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Aliases for C4orf51 Gene

Aliases for C4orf51 Gene

  • Chromosome 4 Open Reading Frame 51 2 3 5

External Ids for C4orf51 Gene

Previous GeneCards Identifiers for C4orf51 Gene

  • GC04P146821
  • GC04P146601
  • GC04P142331

Summaries for C4orf51 Gene

GeneCards Summary for C4orf51 Gene

C4orf51 (Chromosome 4 Open Reading Frame 51) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C4orf51 Gene

Genomics for C4orf51 Gene

Regulatory Elements for C4orf51 Gene

Enhancers for C4orf51 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH04F145803 1.6 FANTOM5 Ensembl ENCODE 10.1 +126.8 126776 6.9 HDGF PKNOX1 FEZF1 GLIS2 ZNF207 FOS SP5 JUNB TBX21 KAT8 ENSG00000251687 C4orf51 ZNF827 ENSG00000279481 GC04M145759
GH04F145720 1 Ensembl ENCODE 11.1 +40.4 40367 0.9 RELA POLR2A EGR1 EED CREM EZH2 MTA2 NFIA BHLHE40 JUNB C4orf51 GC04M145759
GH04F145715 0.9 ENCODE 11.3 +36.4 36411 1.9 ZNF76 RAD21 ZSCAN9 ZNF48 RARA ZEB1 ZNF335 SLC30A9 GLIS2 ZNF366 C4orf51 GC04M145759
GH04F145703 0.8 Ensembl ENCODE 11.8 +24.5 24523 2.5 BRD4 CTBP1 POU5F1 DPF2 C4orf51 MMAA GC04M145759
GH04F145709 0.6 ENCODE 11.3 +29.9 29945 0.9 JUND RFX1 BHLHE40 MNT FOS NFE2L2 C4orf51 MMAA GC04M145759
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around C4orf51 on UCSC Golden Path with GeneCards custom track

Genomic Location for C4orf51 Gene

145,680,104 bp from pter
145,800,392 bp from pter
120,289 bases
Plus strand

Genomic View for C4orf51 Gene

Genes around C4orf51 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C4orf51 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C4orf51 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C4orf51 Gene

Proteins for C4orf51 Gene

  • Protein details for C4orf51 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Uncharacterized protein C4orf51
    Protein Accession:

    Protein attributes for C4orf51 Gene

    202 amino acids
    Molecular mass:
    23001 Da
    Quaternary structure:
    No Data Available

neXtProt entry for C4orf51 Gene

Post-translational modifications for C4orf51 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for C4orf51 Gene

Domains & Families for C4orf51 Gene

Protein Domains for C4orf51 Gene


Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C4orf51: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for C4orf51 Gene

Function for C4orf51 Gene

Phenotypes for C4orf51 Gene

GenomeRNAi human phenotypes for C4orf51:
genes like me logo Genes that share phenotypes with C4orf51: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for C4orf51 Gene

Localization for C4orf51 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C4orf51 gene
Compartment Confidence
extracellular 3
nucleus 2
cytosol 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for C4orf51 Gene

Pathways & Interactions for C4orf51 Gene

SuperPathways for C4orf51 Gene

No Data Available

Interacting Proteins for C4orf51 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000391404 for C4orf51 Gene via STRING

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for C4orf51 Gene


No data available for Pathways by source and SIGNOR curated interactions for C4orf51 Gene

Transcripts for C4orf51 Gene

mRNA/cDNA for C4orf51 Gene

(14) REFSEQ mRNAs :
(0) Additional mRNA sequences :
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for C4orf51 Gene

Chromosome 4 open reading frame 51:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for C4orf51 Gene

No ASD Table

Relevant External Links for C4orf51 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for C4orf51 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for C4orf51 Gene

mRNA differential expression in normal tissues according to GTEx for C4orf51 Gene

This gene is overexpressed in Testis (x50.7).

NURSA nuclear receptor signaling pathways regulating expression of C4orf51 Gene:


SOURCE GeneReport for Unigene cluster for C4orf51 Gene:

genes like me logo Genes that share expression patterns with C4orf51: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for C4orf51 Gene

Orthologs for C4orf51 Gene

This gene was present in the common ancestor of mammals.

Orthologs for C4orf51 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia C4H4orf51 34
  • 99.67 (n)
C4orf51 35
  • 99 (a)
(Bos Taurus)
Mammalia C17H4orf51 34
  • 76.67 (n)
(Mus musculus)
Mammalia 1700011L22Rik 34 16 35
  • 70.05 (n)
(Rattus norvegicus)
Mammalia LOC498933 34
  • 64.18 (n)
Species where no ortholog for C4orf51 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for C4orf51 Gene

Gene Tree for C4orf51 (if available)
Gene Tree for C4orf51 (if available)

Paralogs for C4orf51 Gene

No data available for Paralogs for C4orf51 Gene

Variants for C4orf51 Gene

Sequence variations from dbSNP and Humsavar for C4orf51 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs10002016 -- 145,701,965(+) catat(C/T)ccccc intron-variant
rs10002334 -- 145,702,282(+) accca(C/T)atact intron-variant
rs10003327 -- 145,718,622(+) AATGC(A/C)TAAAC intron-variant
rs10004089 -- 145,750,580(+) tcttt(C/G)acctt intron-variant
rs10006969 -- 145,716,345(+) cacac(A/G)tgctc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for C4orf51 Gene

Variant ID Type Subtype PubMed ID
nsv830105 CNV loss 17160897
nsv1143106 CNV tandem duplication 24896259
esv5587 CNV gain 19470904
esv3388375 OTHER inversion 20981092
esv3368860 OTHER inversion 20981092
esv3303041 CNV tandem duplication 20981092

Variation tolerance for C4orf51 Gene

Residual Variation Intolerance Score: 71.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.47; 64.25% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C4orf51 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C4orf51 Gene

Disorders for C4orf51 Gene

Relevant External Links for C4orf51

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for C4orf51 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C4orf51 Gene

Publications for C4orf51 Gene

  1. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 4 64

Products for C4orf51 Gene

Sources for C4orf51 Gene

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