C5AR1 Gene
protein-coding GIFtS: 59
GCID: GC19P047813
|
|
complement component 5a receptor 1(Previous name: complement component 5 receptor 1 (C5a ligand) )
(Previous symbol: C5R1)
| |
Aliases
for C5AR1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Complement Component 5a Receptor 11 2 | | C5a Anaphylatoxin Chemotactic Receptor2 | | C5AR1 2 3 5 | | C5a Anaphylatoxin Receptor2 | | C5R11 2 3 5 | | C5a Ligand2 | | C5A1 2 | | Complement Component 5 Receptor 12 | | CD881 2 | | C5aR3 | | C5a-R2 3 | | CD88 Antigen3 | | Complement Component 5 Receptor 1 (C5a Ligand)1 | | |
Export aliases for C5AR1 gene to outside databasesPrevious GC identifers: GC19P052505 GC19P044237 |
Summaries
for C5AR1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: C5AR_HUMAN, P21730Function: Receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a. This receptor stimulates chemotaxis,granule enzyme release and superoxide anion production
 summary
for C5AR1: The complement system is a biochemical pathway involved in both innate and adaptive immune responses. There
are four main functions of the complement system; lysis of microorganisms, promotion of phagocytosis,
triggering inflammation and immune clearance. There are three pathways that can activate the complement
system; the classical complement pathway (in response to IgG- or IgM-antigen complexes), the alternative
complement pathway (spontaneous activation) and the mannose-binding lectin pathway (in response to lectin
residues on pathogen cell surface membranes). All three pathway generate variants of C3 convertase, which
cleaves C3 into C3a and C3b. C3a and C3b activate a series of further cleavage events that activates the
complement cascade. This leads to immune defence responses such as degranulation of mast cells, increasing
vascular permeability and initiation of the membrane attack pathway. Deregulation of the complement system
would be extremely damaging to the host, so it is tightly regulated by complement control proteins. These
regulatory proteins are found in much higher concentrations that complement proteins themselves and prevent
complement system activation in 'self' tissues. The complement system has been implicated in many autoimmune
disorders, including systemic lupus erythematosus, multiple sclerosis and arthritis, and more recently has
been suggested to have a pathophysiological role in Alzheimer's and other neurodegenerative disorders.
Gene Wiki entry for C5AR1 (C5a receptor)
|
Genomic Views
for C5AR1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000019.9 NC_018930.1 NT_011109.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the C5AR1 gene promoter:
AhR CREB deltaCREB NF-kappaB NF-kappaB1
Other transcription factors
Search SABiosciences Chromatin IP Primers for C5AR1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C5AR1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19q13.3-q13.4 Ensembl cytogenetic band: 19q13.32 HGNC cytogenetic band: 19q13.3-q13.4C5AR1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19P047813: view genomic region
(about GC identifiers)
Start:
|
47,813,104 bp from pter |
End:
|
47,825,327 bp from pter |
Size:
|
12,224 bases |
Orientation:
|
plus strand |
|
Proteins
for C5AR1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: C5AR_HUMAN, P21730 (See
protein sequence)Recommended Name: C5a anaphylatoxin chemotactic receptor Size: 350 amino acids; 39336 Da
Subunit: Interacts with ARRB1 and ARRB2 (By similarity)
Subcellular location: Cell membrane; Multi-pass membrane proteinExplore the universe of human proteins at neXtProt for C5AR1: NX_P21730
Post-translational modifications:
Sulfation plays a critical role in the association of the receptor with C5a, but no significant role in the ability ofthe receptor to transduce a signal and mobilize calcium in response to a small peptide agonist1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P21730
C5AR1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001727.1
ENSEMBL proteins: ENSP00000347197 Reactome Protein details: P21730
Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
C5AR1 for ontologies About GeneDecksing
