Free for academic non-profit institutions. Other users need a Commercial license

Aliases for C5 Gene

Aliases for C5 Gene

  • Complement Component 5 2 3
  • C3 And PZP-Like Alpha-2-Macroglobulin Domain-Containing Protein 4 3 4
  • C5a Anaphylatoxin 2 3
  • Prepro-C5 2 3
  • CPAMD4 3 4
  • Anaphylatoxin C5a Analog 3
  • Complement C5 3
  • ECLZB 3
  • C5A 3
  • C5D 3
  • C5b 3

External Ids for C5 Gene

Summaries for C5 Gene

Entrez Gene Summary for C5 Gene

  • The protein encoded by this gene is the fifth component of complement, which plays an important role in inflammatory and cell killing processes. This protein is comprised of alpha and beta polypeptide chains that are linked by a disulfide bridge. An activation peptide, C5a, which is an anaphylatoxin that possesses potent spasmogenic and chemotactic activity, is derived from the alpha polypeptide via cleavage with a convertase. The C5b macromolecular cleavage product can form a complex with the C6 complement component, and this complex is the basis for formation of the membrane attack complex, which includes additional complement components. Mutations in this gene cause complement component 5 deficiency, a disease where patients show a propensity for severe recurrent infections. Defects in this gene have also been linked to a susceptibility to liver fibrosis and to rheumatoid arthritis. [provided by RefSeq, Jul 2008]

GeneCards Summary for C5 Gene

C5 (Complement Component 5) is a Protein Coding gene. Diseases associated with C5 include c5 deficiency and rapidly progressive glomerulonephritis. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include receptor binding and endopeptidase inhibitor activity. An important paralog of this gene is CD109.

UniProtKB/Swiss-Prot for C5 Gene

  • Activation of C5 by a C5 convertase initiates the spontaneous assembly of the late complement components, C5-C9, into the membrane attack complex. C5b has a transient binding site for C6. The C5b-C6 complex is the foundation upon which the lytic complex is assembled

  • Derived from proteolytic degradation of complement C5, C5 anaphylatoxin is a mediator of local inflammatory process. Binding to the receptor C5AR1 induces a variety of responses including intracellular calcium release, contraction of smooth muscle, increased vascular permeability, and histamine release from mast cells and basophilic leukocytes (PubMed:8182049). C5a is also a potent chemokine which stimulates the locomotion of polymorphonuclear leukocytes and directs their migration toward sites of inflammation.

Gene Wiki entry for C5 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C5 Gene

Genomics for C5 Gene

Genomic Location for C5 Gene

Start:
120,952,335 bp from pter
End:
121,050,276 bp from pter
Size:
97,942 bases
Orientation:
Minus strand

Genomic View for C5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for C5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C5 Gene

Proteins for C5 Gene

  • Protein details for C5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P01031-CO5_HUMAN
    Recommended name:
    Complement C5
    Protein Accession:
    P01031
    Secondary Accessions:
    • Q14CJ0
    • Q27I61

    Protein attributes for C5 Gene

    Size:
    1676 amino acids
    Molecular mass:
    188305 Da
    Quaternary structure:
    • C5 precursor is first processed by the removal of 4 basic residues, forming two chains, beta and alpha, linked by a disulfide bond. C5 convertase activates C5 by cleaving the alpha chain, releasing C5a anaphylatoxin and generating C5b (beta chain + alpha chain). The C5a anaphylatoxin interacts with C5AR1. Interacts with tick complement inhibitor.

    Three dimensional structures from OCA and Proteopedia for C5 Gene

neXtProt entry for C5 Gene

Proteomics data for C5 Gene at MOPED

Post-translational modifications for C5 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys1305
  • Glycosylation at Asn741, Asn911, Asn1115, and Asn1630

Other Protein References for C5 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for C5 Gene

Domains for C5 Gene

Gene Families for C5 Gene

HGNC:

UniProtKB/Swiss-Prot:

CO5_HUMAN
Domain:
  • Contains 1 anaphylatoxin-like domain.:
    • P01031
  • Contains 1 NTR domain.:
    • P01031
genes like me logo Genes that share domains with C5: view

