C4orf6 Gene
protein-coding GIFtS: 39
GCID: GC04P005591
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chromosome 4 open reading frame 6
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Aliases
for C4orf6 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA
Quality score for the ORGUL clustered with this gene is 3
| Aliases |
|---|
| Chromosome 4 Open Reading Frame 61 2 | | AC13 | | Expressed In Neuroblastoma2 | | Uncharacterized Protein C4orf62 | | AC13 | | Protein AC13 |
| External Ids: | HGNC: 137161 | Entrez Gene: 101412 | Ensembl: ENSG000000829297 | UniProtKB: Q994403 | | ORGUL members: | |
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| NONCODE:n339823 | |
Export aliases for C4orf6 gene to outside databasesPrevious GC identifers: GC04P005404 GC04P005573 GC04P005644
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Summaries
for C4orf6 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for C4orf6:
This gene is expressed in neuroblastoma; however, the function of this gene is not yet determined. (provided by RefSeq,Jul 2008)
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Genomic Views
for C4orf6 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000004.11 NC_018915.1 NT_006051.18
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for C4orf6
Other transcription factors
Search SABiosciences Chromatin IP Primers for C4orf6
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C4orf6 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 4p16.2 Ensembl cytogenetic band: 4p16.2 HGNC cytogenetic band: 4p16C4orf6 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 4 GeneLoc Exon Structure GeneLoc location for GC04P005591: view genomic region
(about GC identifiers)
Start:
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5,526,296 bp from pter |
End:
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5,529,528 bp from pter |
Size:
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3,233 bases |
Orientation:
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plus strand |
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Proteins
for C4orf6 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CD006_HUMAN, Q99440 (See
protein sequence)Recommended Name: Uncharacterized protein C4orf6 Size: 93 amino acids; 10499 Da
Secondary accessions: Q17R65Explore the universe of human proteins at neXtProt for C4orf6: NX_Q99440
C4orf6 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_005741.1
ENSEMBL proteins: ENSP00000195455 ENSP00000424193
Human Recombinant Protein Products:
C4orf6 Antibody Products:
Assay Products for C4orf6: |
Protein
Domains /
Families
for C4orf6 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| ProtoNet protein and cluster: Q99440 |
Function
for C4orf6 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for C4orf6
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for C4orf6
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: C4orf6 (NM_005750) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for C4orf6 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C4orf6 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C4orf6 |
|
Pathways & Interactions
for C4orf6 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for C4orf6
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0007399 | nervous system development |
TAS | 9016955 |
C4orf6 for ontologies About GeneDecksing
|
Drugs & Compounds
for C4orf6 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for C4orf6
Search CenterWatch for drugs/clinical trials and news about C4orf6 / CD006
|
Transcripts
for C4orf6 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for C4orf6 gene: NM_005750.2 Unigene Cluster for C4orf6: Chromosome 4 open reading frame 6 Hs.177972 [show with all ESTs]Unigene Representative Sequence: NM_0057504 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000515342 ENST00000195455(uc003gii.3) ENST00000505296 ENST00000504943
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for C4orf6
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for C4orf6
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: C4orf6 (NM_005750) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for C4orf6 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C4orf6 |
Additional cDNA sequence: BC117444.1 BC117446.1 D82070.1 2 DOTS entries: DT.107738 DT.97805549 11 AceView cDNA sequences: NM_005750 AA281699 BX094519 BU743146 AA400119 D82070 AA400207 BM978917 BM930466 AI590573 AI914644
GeneLoc Exon Structure
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Expression
for C4orf6 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| C4orf6 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTGAAAAGAC
About this image
See C4orf6 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for C4orf6
SOURCE GeneReport for Unigene cluster: Hs.177972
UniProtKB/Swiss-Prot: CD006_HUMAN, Q99440Tissue specificity: Expressed in neuroblastoma
SABiosciences Custom PCR Arrays for C4orf6
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for C4orf6
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat C4orf6 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat C4orf6 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat C4orf6 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C4orf6 |
Orthologs
for C4orf6 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
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ENSEMBL Gene Tree for C4orf6 (if available)
TreeFam Gene Tree for C4orf6 (if available) |
Paralogs
for C4orf6 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for C4orf6 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
| | SABiosciences Cancer Mutation PCR Assays |
|
Disorders
/ Diseases
for C4orf6 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
C4orf6 for disorders About GeneDecksing
3  diseases for C4orf6: About MalaCardsneuroblastoma ellis-van creveld syndrome differentiating neuroblastoma
1 disease from the University of Copenhagen DISEASES database for C4orf6:Ellis-Van Creveld syndrome Export disorders for C4orf6 gene to outside databases
|
Publications
for C4orf6 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for C4orf6 gene integrated from 9 sources:
(articles sorted by number of sources associating them with C4orf6) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Fluorescent differential display analysis of gene expression in differentiating neuroblastoma cells. (PubMed id 9016955)1, 2, 3 Kito K.... Sakaki Y. (1997)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Long interspersed nuclear element-1 (LINE1)-mediated deletion of EVC, EVC2, C4orf6, and STK32B in Ellis-van Creveld syndrome with borderline intelligence. (PubMed id 18454448)1 Temtamy S.A....Ruiz-Perez V.L. (2008)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548)1 Bonaldo M.F.... Soares M.B. (1996)
- Adenylyl cyclase isoform-selective regulation of vascular smooth muscle proliferation and cytoskeletal reorganization. (PubMed id 16973907)9 Gros R....Feldman R.D. (2006)
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External Searches for C4orf6 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing C4orf6 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing C4orf6 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing C4orf6 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for C4orf6 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for C4orf6 gene:
Search GeneIP for patents involving C4orf6
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for C4orf6 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
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 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for C4orf6 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for C4orf6 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for C4orf6 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for C4orf6 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for C4orf6 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for C4orf6 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat C4orf6 | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing C4orf6 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C4orf6 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat C4orf6 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat C4orf6 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat C4orf6 |
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| | | | Search Tocris compounds for C4orf6 |
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 | | | C4orf6 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C4orf6 |
|  |  |  | | | | Search ThermoFisher Antibodies for C4orf6 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C4orf6 |
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