR1 Gene

mRNA expression in normal human tissues for C5AR1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for C5AR1 Gene

This gene is overexpressed in Whole Blood (x31.7).

Protein differential expression in normal tissues from HIPED for C5AR1 Gene

This gene is overexpressed in Nasal epithelium (56.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for C5AR1 Gene



SOURCE GeneReport for Unigene cluster for C5AR1 Gene Hs.2161

genes like me logo Genes that share expression patterns with C5AR1: view

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for C5AR1 Gene

Orthologs for C5AR1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C5AR1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia C5AR1 35
  • 77.08 (n)
  • 71.92 (a)
C5AR1 36
  • 71 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C5AR1 35
  • 75.74 (n)
  • 69.63 (a)
C5AR1 36
  • 63 (a)
OneToOne
mouse
(Mus musculus)
Mammalia C5ar1 35
  • 73.37 (n)
  • 68.05 (a)
C5ar1 16
C5ar1 36
  • 66 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia C5AR1 35
  • 98.86 (n)
  • 97.71 (a)
C5AR1 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia C5ar1 35
  • 72.01 (n)
  • 69.44 (a)
oppossum
(Monodelphis domestica)
Mammalia C5AR1 36
  • 49 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia C5AR1 36
  • 54 (a)
OneToOne
chicken
(Gallus gallus)
Aves C5AR1 35
  • 53.95 (n)
  • 39.64 (a)
C5AR1 36
  • 36 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia C5AR1 36
  • 41 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia c5ar1 35
  • 51.35 (n)
  • 45.65 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5490 35
zebrafish
(Danio rerio)
Actinopterygii C5AR1 36
  • 37 (a)
OneToOne
Species with no ortholog for C5AR1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C5AR1 Gene

ENSEMBL:
Gene Tree for C5AR1 (if available)
TreeFam:
Gene Tree for C5AR1 (if available)

Paralogs for C5AR1 Gene

(23) SIMAP similar genes for C5AR1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with C5AR1: view

Variants for C5AR1 Gene

Sequence variations from dbSNP and Humsavar for C5AR1 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs4077259 -- 47,317,517(+) aaaaa(A/T)aaaTA intron-variant
rs4287683 -- 47,306,414(+) CACAG(A/G/T)CACGT upstream-variant-2KB
rs4337400 -- 47,317,537(+) ATATA(C/G)TGGTT intron-variant
rs4427917 -- 47,312,458(+) ACTGA(C/G)TGAAT intron-variant
rs4462712 -- 47,319,354(+) CCTAA(A/G)CTGGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for C5AR1 Gene

Variant ID Type Subtype PubMed ID
nsv912200 CNV Loss 21882294

Variation tolerance for C5AR1 Gene

Residual Variation Intolerance Score: 46.65% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.85; 17.68% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C5AR1 Gene

HapMap Linkage Disequilibrium report
C5AR1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C5AR1 Gene

Disorders for C5AR1 Gene

MalaCards: The human disease database

(3) MalaCards diseases for C5AR1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
listeria meningitis
  • meningitis, listeria
mast-cell sarcoma
  • mast cell sarcoma
malaria
  • malaria, severe
- elite association
Search C5AR1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for C5AR1

Genetic Association Database (GAD)
C5AR1
Human Genome Epidemiology (HuGE) Navigator
C5AR1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
C5AR1
genes like me logo Genes that share disorders with C5AR1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for C5AR1 Gene

Publications for C5AR1 Gene

  1. Mapping of genes for the human C5a receptor (C5AR), human FMLP receptor (FPR), and two FMLP receptor homologue orphan receptors (FPRH1, FPRH2) to chromosome 19. (PMID: 1612600) Bao L. … Gerard C. (Genomics 1992) 2 23 67
  2. The role of the complement system and the activation fragment C5a in the central nervous system. (PMID: 19763906) Woodruff T.M. … Taylor S.M. (Neuromolecular Med. 2010) 23 67
  3. The C5a receptor (C5aR) C5L2 is a modulator of C5aR-mediated signal transduction. (PMID: 20044484) Bamberg C.E. … Gerard N.P. (J. Biol. Chem. 2010) 23 67
  4. Factors involved in the progress of preclinical atherosclerosis associated with systemic lupus erythematosus: a 2-year longitudinal study. (PMID: 19687018) Rua-Figueroa I. … RodrA-guez-Lozano C. (Ann. Rheum. Dis. 2010) 23 67
  5. Early expression changes of complement regulatory proteins and C5A receptor (CD88) on leukocytes after multiple injury in humans. (PMID: 19864971) Amara U. … Huber-Lang M. (Shock 2010) 23 67

Products for C5AR1 Gene

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Antifungal Response in human,mouse,rat
    • Cell Surface Markers in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate C5AR1
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for C5AR1
    • Block miRNA regulation of C5AR1 using miScript Target Protectors

    Sources for C5AR1 Gene

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