Function for C5 Gene

Molecular function for C5 Gene

GENATLAS Biochemistry: complement component 5,glycoprotein,180kDa,initiating after activation the assembly of the late complement components C5-C9,into the membrane attack complex
UniProtKB/Swiss-Prot Function: Activation of C5 by a C5 convertase initiates the spontaneous assembly of the late complement components, C5-C9, into the membrane attack complex. C5b has a transient binding site for C6. The C5b-C6 complex is the foundation upon which the lytic complex is assembled
UniProtKB/Swiss-Prot Function: Derived from proteolytic degradation of complement C5, C5 anaphylatoxin is a mediator of local inflammatory process. Binding to the receptor C5AR1 induces a variety of responses including intracellular calcium release, contraction of smooth muscle, increased vascular permeability, and histamine release from mast cells and basophilic leukocytes (PubMed:8182049). C5a is also a potent chemokine which stimulates the locomotion of polymorphonuclear leukocytes and directs their migration toward sites of inflammation.

Gene Ontology (GO) - Molecular Function for C5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004866 endopeptidase inhibitor activity IEA --
GO:0005102 receptor binding TAS 10820279
GO:0005515 protein binding IPI 21217642
GO:0008009 chemokine activity TAS 10820279
GO:0031714 C5a anaphylatoxin chemotactic receptor binding IEA --
genes like me logo Genes that share ontologies with C5: view
genes like me logo Genes that share phenotypes with C5: view

miRNA for C5 Gene

miRTarBase miRNAs that target C5

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for C5 Gene

Localization for C5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for C5 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for C5 Gene COMPARTMENTS Subcellular localization image for C5 gene
Compartment Confidence
extracellular 5
plasma membrane 3
endoplasmic reticulum 2
cytoskeleton 1
cytosol 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for C5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005579 membrane attack complex IEA --
GO:0005615 extracellular space IEA --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with C5: view

Pathways for C5 Gene

genes like me logo Genes that share pathways with C5: view

Gene Ontology (GO) - Biological Process for C5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000187 activation of MAPK activity TAS 7649993
GO:0001701 in utero embryonic development IEA --
GO:0002523 leukocyte migration involved in inflammatory response IEA --
GO:0006874 cellular calcium ion homeostasis IEA --
GO:0006935 chemotaxis TAS 10820279
genes like me logo Genes that share ontologies with C5: view

Compounds for C5 Gene

(2) Drugbank Compounds for C5 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Eculizumab
219685-50-4 target antibody
Intravenous Immunoglobulin
  • Ig alpha-2 chain C region
9007-83-4 target binder

(3) Novoseek inferred chemical compound relationships for C5 Gene

Compound -log(P) Hits PubMed IDs
anaphylatoxin 81.7 2
chloramine t 65.8 5
methionine 21.6 5

(1) PharmGKB related drug/compound annotations for C5 Gene

Drug/compound Annotation
eculizumab CA
genes like me logo Genes that share compounds with C5: view

Transcripts for C5 Gene

Unigene Clusters for C5 Gene

Complement component 5:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for C5 Gene

No ASD Table

Relevant External Links for C5 Gene

GeneLoc Exon Structure for
C5
ECgene alternative splicing isoforms for
C5

Expression for C5 Gene

mRNA expression in normal human tissues for C5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for C5 Gene

This gene is overexpressed in Liver (33.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for C5 Gene

SOURCE GeneReport for Unigene cluster for C5 Gene Hs.494997

genes like me logo Genes that share expressions with C5: view

Orthologs for C5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C5 36
  • 99.48 (n)
  • 99.28 (a)
C5 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia C5 36
  • 85.14 (n)
  • 81.71 (a)
C5 37
  • 80 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C5 36
  • 79.87 (n)
  • 78.23 (a)
C5 37
  • 78 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Hc 36
  • 81.13 (n)
  • 77.91 (a)
Hc 16
Hc 37
  • 78 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia C5 37
  • 66 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia C5 37
  • 63 (a)
OneToOne
chicken
(Gallus gallus)
Aves C5 36
  • 63.65 (n)
  • 55.58 (a)
C5 37
  • 55 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia c5 36
  • 55.34 (n)
  • 47.68 (a)
zebrafish
(Danio rerio)
Actinopterygii c5 36
  • 51.05 (n)
  • 40.27 (a)
c5 37
  • 38 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 20 (a)
ManyToMany
CSA.4097 37
  • 20 (a)
ManyToMany
Species with no ortholog for C5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C5 Gene