C5AR1 Antibody Products:
Assay Products for C5AR1: |
Protein
Domains /
Families
for C5AR1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
C5AR1 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P21730ProtoNet protein and cluster: P21730 2 Blocks protein families: IPB001274 C5A-anaphylatoxin receptor signature IPB002234 Anaphylatoxin chemotactic receptor signature
UniProtKB/Swiss-Prot: C5AR_HUMAN, P21730Similarity: Belongs to the G-protein coupled receptor 1 family |
Function
for C5AR1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: C5AR_HUMAN, P21730Function: Receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a. This receptor stimulates chemotaxis,granule enzyme release and superoxide anion production
Clone
Products: |  | EMD Millipore Clones for the Expression of C5AR1 | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for C5AR1 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for C5AR1 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: C5AR1 (NM_001736) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for C5AR1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C5AR1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C5AR1 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0001856 | complement component C5a binding |
IEA | -- | | GO:0004944 | C5a anaphylatoxin receptor activity |
IEA | -- |
C5AR1 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for C5AR1:
Animal Models:
Mouse knock-outs for C5AR1: C5ar1tm1Raw C5ar1tm1Cge
6 MGI mutant phenotypes (inferred from 3 alleles ) (MGI details for C5ar1):
C5AR1 for phenotypes About GeneDecksing
|
Pathways & Interactions
for C5AR1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/8 super-pathways (see all 8) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Class A/1 (Rhodopsin-like receptors) | | | 2 | Immune response_Alternative complement pathway | | | 3 | Signaling by GPCR | | | 4 | Immune response_Classical complement pathway | | | 5 | Neuropeptides signaling through G-protein alpha-i & G-protein alpha-q | |
Pathway sources
See GeneCards unified pathways
Show all pathways
5 EMD Millipore Pathways for C5AR1
3  GeneGo (Thomson Reuters) Pathways for C5AR1
2  BioSystems Pathways for C5AR1
5/7 
Reactome Pathways for C5AR1 (see all 7)
3 
Kegg Pathways (Kegg details for C5AR1):
C5AR1 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for C5AR1
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/150 Interacting proteins for C5AR1 (P217303 ENSP000003471974) via UniProtKB, MINT, STRING, and/or I2D (see all 150)About this table
Gene Ontology (GO): 5/18 biological process terms (GO ID links to tree view) (see all 18): About this table
C5AR1 for ontologies About GeneDecksing
|
Drugs & Compounds
for C5AR1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
C5AR1 for compounds About GeneDecksing
Compounds for C5AR1 available from Tocris Bioscience About this table
| Compound | Action |
CAS
# |
|---|
| NDT 9513727 | Potent, selective human C5a receptor antagonist | [439571-48-9] |
1 HMDB Compound for C5AR1 About this table
10/70 Novoseek chemical compound relationships for C5AR1 gene (see all 70) About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| anaphylatoxin |
97.5 |
176 |
1732540 (4), 10508278 (3), 9218605 (3), 7556629 (3) (see all 96) |
| fmlp |
83.7 |
114 |
9036983 (5), 8699129 (5), 17724165 (5), 2159036 (4) (see all 58) |
| fmlpl |
82 |
5 |
1564402 (3), 2161893 (1), 2295813 (1) |
| leukotriene b4 |
72.6 |
52 |
12141728 (4), 7722425 (3), 1966131 (3), 8683135 (2) (see all 30) |
| n-formylmethionyl-leucylphenylalanine |
70.4 |
15 |
7722425 (2), 1722562 (1), 8699129 (1), 9358848 (1) (see all 14) |
| rantes |
50.1 |
16 |
9426639 (4), 1281207 (3), 7542307 (3), 9036983 (2) (see all 7) |
| calcium |
49 |
62 |
2159036 (4), 8223566 (3), 1472004 (2), 11342590 (2) (see all 35) |
| superoxide |
44.1 |
12 |
1966131 (2), 2159036 (1), 7722425 (1), 1850304 (1) (see all 8) |
| histamine |
42.5 |
23 |
7513741 (6), 12527821 (3), 11799375 (2), 17389757 (1) (see all 12) |
| pertussis |
41.9 |
4 |
10233875 (1), 16879222 (1), 10706729 (1), 9838061 (1) |
Search CenterWatch for drugs/clinical trials and news about C5AR1 / C5AR