ENSEMBL:
Gene Tree for C5 (if available)
TreeFam:
Gene Tree for C5 (if available)

Paralogs for C5 Gene

Paralogs for C5 Gene

Selected SIMAP similar genes for C5 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with C5: view

Variants for C5 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for C5 Gene

P01031-CO5_HUMAN
C5 variants are responsible for poor response to eculizumab [MIM:615749]. Eculizumab is a monoclonal antibody highly effective in reducing intravascular hemolysis in patients with paroxysmal nocturnal hemoglobinuria. It specifically binds to the terminal complement protein C5, inhibits its cleavage into C5a and C5b, and prevents the formations of the cytolytic complement pore

Sequence variations from dbSNP and Humsavar for C5 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs17609 - 120,989,119(-) TAGGG(A/T)TGTTG reference, missense
rs17610 - 120,974,867(-) CTTGA(A/G)TATGG missense, reference
rs17611 - 121,006,922(-) AAGGC(A/G)TTGGC missense, reference
rs17612 - 120,963,648(-) GAAGA(A/C)GACTT reference, missense
rs25681 -- 121,017,727(-) TATTA(C/T)ATCGT reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for C5 Gene

Variant ID Type Subtype PubMed ID
dgv2419e1 CNV Complex 17122850
nsv893810 CNV Gain 21882294
nsv507529 CNV Insertion 20534489
nsv893811 CNV Gain 21882294
nsv893812 CNV Loss 21882294

Relevant External Links for C5 Gene

HapMap Linkage Disequilibrium report
C5
Human Gene Mutation Database (HGMD)
C5
Locus Specific Mutation Databases (LSDB)
C5

Disorders for C5 Gene

(1) OMIM Diseases for C5 Gene (120900)

UniProtKB/Swiss-Prot

CO5_HUMAN
  • Complement component 5 deficiency (C5D) [MIM:609536]: A rare defect of the complement classical pathway associated with susceptibility to severe recurrent infections, predominantly by Neisseria gonorrhoeae or Neisseria meningitidis. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Note=An association study of C5 haplotypes and genotypes in individuals with chronic hepatitis C virus infection shows that individuals homozygous for the C5_1 haplotype have a significantly higher stage of liver fibrosis than individuals carrying at least 1 other allele. {ECO:0000269 PubMed:15995705}.

(1) University of Copenhagen DISEASES for C5 Gene

Genatlas disease for C5 Gene

neisserial recurrent infections,lupus systemic syndrome

Relevant External Links for C5

Genetic Association Database (GAD)
C5
Human Genome Epidemiology (HuGE) Navigator
C5
genes like me logo Genes that share disorders with C5: view

Publications for C5 Gene

  1. Variations in the C3, C3a receptor, and C5 genes affect susceptibility to bronchial asthma. (PMID: 15278436) Hasegawa K. … Suzuki Y. (Hum. Genet. 2004) 3 23 49
  2. rC5a directs the in vitro migration of human memory and naive tonsillar B lymphocytes: implications for B cell trafficking in secondary lymphoid tissues. (PMID: 10352266) Ottonello L. … Dallegri F. (J. Immunol. 1999) 3 23
  3. Complete cDNA sequence of human complement pro-C5. Evidence of truncated transcripts derived from a single copy gene. (PMID: 1984448) Haviland D.L. … Wetsel R.A. (J. Immunol. 1991) 3 4
  4. Group B streptococci inactivate complement component C5a by enzymic cleavage at the C-terminus. (PMID: 1996961) Bohnsack J.F. … Hill H.R. (Biochem. J. 1991) 3 4
  5. Isolation and sequence analysis of a cDNA clone encoding the fifth complement component. (PMID: 2579066) Lundwall A.B. … Tack B.F. (J. Biol. Chem. 1985) 3 4

Products for C5 Gene

Sources for C5 Gene

Back to Top

Content