|
Transcripts
for C5AR1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for C5AR1 gene: NM_001736.3 Unigene Cluster for C5AR1: Complement component 5a receptor 1 Hs.2161 [show with all ESTs]Unigene Representative Sequence: NM_0017361 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000355085(uc002pgj.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for C5AR1 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for C5AR1 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: C5AR1 (NM_001736) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for C5AR1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C5AR1 |
Additional cDNA sequence: BC008982.1 BT007358.1 M62505.1 X57250.1 3 DOTS entries: DT.95263655 DT.100877901 DT.92062932 1 AceView cDNA sequence: BF901094
GeneLoc Exon Structure
|
Expression
for C5AR1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| C5AR1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See C5AR1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for C5AR1
SOURCE GeneReport for Unigene cluster: Hs.2161
SABiosciences Expression via Pathway-Focused PCR Arrays including C5AR1: | Innate & Adaptive Immune Responses in human mouse rat | | G Protein Coupled Receptors 384HT in human mouse rat | | Cell Surface Markers in human mouse rat | | Antifungal Response in human mouse rat | | Chemokines & Receptors in human mouse rat |
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for C5AR1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat C5AR1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat C5AR1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat C5AR1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C5AR1 |
Orthologs
for C5AR1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for C5AR1 gene from 3/9 species (see all 9) About this table
ENSEMBL Gene Tree for C5AR1 (if available)
TreeFam Gene Tree for C5AR1 (if available) |
Paralogs
for C5AR1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for C5AR1 gene
- LTB4R2 LTB4R22 FPR32 FPR12 GPR322 GPR1522 FPR22 C5AR22
- C3AR12 PTGDR22 GPR12 CMKLR12
18/22 SIMAP similar genes for C5AR1 using alignment to 2 protein entries: C5AR_HUMAN (see all proteins)
(see all similar genes):CCR5 GPR77 FPR2 GPR1 GPR18 CMKLR1
FPR1 CCR3 FPR3 FPRL2 GPR33 CCR1
CCR7 PTGDR2 gpcr AGTR1 CXCR1 CXCR2
C5AR1 for paralogs About GeneDecksing
|
Genomic Variants
for C5AR1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 19 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for C5AR1 (47813104 - 47825327 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for C5AR1: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing C5AR1 |
|
Disorders
/ Diseases
for C5AR1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
C5AR1 for disorders About GeneDecksing
OMIM gene information: 113995
OMIM disorders: --
20/74  diseases for C5AR1 (see all 74): About MalaCardssystemic lupus erythematosus lupus erythematosus complement component 5 deficiency arthritis
hypersensitivity reaction type ii disease age related macular degeneration adult respiratory distress syndrome mast-cell sarcoma
wiskott-aldrich syndrome lichen planus familial mediterranean fever severe congenital neutropenia
non-hodgkin lymphoma hypereosinophilic syndrome macular degeneration lupus nephritis
chronic obstructive pulmonary disease complement deficiency leukostasis multiple sclerosis
10 diseases from the University of Copenhagen DISEASES database for C5AR1:Adult respiratory distress syndrome Leukopenia Urticaria Asthma
Hypersensitivity reaction type III disease Complement deficiency Hypersensitivity reaction type II disease Peritonitis
Arthritis Leukostasis 10/52 Novoseek disease relationships for C5AR1 gene (see all 52) About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| leukemia basophilic |
56.6 |
4 |
7957584 (2), 7622471 (1), 10195437 (1) |
| inflammation |
54.6 |
37 |
17965442 (2), 1489124 (1), 7541417 (1), 10706689 (1) (see all 26) |
| immune complex diseases |
35.8 |
2 |
12869020 (1), 10395696 (1) |
| necrosis |
31.5 |
22 |
16499574 (2), 7978476 (2), 1489124 (1), 8391001 (1) (see all 19) |
| shock septic |
28 |
4 |
12225614 (2), 1847994 (1), 10927032 (1) |
| sepsis |
22.6 |
44 |
14676676 (5), 12225614 (4), 12960283 (3), 18848819 (3) (see all 9) |
| neutropenia |
20.5 |
6 |
19285573 (2), 10188960 (1), 1751793 (1), 10927032 (1) (see all 5) |
| hypereosinophilic syndrome |
18 |
2 |
2040692 (1), 7705383 (1) |
| intestinal ischemia |
17.8 |
2 |
10395696 (1), 15159277 (1) |
| drusen |
13.7 |
3 |
16452172 (2) |
Human Genome Epidemiology (HuGE) Navigator: C5AR1 (12 documents)
Export disorders for C5AR1 gene to outside databases
|
Publications
for C5AR1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for C5AR1 gene, integrated from 9 sources (see all 492):
(articles sorted by number of sources associating them with C5AR1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Sulfated tyrosines contribute to the formation of the c5a docking site of the human c5a anaphylatoxin receptor. (PubMed id 11342590)1, 2, 9 Farzan M.... Choe H. (2001)
- Identification of the major phosphorylation sites in human C5a anaphylatoxin receptor in vivo. (PubMed id 7642584)1, 2, 9 Giannini E.... Boulay F. (1995)
- Mapping of genes for the human C5a receptor (C5AR), human FMLP receptor (FPR), and two FMLP receptor homologue orphan receptors (FPRH1, FPRH2) to chromosome 19. (PubMed id 1612600)1, 3, 9 Bao L.... Gerard C. (1992)
- Human chemotaxis receptor genes cluster at 19q13.3-13.4. Characterization of the human C5a receptor gene. (PubMed id 8383526)1, 2, 9 Gerard N.P....Gerard C. (1993)
- The chemotactic receptor for human C5a anaphylatoxin. (PubMed id 1847994)1, 2, 9 Gerard N.P. and Gerard C. (1991)
- Expression cloning of a receptor for C5a anaphylatoxin on differentiated HL-60 cells. (PubMed id 2007135)1, 2, 9 Boulay F.... Vignais P. (1991)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Residues 21-30 within the extracellular N-terminal region of the C5a receptor represent a binding domain for the C5a anaphylatoxin. (PubMed id 9553099)1, 9 Chen Z....Ni F. (1998)
- C5a mutants are potent antagonists of the C5a receptor (CD88) and of C5L2: position 69 is the locus that determines agonism or antagonism. (PubMed id 14570896)1, 9 Otto M....Kohl J. (2004)
- Mapping the ligand-binding site on the C5a receptor: arginine74 of C5a contacts aspartate282 of the C5a receptor. (PubMed id 11705397)1, 9 Cain S.A....Monk P.N. (2001)
|
External Searches for C5AR1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing C5AR1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing C5AR1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing C5AR1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for C5AR1 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for C5AR1 gene:
Search GeneIP for patents involving C5AR1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for C5AR1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for C5AR1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for C5AR1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for C5AR1 | | | OriGene Protein Over-expression Lysate for C5AR1 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for C5AR1 | | OriGene 3'-UTR Clone for C5AR1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for C5AR1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for C5AR1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for C5AR1 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for C5AR1 | | OriGene Custom Protein Services for C5AR1 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat C5AR1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing C5AR1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C5AR1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat C5AR1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat C5AR1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat C5AR1 |
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| | | | Tocris compounds for C5AR1 |
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 | | | C5AR1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C5AR1 |
|  |  |  | | | | ThermoFisher Antibodies for C5AR1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C5AR1 |
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